The potential for renal injury elicited by physical work in the heat

Nutrients

Volumn 11, Issue 9, 2019, Pages

  Schlader, Zachary J ^a,b   Hostler, David ^a   Parker, Mark D ^c   Pryor, Riana R ^a   Lohr, James W ^c   Johnson, Blair D ^a   Chapman, Christopher L ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Acute kidney injury; Chronic kidney disease; Dehydration; Exercise; Heat stress

Indexed keywords

BIOLOGICAL MARKER; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CREATININE; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 7; KIDNEY INJURY MOLECULE 1; LIVER TYPE FATTY ACID BINDING PROTEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; SOMATOMEDIN; UNCLASSIFIED DRUG; VASOPRESSIN;

ACUTE KIDNEY FAILURE; CHRONIC KIDNEY FAILURE; CREATININE CLEARANCE; CREATININE URINE LEVEL; DIALYSIS; ENZYME ACTIVITY; ENZYME KINETICS; EXERCISE; GLOMERULAR DYSFUNCTION; GLOMERULUS FILTRATION RATE; HUMAN; HYPERURICEMIA; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TUBULE ABSORPTION; MUSCLE INJURY; PROTEIN DEPLETION; PROTEIN EXPRESSION; REVIEW; URINE VOLUME; WORK CAPACITY; WORK ENVIRONMENT; ANIMAL; HEAT; WORK;

ACUTE KIDNEY INJURY; ANIMALS; HOT TEMPERATURE; HUMANS; PHYSICAL EXERTION; RENAL INSUFFICIENCY, CHRONIC; WORK;

EID: 85071769315     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu11092087     Document Type: Review

References (191)

