Scientific Opinion on the use of cobalt compounds as additives in animal nutrition

EFSA Journal

Volumn 7, Issue 12, 2009, Pages

[No Author Info available]

Author keywords

cobalt; cobalt compounds; compound of trace elements; Nutritional additive; safety; vitamin B12

Indexed keywords

EID: 85074993989     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2009.1383     Document Type: Article

References (191)

1. ATSDR. 2004. Agency For Toxic Substances And Disease Registry. Toxicological profile for cobalt. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
2. Ayala-Fierro F., Firriolo, J.M., Carter D.E. 1999. Disposition, toxicity, and intestinal absorption of cobaltous chloride in male Fischer 344 rats. J. Toxicol. Environ. Health, Part A, 56:571–591.
3. Barceloux D.G. 1999. Cobalt. J. Toxicol. Clin. Toxicol. 37:201–6.
4. Beyersmann D, Hartwig A. 2008. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms Arch Toxicol 82:493–512.
5. Biego G.H., Joyeux M., Hartmann P., Debry G. 1998. Daily intake of essential minerals and metallic micropollutants from foods in France. Sci. Total Environ. 217:27–36.
6. Blalock, T.L. 1985. Studies on the role of iron in the reversal of zinc, cadmium, vanadium, nickel, and cobalt toxicities in broiler pullets. PhD dissertation, North Carolina State University, Raleigh.
7. Chen, M., Wolin, M.J. 1981. Influence of heme and vitamin B12 on growth and fermentations of Bacteroides species. J. Bacteriol. 145, 466–471.
8. Cobalt Development Institute. 2006. Cobalt in food. www.thecdi.com.
9. Camean A, Lopez-Artiguez M, Roca I, et al. 1998. Determination of cobalt, manganese, and alcohol content in beers. J Food Prot 61(1):129–131.
10. Cornelis R., Sabbioni E., Van der Venne M.T. 1994. Trace element reference values in tissues from inhabitants of the European community. VII. Review of trace elements in blood, serum and urine of the Belgian population and critical evaluation of their possible use as reference values. Sci. Total Environ. 158, 191–226.
11. Dabeka R.W., McKenzie A.D. 1995. Survey of lead, cadmium, fluoride, nickel and cobalt in food composites and estimation of dietary intakes of these elements by Canadians in 1986–1988. J. AOAC Int 78(4): 897–909.
12. De Boeck M, Lardau S, Buchet JP, Kirsch-Volders M, Lison D. 2000. Absence of significant genotoxicity in lymphocytes and urine from workers exposed to moderate levels of cobalt-containing dust: a cross-sectional study. Environ Mol Mutagen. 36, 151–60.
13. De Boeck M., Lison D., Kirsch-Volders M. 1998. Evaluation of the in vitro direct and indirect genotoxic effects of cobalt compounds using the alkaline comet assay. Influence of interdonor and interexperimental variability. Carcinogenesis. 19: 2021–2029.
14. EVM. 2002. Review of cobalt. Expert Group on Vitamins and Minerals Secretariats. www.foodstandards.gov.uk.
15. Gál J, Hursthouse A, Tatner P, Stewart F, Welton R. 2008. Cobalt and secondary poisoning in the terrestrial food chain: data review and research gaps to support risk assessment. Environ Int. 34, 821–38.
16. Girard CL, Santschi DE, Stabler SP, Allen RH. 2009 Appararent ruminal synthesis and intestinal disappearance of vitamin B12 and its analogs in dairy cows. J Dairy Sci 92, 4524–29.
17. Girard, C.L., Lapierre, H., Desrochers, A., Benchaar, C., Matte, J.J., D. Rémond. 2001. Net flux of folates and vitamin B12 through the gastrointestinal tract and the liver of lactating dairy cows. Br. J. Nutr. 86, 707–715.
18. Henry, P.R., Little, R.C., Ammerman C.B. 1997. Bioavailability of cobalt sources for ruminants: 1. Effects of time and dietary cobalt concentration on tissue cobalt concentration. Nutr. Res. 17, 947–955.
19. Huck, D.W., Clawson, A.J. Excess dietary cobalt in pigs. 1976. J. Anim. Sci. 43, 1231–1246.
20. Jenkins DW. 1980. Biological monitoring of toxic trace metals: Volume 1. Biological monitoring and surveillance.
21. Jorhem L., Sundstrom B. 1993. Levels of lead, cadmium, zinc, copper, nickel, chromium, manganese, and cobalt in foods on the Swedish market, 1983–1990. J Food Comp Anal 6:223–241.
22. Jorhem L., Sundström B. 1998. Journal of Food Composition and Analysis, 6, 223–248.
23. IARC. 1991. Chlorinated drinking-water; chlorination by products; some other halogenated compounds; cobalt and cobalt compounds. World Health Organization. International Agency For Research On Cancer, Lyon, France. Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 52.
