Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology

Archives of Toxicology

Volumn 93, Issue 11, 2019, Pages 3229-3247

  Iskandar, Anita R ^a   Zanetti, Filippo ^a   Marescotti, Diego ^a   Titz, Bjorn ^a   Sewer, Alain ^a   Kondylis, Athanasios ^a   Leroy, Patrice ^a   Belcastro, Vincenzo ^a   Torres, Laura Ortega ^a   Acali, Stefano ^a   Majeed, Shoaib ^a   Steiner, Sandro ^a   Trivedi, Keyur ^a   Guedj, Emmanuel ^a   Merg, Celine ^a   Schneider, Thomas ^a   Frentzel, Stefan ^a   Martin, Florian ^a   Ivanov, Nikolai V ^a   Peitsch, Manuel C ^a   Hoeng, Julia ^a   more..

^a PHILIP MORRIS PRODUCTS S A   (Switzerland)

Author keywords

Airway epithelial; E cigarettes; High content screening; Systems toxicology; Transcriptomics

Indexed keywords

ALDH1A3 PROTEIN; ALDH3A1 PROTEIN; ALDO KETO REDUCTASE FAMILY 1 MEMBER B10; ALDO KETO REDUCTASE FAMILY 1 MEMBER C2; CIGARETTE SMOKE; CXCL1 CHEMOKINE; CYTOCHROME C; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GCLC PROTEIN; GCLM PROTEIN; GLUTATHIONE; HEME OXYGENASE 1; HISTONE H2AX; HUMECTANT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MESSENGER RNA; MICRORNA; NICOTINE; PINK1 PROTEIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN REDUCTASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TXN PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN A; ADENYLATE KINASE; PROTEOME; TRANSCRIPTOME;

AEROSOL; AIR LIQUID INTERFACE; AIRWAY EPITHELIUM CELL; ARTICLE; BIOLOGICAL ACTIVITY; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CHEEK CELL; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; EXPLORATORY RESEARCH; FLAVOR; HBEC CELL LINE (BRONCHIAL EPITHELIUM); HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID; NORMAL HUMAN; OXIDATIVE STRESS; PARTICULATE MATTER; PHYSICAL PARAMETERS; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; SYSTEMS TOXICOLOGY; TOBACCO; TOXIC CONCENTRATION; TOXICOLOGY; TRANSCRIPTOMICS; BRONCHUS; CELL LINE; CELL SURVIVAL; DRUG EFFECT; ELECTRONIC CIGARETTE; EPITHELIUM CELL; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; TOXICITY; TOXICITY TESTING;

ADENYLATE KINASE; AEROSOLS; BRONCHI; CELL LINE; CELL SURVIVAL; ELECTRONIC NICOTINE DELIVERY SYSTEMS; EPITHELIAL CELLS; HUMANS; MALE; MIDDLE AGED; PRIMARY CELL CULTURE; PROTEOME; TOBACCO PRODUCTS; TOXICITY TESTS; TRANSCRIPTOME;

EID: 85073976471     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-019-02565-9     Document Type: Article

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