1. Chatterjee, R. Occupational hazard. Science 2016, 352, 24-27.
2. Johnson, R.J.; Wesseling, C.; Newman, L.S. Chronic kidney disease of unknown cause in agricultural communities. New Engl. J. Med. 2019, 380, 1843-1852.
3. Trabanino, R.G.; Aguilar, R.; Silva, C.R.; Mercado, M.O.; Merino, R.L. Nefropatía terminal en pacientes de un hospital de referencia en El Salvador. Revista Panamericana de Salud Pública 2002, 12, 202-206.
4. Torres, C.; Aragón, A.; González, M.; Jakobsson, K.; Elinder, C.-G.; Lundberg, I.; Wesseling, C. Decreased kidney function of unknown cause in Nicaragua: A community-based survey. Am. J. Kidney Dis. 2010, 55, 485-496.
5. O’Donnell, J.K.; Tobey, M.; Weiner, D.E.; Stevens, L.A.; Johnson, S.; Stringham, P.; Cohen, B.; Brooks, D.R. Prevalence of and risk factors for chronic kidney disease in rural Nicaragua. Nephrol. Dial. Transplant. 2011, 26, 2798-2805.
6. Peraza, S.; Wesseling, C.; Aragon, A.; Leiva, R.; García-Trabanino, R.A.; Torres, C.; Jakobsson, K.; Elinder, C.G.; Hogstedt, C. Decreased kidney function among agricultural workers in El Salvador. Am. J. Kidney Dis. 2012, 59, 531-540.
7. Glaser, J.; Lemery, J.; Rajagopalan, B.; Diaz, H.F.; García-Trabanino, R.; Taduri, G.; Madero, M.; Amarasinghe, M.; Abraham, G.; Anutrakulchai, S. Climate Change and the Emergent Epidemic of CKD from Heat Stress in Rural Communities: The Case for Heat Stress Nephropathy. Clin. J. Am. Soc. Nephrol. 2016, 11, 1472-1483.
8. Flores, S.; Rider, A.C.; Alter, H.J. Mesoamerican nephropathy: A novel case of kidney failure in a US ED. Am. J. Emerg Med. 2015, 34, 1323.e5-1323.e6.
9. Organization, P.A.H. Epidemic of Chronic Kidney Disease in Agricultural Communities in Central America Case Definitions, Methodological Basis and Approaches for Public Health Surveillance; Pan American Health Organization: Washington, DC, USA, 2017.
10. Elledge, M.F.; Redmon, J.H.; Levine, K.E.; Wickremasinghe, R.J.; Wanigasariya, K.P.; Peiris-John, R.J. Chronic Kidney Disease of Unknown Etiology in Sri Lanka: Quest for Understanding and Global Implications; RTI Research Brief. Research; RTI Press: Triangle Park, NC, USA, 2014.
11. Flouris, A.D.; Dinas, P.C.; Ioannou, L.G.; Nybo, L.; Havenith, G.; Kenny, G.P.; Kjellstrom, T. Workers’ health and productivity under occupational heat strain: A systematic review and meta-analysis. Lancet Planet. Health 2018, 2, e521-e531.
12. Pearce, N.; Caplin, B. Let’s Take the Heat OUT of the CKDu Debate: More Evidence Is Needed; BMJ Publishing Group Ltd.: London, UK, 2019.
13. Wijkström, J.; Leiva, R.; Elinder, C.-G.; Leiva, S.; Trujillo, Z.; Trujillo, L.; Söderberg, M.; Hultenby, K.; Wernerson, A. Clinical and pathological characterization of Mesoamerican nephropathy: A new kidney disease in Central America. Am. J. Kidney Dis. 2013, 62, 908-918.
14. Correa-Rotter, R.; Wesseling, C.; Johnson, R.J. CKD of unknown origin in Central America: The case for a Mesoamerican nephropathy. Am. J. Kidney Dis. 2014, 63, 506-520.
15. Roncal-Jimenez, C.; Lanaspa, M.; Jensen, T.; Sanchez-Lozada, L.; Johnson, R. Mechanisms by which dehydration may lead to chronic kidney disease. Ann. Nutr. Metab. 2015, 66, 10-13.
16. Roncal-Jimenez, C.A.; García-Trabanino, R.; Wesseling, C.; Johnson, R.J. Mesoamerican Nephropathy or Global Warming Nephropathy? Blood Purif. 2016, 41, 135-138.
17. Orantes, C.M.; Herrera, R.; Almaguer, M.; Brizuela, E.G.; Hernández, C.E.; Bayarre, H.; Amaya, J.C.; Calero, D.J.; Orellana, P.; Colindres, R.M. Chronic kidney disease and associated risk factors in the Bajo Lempa region of El Salvador: Nefrolempa study, 2009. Med. Rev. 2011, 13, 14-22.
18. Herrera, R.; Orantes, C.M.; Almaguer, M.; Alfonso, P.; Bayarre, H.D.; Leiva, I.M.; Smith, M.J.; Cubias, R.A.; Almendárez, W.O.; Cubias, F.R. Clinical characteristics of chronic kidney disease of nontraditional causes in Salvadoran farming communities. Med. Rev. 2014, 16, 39-48.