24. IARC. 2006. Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide. World Health Organization. International Agency For Research On Cancer, Lyon, France. Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 86.
25. Keegan G.M., Learmonth I.D., Case C.P. 2008. A systematic comparison of the actual, potential, and theoretical health effects of cobalt and chromium exposures from industry and surgical implants. Crit Rev Toxicol. 38, 645–74.
26. Kelly, R.J., Gruner, T.M., Furlong, J.M., Sykes A.R. 2006. Analysis of corrinoids in ovine tissues. Biomed. Chromatogr. 20, 806–814.
27. Kennedy DG, Kennedy S, Young PB. 1996. Effects of low concentrations of dietary cobalt on rumen succinate concentration in sheep. Int. J. Vitam. Nutr. Res. 66, 86–92.
28. Kennedy, D.G., Young, P.B., Blanchflower, W.J., Scott, J.M., Weir, D.G., Molloy, A.M., Kennedy, S. 1994. Cobalt-vitamin B12 deficiency causes lipid accumulation, lipid peroxidation and decreased alpha-tocopherol concentrations in the liver of sheep. Int. J. Vitam. Nutr. Res. 64, 270–276.
29. Kennedy, D.G., Young, P.B., Mc Caughey, W.J., Kennedy, S., Blanchflower, W.J. 1991. Rumen succinate production may ameliorate the effects of cobalt-vitamin-B12 deficiency on methylmalonyl CoA mutase in sheep. J. Nutr. 121, 1236–1242.
30. Kusaka Y., Ichikawa Y., Shirakawa T., Goto S. 1986. Effects of hard metal dust in ventilatory function. Brit. J. Ind. Med. 43: 486–489.
31. Leblanc J.C., Guérin T., Noël L., Calamassi-Tran G., Volatier J.L., Verger P. 2005 Dietary exposure estimates of 18 elements from the 1st French Total Diet Study, Food Additives & Contaminants: Part A, 22, 624–641*.
32. Lison D. Cobalt. 2007. In Nordberg G.F., Fowler B.A., Nordberg M., Friberg L.T. Hanbook of the Toxicology of Metals. 3rd Ed. Elsevier-Academic Press Amsterdam, pp.511–528.
33. Lison D., De Boeck M., Verougstraete V., Kirsch-Volders M. 2001. Update on the genotoxicity and carcinogenicity of cobalt compounds Occup. Environ. Med. 58, 619–625.
34. Lopez-Guisa, J.M., Satter, I.D. 1992. Effect of copper and cobalt addition on digestion and growth in heifers fed diets containing alfalfa silage on corn crop residues. J. Dairy Sci. 75, 247–256.
35. MAFF. 1997. 1994 total diet study: metals and other elements. London, United Kingdom Ministry of Agriculture, Food and Fish Series, Food Standards Agency (Food Surveillance Information Sheet N. 131).
36. McDowell, L.R. 1997. Nutrition of grazing ruminants in tropical climates. Third Edition, University of Florida, Gainesville, Florida.
37. McDowell, L.R. 2000. Vitamins in animal and human nutrition. 2nd edition. Wiley-Blackwell.
38. McDowell, L.R. 2003. Minerals in animal and human nutrition. 2nd edition. Elsevier Health Sciences.
39. Nemery B., Casier P., Roosels D., Lahaye D., Demedts M. 1992. Survey of cobalt exposure and respiratory health in diamonds polishers. AM. Rev. Respir. Dis. 145: 610–616.
40. NRC. 1980. Mineral tolerance of animals. National Academy of Sciences, Washington D.C.
41. NRC. 1989a. Nutrient requirements of dairy cattle. National Academy Press, Washington D.C. 6th Edition.
42. NRC. 1989b. Nutrient requirements of horses. Fifth revised edition. National Academies Press. Washington D.C.
43. NRC. 1993. Nutrient requirements of fish. National Academies Press. Washington D.C.
44. NRC. 1994. Nutrient requirements of poultry., Ninth Edition. National Academies Press. Washington D.C.
45. NRC. 1998. Nutrient requirements of swine. Tenth Edition. National Academies Press. Washington D.C.
46. NRC. 2000. Nutrient Requirements of Beef Cattle. Update 2000. National Academies Press. Washington D.C.
47. NRC. 2001. Nutrient requirements of dairy cattle. Seventh revised edition. National Academy Press, Washington D.C.
48. NRC. 2005. Mineral tolerance of animals. National Academy Press, Washington D.C.
49. NRC. 2006. Nutrient requirements of small ruminants: sheep, goats, cervids, and New World camelids. National Academies Press. Washington D.C.
