-
1
-
-
0014718419
-
The thymus as an endocrine gland: properties of thymosin, a new thymus hormone
-
4394273
-
Goldstein AL, Asanuma Y, White A. The thymus as an endocrine gland: properties of thymosin, a new thymus hormone. Recent Prog Horm Res. (1970) 26:505–38. 10.1016/B978-0-12-571126-5.50016-94394273
-
(1970)
Recent Prog Horm Res
, vol.26
, pp. 505-538
-
-
Goldstein, A.L.1
Asanuma, Y.2
White, A.3
-
2
-
-
0017399007
-
The Gordon Wilson lecture. The history of the development of thymosin: chemistry, biology and clinical applications
-
331647
-
Goldstein AL. The Gordon Wilson lecture. The history of the development of thymosin: chemistry, biology and clinical applications. Trans Am Clin Climatol Assoc. (1977) 88:79–94. 331647
-
(1977)
Trans Am Clin Climatol Assoc
, vol.88
, pp. 79-94
-
-
Goldstein, A.L.1
-
3
-
-
35348960340
-
History of the discovery of the thymosins
-
17600284
-
Goldstein AL. History of the discovery of the thymosins. Ann N Y Acad Sci. (2007) 1112:1–13. 10.1196/annals.1415.04517600284
-
(2007)
Ann N Y Acad Sci
, vol.1112
, pp. 1-13
-
-
Goldstein, A.L.1
-
4
-
-
0013945220
-
Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin)
-
5230175
-
Goldstein AL, Slater FD, White A. Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin). Proc Natl Acad Sci USA. (1966) 56:1010–7. 10.1073/pnas.56.3.10105230175
-
(1966)
Proc Natl Acad Sci USA
, vol.56
, pp. 1010-1017
-
-
Goldstein, A.L.1
Slater, F.D.2
White, A.3
-
5
-
-
0014751029
-
Reduction in the incidence of wasting disease in neonatally thymectomized CBA-W mice by the injection of thymosin
-
4391388
-
Asanuma Y, Goldstein AL, White A. Reduction in the incidence of wasting disease in neonatally thymectomized CBA-W mice by the injection of thymosin. Endocrinology. (1970) 86:600–10. 10.1210/endo-86-3-6004391388
-
(1970)
Endocrinology
, vol.86
, pp. 600-610
-
-
Asanuma, Y.1
Goldstein, A.L.2
White, A.3
-
6
-
-
0014433251
-
Influence of thymosin on immunological competence of lymphoid cells from thymectomized mice
-
5678029
-
Law LW, Goldstein AL, White A. Influence of thymosin on immunological competence of lymphoid cells from thymectomized mice. Nature. (1968) 219:1391–2. 10.1038/2191391a05678029
-
(1968)
Nature
, vol.219
, pp. 1391-1392
-
-
Law, L.W.1
Goldstein, A.L.2
White, A.3
-
7
-
-
0014734022
-
Influence of thymosin on cell-mediated and humoral immune responses in normal and in immunologically deficient mice
-
4904881
-
Goldstein AL, Asanuma Y, Battisto JR, Hardy MA, Quint J, White A. Influence of thymosin on cell-mediated and humoral immune responses in normal and in immunologically deficient mice. J Immunol. (1970) 104:359–66. 4904881
-
(1970)
J Immunol
, vol.104
, pp. 359-366
-
-
Goldstein, A.L.1
Asanuma, Y.2
Battisto, J.R.3
Hardy, M.A.4
Quint, J.5
White, A.6
-
8
-
-
0016592376
-
Purification and properties of bovine thymosin
-
236717
-
Hooper JA, McDaniel MC, Thurman GB, Cohen GH, Schulof RS, Goldstein AL. Purification and properties of bovine thymosin. Ann N Y Acad Sci. (1975) 249:125–44. 10.1111/j.1749-6632.1975.tb29063.x236717
-
(1975)
Ann N Y Acad Sci
, vol.249
, pp. 125-144
-
-
Hooper, J.A.1
McDaniel, M.C.2
Thurman, G.B.3
Cohen, G.H.4
Schulof, R.S.5
Goldstein, A.L.6
-
9
-
-
0017334767
-
Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide
-
265536
-
Goldstein AL, Low TL, McAdoo M, McClure J, Thurman GB, Rossio J. Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. Proc Natl Acad Sci USA. (1977) 74:725–9. 10.1073/pnas.74.2.725265536
-
(1977)
Proc Natl Acad Sci USA
, vol.74
, pp. 725-729
-
-
Goldstein, A.L.1
Low, T.L.2
McAdoo, M.3
McClure, J.4
Thurman, G.B.5
Rossio, J.6
-
10
-
-
0022382799
-
Thymic peptide hormones: basic properties and clinical applications in cancer
-
3902261
-
Schulof RS. Thymic peptide hormones: basic properties and clinical applications in cancer. Crit Rev Oncol Hematol. (1985) 3:309–76. 10.1016/S1040-8428(85)80035-43902261
-
(1985)
Crit Rev Oncol Hematol
, vol.3
, pp. 309-376
-
-
Schulof, R.S.1
-
11
-
-
84909676456
-
Thymosin alpha1: First clinical trial and comparison with thymosin fraction 5
-
Serrou B., Rosenfeld C., Daniels J.C., Saunders J.P., (eds), Amsterdam, Elsevier Biomedical Press, In:, editors., :, p
-
Baskies AM, Ommaya AK, Chretien PB. Thymosin alpha1: First clinical trial and comparison with thymosin fraction 5. In: Serrou B, Rosenfeld C, Daniels JC, Saunders JP, editors. Current Concepts in Human Immunology and Cancer Immunomodulation. Amsterdam: Elsevier Biomedical Press (1982). p. 567–74.
-
(1982)
Current Concepts in Human Immunology and Cancer Immunomodulation
, pp. 567-574
-
-
Baskies, A.M.1
Ommaya, A.K.2
Chretien, P.B.3
-
12
-
-
0021618296
-
The thymosins–preclinical and clinical studies with fraction V and alpha-I
-
6234058
-
Smalley RV, Talmadge J, Oldham RK, Thurman GB. The thymosins–preclinical and clinical studies with fraction V and alpha-I. Cancer Treat Rev. (1984) 11:69–84. 10.1016/0305-7372(84)90017-36234058
-
(1984)
Cancer Treat Rev
, vol.11
, pp. 69-84
-
-
Smalley, R.V.1
Talmadge, J.2
Oldham, R.K.3
Thurman, G.B.4
-
13
-
-
0020569862
-
Protective activity of thymosin against opportunistic infections in animal models
-
6404549
-
Ishitsuka H, Umeda Y, Nakamura J, Yagi Y. Protective activity of thymosin against opportunistic infections in animal models. Cancer Immunol Immunother. (1983) 14:145–50. 10.1007/BF002053526404549
-
(1983)
Cancer Immunol Immunother
, vol.14
, pp. 145-150
-
-
Ishitsuka, H.1
Umeda, Y.2
Nakamura, J.3
Yagi, Y.4
-
14
-
-
0020510787
-
Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays
-
Umeda Y, Sakamoto A, Nakamura J, Ishitsuka H, Yagi Y. Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays. Cancer Immunol Immunother. (1983) 15:78–83. 10.1007/BF00199694
-
(1983)
Cancer Immunol Immunother
, vol.15
, pp. 78-83
-
-
Umeda, Y.1
Sakamoto, A.2
Nakamura, J.3
Ishitsuka, H.4
Yagi, Y.5
-
15
-
-
0020986329
-
Protective activity of thymosin alpha 1 against tumor progression in immunosuppressed mice
-
6650286
-
Ishitsuka H, Umeda Y, Sakamoto A, Yagi Y. Protective activity of thymosin alpha 1 against tumor progression in immunosuppressed mice. Adv Exp Med Biol. (1983) 166:89–100. 10.1007/978-1-4757-1410-4_96650286
-
(1983)
Adv Exp Med Biol
, vol.166
, pp. 89-100
-
-
Ishitsuka, H.1
Umeda, Y.2
Sakamoto, A.3
Yagi, Y.4
-