19. Butler-Dawson, J.; Krisher, L.; Asensio, C.; Cruz, A.; Tenney, L.; Weitzenkamp, D.; Dally, M.; Asturias, E.J.; Newman, L.S. Risk factors for declines in kidney function in sugarcane workers in Guatemala. J. Occup. Environ. Med. 2018, 60, 548.
20. González-Quiroz, M.; Pearce, N.; Caplin, B.; Nitsch, D. What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis. Clin. Kidney J. 2017, 11, 496-506.
21. McClean, M.; Amador, J.J.; Laws, R.; Kaufman, J.S.; Weiner, D.E.; Sanchez-Rodriguez, J.; Brooks, D. Biological Sampling Report: Investigating Biomarkers of Kidney Injury and Chronic Kidney Disease among Workers in Western Nicaragua; University School of Public Health; Compliance Advisor Ombudsman: Boston, MA, USA, 2012.
22. Gifford, F.J.; Gifford, R.M.; Eddleston, M.; Dhaun, N. Endemic Nephropathy Across the World. Kidney Int. 2016, 2, 282-292.
23. Johnson, R.J.; Glaser, J.; Sánchez-Lozada, L.G. Chronic kidney disease of unknown etiology: A disease related to global warming? Med. Rev. 2014, 16, 79.
24. Chapman, E.; Haby, M.M.; Illanes, E.; Sanchez-Viamonte, J.; Elias, V.; Reveiz, L. Risk factors for chronic kidney disease of non-traditional causes: A systematic review. Pan Am. J. Pub. Health 2019, 43, e35.
25. Valcke, M.; Levasseur, M.-E.; da Silva, A.S.; Wesseling, C. Pesticide exposures and chronic kidney disease of unknown etiology: An epidemiologic review. Environ. Health 2017, 16, 49.
26. Sorensen, C.J.; Butler-Dawson, J.; Dally, M.; Krisher, L.; Griffin, B.R.; Johnson, R.J.; Lemery, J.; Asensio, C.; Tenney, L.; Newman, L.S. Risk Factors and Mechanisms Underlying Cross-Shift Decline in Kidney Function in Guatemalan Sugarcane Workers. J. Occup. Environ. Med. 2019, 61, 239.
27. Roncal-Jimenez, C.; García-Trabanino, R.; Barregard, L.; Lanaspa, M.A.; Wesseling, C.; Harra, T.; Aragón, A.; Grases, F.; Jarquin, E.R.; González, M.A. Heat stress nephropathy from exercise-induced uric acid crystalluria: A perspective on Mesoamerican nephropathy. Am. J. Kidney Dis. 2016, 67, 20-30.
28. Madero, M.; García-Arroyo, F.E.; Sánchez-Lozada, L.-G. Pathophysiologic insight into MesoAmerican nephropathy. Curr. Opin. Nephrol. Hypertens. 2017, 26, 296-302.
29. Schlader, Z.J.; Chapman, C.L.; Sarkar, S.; Russo, L.; Rideout, T.C.; Parker, M.D.; Johnson, B.D.; Hostler, D. Firefighter work duration influences the extent of acute kidney injury. Med. Sci. Sport Exerc. 2017, 49, 1745-1753.
30. Chapman, C.L.; Johnson, B.D.; Sackett, J.R.; Parker, M.D.; Schlader, Z.J. Soft drink consumption during and following exercise in the heat elevates biomarkers of acute kidney injury. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2019, 316, R189-R198.
31. Laws, R.L.; Brooks, D.R.; Amador, J.J.; Weiner, D.E.; Kaufman, J.S.; Ramírez-Rubio, O.; Riefkohl, A.; Scammell, M.K.; López-Pilarte, D.; Sánchez, J.M. Biomarkers of kidney injury among Nicaraguan sugarcane workers. Am. J. Kidney Dis. 2016, 67, 209-217.
32. Butler-Dawson, J.; Krisher, L.; Yoder, H.; Dally, M.; Sorensen, C.; Johnson, R.J.; Asensio, C.; Cruz, A.; Johnson, E.C.; Carlton, E.J. Evaluation of heat stress and cumulative incidence of acute kidney injury in sugarcane workers in Guatemala. Int. Arch. Occup. Environ. Health 2019, 1-14.
33. Au, V.; Feit, J.; Barasch, J.; Sladen, R.N.; Wagener, G. Urinary neutrophil gelatinase-associated lipocalin (NGAL) distinguishes sustained from transient acute kidney injury after general surgery. Kidney Int. Rep. 2016, 1, 3-9.
34. Rawson, E.S.; Clarkson, P.M.; Tarnopolsky, M.A. Perspectives on exertional rhabdomyolysis. Sports Med. 2017, 47, 33-49.
35. Correa-Rotter, R.; García-Trabanino, R. Mesoamerican nephropathy. Semin. Nephrol. 2019, 39, 263-271.