50. Ouzouni P.K., Veltsistas P.G., Paleologos E.K., Riganakos K. A. 2007. Determination of metal content in wild edible mushroom species from regions of Greece. J. Food Composition and Analysis 20, 480–486.
51. Paterson, J.E., MacPherson, A. 1990. A comparison of serum vitamin B12 and serum methylmalonic acid as diagnostic measures of cobalt status in cattle. Vet. Record, 126, 329–332.
52. Shirakawa T, Kusaka Y, Fujimura N, Goto S, Morimoto K. 1988. The existence of specific antibodies to cobalt in hard metal asthma. Clin Allergy 18, 451–460.
53. Smith, R.M. 1987. Cobalt. In: W. Mertz (Ed)., Trace Elements in Human and Animal Nutrition, Vol. I, Academic Press, New York, 143–183.
54. Smith, R.M., Marston, H.R. 1970. Production, absorption, distribution, and excretion of vitamin B12 in sheep. Br. J. Nutr. 24, 857–877.
55. Squires M.W., Naber E.C. (1992): Vitamin profiles of eggs as indicators nutritional status in the hen: vitamin B12 study. Poultry Sci. 71, 2075–82.
56. Stangl, G.I., Schwarz F.J., Kirchgessner, M. 1998. Moderate long-term cobalt-deficiency affects liver, brain and erythrocyte lipids and lipoproteins of cattle. Nutr. Res. 19, 415–427.
57. Stangl, G.I., Schwarz, F.J., Jahn, B. and Kirchgessner, M. 2000. Cobalt-deficiency-induced hyperhomocysteinaemia and oxidative status of cattle. Br. J. Nutr. 83, 3–6.
58. Stemme, K., Lebzien, P., Flachowsky, G. and Scholz, H. 2008. The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B12 synthesis in the rumen of dairy cows. Arch. Anim. Nutr., 62, 207–218.
59. Stuckert J, Nedorost S. Low-cobalt diet for dyshidrotic eczema patients. 2008. Contact Dermatitis. 59, 361–5.
60. Strobel, H.J. 1992. Vitamin B12-dependent propionate production by the ruminal bacterium Prevotella ruminicola 23. Appl. Environ. Microbiol. 58, 2331–2333.
61. Underwood, E.J., Suttle, N.F. 1999. The Mineral Nutrition of Livestock, Third edition. CABI Publishing, Wallingford, United Kingdom.
62. WHO 2006. Cobalt and inorganic cobalt compounds. World Health Organisation. Concise International Chemical Assessment Document 69.
63. Yamagata N. Kurioka W. Shimitzu T. 1963. Balance of cobalt in Japanese people and diet. J. Radiation Research. 5, 4–8.
64. Zeleňák I., Jalč D, Plachá I., Sviatko P., Vendrák T., Siroka P., Gyulai F. 1992. The effect of copper and cobalt supplementation on the digestibility of fibrous feed in sheep. Vet Med (Prague), 37, 221–229.
65. ATSDR. 2004. Agency For Toxic Substances And Disease Registry. Toxicological profile for cobalt. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
66. Barceloux D.G. 1999. Cobalt. J Toxicol Clin Toxicol. 37:201–6.
67. Becker D.E., Smith S.E. 1951. The level of cobalt tolerance in yearling sheep. J. Anim Sci. 10, 266–271.
68. Beyersmann D, Hartwig A. 2008. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms Arch Toxicol 82:493–512.
69. Bucher J.R., Hailey J.R.,. Roycroft J.R, Haseman J.K., Sills R.C., Grumbein S.L., Mellick P.W., Chou B.J. 1999. Inhalation toxicity and carcinogenicity studies of cobalt sulfate. Toxicol. Sci. 49, 56–67.
70. Bucher J.R., Elwell M.R., Thompson M.B., Renne R., Ragan H.A. 1990. Inhalation toxicity studies of cobalt sulphate in F344'N rats and B6C3F1 mice. Fubdamental and Applied Toxicology 15, 357–372.
71. Cirla A M Cobalt-related asthma: clinical and immunological aspects. 1994. Sci Total Environ: 150, 85–94.
72. Corrier DE, Mollenhauer HH, Clark DE, Hare MF, Elissalde MH. 1985. Testicular degeneration and necrosis induced by dietary cobalt. Vet Pathol. 22, 610–6.
73. De Boeck M., Kirsch-Volders M., Lison D. 2003. Cobalt and antimony: genotoxicity and carcinogenicity. Mutat Res. 533, 135–52.
74. De Boeck M., Lardau S., Buchet J.P., Kirsch-Volders M., Lison D. 2000. Absence of significant genotoxicity in lymphocytes and urine from workers exposed to moderate levels of cobalt-containing dust: a cross-sectional study. Environ Mol Mutagen. 36, 151–60.