16
-
-
0022218775
-
Modulation of natural killer activity by thymosin alpha 1 and interferon
-
3851698
-
Favalli C, Jezzi T, Mastino A, Rinaldi-Garaci C, Riccardi C, Garaci E. Modulation of natural killer activity by thymosin alpha 1 and interferon. Cancer Immunol Immunother. (1985) 20:189–92. 10.1007/BF002055743851698
-
(1985)
Cancer Immunol Immunother
, vol.20
, pp. 189-192
-
-
Favalli, C.1
Jezzi, T.2
Mastino, A.3
Rinaldi-Garaci, C.4
Riccardi, C.5
Garaci, E.6
-
17
-
-
33645456896
-
Combined treatment with thymosin alpha 1 and interferon enhances NK activity in immunosuppressed tumor bearing mice
-
16312818
-
Pica F, Mastino A, Grelli S, Jezzi T, Favalli C. Combined treatment with thymosin alpha 1 and interferon enhances NK activity in immunosuppressed tumor bearing mice. J Chemother. (1989) 1(4 Suppl.):1167–9. 16312818
-
(1989)
J Chemother
, vol.1
, pp. 1167-1169
-
-
Pica, F.1
Mastino, A.2
Grelli, S.3
Jezzi, T.4
Favalli, C.5
-
18
-
-
0024454795
-
Synergistic effect of thymosin alpha 1 and alpha beta-interferon on NK activity in tumor-bearing mice
-
2807622
-
Favalli C, Mastino A, Jezzi T, Grelli S, Goldstein AL, Garaci E. Synergistic effect of thymosin alpha 1 and alpha beta-interferon on NK activity in tumor-bearing mice. Int J Immunopharmacol. (1989) 11:443–50. 10.1016/0192-0561(89)90172-02807622
-
(1989)
Int J Immunopharmacol
, vol.11
, pp. 443-450
-
-
Favalli, C.1
Mastino, A.2
Jezzi, T.3
Grelli, S.4
Goldstein, A.L.5
Garaci, E.6
-
19
-
-
0024502419
-
Enhanced immune response and antitumor immunity with combinations of biological response modifiers
-
2481523
-
Garaci E, Mastino A, Favalli C. Enhanced immune response and antitumor immunity with combinations of biological response modifiers. Bull N Y Acad Med. (1989) 65:111–9. 2481523
-
(1989)
Bull N Y Acad Med
, vol.65
, pp. 111-119
-
-
Garaci, E.1
Mastino, A.2
Favalli, C.3
-
20
-
-
0031762984
-
High doses of thymosin alpha 1 enhance the anti-tumor efficacy of combination chemo-immunotherapy for murine B16 melanoma
-
9858941
-
Pica F, Fraschetti M, Matteucci C, Tuthill C, Rasi G. High doses of thymosin alpha 1 enhance the anti-tumor efficacy of combination chemo-immunotherapy for murine B16 melanoma. Anticancer Res. (1998) 18:3571–8. 9858941
-
(1998)
Anticancer Res
, vol.18
, pp. 3571-3578
-
-
Pica, F.1
Fraschetti, M.2
Matteucci, C.3
Tuthill, C.4
Rasi, G.5
-
21
-
-
0026092975
-
Thymosin alpha 1 potentiates interleukin 2-induced cytotoxic activity in mice
-
1991327
-
Mastino A, Favalli C, Grelli S, Innocenti F, Garaci E. Thymosin alpha 1 potentiates interleukin 2-induced cytotoxic activity in mice. Cell Immunol. (1991) 133:196–205. 10.1016/0008-8749(91)90191-D1991327
-
(1991)
Cell Immunol
, vol.133
, pp. 196-205
-
-
Mastino, A.1
Favalli, C.2
Grelli, S.3
Innocenti, F.4
Garaci, E.5
-
22
-
-
0024453551
-
Characterization of the immunoregulatory properties of thymosin alpha 1 on interleukin-2 production and interleukin-2 receptor expression in normal human lymphocytes
-
2599716
-
Sztein MB, Serrate SA. Characterization of the immunoregulatory properties of thymosin alpha 1 on interleukin-2 production and interleukin-2 receptor expression in normal human lymphocytes. Int J Immunopharmacol. (1989) 11:789–800. 10.1016/0192-0561(89)90133-12599716
-
(1989)
Int J Immunopharmacol
, vol.11
, pp. 789-800
-
-
Sztein, M.B.1
Serrate, S.A.2
-
23
-
-
0025019511
-
Thymosin alpha 1 modulates the expression of high affinity interleukin-2 receptors on normal human lymphocytes
-
2303316
-
Leichtling KD, Serrate SA, Sztein MB. Thymosin alpha 1 modulates the expression of high affinity interleukin-2 receptors on normal human lymphocytes. Int J Immunopharmacol. (1990) 12:19–29. 10.1016/0192-0561(90)90064-T2303316
-
(1990)
Int J Immunopharmacol
, vol.12
, pp. 19-29
-
-
Leichtling, K.D.1
Serrate, S.A.2
Sztein, M.B.3
-
24
-
-
0026586234
-
Combination therapy with thymosin alpha 1 potentiates the anti-tumor activity of interleukin-2 with cyclophosphamide in the treatment of the Lewis lung carcinoma in mice
-
1735618
-
Mastino A, Favalli C, Grelli S, Rasi G, Pica F, Goldstein AL. Combination therapy with thymosin alpha 1 potentiates the anti-tumor activity of interleukin-2 with cyclophosphamide in the treatment of the Lewis lung carcinoma in mice. Int J Cancer. (1992) 50:493–9. 10.1002/ijc.29105003271735618
-
(1992)
Int J Cancer
, vol.50
, pp. 493-499
-
-
Mastino, A.1
Favalli, C.2
Grelli, S.3
Rasi, G.4
Pica, F.5
Goldstein, A.L.6
-
25
-
-
0028168087
-
Biochemotherapy with thymosin alpha 1, interleukin-2 and dacarbazine in patients with metastatic melanoma: clinical and immunological effects
-
7826907
-
Lopez M, Carpano S, Cavaliere R, Di Lauro L, Ameglio F, Vitelli G. Biochemotherapy with thymosin alpha 1, interleukin-2 and dacarbazine in patients with metastatic melanoma: clinical and immunological effects. Ann Oncol. (1994) 5:741–6. 10.1093/oxfordjournals.annonc.a0589797826907
-
(1994)
Ann Oncol
, vol.5
, pp. 741-746
-
-
Lopez, M.1
Carpano, S.2
Cavaliere, R.3
Di Lauro, L.4
Ameglio, F.5
Vitelli, G.6
-
26
-
-
0006724544
-
Combined treatment with thymosin-alpha1 and low dose interferon-alpha after dacarbazine in advanced melanoma
-
10803720
-
Rasi G, Terzoli E, Izzo F, Pierimarchi P, Ranuzzi M, Sinibaldi-Vallebona P. Combined treatment with thymosin-alpha1 and low dose interferon-alpha after dacarbazine in advanced melanoma. Melanoma Res. (2000) 10:189–92. 10.1097/00008390-200010020-0001210803720
-
(2000)
Melanoma Res
, vol.10
, pp. 189-192
-
-
Rasi, G.1
Terzoli, E.2
Izzo, F.3
Pierimarchi, P.4
Ranuzzi, M.5
Sinibaldi-Vallebona, P.6
-
27
-
-
77950469665
-
Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma
-
Maio M, Mackiewicz A, Testori A, Trefzer U, Ferraresi V, Jassem J. Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma. J Clin Oncol. (2010) 28:1780–7. 10.1200/JCO.2009.25.5208
-
(2010)
J Clin Oncol
, vol.28
, pp. 1780-1787
-
-
Maio, M.1
Mackiewicz, A.2
Testori, A.3
Trefzer, U.4
Ferraresi, V.5
Jassem, J.6
-
28
-
-
84867370942
-
Thymosin alpha1 in melanoma: from the clinical trial setting to the daily practice and beyond
-
23050811
-
Danielli R, Fonsatti E, Calabro L, Di Giacomo AM, Maio M. Thymosin alpha1 in melanoma: from the clinical trial setting to the daily practice and beyond. Ann N Y Acad Sci. (2012) 1270:8–12. 10.1111/j.1749-6632.2012.06757.x23050811