36. Junglee, N.A.; Di Felice, U.; Dolci, A.; Fortes, M.B.; Jibani, M.M.; Lemmey, A.B.; Walsh, N.P.; Macdonald, J.H. Exercising in a hot environment with muscle damage: Effects on acute kidney injury biomarkers and kidney function. Am. J. Physiol. Ren. Physiol. 2013, 305, F813-F820.
37. Sánchez-Lozada, L.-G.; García-Arroyo, F.E.; Gonzaga, G.; Silverio, O.; Blas-Marron, M.G.; Muñoz-Jimenez, I.; Tapia, E.; Osorio-Alonso, H.; Madero, M.; Roncal-Jiménez, C.A. Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate. Am. J. Nephrol. 2018, 48, 339-348.
38. Brown, S.J.; Child, R.B.; Day, S.H.; Donnelly, A.E. Exercise-induced skeletal muscle damage and adaptation following repeated bouts of eccentric muscle contractions. J. Sports Sci. 1997, 15, 215-222.
39. Herath, C.; Jayasumana, C.; De Silva, P.M.C.; De Silva, P.C.; Siribaddana, S.; De Broe, M.E. Kidney diseases in agricultural communities: A case against heat-stress nephropathy. Kidney Int. Rep. 2018, 3, 271-280.
40. Basile, D.P.; Bonventre, J.V.; Mehta, R.; Nangaku, M.; Unwin, R.; Rosner, M.H.; Kellum, J.A.; Ronco, C. Progression after AKI: Understanding maladaptive repair processes to predict and identify therapeutic treatments. J. Am. Soc. Nephrol. 2015, 27, 687-697.
41. Basile, D.P.; Anderson, M.D.; Sutton, T.A. Pathophysiology of acute kidney injury. Compr. Physiol. 2011, 2, 1303-1353.
42. Basile, D.P.; Donohoe, D.; Roethe, K.; Osborn, J.L. Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am. J. Physiol. Ren. Physiol. 2001, 281, F887-F899.
43. Tanaka, S.; Tanaka, T.; Nangaku, M. Hypoxia as a key player in the AKI-to-CKD transition. Am. J. Physiol. Ren. Physiol. 2014, 307, F1187-F1195.
44. Ferenbach, D.A.; Bonventre, J.V. Acute kidney injury and chronic kidney disease: From the laboratory to the clinic. Nephrol. Ther. 2016, 12, S41-S48.
45. Humphreys, B.D. Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition. Nephron 2017, 137, 264-267.
46. Ko, G.J.; Grigoryev, D.N.; Linfert, D.; Jang, H.R.; Watkins, T.; Cheadle, C.; Racusen, L.; Rabb, H. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition. Am. J. Physiol. Ren. Physiol. 2010, 298, F1472-F1483.
47. Roncal-Jimenez, C.A.; Ishimoto, T.; Lanaspa, M.A.; Rivard, C.J.; Nakagawa, T.; Ejaz, A.A.; Cicerchi, C.; Inaba, S.; Le, M.; Miyazaki, M. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2014, 86, 294-302.
48. Roncal-Jimenez, C.A.; Milagres, T.; Andres-Hernando, A.; Kuwabara, M.; Jensen, T.; Song, Z.; Bjornstad, P.; Garcia, G.E.; Sato, Y.; Sanchez-Lozada, L.G. Effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Am. J. Physiol. Ren. Physiol. 2017, 312, F418-F426.
49. Roncal-Jimenez, C.A.; Sato, Y.; Milagres, T.; Andres-Hernando, A.; Garcia, G.E.; Bjornstad, P.; Butler-Dawson, J.; Sorensen, C.; Newman, L.; Krisher, L. Experimental Heat Stress Nephropathy and Liver Injury are Improved by Allopurinol. Am. J. Physiol. Ren. Physiol. 2018, 315, F726-F733.
50. Moyce, S.; Joseph, J.; Tancredi, D.; Mitchell, D.; Schenker, M. Cumulative Incidence of Acute Kidney Injury in California’s Agricultural Workers. J. Occup. Environ. Med. 2016, 58, 391-397.
51. García-Trabanino, R.; Jarquín, E.; Wesseling, C.; Johnson, R.J.; González-Quiroz, M.; Weiss, I.; Glaser, J.; Vindell, J.J.; Stockfelt, L.; Roncal, C. Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador—A cross-shift study of workers at risk of Mesoamerican nephropathy. Environ. Res. 2015, 142, 746-755.
52. Laws, R.L.; Brooks, D.R.; Amador, J.J.; Weiner, D.E.; Kaufman, J.S.; Ramírez-Rubio, O.; Riefkohl, A.; Scammell, M.K.; López-Pilarte, D.; Sánchez, J.M. Changes in kidney function among Nicaraguan sugarcane workers. Int. J. Occup. Environ. Health 2015, 21, 241-250.
53. Santos, U.P.; Zanetta, D.M.T.; Terra-Filho, M.; Burdmann, E.A. Burnt sugarcane harvesting is associated with acute renal dysfunction. Kidney Int. 2015, 87, 792-799.
