Toward the identification of ZDHHC enzymes required for palmitoylation of viral protein as potential drug targets

Expert Opinion on Drug Discovery

Volumn 15, Issue 2, 2020, Pages 159-177

  Gadalla, Mohamed Rasheed ^a,b   Veit, Michael ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Cairo University   (Egypt)

Author keywords

Acylation; acylprotein thioesterase; drug target; hemagglutinin; Influenza virus; M2; palmitoyl acyltransferase; protein palmitoylation; virus; ZDHHC

Indexed keywords

CELL PROTEIN; CYSTEINE; ENZYME; LIPID; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VIRAL PROTEIN; ZDHHC PROTEIN; ACYLTRANSFERASE; ANTIVIRUS AGENT; FATTY ACID;

ACYLATION; BINDING SITE; CHIKUNGUNYA VIRUS; CYTOMEGALOVIRUS; EBOLAVIRUS; ENZYME SPECIFICITY; ENZYME STABILITY; HENDRA VIRUS; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HEPATITIS E VIRUS; HERPES SIMPLEX VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; INFLUENZA VIRUS; MARBURGVIRUS; MEASLES VIRUS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NIPAH VIRUS; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN STRUCTURE; RABIES VIRUS; REGULATORY MECHANISM; REVIEW; SARS CORONAVIRUS; VIRUS INFECTION; VIRUS REPLICATION; ANIMAL; DRUG DEVELOPMENT; ENZYMOLOGY; HUMAN; LIPOYLATION; METABOLISM; PHYSIOLOGY; VIROLOGY;

ACYLATION; ACYLTRANSFERASES; ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; DRUG DEVELOPMENT; FATTY ACIDS; HUMANS; LIPOYLATION; VIRAL PROTEINS; VIRUS DISEASES;

EID: 85076416462     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1080/17460441.2020.1696306     Document Type: Review

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