75. De Boeck M., Lison D., Kirsch-Volders M. 1998. Evaluation of the in vitro direct and indirect genotoxic effects of cobalt compounds using the alkaline comet assay. Influence of interdonor and interexperimental variability. Carcinogenesis. 19: 2021–2029.
76. Diaz GJ, Julian RJ, Squires EJ. 1994. Cobalt-induced polycythaemia causing right ventricular hypertrophy and ascites in meat-type chickens. Avian Pathol. 23: 91–104.
77. Elbirt KK, Bonkovsky HL. 1999. Heme oxygenase: recent advances in understanding its regulation and role. Proc Assoc Am Phys 111, 438–447.
78. Ely R.E., Dunn, K.M., * Huffman C.F. 1948. Cobalt toxicity in calves resulting from high oral administration J Anim Sci 7, 239–246.
79. Gál J, Hursthouse A, Tatner P, Stewart F, Welton R. 2008. Cobalt and secondary poisoning in the terrestrial food chain: data review and research gaps to support risk assessment. Environ Int. 34, 821–38.
80. Garner, LA. 2004. Contact dermatitis to metals. Dermatol Ther 17, 321–327.
81. Gonzales S, Polizio AH, Erario MA, Tomaro ML. 2005. Glutamine is highly effective in preventing in vivo cobalt-induced oxidative stress in rat liver. World J Gastroenterol. 21, 3533–8. PubMed PMID: 15962369.
82. Huck, D.W., Clawson, A.J. Excess dietary cobalt in pigs. 1976. J. Anim. Sci. 43, 1231–1246.
83. IARC. 2006. Cobalt in Hard Metals and Cobalt Sulfate, Gallium Arsenide, Indium Phosphide and Vanadium Pentoxide. World Health Organization. International Agency For Research On Cancer, Lyon, France. Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 86.
84. James J., Warin R.P. 1971 Sensitivity to cyanocobalamin and hydroxocobalamin. Br Med J. 2:262.
85. Kasprzak K.S., Zastawny T.H., North S.L., Riggs C.W., Diwan B.A., Rice J.M., Dizdaroglu M. 1994. Oxidative DNA base damage in renal, hepatic, and pulmonary chromatin of rats after intraperitoneal injection of cobalt(II) acetate. Chem. Res. Toxicol. 7, 329–335.
86. Keegan G.M., Learmonth I.D., Case C.P. 2008. A systematic comparison of the actual, potential, and theoretical health effects of cobalt and chromium exposures from industry and surgical implants. Crit Rev Toxicol. 38, 645–74.
87. Keener H.A., Percival, G.P., Morrow K.S., Ellis, G.H. 1949. Cobalt tolerance in young dairy cattle. J. Dairy Sci. 32, 527–533.
88. Kumar GP, Laloraya M, Laloraya MM. 1990. Powerful anti-sperm motility action of cobaltous ions and its recovery by a sulfhydryl compound. Contraception 41(6):633–639.
89. Lane LA, Rojas-Fernandez C. 2002. Treatment of vitamin B12-deficiency anemia: oral versus parenteral therapy. Ann Pharmacother. 36, 1268–72.
90. Lippi G, Franchini M, Guidi G.C. 2005. Cobalt chloride administration in athletes. A new perspective in blood doping? Br. J. Sports Med. 39:872–873.
91. Lison D. Cobalt. 2007. In Nordberg G.F., Fowler B.A., Nordberg M., Friberg L.T. Hanbook of the Toxicology of Metals. 3rd Ed. Elsevier-Academic Press Amsterdam, 511–528.
92. Lison D., De Boeck M, Verougstraete V, Kirsch-Volders M. 2001. Update on the genotoxicity and carcinogenicity of cobalt compounds Occup. Environ. Med. 58, 619–625.
93. Lloyd DR, Phillips DH, Carmichael PL. 1997. Generation of putative intrastrand cross-links and strand breaks in DNA by transition metal ion-mediated oxygen radical attack. Chem Res Toxicol 10:393–400.
94. McLaren, A.P., Johnston, W.G., Voss R.C. 1964 Cobalt poisoning in cattle. Vet. Rec 76, 1148.
95. Marr J.C.A., Hansen, J.A., Meyer, J.S., Cacela, D., Podrabsky, T., Lipton, J., Bergman, H.L. 1998. Toxicity of cobalt and copper to rainbow trout: application of a mechanistic model for predicting survival. Aquatic Toxicology, 43, 225–238.
96. Maxwell P, Salnikow K. HIF-1: an oxygen and metal responsive transcription factor. Cancer Biol Ther. 2004, 3, 29–35.
97. Méplan, C., Richard, M.J, Hainaut, P. 2000. Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells. Oncogene 19, 5227–5236.