-
(2012)
Ann N Y Acad Sci
, vol.1270
, pp. 8-12
-
-
Danielli, R.1
Fonsatti, E.2
Calabro, L.3
Di Giacomo, A.M.4
Maio, M.5
-
29
-
-
85051060309
-
Long-term follow up of metastatic melanoma patients treated with Thymosin alpha-1: investigating immune checkpoints synergy
-
30063847
-
Danielli R, Cisternino F, Giannarelli D, Calabro L, Camerini R, Savelli V. Long-term follow up of metastatic melanoma patients treated with Thymosin alpha-1: investigating immune checkpoints synergy. Expert Opin Biol Ther. (2018) 18(Suppl. 1):77–83. 10.1080/14712598.2018.149471730063847
-
(2018)
Expert Opin Biol Ther
, vol.18
, pp. 77-83
-
-
Danielli, R.1
Cisternino, F.2
Giannarelli, D.3
Calabro, L.4
Camerini, R.5
Savelli, V.6
-
30
-
-
84957789652
-
Evaluation of thymosin alpha 1 in nonclinical models of the immune-suppressing indications melanoma and sepsis
-
25643200
-
King RS, Tuthill C. Evaluation of thymosin alpha 1 in nonclinical models of the immune-suppressing indications melanoma and sepsis. Expert Opin Biol Ther. (2015) 15(Suppl. 1):S41–9. 10.1517/14712598.2015.100844625643200
-
(2015)
Expert Opin Biol Ther
, vol.15
, pp. S41-S49
-
-
King, R.S.1
Tuthill, C.2
-
31
-
-
79960136040
-
Expression, purification and characterization of a novel soluble human thymosin alpha1 concatemer exhibited a stronger stimulation on mice lymphocytes proliferation and higher anti-tumor activity
-
21647330
-
Li W, Song L, Wu S, Xue X, Zhang L, He L. Expression, purification and characterization of a novel soluble human thymosin alpha1 concatemer exhibited a stronger stimulation on mice lymphocytes proliferation and higher anti-tumor activity. Int J Biol Sci. (2011) 7:618–28. 10.7150/ijbs.7.61821647330
-
(2011)
Int J Biol Sci
, vol.7
, pp. 618-628
-
-
Li, W.1
Song, L.2
Wu, S.3
Xue, X.4
Zhang, L.5
He, L.6
-
32
-
-
84880507567
-
The in vivo immunomodulatory and synergistic anti-tumor activity of thymosin alpha1-thymopentin fusion peptide and its binding to TLR2
-
23684552
-
Li J, Cheng Y, Zhang X, Zheng L, Han Z, Li P. The in vivo immunomodulatory and synergistic anti-tumor activity of thymosin alpha1-thymopentin fusion peptide and its binding to TLR2. Cancer Lett. (2013) 337:237–47. 10.1016/j.canlet.2013.05.00623684552
-
(2013)
Cancer Lett
, vol.337
, pp. 237-247
-
-
Li, J.1
Cheng, Y.2
Zhang, X.3
Zheng, L.4
Han, Z.5
Li, P.6
-
33
-
-
85051555472
-
Effect of a C-end rule modification on antitumor activity of thymosin alpha1
-
30096371
-
Wang F, Xu C, Peng R, Li B, Shen X, Zheng H. Effect of a C-end rule modification on antitumor activity of thymosin alpha1. Biochimie. (2018) 154:99–106. 10.1016/j.biochi.2018.08.00130096371
-
(2018)
Biochimie
, vol.154
, pp. 99-106
-
-
Wang, F.1
Xu, C.2
Peng, R.3
Li, B.4
Shen, X.5
Zheng, H.6
-
34
-
-
85048703607
-
Immunomodulatory and enhanced antitumor activity of a modified thymosin alpha1 in melanoma and lung cancer
-
29933059
-
Wang F, Li B, Fu P, Li Q, Zheng H, Lao X. Immunomodulatory and enhanced antitumor activity of a modified thymosin alpha1 in melanoma and lung cancer. Int J Pharm. (2018) 547:611–20. 10.1016/j.ijpharm.2018.06.04129933059
-
(2018)
Int J Pharm
, vol.547
, pp. 611-620
-
-
Wang, F.1
Li, B.2
Fu, P.3
Li, Q.4
Zheng, H.5
Lao, X.6
-
35
-
-
85051714656
-
Thymosin alpha1-Fc modulates the immune system and down-regulates the progression of melanoma and breast cancer with a prolonged half-life
-
30120362
-
Wang F, Yu T, Zheng H, Lao X. Thymosin alpha1-Fc modulates the immune system and down-regulates the progression of melanoma and breast cancer with a prolonged half-life. Sci Rep. (2018) 8:12351. 10.1038/s41598-018-30956-y30120362
-
(2018)
Sci Rep
, vol.8
, pp. 12351
-
-
Wang, F.1
Yu, T.2
Zheng, H.3
Lao, X.4
-
36
-
-
77955466663
-
Hepatocellular carcinoma: a global view
-
20628345
-
Yang JD, Roberts LR. Hepatocellular carcinoma: a global view. Nat Rev Gastroenterol Hepatol. (2010) 7:448–58. 10.1038/nrgastro.2010.10020628345
-
(2010)
Nat Rev Gastroenterol Hepatol
, vol.7
, pp. 448-458
-
-
Yang, J.D.1
Roberts, L.R.2
-
37
-
-
0018760127
-
In vitro thymosin effect on T lymphocytes in alcoholic liver disease
-
313287
-
Mutchnick MG, Goldstein AL. In vitro thymosin effect on T lymphocytes in alcoholic liver disease. Clin Immunol Immunopathol. (1979) 12:271–80. 10.1016/0090-1229(79)90030-8313287
-
(1979)
Clin Immunol Immunopathol
, vol.12
, pp. 271-280
-
-
Mutchnick, M.G.1
Goldstein, A.L.2
-
38
-
-
0018854508
-
Lymphocyte cytotoxicity in human liver disease using rat hepatocyte monolayer cultures
-
7408232
-
Mutchnick MG, Missirian A, Johnson AG. Lymphocyte cytotoxicity in human liver disease using rat hepatocyte monolayer cultures. Clin Immunol Immunopathol. (1980) 16:423–37. 10.1016/0090-1229(80)90184-17408232
-
(1980)
Clin Immunol Immunopathol
, vol.16
, pp. 423-437
-
-
Mutchnick, M.G.1
Missirian, A.2
Johnson, A.G.3
-
39
-
-
0020574851
-
Increased thymic hormone responsive suppressor T lymphocyte function in chronic active hepatitis
-
6219866
-
Mutchnick MG, Schaffner JA, Prieto JA, Weller FE, Goldstein AL. Increased thymic hormone responsive suppressor T lymphocyte function in chronic active hepatitis. Dig Dis Sci. (1983) 28:328–34. 10.1007/BF013249496219866
-
(1983)
Dig Dis Sci
, vol.28
, pp. 328-334
-
-
Mutchnick, M.G.1
Schaffner, J.A.2
Prieto, J.A.3
Weller, F.E.4
Goldstein, A.L.5
-
40
-
-
0026042722
-
Thymosin treatment of chronic hepatitis B: a placebo-controlled pilot trial
-
1874487
-
Mutchnick MG, Appelman HD, Chung HT, Aragona E, Gupta TP, Cummings GD. Thymosin treatment of chronic hepatitis B: a placebo-controlled pilot trial. Hepatology. (1991) 14:409–15. 10.1002/hep.18401403021874487
-
(1991)
Hepatology
, vol.14
, pp. 409-415
-
-
Mutchnick, M.G.1
Appelman, H.D.2
Chung, H.T.3
Aragona, E.4
Gupta, T.P.5
Cummings, G.D.6
-
41
-
-
0026042728
-
Treatment of chronic hepatitis B
-
Davis GL. Treatment of chronic hepatitis B. Hepatology. (1991) 14:567–9. 10.1016/0270-9139(91)90199-6
-
(1991)
Hepatology
, vol.14
, pp. 567-569
-
-
Davis, G.L.1
-
42
-
-
0002718823
-
Thymosin a1 versus a2 interferon treatment of HBsAg, HBeAb, HBV-DNA positive chronic active hepatitis
-
Rezakovic I, Mondazzi L, Asti L, Ideo G. Thymosin a1 versus a2 interferon treatment of HBsAg, HBeAb, HBV-DNA positive chronic active hepatitis. Hepatology. (1992) 16:67A.
