A double-blind, placebo-controlled, pilot trial of thymosin alpha1 for the treatment of chronic hepatitis C

Liver

Volumn 16, Issue 3, 1996, Pages 207-210

  Andreone, Pietro ^a   Cursaro, Carmela ^a   Gramenzi, Annagiulia ^a   Buzzi, Andrea ^a   Covarelli, Maria Grazia ^a   Di Giammarino, Loriana ^a   Miniero, Rita ^b   Arienti, Vincenzo ^a   Bernardi, Mauro ^a   Gasbarrini, Giovanni ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Chronic hepatitis C; Therapy; Thymosin alpha1

Indexed keywords

ALANINE AMINOTRANSFERASE; THYMOSIN ALPHA1; VIRUS RNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INJECTION PAIN; MALE; POLYMERASE CHAIN REACTION; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 9444228221     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0676.1996.tb00729.x     Document Type: Article

References (20)

1. DAVIS GL, BALART LA, SCHIFF ER, et al. Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized trial. N Engl J Med 1989: 321: 1501-1506.
2. TINE F, MAGRIN S, CRAXI A, PAGLIARO L. Interferon for non-A, non-B chronic hepatitis. A meta-analysis of randomized clinical trials. J Hepatol 1991: 13: 192-199.
3. SHINDO M, DI BISCEGLIE AM, HOOFNAGLE JH. Long-term follow-up of patients with chronic hepatitis C treated with alfa-interferon. Hepatology 1992: 15: 1013-1016.
4. CAMPS J, CORDOBA J, ESTEBAN JI. Pathophysiology of chronic hepatitis C. In: Miguet JP, Dhumeaux D, eds. Progress in hepatology 93. Paris: John Libbey Eurotext, 1993: 63-68.
5. NEGRO F, PACCHIONI D, SHIMIZU Y, et al. Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology. Proc Natl Acad Sci USA 1992: 89: 2247-2251.
6. BOTARELLI P, BRUNETTO MR, MINUTELLO MA, et al. T-lymphocyte response to hepatitis C virus in different clinical courses of infection. Gastroenterology 1993: 104: 580-587.
7. SZTEIN MB, GOLDSTEIN AL. Thymic hormones: a clinical update. Springer Semin Immunopathol 1986: 9: 1-22.
8. SZTEIN MB, SERRATE SA. Characterization of the immunoregulatory properties of thymosin alpha 1 on interleukin-2 production and interleukin-2 receptor expression in normal human lymphocytes. Int J Immunopharmac 1989: 11: 789-800.
9. HUANG KY, KIND PD, JAGODA EM, GOLDSTEIN AL. Thymosin treatment modulates production of interferon. J Interferon Res 1981: 1: 411-420.
10. SVEDERSKY LP, HUI A, MAY L, MC KAY P, STEBBING N. Induction and augmentation of mitogen-induced immune interferon production in human peripheral blood lymphocytes by desacetyl thymosin alpha 1. Eur J Immunol 1982: 12: 244-247.
11. GOLDSTEIN AL, LOW TL, MCADOO M, et al. Thymosin alpha 1: isolation and sequence analysis of an immunologically active thymic polypeptide. Proc Natl Acad Sci USA 1977: 74: 725-729.
12. HARITOS AA, GOODALL GJ, HORECKER BL. Prothymosin alpha: isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus. Proc Natl Acad Sci USA 1984: 81: 1008-1011.
13. SZTEIN MB, SERRATE SA, GOLDSTEIN AL. Modulation of interleukin-2 receptor expression on human normal lymphocytes by thymic hormones. Proc Natl Acad Sci USA 1986: 83: 6107-6111.
14. MASTINO A, FAVALLI C, GRELLI S, GARACI E. Thymic hormones and cytokines. Int J Immunopathol Pharmacol 1992: 5: 77-82.
15. KORBA BE, TENNANT BC, COTE PJ, MUTCHNICK MG, GERIN JL. Treatment of chronic woodchuck hepatitis virus infection with thymosin alfa-1 (abstract). Hepatology 1990: 12: 880.
16. MUTCHNICK MG, APPELMAN HD, CHUNG HT, et al. Thymosin treatment of chronic active hepatitis B: a placebo-controlled trial. Hepatology 1991: 13: 409-415.
17. 1 versus IFN-α treatment in patients with HBeAg negative and HBV-DNA positive chronic active hepatitis. Int J Immunotherapy 1993: 9: 201-205.
18. FATTOVICH G, GIUSTINA G, ALBERTI A, et al. A randomized controlled trial of thymopentin therapy in patients with chronic hepatitis B. J Hepatol 1994: 21: 361-366.
19. FARHAT BA, MARINOS G, DANIELS HM, NAOUMOV NV, WILLIAMS R. Evaluation of efficacy and safety of thymus humoral factor-gamma 2 in the management of chronic hepatitis B. J Hepatol 1995: 23: 21-27.
20. BEPLER G. Thymosin alpha-1 as adjunct for conventional therapy of malignant tumors: a review. Cancer Investigation 1994: 12: 491-496.