Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B

Proceedings of the National Academy of Sciences of the United States of America

Volumn 116, Issue 36, 2019, Pages 18098-18108

  Flores, Alessandra ^a,b   Ramirez Franco, Jorge ^a,b   Desplantes, Richard ^a,b   Debreux, Kévin ^a,b   Ferracci, Géraldine ^b,c   Wernert, Florian ^a,b   Blanchard, Marie Pierre ^b,c   Maulet, Yves ^a,b   Youssouf, Fahamoe ^a,b   Sangiardi, Marion ^a,b   Iborra, Cécile ^a,b   Popoff, Michel Robert ^d   Seagar, Michael ^a,b   Fantini, Jacques ^a,b   Lévêque, Christian ^a,b   El Far, Oussama ^a,b  

^a Aix Marseille University   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c UMR CNRS 7051 Aix Marseille University   (France)

^d INSTITUT PASTEUR   (France)

Author keywords

Botulinum neurotoxin B receptor; Gangliosides; Synaptotagmin

Indexed keywords

BOTULINUM TOXIN B; CERAMIDE; GANGLIOSIDE GT 1B; OLIGOSACCHARIDE; SYNAPTOTAGMIN; TRYPTOPHAN; BOTULINUM TOXIN A; GANGLIOSIDE; SYNAPTOTAGMIN I; SYNAPTOTAGMIN II; SYT1 PROTEIN, RAT; SYT2 PROTEIN, RAT; TRISIALOGANGLIOSIDE GT1;

ADULT; ALPHA HELIX; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; ENZYME INHIBITION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; RAT; RECEPTOR AFFINITY; SPECTROFLUOROMETRY; SURFACE PLASMON RESONANCE; ANIMAL; BINDING SITE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN DOMAIN;

ANIMALS; BINDING SITES; BOTULINUM TOXINS, TYPE A; GANGLIOSIDES; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN DOMAINS; RATS; SYNAPTOTAGMIN I; SYNAPTOTAGMIN II;

EID: 85071788842     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1908051116     Document Type: Article

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