-
(1992)
Hepatology
, vol.16
, pp. 67A
-
-
Rezakovic, I.1
Mondazzi, L.2
Asti, L.3
Ideo, G.4
-
43
-
-
10144241676
-
A randomized controlled trial of thymosin-alpha1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody–and hepatitis B virus DNA–positive chronic hepatitis B
-
8855175
-
Andreone P, Cursaro C, Gramenzi A, Zavagliz C, Rezakovic I, Altomare E. A randomized controlled trial of thymosin-alpha1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody–and hepatitis B virus DNA–positive chronic hepatitis B. Hepatology. (1996) 24:774–7. 10.1053/jhep.1996.v24.pm00088551758855175
-
(1996)
Hepatology
, vol.24
, pp. 774-777
-
-
Andreone, P.1
Cursaro, C.2
Gramenzi, A.3
Zavagliz, C.4
Rezakovic, I.5
Altomare, E.6
-
44
-
-
0031596591
-
Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial
-
9581695
-
Chien RN, Liaw YF, Chen TC, Yeh CT, Sheen IS. Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial. Hepatology. (1998) 27:1383–7. 10.1002/hep.5102705279581695
-
(1998)
Hepatology
, vol.27
, pp. 1383-1387
-
-
Chien, R.N.1
Liaw, Y.F.2
Chen, T.C.3
Yeh, C.T.4
Sheen, I.S.5
-
45
-
-
0028305082
-
Prospectives on the treatment of chronic hepatitis B and chronic hepatitis C with thymic peptides and antiviral agents
-
7526795
-
Mutchnick MG, Ehrinpreis MN, Kinzie JL, Peleman RR. Prospectives on the treatment of chronic hepatitis B and chronic hepatitis C with thymic peptides and antiviral agents. Antiviral Res. (1994) 24:245–57. 10.1016/0166-3542(94)90071-X7526795
-
(1994)
Antiviral Res
, vol.24
, pp. 245-257
-
-
Mutchnick, M.G.1
Ehrinpreis, M.N.2
Kinzie, J.L.3
Peleman, R.R.4
-
46
-
-
0032585756
-
Thymosin alpha1 treatment of chronic hepatitis B: results of a phase III multicentre, randomized, double-blind and placebo-controlled study
-
10607256
-
Mutchnick MG, Lindsay KL, Schiff ER, Cummings GD, Appelman HD, Peleman RR. Thymosin alpha1 treatment of chronic hepatitis B: results of a phase III multicentre, randomized, double-blind and placebo-controlled study. J Viral Hepat. (1999) 6:397–403. 10.1046/j.1365-2893.1999.00181.x10607256
-
(1999)
J Viral Hepat
, vol.6
, pp. 397-403
-
-
Mutchnick, M.G.1
Lindsay, K.L.2
Schiff, E.R.3
Cummings, G.D.4
Appelman, H.D.5
Peleman, R.R.6
-
47
-
-
0034112421
-
A randomized, controlled study of thymosin-alpha1 therapy in patients with anti-HBe, HBV-DNA-positive chronic hepatitis B
-
10759236
-
Zavaglia C, Severini R, Tinelli C, Franzone JS, Airoldi A, Tempini S. A randomized, controlled study of thymosin-alpha1 therapy in patients with anti-HBe, HBV-DNA-positive chronic hepatitis B. Dig Dis Sci. (2000) 45:690–6. 10.1023/A:100543132394510759236
-
(2000)
Dig Dis Sci
, vol.45
, pp. 690-696
-
-
Zavaglia, C.1
Severini, R.2
Tinelli, C.3
Franzone, J.S.4
Airoldi, A.5
Tempini, S.6
-
48
-
-
0030179606
-
Combination low-dose lymphoblastoid interferon and thymosin alpha 1 therapy in the treatment of chronic hepatitis B
-
8871880
-
Rasi G, Mutchnick MG, Di Virgilio D, Sinibaldi-Vallebona P, Pierimarchi P, Colella F. Combination low-dose lymphoblastoid interferon and thymosin alpha 1 therapy in the treatment of chronic hepatitis B. J Viral Hepat. (1996) 3:191–6. 10.1111/j.1365-2893.1996.tb00094.x8871880
-
(1996)
J Viral Hepat
, vol.3
, pp. 191-196
-
-
Rasi, G.1
Mutchnick, M.G.2
Di Virgilio, D.3
Sinibaldi-Vallebona, P.4
Pierimarchi, P.5
Colella, F.6
-
49
-
-
0036016778
-
Combination thymosin-alpha 1 and interferon-alpha 2b in the treatment of anti-HBe-positive chronic hepatitis B in Turkey
-
12063993
-
Saruc M, Yuceyar H, Kucukmetin N, Demir MA, Kandiloglu AR. Combination thymosin-alpha 1 and interferon-alpha 2b in the treatment of anti-HBe-positive chronic hepatitis B in Turkey. Hepatogastroenterology. (2002) 49:798–802. 10.1016/S0016-5085(08)81888-412063993
-
(2002)
Hepatogastroenterology
, vol.49
, pp. 798-802
-
-
Saruc, M.1
Yuceyar, H.2
Kucukmetin, N.3
Demir, M.A.4
Kandiloglu, A.R.5
-
50
-
-
33645500290
-
A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B
-
16640105
-
Lim SG, Wai CT, Lee YM, Dan YY, Sutedja DS, Wee A. A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B. Antivir Ther. (2006) 11:245–53. 16640105
-
(2006)
Antivir Ther
, vol.11
, pp. 245-253
-
-
Lim, S.G.1
Wai, C.T.2
Lee, Y.M.3
Dan, Y.Y.4
Sutedja, D.S.5
Wee, A.6
-
51
-
-
0038082975
-
Long-term outcomes of thymosin-alpha 1 and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B
-
12820143
-
Saruc M, Ozden N, Turkel N, Ayhan S, Hock LM, Tuzcuoglu I. Long-term outcomes of thymosin-alpha 1 and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B. J Pharm Sci. (2003) 92:1386–95. 10.1002/jps.1040112820143
-
(2003)
J Pharm Sci
, vol.92
, pp. 1386-1395
-
-
Saruc, M.1
Ozden, N.2
Turkel, N.3
Ayhan, S.4
Hock, L.M.5
Tuzcuoglu, I.6
-
52
-
-
84865778313
-
Efficacy of thymosin alpha-1 plus peginterferon alpha-2a combination therapy compared with peginterferon alpha-2a monotherapy in HBeAg-positive chronic hepatitis B: a prospective, multicenter, randomized, open-label study
-
22726105
-
Kim BH, Lee YJ, Kim W, Yoon JH, Jung EU, Park SJ. Efficacy of thymosin alpha-1 plus peginterferon alpha-2a combination therapy compared with peginterferon alpha-2a monotherapy in HBeAg-positive chronic hepatitis B: a prospective, multicenter, randomized, open-label study. Scand J Gastroenterol. (2012) 47:1048–55. 10.3109/00365521.2012.69490222726105
-
(2012)
Scand J Gastroenterol
, vol.47
, pp. 1048-1055
-
-
Kim, B.H.1
Lee, Y.J.2
Kim, W.3
Yoon, J.H.4
Jung, E.U.5
Park, S.J.6
-
53
-
-
0030452149
-
Combination thymosin alpha 1 and lymphoblastoid interferon treatment in chronic hepatitis C
-
9026482
-
Rasi G, DiVirgilio D, Mutchnick MG, Colella F, Sinibaldi-Vallebona P, Pierimarchi P. Combination thymosin alpha 1 and lymphoblastoid interferon treatment in chronic hepatitis C. Gut. (1996) 39:679–83. 10.1136/gut.39.5.6799026482
-
(1996)
Gut
, vol.39
, pp. 679-683
-
-
Rasi, G.1
DiVirgilio, D.2
Mutchnick, M.G.3
Colella, F.4
Sinibaldi-Vallebona, P.5
Pierimarchi, P.6
-
54
-
-
0008181666
-
A pilot study of thymosin alpha 1 therapy in chronic active hepatitis C
-
Rezakovic I, Zavaglia C, Bottelli R, Ideo G. A pilot study of thymosin alpha 1 therapy in chronic active hepatitis C. Hepatology. (1993) 18:252A. 10.1016/0270-9139(93)92530-D
-
(1993)
Hepatology
, vol.18
, pp. 252A
-
-
Rezakovic, I.1
Zavaglia, C.2
Bottelli, R.3
Ideo, G.4
-
55
-
-
9444228221
-
A double-blind, placebo-controlled, pilot trial of thymosin alpha 1 for the treatment of chronic hepatitis C
-
8873009
-
Andreone P, Cursaro C, Gramenzi A, Buzzi A, Covarelli MG, Di Giammarino L. A double-blind, placebo-controlled, pilot trial of thymosin alpha 1 for the treatment of chronic hepatitis C. Liver. (1996) 16:207–10. 10.1111/j.1600-0676.1996.tb00729.x8873009
-
(1996)
Liver
, vol.16
, pp. 207-210
-
-
Andreone, P.1
Cursaro, C.2
Gramenzi, A.3
Buzzi, A.4
Covarelli, M.G.5
Di Giammarino, L.6
-
56
-
-
17344368726
-
Combination therapy with thymosin alpha1 and interferon for the treatment of chronic hepatitis C infection: a randomized, placebo-controlled double-blind trial