98. Palit S., Ghosh A.K., Sharma A., Talukder G. 1991 (a). Modification of the clastogenic effects of cobalt by calcium in bone marrow cells of mice in vivo. Cytologia, 56:373–377.
99. Palit S., Sharma A., Talukder G. 1991 (b). Chromosomal aberrations induced by cobaltous chloride in mice in vivo. Biological Trace Element Research, 29:139–145.
100. Palit S., Sharma A., Talukder G. 1991 (c). Cytotoxic effects of cobalt chloride on mouse bone marrow cells in vivo. Cytobios, 65:85–89.
101. Palit S., Sharma A., Talukder G. 1991 (d). Protection by chlorophyllin against induction of chromosomal aberrations by cobalt in bone marrow cells of mice in vivo. Fitoterapia, 62(5):425–428.
102. Prescott E, Netterstrøm B, Faber J, Hegedüs L, Suadicani P, Christensen JM. Effect of occupational exposure to cobalt blue dyes on the thyroid volume and function of female plate painters. 1992. Scand J Work Environ Health 18: 101–4.
103. Roy PE, Bonenfant JT, Turcot L. 1968. Thyroid changes in cases of Quebec beer drinkers myocardosis. Am J Clin Pathol 50:234–239.
104. Schirrmacher UO. 1967. Case of cobalt poisoning. Br Med J. 1:544–5.
105. Shirakawa T, Kusaka Y, Fujimura N, Goto S, Morimoto K. 1988. The existence of specific antibodies to cobalt in hard metal asthma. Clin Allergy 18, 451–460.
106. Shirakawa T, Morimoto K. 1997. Interplay of cigarette smoking and occupational exposure on specific immunoglobulin E antibodies to cobalt. Arch Environ Health 52:124–8.
107. Southern LL, Baker DH.* 1981. The effect of methionine or cysteine on cobalt toxicity in the chick. Poult Sci. 60, 1303–8.
108. Steinhoff D, Mohr U. 1991 On the question of a carcinogenic action of cobalt-containing compounds. Exp Pathol 41:169–174.
109. Stuckert J, Nedorost S. Low-cobalt diet for dyshidrotic eczema patients. 2008. Contact Dermatitis. 59, 361–5.
110. Suzuki Y., Shimizu H., Nagae Y., Fukumoto M., Okonogi H., Kadokura M. 1993. Micronucleus test and erythropoiesis: Effect of cobalt on the induction of micronuclei by mutagens. Environmental and Molecular Mutagenesis 22:101–106.
111. Szakmáry E, Ungváry G, Hudák A, Tátrai E, Náray M, Morvai V. 2001. Effects of cobalt sulfate on prenatal development of mice, rats, and rabbits, and on early postnatal development of rats. J Toxicol Environ Health A. 62, 367–86.
112. Thierse H.J, Gamerdinger K, Junkes C, Guerreiro N, Weltzien H.U. 2005. T cell receptor (TCR) interaction with haptens: metal ions as non-classical haptens. Toxicology 209, 101–7.
113. Van Vleet JF, Rebar AH, Ferrans VJ. 1977. Acute cobalt and isoproterenol cardiotoxicity in swine: protection by selenium-vitamin E supplementation and potentiation by stress-susceptible phenotype. Am J Vet Res. 1977.
114. Washburn T.C. and Kaplan E. Cobalt therapy and goiter (1964) Clinical Pediatrics 3, 89–92.
115. Webb, M. 1964. Biological action of cobalt and other metals: Inhibition of alpha-oxo-glutarate dehydrogenase. Biochem. Biophys. Acta 89:431–436.
116. WHO 2006. Cobalt and inorganic cobalt compounds. Concise International Chemical Assessment Document 69. www.inchem.org/documents.
117. Ammerman, C.B. 1970. Recent developments in cobalt and copper in ruminant nutrition: A review. J. Dairy Sci. 53:1097–1107.
118. Andrews, E.D. 1956. Cobalt deficiency. N.Z. J. Agric., 92: 239–244.
119. Andrews, E.D., Hart, L.I. and Stephenson, B.J. 1960. N.Z.J. Sci. Technol., A35, 483.
120. Ayala-Fierro F., Firriolo, J.M. and Carter D.E. 1999. Disposition, toxicity, and intestinal absorption of cobaltous chloride in male Fischer 344 rats. J. Toxicol. Environ. Health, Part A, 56, 571–591.
121. Baker, D.H. and Czarnecki-Maulden, G.L. 1987. Pharmacologic role of cysteine in ameliorating or exacerbating mineral toxicities. 1987. J. Nutr. 117, 1003–1010.
122. Barnaby, C.F., Smith, T. and Thompson, B.D. 1968. Dosimetry of the radioisotopes of cobalt. Phys. Med. Biol. 13, 421–433.
