Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 8, 2017, Pages E1365-E1374

  Greaves, Jennifer ^a   Munro, Kevin R ^a   Davidson, Stuart C ^a   Riviere, Matthieu ^a   Wojno, Justyna ^a   Smith, Terry K ^b   Tomkinson, Nicholas C O ^a   Chamberlain, Luke H ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Acyl CoA; Click chemistry; Palmitoylation; S acylation; zDHHC enzyme

Indexed keywords

ACYL COENZYME A; ACYLTRANSFERASE; ALKYNE; AZIDE; FATTY ACID; ISOLEUCINE; MEMBRANE PROTEIN; RECOMBINANT ENZYME; TRANSMEMBRANE DOMAIN 3; UNCLASSIFIED DRUG; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN 3; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN 7; ZINC FINGER PROTEIN;

ACYLATION; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LABELING; CELL TRANSFORMATION; CLICK CHEMISTRY; CONTROLLED STUDY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; FATTY ACID ANALYSIS; FATTY ACID METABOLISM; HEK293 CELL LINE; HUMAN; HUMAN CELL; MOLECULAR PROBE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROCESSING; ANIMAL; CELL LINE; ENZYME SPECIFICITY; METABOLISM; MOUSE; PHYSIOLOGY; PROCEDURES;

ACYL COENZYME A; ACYLATION; ACYLTRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CLICK CHEMISTRY; FATTY ACIDS; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MICE; SUBSTRATE SPECIFICITY; ZINC FINGERS;

EID: 85013276170     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1612254114     Document Type: Article

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