-
9537454
-
Sherman KE, Sjogren M, Creager RL, Damiano MA, Freeman S, Lewey S. Combination therapy with thymosin alpha1 and interferon for the treatment of chronic hepatitis C infection: a randomized, placebo-controlled double-blind trial. Hepatology. (1998) 27:1128–35. 10.1002/hep.5102704309537454
-
(1998)
Hepatology
, vol.27
, pp. 1128-1135
-
-
Sherman, K.E.1
Sjogren, M.2
Creager, R.L.3
Damiano, M.A.4
Freeman, S.5
Lewey, S.6
-
57
-
-
0031752774
-
Interferon and thymosin combination therapy in naive patients with chronic hepatitis C: preliminary results
-
9831367
-
Moscarella S, Buzzelli G, Romanelli RG, Monti M, Giannini C, Careccia G. Interferon and thymosin combination therapy in naive patients with chronic hepatitis C: preliminary results. Liver. (1998) 18:366–9. 10.1111/j.1600-0676.1998.tb00819.x9831367
-
(1998)
Liver
, vol.18
, pp. 366-369
-
-
Moscarella, S.1
Buzzelli, G.2
Romanelli, R.G.3
Monti, M.4
Giannini, C.5
Careccia, G.6
-
58
-
-
10744223894
-
Thymosin-alpha 1 plus interferon-alpha for naive patients with chronic hepatitis C: results of a randomized controlled pilot trial
-
14738560
-
Andreone P, Gramenzi A, Cursaro C, Felline F, Loggi E, D'Errico A. Thymosin-alpha 1 plus interferon-alpha for naive patients with chronic hepatitis C: results of a randomized controlled pilot trial. J Viral Hepat. (2004) 11:69–73. 10.1046/j.1365-2893.2003.00470.x14738560
-
(2004)
J Viral Hepat
, vol.11
, pp. 69-73
-
-
Andreone, P.1
Gramenzi, A.2
Cursaro, C.3
Felline, F.4
Loggi, E.5
D'Errico, A.6
-
59
-
-
0030477782
-
Thymosin-alpha 1, but not interferon-alpha, specifically inhibits anchorage-independent growth of hepatitis B viral transfected HepG2 cells
-
Moshier JA, Mutchnick MG, Dosescu J, Holtz TK, Akkary S, Mahakala K. Thymosin-alpha 1, but not interferon-alpha, specifically inhibits anchorage-independent growth of hepatitis B viral transfected HepG2 cells. J Hepatol. (1996) 25:814–20. 10.1016/S0168-8278(96)80283-2
-
(1996)
J Hepatol
, vol.25
, pp. 814-820
-
-
Moshier, J.A.1
Mutchnick, M.G.2
Dosescu, J.3
Holtz, T.K.4
Akkary, S.5
Mahakala, K.6
-
60
-
-
0032145270
-
Cytokine-mediated apoptosis and inhibition of virus production and anchorage independent growth of viral transfected hepatoblastoma cells
-
9722931
-
Yared G, Hussain KB, Nathani MG, Moshier JA, Dosescu J, Mutchnick MG. Cytokine-mediated apoptosis and inhibition of virus production and anchorage independent growth of viral transfected hepatoblastoma cells. Cytokine. (1998) 10:586–95. 10.1006/cyto.1998.03409722931
-
(1998)
Cytokine
, vol.10
, pp. 586-595
-
-
Yared, G.1
Hussain, K.B.2
Nathani, M.G.3
Moshier, J.A.4
Dosescu, J.5
Mutchnick, M.G.6
-
61
-
-
0034982919
-
In vitro effect of thymosin-alpha1 and interferon-alpha on Th1 and Th2 cytokine synthesis in patients with chronic hepatitis C
-
11380797
-
Andreone P, Cursaro C, Gramenzi A, Margotti M, Ferri E, Talarico S. In vitro effect of thymosin-alpha1 and interferon-alpha on Th1 and Th2 cytokine synthesis in patients with chronic hepatitis C. J Viral Hepat. (2001) 8:194–201. 10.1046/j.1365-2893.2001.00285.x11380797
-
(2001)
J Viral Hepat
, vol.8
, pp. 194-201
-
-
Andreone, P.1
Cursaro, C.2
Gramenzi, A.3
Margotti, M.4
Ferri, E.5
Talarico, S.6
-
62
-
-
0036633685
-
Thymosin-alpha1 and famciclovir combination therapy activates T-cell response in patients with chronic hepatitis B virus infection in immune-tolerant phase
-
12081605
-
Lau GK, Nanji A, Hou J, Fong DY, Au WS, Yuen ST. Thymosin-alpha1 and famciclovir combination therapy activates T-cell response in patients with chronic hepatitis B virus infection in immune-tolerant phase. J Viral Hepat. (2002) 9:280–7. 10.1046/j.1365-2893.2002.00361.x12081605
-
(2002)
J Viral Hepat
, vol.9
, pp. 280-287
-
-
Lau, G.K.1
Nanji, A.2
Hou, J.3
Fong, D.Y.4
Au, W.S.5
Yuen, S.T.6
-
63
-
-
67649920809
-
Treatment with lamivudine versus lamivudine and thymosin alpha-1 for e antigen-positive chronic hepatitis B patients: a meta-analysis
-
19467157
-
Zhang YY, Chen EQ, Yang J, Duan YR, Tang H. Treatment with lamivudine versus lamivudine and thymosin alpha-1 for e antigen-positive chronic hepatitis B patients: a meta-analysis. Virol J. (2009) 6:63. 10.1186/1743-422X-6-6319467157
-
(2009)
Virol J
, vol.6
, pp. 63
-
-
Zhang, Y.Y.1
Chen, E.Q.2
Yang, J.3
Duan, Y.R.4
Tang, H.5
-
64
-
-
85039036415
-
Entecavir versus entecavir-thymosin alpha-1 combination therapy for chronic hepatitis B: a meta-analysis
-
(,) 9
-
Qu L, Tian Z, Bao X, Lyu Y, Lyu J. Entecavir versus entecavir-thymosin alpha-1 combination therapy for chronic hepatitis B: a meta-analysis. Mod J Integr Tradit Chin West Med. (2015) 9.
-
(2015)
Mod J Integr Tradit Chin West Med
-
-
Qu, L.1
Tian, Z.2
Bao, X.3
Lyu, Y.4
Lyu, J.5
-
65
-
-
85051057290
-
Combination of entecavir with thymosin alpha-1 in HBV-related compensated cirrhosis: a prospective multicenter randomized open-label study
-
30063860
-
Wu X, Shi Y, Zhou J, Sun Y, Piao H, Jiang W. Combination of entecavir with thymosin alpha-1 in HBV-related compensated cirrhosis: a prospective multicenter randomized open-label study. Expert Opin Biol Ther. (2018) 18(Suppl. 1):61–9. 10.1080/14712598.2018.145151130063860
-
(2018)
Expert Opin Biol Ther
, vol.18
, pp. 61-69
-
-
Wu, X.1
Shi, Y.2
Zhou, J.3
Sun, Y.4
Piao, H.5
Jiang, W.6
-
66
-
-
11144248534
-
Triple combination of thymalfasin, peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior interferon and ribavirin treatment: 24-week interim results of a pilot study
-
Poo JL, Sanchez-Avila F, Kershenobich D, Garcia-Samper X, Gongora J, Uribe M. Triple combination of thymalfasin, peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior interferon and ribavirin treatment: 24-week interim results of a pilot study. J Gastroenterol Hepatol. (2004) 19(Suppl. 6):S79–81. 10.1111/j.1440-1746.2004.03634.x
-
(2004)
J Gastroenterol Hepatol
, vol.19
, pp. S79-S81
-
-
Poo, J.L.1
Sanchez-Avila, F.2
Kershenobich, D.3
Garcia-Samper, X.4
Gongora, J.5
Uribe, M.6
-
67
-
-
70349310398
-
Thymosin alpha-1 in combination with pegylated interferon and ribavirin in chronic hepatitis c patients who have failed to prior pegylated interferon and ribavirin treatment
-
20485665
-
Baek YH, Lee SW, Yoo HS, Yoon HA, Kim JW, Kim YH. Thymosin alpha-1 in combination with pegylated interferon and ribavirin in chronic hepatitis c patients who have failed to prior pegylated interferon and ribavirin treatment. Gut Liver. (2007) 1:87–9. 10.5009/gnl.2007.1.1.8720485665
-
(2007)
Gut Liver
, vol.1
, pp. 87-89
-
-
Baek, Y.H.1
Lee, S.W.2
Yoo, H.S.3
Yoon, H.A.4
Kim, J.W.5
Kim, Y.H.6
-
68
-
-
11144326821
-
Thymosin alpha 1 in combination with interferon alpha and ribavirin in chronic hepatitis C patients who are non-responders or relapsers to interferon alpha plus ribavirin
-
Abbas Z, Hamid SS, Tabassum S, Jafri W. Thymosin alpha 1 in combination with interferon alpha and ribavirin in chronic hepatitis C patients who are non-responders or relapsers to interferon alpha plus ribavirin. J Pak Med Assoc. (2004) 54:571–4.