123. Blalock, T.L. 1985. Studies on the role of iron in the reversal of zinc, cadmium, vanadium, nickel, and cobalt toxicities in broiler pullets. PhD dissertation, North Carolina State University, Raleigh.
124. CBN, 1976. The Nomenclature of Corrinoids. Pure and Appl. Chem. 48, 495–502.
125. Chen, M. and Wolin, M. J. 1981. Influence of heme and vitamin B12 on growth and fermentations of Bacteroides species. J. Bacteriol. 145, 466–471.
126. FAO/WHO, 2002. Human vitamin and mineral requirements. Report of a joint FAO/WHO expert consultation Bangkok, Thailand.
127. Girard, C. L., Lapierre, H., Desrochers, A., Benchaar, C., Matte, J. J. and D. Rémond. 2001. Net flux of folates and vitamin B12 through the gastrointestinal tract and the liver of lactating dairy cows. Br. J. Nutr. 86, 707–715.
128. Girard, C.L. and Matte, J.J. 2005. Effects of intramuscular injections of vitamin B12 on lactation performance of dairy cows fed dietary supplements of folic acid and rumen-protected methionine. J. Dairy Sci. 88, 671–676.
129. Girard, C.L., Santschi, D.E., Stabler, S.P. and Allen, R.H. 2009. Apparent ruminal synthesis and intestinal disappearance of vitamin B12 and its analogs in dairy cows. J. Dairy Sci., 92, 4524–4529.
130. Graham, T.W. 1991. Trace element deficiencies in cattle. Vet. Clin. N. Am.: Food Anim. Pract. 7, 153–215.
131. Graulet, B., Matte, J. J., Desrochers, A., Doepel, L., Palin, M. F. and Girard, C. L. 2007. Effects of dietary supplements of folic acid and vitamin B12 on metabolism of dairy cows in early lactation. J. Dairy Sci. 90, 3442–3455.
132. Henry, P.R., Little, R.C. and Ammerman C.B. 1997. Bioavailability of cobalt sources for ruminants: 1. Effects of time and dietary cobalt concentration on tissue cobalt concentration. Nutr. Res. 17, 947–955.
133. Hollins, J.G. and McCullough, R.S. 1971. Radiation dosimetry of internal contamination by inorganic compounds of cobalt: An analysis of cobalt metabolism in rats. Health Phys. 21, 233–246.
134. Huck, D.W. and Clawson, A.J. Excess dietary cobalt in pigs. 1976. J. Anim. Sci. 43, 1231–1246.
135. Hussein, H.S., Fahey, G.C., Wolf, B.W. and Berger, L.L., 1994. Effects of cobalt on in vitro fiber digestion of forages and by-products containing fiber. J. Dairy Sci. 77, 3432–3440.
136. Kawashima, T., Henry, P. R., Ammerman, C. B., Littell, R. C. and Price. J. 1997. Bioavailability of cobalt sources for ruminants. 2. Estimation of the relative value of reagent grade and feed grade cobalt sources from tissue cobalt accumulation and vitamin B12 concentrations. Nutr. Res. 17:957–974.
137. Kelly, R.J., Gruner, T.M., Furlong, J.M. and Sykes A.R. 2006. Analysis of corrinoids in ovine tissues. Biomed. Chromatogr. 20, 806–814.
138. Kennedy, D.G., Young, P.B., Mc Caughey, W.J., Kennedy, S. and Blanchflower, W.J. 1991. Rumen succinate production may ameliorate the effects of cobalt-vitamin-B12 deficiency on methylmalonyl CoA mutase in sheep. J. Nutr. 121, 1236–1242.
139. Kennedy, D.G., Blanchflower, W.J., Scott, J.M., Weir, D.G., Molloy, A.M., Kennedy, S. and Young PB. 1992. Cobalt-vitamin B-12 deficiency decreases methionine synthase activity and phospholipid methylation in sheep. J. Nutr. 122, 1384–1390.
140. Kennedy, D.G., Young, P.B., Blanchflower, W.J., Scott, J.M., Weir, D.G., Molloy, A.M. and Kennedy, S. 1994. Cobalt-vitamin B12 deficiency causes lipid accumulation, lipid peroxidation and decreased alpha-tocopherol concentrations in the liver of sheep. Int. J. Vitam. Nutr. Res. 64, 270–276.
141. Kennedy, D.G., Young, P.B., Kennedy, S., Scott, J.M., Molloy, A.M., Weir, D.G. and Price, J. 1995. Cobalt-Vitamin B12 deficiency and the activity of methylmalonyl CoA mutase and methionine synthase in cattle. Inter J. Vitamin Nutr. Res. 65, 241–247.
142. Kennedy DG, Kennedy S, Young PB. 1996. Effects of low concentrations of dietary cobalt on rumen succinate concentration in sheep. Int. J. Vitam. Nutr. Res. 66, 86–92.