-
(2004)
J Pak Med Assoc
, vol.54
, pp. 571-574
-
-
Abbas, Z.1
Hamid, S.S.2
Tabassum, S.3
Jafri, W.4
-
69
-
-
56749097120
-
Efficacy of triple therapy with thymalfasin, peginterferon alpha-2a, and ribavirin for the treatment of hispanic chronic HCV nonresponders
-
19034238
-
Poo JL, Sanchez Avila F, Kershenobich D, Garcia Samper X, Torress-Ibarra R, Gongora J. Efficacy of triple therapy with thymalfasin, peginterferon alpha-2a, and ribavirin for the treatment of hispanic chronic HCV nonresponders. Ann Hepatol. (2008) 7:369–75. 10.1016/S1665-2681(19)31839-319034238
-
(2008)
Ann Hepatol
, vol.7
, pp. 369-375
-
-
Poo, J.L.1
Sanchez Avila, F.2
Kershenobich, D.3
Garcia Samper, X.4
Torress-Ibarra, R.5
Gongora, J.6
-
70
-
-
84855669391
-
Thymosin alpha-1 with peginterferon alfa-2a/ribavirin for chronic hepatitis C not responsive to IFN/ribavirin: an adjuvant role?
-
Ciancio A, Andreone P, Kaiser S, Mangia A, Milella M, Sola R. Thymosin alpha-1 with peginterferon alfa-2a/ribavirin for chronic hepatitis C not responsive to IFN/ribavirin: an adjuvant role? J Viral Hepatol. (2012) 19(Suppl. 1):52–9. 10.1111/j.1365-2893.2011.01524.x
-
(2012)
J Viral Hepatol
, vol.19
, pp. 52-59
-
-
Ciancio, A.1
Andreone, P.2
Kaiser, S.3
Mangia, A.4
Milella, M.5
Sola, R.6
-
71
-
-
85018316080
-
Thymalfasin, a promising adjuvant therapy in small hepatocellular carcinoma after liver resection
-
28422855
-
He C, Peng W, Li C, Wen TF. Thymalfasin, a promising adjuvant therapy in small hepatocellular carcinoma after liver resection. Medicine. (2017) 96:e6606. 10.1097/MD.000000000000660628422855
-
(2017)
Medicine
, vol.96
, pp. e6606
-
-
He, C.1
Peng, W.2
Li, C.3
Wen, T.F.4
-
72
-
-
84990041371
-
Thymosin alpha1 therapy subsequent to radical hepatectomy in patients with hepatitis B virus-associated hepatocellular carcinoma: a retrospective controlled study
-
27900029
-
Liang YR, Guo Z, Jiang JH, Xiang BD, Li LQ. Thymosin alpha1 therapy subsequent to radical hepatectomy in patients with hepatitis B virus-associated hepatocellular carcinoma: a retrospective controlled study. Oncol Lett. (2016) 12:3513–8. 10.3892/ol.2016.512127900029
-
(2016)
Oncol Lett
, vol.12
, pp. 3513-3518
-
-
Liang, Y.R.1
Guo, Z.2
Jiang, J.H.3
Xiang, B.D.4
Li, L.Q.5
-
73
-
-
0031888375
-
Alpha-1-thymosin and transcatheter arterial chemoembolization in hepatocellular carcinoma patients: a preliminary experience
-
9496515
-
Stefanini GF, Foschi FG, Castelli E, Marsigli L, Biselli M, Mucci F. Alpha-1-thymosin and transcatheter arterial chemoembolization in hepatocellular carcinoma patients: a preliminary experience. Hepatogastroenterology. (1998) 45:209–15. 9496515
-
(1998)
Hepatogastroenterology
, vol.45
, pp. 209-215
-
-
Stefanini, G.F.1
Foschi, F.G.2
Castelli, E.3
Marsigli, L.4
Biselli, M.5
Mucci, F.6
-
74
-
-
68949151592
-
A randomized controlled trial of thymalfasin plus transarterial chemoembolization for unresectable hepatocellular carcinoma
-
19669251
-
Gish RG, Gordon SC, Nelson D, Rustgi V, Rios I. A randomized controlled trial of thymalfasin plus transarterial chemoembolization for unresectable hepatocellular carcinoma. Hepatol Int. (2009) 3:480–9. 10.1007/s12072-009-9132-319669251
-
(2009)
Hepatol Int
, vol.3
, pp. 480-489
-
-
Gish, R.G.1
Gordon, S.C.2
Nelson, D.3
Rustgi, V.4
Rios, I.5
-
75
-
-
3342975494
-
Combination transcatheter hepatic arterial chemoembolization with thymosin alpha1 on recurrence prevention of hepatocellular carcinoma
-
15362772
-
Shuqun C, Mengchao W, Han C, Feng S, Jiahe Y, Wenming C. Combination transcatheter hepatic arterial chemoembolization with thymosin alpha1 on recurrence prevention of hepatocellular carcinoma. Hepatogastroenterology. (2004) 51:1445–7. 15362772
-
(2004)
Hepatogastroenterology
, vol.51
, pp. 1445-1447
-
-
Shuqun, C.1
Mengchao, W.2
Han, C.3
Feng, S.4
Jiahe, Y.5
Wenming, C.6
-
76
-
-
33645569173
-
Antiviral therapy using lamivudine and thymosin alpha1 for hepatocellular carcinoma coexisting with chronic hepatitis B infection
-
16608033
-
Shuqun C, Mengchao W, Han C, Feng S, Jiahe Y, Wenming C. Antiviral therapy using lamivudine and thymosin alpha1 for hepatocellular carcinoma coexisting with chronic hepatitis B infection. Hepatogastroenterology. (2006) 53:249–52. 16608033
-
(2006)
Hepatogastroenterology
, vol.53
, pp. 249-252
-
-
Shuqun, C.1
Mengchao, W.2
Han, C.3
Feng, S.4
Jiahe, Y.5
Wenming, C.6
-
77
-
-
84983462456
-
Efficacy of sorafenib with thymosin a1 for patients with advanced hepatocellular carcinoma
-
(,) 10
-
Gu X, Jiang Z, Yang M. Efficacy of sorafenib with thymosin a1 for patients with advanced hepatocellular carcinoma. Jiangsu Med J. (2010) 10.
-
(2010)
Jiangsu Med J
-
-
Gu, X.1
Jiang, Z.2
Yang, M.3
-
78
-
-
0021948698
-
T-cell abnormalities after mediastinal irradiation for lung cancer. The in vitro influence of synthetic thymosin alpha-1
-
3155644
-
Schulof RS, Chorba TL, Cleary PA, Palaszynski SR, Alabaster O, Goldstein AL. T-cell abnormalities after mediastinal irradiation for lung cancer. The in vitro influence of synthetic thymosin alpha-1. Cancer. (1985) 55:974–83. 10.1002/1097-0142(19850301)55:5<974::AID-CNCR2820550510>3.0.CO;2-I3155644
-
(1985)
Cancer
, vol.55
, pp. 974-983
-
-
Schulof, R.S.1
Chorba, T.L.2
Cleary, P.A.3
Palaszynski, S.R.4
Alabaster, O.5
Goldstein, A.L.6
-
79
-
-
0022362208
-
A randomized trial to evaluate the immunorestorative properties of synthetic thymosin-alpha 1 in patients with lung cancer
-
3998766
-
Schulof RS, Lloyd MJ, Cleary PA, Palaszynski SR, Mai DA, Cox JW, Jr. A randomized trial to evaluate the immunorestorative properties of synthetic thymosin-alpha 1 in patients with lung cancer. J Biol Response Mod. (1985) 4:147–58. 3998766
-
(1985)
J Biol Response Mod
, vol.4
, pp. 147-158
-
-
Schulof, R.S.1
Lloyd, M.J.2
Cleary, P.A.3
Palaszynski, S.R.4
Mai, D.A.5
Cox, J.W.6
-
80
-
-
0025696176
-
Combination treatment using thymosin alpha 1 and interferon after cyclophosphamide is able to cure Lewis lung carcinoma in mice
-
2126987
-
Garaci E, Mastino A, Pica F, Favalli C. Combination treatment using thymosin alpha 1 and interferon after cyclophosphamide is able to cure Lewis lung carcinoma in mice. Cancer Immunol Immunother. (1990) 32:154–60. 10.1007/BF017714502126987
-
(1990)
Cancer Immunol Immunother
, vol.32
, pp. 154-160
-
-
Garaci, E.1
Mastino, A.2
Pica, F.3
Favalli, C.4
-
81
-
-
0029583567
-
Sequential chemoimmunotherapy for advanced non-small cell lung cancer using cisplatin, etoposide, thymosin-alpha 1 and interferon-alpha 2a
-
8652276
-
Garaci E, Lopez M, Bonsignore G, Della Giulia M, D'Aprile M, Favalli C. Sequential chemoimmunotherapy for advanced non-small cell lung cancer using cisplatin, etoposide, thymosin-alpha 1 and interferon-alpha 2a. Eur J Cancer. (1995) 31A:2403–5. 10.1016/0959-8049(95)00477-78652276
-
(1995)
Eur J Cancer
, vol.31A
, pp. 2403-2405
-
-
Garaci, E.1
Lopez, M.2
Bonsignore, G.3
Della Giulia, M.4
D'Aprile, M.5
Favalli, C.6
-
82
-
-
0030008531
-
Combined treatment with thymosin-alpha1 and low-dose interferon-alpha after ifosfamide in non-small cell lung cancer: a phase-II controlled trial
-
8687090
-
Salvati F, Rasi G, Portalone L, Antilli A, Garaci E. Combined treatment with thymosin-alpha1 and low-dose interferon-alpha after ifosfamide in non-small cell lung cancer: a phase-II controlled trial. Anticancer Res. (1996) 16:1001–4. 8687090
-
(1996)
Anticancer Res
, vol.16
, pp. 1001-1004
-
-
Salvati, F.1
Rasi, G.2
Portalone, L.3
Antilli, A.4
Garaci, E.5
-
83
-
-
84861393221
-
Thymosin plus cisplatin with vinorelbine or gemcitabine for non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials
-
27755854
-
Jiang J, Wang X, Tian J, Li L, Lin Q. Thymosin plus cisplatin with vinorelbine or gemcitabine for non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials. Thorac Cancer. (2011) 2:213–20. 10.1111/j.1759-7714.2011.00057.x27755854
-
(2011)
Thorac Cancer
, vol.2
, pp. 213-220
-
-
Jiang, J.1
Wang, X.2
Tian, J.3
Li, L.4
Lin, Q.5
-
84
-
-
84937634687
-
Thymosin alpha1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1
-
26111447
-
Yuan C, Zheng Y, Zhang B, Shao L, Liu Y, Tian T. Thymosin alpha1 promotes the activation of myeloid-derived suppressor cells in a Lewis lung cancer model by upregulating Arginase 1. Biochem Biophys Res Commun. (2015) 464:249–55. 10.1016/j.bbrc.2015.06.13226111447
-
(2015)
Biochem Biophys Res Commun
, vol.464
, pp. 249-255
-
-
Yuan, C.1
Zheng, Y.2
Zhang, B.3
Shao, L.4
Liu, Y.5
Tian, T.6
-
85
-
-
0027420351
-
Thymosin alpha 1 down-regulates the growth of human non-small cell lung cancer cells in vitro and in vivo
-
8221658
-
Moody TW, Fagarasan M, Zia F, Cesnjaj M, Goldstein AL. Thymosin alpha 1 down-regulates the growth of human non-small cell lung cancer cells in vitro and in vivo. Cancer Res. (1993) 53:5214–8. 8221658
-
(1993)
Cancer Res
, vol.53
, pp. 5214-5218
-
-
Moody, T.W.1
Fagarasan, M.2
Zia, F.3
Cesnjaj, M.4
Goldstein, A.L.5
-
86
-
-
0034738174
-
Thymosinalpha1 is chemopreventive for lung adenoma formation in A/J mice
-
10822126
-
Moody TW, Leyton J, Zia F, Tuthill C, Badamchian M, Goldstein AL. Thymosinalpha1 is chemopreventive for lung adenoma formation in A/J mice. Cancer Lett. (2000) 155:121–7. 10.1016/S0304-3835(00)00405-510822126
-
(2000)
Cancer Lett
, vol.155
, pp. 121-127
-
-
Moody, T.W.1
Leyton, J.2
Zia, F.3
Tuthill, C.4
Badamchian, M.5
Goldstein, A.L.6
-
87
-
-
35348966132
-
Thymosin alpha1 as a chemopreventive agent in lung and breast cancer
-
17567944
-
Moody TW. Thymosin alpha1 as a chemopreventive agent in lung and breast cancer. Ann N Y Acad Sci. (2007) 1112:297–304. 10.1196/annals.1415.04017567944
-
(2007)
Ann N Y Acad Sci
, vol.1112
, pp. 297-304
-
-
Moody, T.W.1
-
88
-
-
85065523917
-
Thymosin alpha-1; a natural peptide inhibits cellular proliferation, cell migration, the level of reactive oxygen species and promotes the activity of antioxidant enzymes in human lung epithelial adenocarcinoma cell line (A549)
-
31067016
-
Kharazmi-Khorassani J, Asoodeh A. Thymosin alpha-1; a natural peptide inhibits cellular proliferation, cell migration, the level of reactive oxygen species and promotes the activity of antioxidant enzymes in human lung epithelial adenocarcinoma cell line (A549). Environ Toxicol. (2019) 34:941–9. 10.1002/tox.2276531067016
-
(2019)
Environ Toxicol
, vol.34
, pp. 941-949
-
-
Kharazmi-Khorassani, J.1
Asoodeh, A.2
-
89
-
-
85057751873
-
Thymosin alpha1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3-MMP2 signaling
-
30425517
-
Bo C, Wu Q, Zhao H, Li X, Zhou Q. Thymosin alpha1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3-MMP2 signaling. Onco Targets Ther. (2018) 11:7255–70. 10.2147/OTT.S17794330425517
-
(2018)
Onco Targets Ther
, vol.11
, pp. 7255-7270
-
-
Bo, C.1
Wu, Q.2
Zhao, H.3
Li, X.4
Zhou, Q.5
-
90
-
-
84889052859
-
A tumor-penetrating peptide modification enhances the antitumor activity of thymosin alpha 1
-
23977262
-
Lao X, Liu M, Chen J, Zheng H. A tumor-penetrating peptide modification enhances the antitumor activity of thymosin alpha 1. PLoS ONE. (2013) 8:e72242. 10.1371/journal.pone.007224223977262
-
(2013)
PLoS ONE
, vol.8
, pp. e72242
-
-
Lao, X.1
Liu, M.2
Chen, J.3
Zheng, H.4
-
91
-
-
84866060623
-
Immunotherapy of cancer in 2012
-
22576456
-
Kirkwood JM, Butterfield LH, Tarhini AA, Zarour H, Kalinski P, Ferrone S. Immunotherapy of cancer in 2012. CA Cancer J Clin. (2012) 62:309–35. 10.3322/caac.2013222576456
-
(2012)
CA Cancer J Clin
, vol.62
, pp. 309-335
-
-
Kirkwood, J.M.1
Butterfield, L.H.2
Tarhini, A.A.3
Zarour, H.4
Kalinski, P.5
Ferrone, S.6
-
92
-
-