143. Kincaid R.L. and. Socha M.T (2007): Effect of cobalt supplementation during late gestation and early lactation on milk and serum measures. J. Dairy Sci. 90, 1880–1886.
144. Kirchgessner, M., Reuber, S. and Kreuzer, M. 1994. Endogenous excretion and true absorption of cobalt as affected by the oral supply of cobalt. Biol. Trace Elem. Rese., 41, 175–189.
145. Kwong R.W. and Niyogi S. 2009. The interactions of iron with other divalent metals in the intestinal tract of a freshwater teleost, rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. C Toxicol. Pharmacol., 150, 442–449.
146. Looney, J.W., Gille, G., Preston, R.L., Graham, E.R., Pfander, W.H. 1976. Effects of plant species and cobalt intake upon cobalt utilization and ration digestibility by sheep. J. Anim. Sci. 42, 693–398.
147. Lopez-Guisa, J.M. and Satter, I. D. 1992. Effect of copper and cobalt addition on digestion and growth in heifers fed diets containing alfalfa silage ot corn crop residues. J. Dairy Sci. 75, 247–256.
148. McDowell, L. R. 1997. Nutrition of grazing ruminants in tropical climates. Third Edition, University of Florida, Gainesville, Florida.
149. McDowell, L. R. 2000. Vitamins in animal and human nutrition. 2nd edition. Wiley-Blackwell.
150. McDowell, L. R. 2003. Minerals in animal and human nutrition. Second edition. Elsevier Health Sciences.
151. Miller, J. K., N. Ramsey, and F. C. Madsen. 1988. The trace elements. The Ruminant Animal: Digestive Physiology and Nutrition. D. C. Church, ed. Prentice Hall, Englewood Cliffs, NJ.
152. Mills, C. F. 1981. Cobalt deficiency and cobalt requirements of ruminants. In: W. Haresign (ed.) Recent Advances in Animal Nutrition. pp 129–141. Butterworths, London.
153. Naylor, G.P.L. and Harrison J.D. 1995. Gastrointestinal iron and cobalt absorption and iron status in young rats and guinea pigs. Human Exp. Toxicol., 14, 949–954.
154. NRC 1989. Nutrient requirements of dairy cattle. Sixth Revised Edition. National Academy of Sciences, Washington D.C.
155. NRC 1993. Nutrient requirements of fish. National Academy of Sciences, Washington D.C.
156. NRC 1994. Nutrient requirements of poultry., Ninth Revised Edition. National Academy of Sciences, Washington D.C.
157. NRC 1998. Nutrient requirements of swine. Tenth Revised Edition. National Academy of Sciences, Washington D.C.
158. NRC 2000. Nutrient Requirements of Beef Cattle. Update 2000. National Academy of Sciences, Washington D.C.
159. NRC 2001. Nutrient Requirements of Dairy Cattle: Seventh Revised Edition, 2001. National Academy of Sciences, Washington D.C.
160. NRC 2005. Mineral tolerance of animals. National Academy of Sciences, Washington D.C.
161. NRC 2006. Nutrient Requirements of dogs and cats: Sixth Revised Edition. National Academy of Sciences, Washington D.C.
162. NRC 2007a. Nutrient Requirements of Horses: Sixth Revised Edition, 2007.
163. NRC 2007b. Nutrient Requirements of Small Ruminants: Sheep, Goats, Cervids, and New World Camelids. National Academy of Sciences, Washington D.C.
164. Paragon, B.M. 1993. Readjustment of the supply of cobalt in the ruminant: critical approach. Recueil de Medecine Veterinaire de l'Ecole d'Alfort 169, 759–761.
165. Paterson, J.E. and MacPherson, A. 1990. A comparison of serum vitamin B12 and serum methylmalonic acid as diagnostic measures of cobalt status in cattle. Vet. Record, 126, 329–332.
166. Quirk, M.F. and Norton, B.W. 1988. Detection of cobalt deficiency in lactating heifers and their calves. J. Agri. Sci. 110, 465–470.
167. Santschi, D. E., Berthiaume, R., Matte, J. J., Mustafa A. F. and Girard, C. L. 2005. Fate of supplementary B-vitamins in the gastrointestinal tract of dairy cows. J. Dairy Sci. 88, 2043–2054.
168. SCF (1993). Nutrient and energy intakes for the European Community. Reports of the Scientific Committee for Food, Thirty First Series. European Commission, Luxembourg.
169. Schwarz, F.J., Kirchgessner, M. and Stangl, G.I. 2000. Cobalt requirement of beef cattle-feed intake and growth at different levels of cobalt supply. J. Anim. Physiol. Anim. Nutr. 83, 121–131.