85046048189
-
The cancer immunotherapy revolution
-
29567702
-
Kelly PN. The cancer immunotherapy revolution. Science. (2018) 359:1344–5. 10.1126/science.359.6382.134429567702
-
(2018)
Science
, vol.359
, pp. 1344-1345
-
-
Kelly, P.N.1
-
93
-
-
84921418427
-
Classification of current anticancer immunotherapies
-
25537519
-
Galluzzi L, Vacchelli E, Bravo-San Pedro JM, Buque A, Senovilla L, Baracco EE. Classification of current anticancer immunotherapies. Oncotarget. (2014) 5:12472–508. 10.18632/oncotarget.299825537519
-
(2014)
Oncotarget
, vol.5
, pp. 12472-12508
-
-
Galluzzi, L.1
Vacchelli, E.2
Bravo-San Pedro, J.M.3
Buque, A.4
Senovilla, L.5
Baracco, E.E.6
-
94
-
-
85045378539
-
Cancer immunotherapy using checkpoint blockade
-
29567705
-
Ribas A, Wolchok JD. Cancer immunotherapy using checkpoint blockade. Science. (2018) 359:1350–5. 10.1126/science.aar406029567705
-
(2018)
Science
, vol.359
, pp. 1350-1355
-
-
Ribas, A.1
Wolchok, J.D.2
-
95
-
-
85059563404
-
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
-
30610226
-
Galon J, Bruni D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov. (2019) 18:197–218. 10.1038/s41573-018-0007-y30610226
-
(2019)
Nat Rev Drug Discov
, vol.18
, pp. 197-218
-
-
Galon, J.1
Bruni, D.2
-
96
-
-
85065986843
-
Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance
-
31092901
-
Martins F, Sofiya L, Sykiotis GP, Lamine F, Maillard M, Fraga M. Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance. Nat Rev Clin Oncol. (2019) 16:563–80. 10.1038/s41571-019-0218-031092901
-
(2019)
Nat Rev Clin Oncol
, vol.16
, pp. 563-580
-
-
Martins, F.1
Sofiya, L.2
Sykiotis, G.P.3
Lamine, F.4
Maillard, M.5
Fraga, M.6
-
97
-
-
0033621845
-
Thymosin-alpha1 regulates MHC class I expression in FRTL-5 cells at transcriptional level
-
10741392
-
Giuliani C, Napolitano G, Mastino A, Di Vincenzo S, D'Agostini C, Grelli S. Thymosin-alpha1 regulates MHC class I expression in FRTL-5 cells at transcriptional level. Eur J Immunol. (2000) 30:778–86.3.3. 10.1002/1521-4141(200003)30:3<778::AID-IMMU778>3.3.CO;2-910741392
-
(2000)
Eur J Immunol
, vol.30
, pp. 778
-
-
Giuliani, C.1
Napolitano, G.2
Mastino, A.3
Di Vincenzo, S.4
D'Agostini, C.5
Grelli, S.6
-
98
-
-
85067218401
-
Modulating inflammation for cancer therapy
-
31023715
-
Ritter B, Greten FR. Modulating inflammation for cancer therapy. J Exp Med. (2019) 216:1234–43. 10.1084/jem.2018173931023715
-
(2019)
J Exp Med
, vol.216
, pp. 1234-1243
-
-
Ritter, B.1
Greten, F.R.2
-
99
-
-
85044269307
-
Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management
-
29512649
-
Samaan MA, Pavlidis P, Papa S, Powell N, Irving PM. Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management. Nat Rev Gastroenterol Hepatol. (2018) 15:222–34. 10.1038/nrgastro.2018.1429512649
-
(2018)
Nat Rev Gastroenterol Hepatol
, vol.15
, pp. 222-234
-
-
Samaan, M.A.1
Pavlidis, P.2
Papa, S.3
Powell, N.4
Irving, P.M.5
-
100
-
-
33749335671
-
Thymosin alpha1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance
-
16741252
-
Romani L, Bistoni F, Perruccio K, Montagnoli C, Gaziano R, Bozza S. Thymosin alpha1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance. Blood. (2006) 108:2265–74. 10.1182/blood-2006-02-00476216741252
-
(2006)
Blood
, vol.108
, pp. 2265-2274
-
-
Romani, L.1
Bistoni, F.2
Perruccio, K.3
Montagnoli, C.4
Gaziano, R.5
Bozza, S.6
-
101
-
-
85017218584
-
Thymosin alpha1 represents a potential potent single-molecule-based therapy for cystic fibrosis
-
28394330
-
Romani L, Oikonomou V, Moretti S, Iannitti RG, D'Adamo MC, Villella VR. Thymosin alpha1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nat Med. (2017) 23:590–600. 10.1038/nm.430528394330
-
(2017)
Nat Med
, vol.23
, pp. 590-600
-
-
Romani, L.1
Oikonomou, V.2
Moretti, S.3
Iannitti, R.G.4
D'Adamo, M.C.5
Villella, V.R.6
-
102
-
-
85040181367
-
Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade
-
29255057
-
Wang F, Yin Q, Chen L, Davis MM. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. Proc Natl Acad Sci USA. (2018) 115:157–61. 10.1073/pnas.171290111529255057
-
(2018)
Proc Natl Acad Sci USA
, vol.115
, pp. 157-161
-
-
Wang, F.1
Yin, Q.2
Chen, L.3
Davis, M.M.4
-
103
-
-
85065226493
-
Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy
-
31043740
-
Perez-Ruiz E, Minute L, Otano I, Alvarez M, Ochoa MC, Belsue V. Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy. Nature. (2019) 569:428–32. 10.1038/s41586-019-1162-y31043740
-
(2019)
Nature
, vol.569
, pp. 428-432
-
-
Perez-Ruiz, E.1
Minute, L.2
Otano, I.3
Alvarez, M.4
Ochoa, M.C.5
Belsue, V.6
-
104
-
-
85046048647
-
The microbiome in cancer immunotherapy: diagnostic tools and therapeutic strategies
-
29567708
-
Zitvogel L, Ma Y, Raoult D, Kroemer G, Gajewski TF. The microbiome in cancer immunotherapy: diagnostic tools and therapeutic strategies. Science. (2018) 359:1366–70. 10.1126/science.aar691829567708
-
(2018)
Science
, vol.359
, pp. 1366-1370
-
-
Zitvogel, L.1
Ma, Y.2
Raoult, D.3
Kroemer, G.4
Gajewski, T.F.5
-
105
-
-
85065837508
-
Role of osteopontin in dendritic cell shaping of immune responses
-
31126876, [Epub ahead of print]
-
Del Prete A, Scutera S, Sozzani S, Musso T. Role of osteopontin in dendritic cell shaping of immune responses. Cytokine Growth Factor Rev. (2019). 10.1016/j.cytogfr.2019.05.004 [Epub ahead of print]. 31126876
-
(2019)
Cytokine Growth Factor Rev
-
-
Del Prete, A.1
Scutera, S.2
Sozzani, S.3
Musso, T.4
-
106
-
-
79952693708
-
Intracellular osteopontin (iOPN) and immunity
-
21136203
-
Inoue M, Shinohara ML. Intracellular osteopontin (iOPN) and immunity. Immunol Res. (2011) 49:160–72. 10.1007/s12026-010-8179-521136203
-
(2011)
Immunol Res
, vol.49
, pp. 160-172
-
-
Inoue, M.1
Shinohara, M.L.2
-
107
-
-
84920671403
-
Intracellular Osteopontin inhibits toll-like receptor signaling and impedes liver carcinogenesis
-
25398438
-
Fan X, He C, Jing W, Zhou X, Chen R, Cao L. Intracellular Osteopontin inhibits toll-like receptor signaling and impedes liver carcinogenesis. Cancer Res. (2015) 75:86–97. 10.1158/0008-5472.CAN-14-061525398438
-
(2015)
Cancer Res
, vol.75
, pp. 86-97
-
-
Fan, X.1
He, C.2
Jing, W.3
Zhou, X.4
Chen, R.5
Cao, L.6
-
108
-
-
85026401742
-
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin
-
28671690
-
Kanayama M, Xu S, Danzaki K, Gibson JR, Inoue M, Gregory SG. Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nat Immunol. (2017) 18:973–84. 10.1038/ni.379128671690
-
(2017)
Nat Immunol
, vol.18
, pp. 973-984
-
-
Kanayama, M.1
Xu, S.2
Danzaki, K.3
Gibson, J.R.4
Inoue, M.5
Gregory, S.G.6
-
109
-
-
84939121706
-
Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy
-
25432147
-
Messmer MN, Netherby CS, Banik D, Abrams SI. Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy. Cancer Immunol Immunother. (2015) 64:1–13. 10.1007/s00262-014-1639-325432147
-
(2015)
Cancer Immunol Immunother
, vol.64
, pp. 1-13
-
-
Messmer, M.N.1
Netherby, C.S.2
Banik, D.3
Abrams, S.I.4
|