170. Singh, K.K. and Chhabra, A. 1995. Effect of dietary cobalt on ruminal vitamin B-12 synthesis and rumen metabolites. J. Nuclear Agri. Biol. 24, 112–116.
171. Smith, R.M. and Marston, H.R. 1970. Production, absorption, distribution, and excretion of vitamin B12 in sheep. Br. J. Nutr. 24, 857–877.
172. Smith, T., Edmonds, C.J. and Barnaby, C.F. 1972. Absorption and retention of cobalt in man by whole-body counting. Health Phys. 22, 359–367.
173. Smith, R.M. 1987. Cobalt. In: W. Mertz (Ed)., Trace Elements in Human and Animal Nutrition, Vol. I, Academic Press, New York, 143–183.
174. Schneider, Z. and Stroi$nski, A. 1987. Comprehensive B12 Chemistry, Biochemistry, Nutrition, Ecology, Medicine. Walter de Gruyter, Berlin, Germany.
175. Southern LL, Baker DH.* 1981. The effect of methionine or cysteine on cobalt toxicity in the chick. Poult Sci. 60, 1303–1308.
176. Stangl, G.I., Schwarz F.J. and Kirchgessner, M. 1998. Moderate long-term cobalt-deficiency affects liver, brain and erythrocyte lipids and lipoproteins of cattle. Nutr. Res. 19, 415–427.
177. Stangl, G. I., Schwarz, F. J. & Kirchgessner, M. (1999) Cobalt deficiency effects on trace elements, hormones and enzymes involved in energy metabolism of cattle. Int. J. Vit. Nutr. Res. 69: 120–126.
178. Stangl, G.I., Roth-Maier, D.A. and Kirchgessner, M. 2000a. Vitamin B-12 deficiency and hyperhomocysteinemia are partly ameliorated by cobalt and nickel supplementation in pigs. J. Nutr., 130, 3038–3044.
179. Stangl, G.I., Schwarz, F.J. Müller, H. and Kirchgessner, M. 2000b. Evaluation of the cobalt requirement of beef cattle based on vitamin B12, folate, homocysteine and methylmalonic acid. Br. J. Nutr., 2000, 84, 645–653.
180. Stangl, G.I., Schwarz, F.J., Jahn, B. and Kirchgessner, M. 2000c. Cobalt-deficiency-induced hyperhomocysteinaemia and oxidative status of cattle. Br. J. Nutr. 83, 3–6.
181. Stemme, K., Lebzien, P., Flachowsky, G. and Scholz, H. 2008. The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B12 synthesis in the rumen of dairy cows. Arch. Anim. Nutr., 62, 207–218.
182. Strobel, H.J. Vitamin B12-dependent propionate production by the ruminal bacterium Prevotella ruminicola 23. Appl. Environ. Microbiol. 1992, 58, 2331–2333.
183. Sutton, A. L. and Elliot, J. M. 1972. Effect of ratio of roughage to concentrate and level of feed intake on ovine ruminal vitamin B12 production. J. Nutr. 102, 1341–1346.
184. Thomson, A.B.R., Valberg, L.S., Sinclair, D.C. 1971 Competitive nature of the intestinal transport mechanism for cobalt and iron in the rat. J. Clin. Invest. 50, 2384–2394.
185. Tiffany, M.E., Fellner, V. and Spears, J.W. 2006. Influence of cobalt concentration on vitamin B12 production and fermentation of mixed ruminal microorganisms grown in continuous culture flow-through fermentors. J Anim Sci. 84, 635–640.
186. Tokarnia, C.H. and Döbereiner, J. 1978. In: J.H. Conrad and L.R. McDowell (eds), Proceedings Latin Symposium on Mineral Nutrition Research with Grazing Ruminants. J. H. Conrad and L. R. McDowell (eds). p. 163, University of Florida, Gainesville.
187. Underwood, E.J. 1977. Trace elements in human and animal nutrition. Academic Press, New York.
188. Underwood, E.J. 1981. The mineral nutrition of livestock. Second edition. Commonwealth Agricultural Bureaux, Slough, England.
189. Underwood, E.J. and Suttle, N.F. 1999. The Mineral Nutrition of Livestock, Third edition. CABI Publishing, Wallingford, United Kingdom.
190. Van Bruwaene, R., Gerber, G.B., Kirchman, R., Colard, J., Van Kerkom, J. 1984. Metabolism of 51Cr, 54Mn, 59Fe and 60Co in lactating dairy cows. Health Phys. 46, 1069–1082.
191. Zeleňák, I., Jalč, D, Plachá, I., Sviatko, P., Vendrák, T., Siroka, P. and Gyulai, F. 1992. The effect of copper and cobalt supplementation on the digestibility of fibrous feed in sheep. Vet Med (Prague), 37, 221–229.