54. Wesseling, C.; Aragón, A.; González, M.; Weiss, I.; Glaser, J.; Bobadilla, N.A.; Roncal-Jiménez, C.; Correa-Rotter, R.; Johnson, R.J.; Barregard, L. Kidney function in sugarcane cutters in Nicaragua-A longitudinal study of workers at risk of Mesoamerican nephropathy. Environ. Res. 2016, 147, 125-132.
55. Moyce, S.; Mitchell, D.; Armitage, T.; Tancredi, D.; Joseph, J.; Schenker, M. Heat strain, volume depletion and kidney function in California agricultural workers. Occup. Environ. Med. 2017, 74, 402-409.
56. Wesseling, C.; García-Trabanino, R.; Wegman, D.H. Mesoamerican Nephropathy: Do Novel Biomarkers of Kidney Damage Have a Role to Play? Am. J. Kidney Dis. 2016, 67, 173-175.
57. Heung, M.; Steffick, D.E.; Zivin, K.; Gillespie, B.W.; Banerjee, T.; Hsu, C.-Y.; Powe, N.R.; Pavkov, M.E.; Williams, D.E.; Saran, R. Acute kidney injury recovery pattern and subsequent risk of CKD: An analysis of veterans health administration data. Am. J. Kidney Dis. 2016, 67, 742-752.
58. Coca, S.G.; Singanamala, S.; Parikh, C.R. Chronic kidney disease after acute kidney injury: A systematic review and meta-analysis. Kidney Int. 2012, 81, 442-448.
59. Arias-Cabrales, C.; Rodríguez, E.; Bermejo, S.; Sierra, A.; Burballa, C.; Barrios, C.; Soler, M.J.; Pascual, J. Short-and long-term outcomes after non-severe acute kidney injury. Clin. Exp. Nephrol. 2017, 1-7.
60. Ishani, A.; Xue, J.L.; Himmelfarb, J.; Eggers, P.W.; Kimmel, P.L.; Molitoris, B.A.; Collins, A.J. Acute kidney injury increases risk of ESRD among elderly. J. Am. Soc. Nephrol. 2009, 20, 223-228.
61. Schiffl, H.; Fischer, R. Five-year outcomes of severe acute kidney injury requiring renal replacement therapy. Nephrol. Dial. Transplant. 2008, 23, 2235-2241.
62. Uchino, S.; Bellomo, R.; Bagshaw, S.M.; Goldsmith, D. Transient azotaemia is associated with a high risk of death in hospitalized patients. Nephrol. Dial. Transplant. 2010, 25, 1833-1839.
63. Chawla, L.S.; Eggers, P.W.; Star, R.A.; Kimmel, P.L. Acute kidney injury and chronic kidney disease as interconnected syndromes. New Engl. J. Med. 2014, 371, 58-66.
64. Chawla, L.S.; Kimmel, P.L. Acute kidney injury and chronic kidney disease: An integrated clinical syndrome. Kidney Int. 2012, 82, 516-524.
65. Belayev, L.Y.; Palevsky, P.M. The link between AKI and CKD. Curr. Opin. Nephrol. Hypertens. 2014, 23, 149.
66. Roncal, C.A.; Mu, W.; Croker, B.; Reungjui, S.; Ouyang, X.; Tabah-Fisch, I.; Johnson, R.J.; Ejaz, A.A. Effect of elevated serum uric acid on cisplatin-induced acute renal failure. Am. J. Physiol. Ren. Physiol. 2007, 292, F116-F122.
67. Ryu, E.-S.; Kim, M.J.; Shin, H.-S.; Jang, Y.-H.; Choi, H.S.; Jo, I.; Johnson, R.J.; Kang, D.-H. Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease. Am. J. Physiol. Ren. Physiol. 2013, 304, F471-F480.
68. Suga, S.-I.; Phillips, M.I.; Ray, P.E.; Raleigh, J.A.; Vio, C.P.; Kim, Y.-G.; Mazzali, M.; Gordon, K.L.; Hughes, J.; Johnson, R.J. Hypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity. Am. J. Physiol. Ren. Physiol. 2001, 281, F620-F629.
69. Perner, A.; Prowle, J.; Joannidis, M.; Young, P.; Hjortrup, P.B.; Pettilä, V. Fluid management in acute kidney injury. Intensive Care Med. 2017, 43, 807-815.
70. McDermott, B.P.; Smith, C.R.; Butts, C.L.; Caldwell, A.R.; Lee, E.C.; Vingren, J.L.; Munoz, C.X.; Kunces, L.J.; Williamson, K.; Ganio, M.S. Renal stress and kidney injury biomarkers in response to endurance cycling in the heat with and without ibuprofen. J. Sci. Med. Sport 2018, 21, 1180-1184.
71. Kellum, J.A.; Lameire, N.; Aspelin, P.; Barsoum, R.S.; Burdmann, E.A.; Goldstein, S.L.; Herzog, C.A.; Joannidis, M.; Kribben, A.; Levey, A.S. Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. Suppl. 2012, 2, 1-138.
72. Levey, A.S.; Eckardt, K.-U.; Tsukamoto, Y.; Levin, A.; Coresh, J.; Rossert, J.; Zeeuw, D.D.; Hostetter, T.H.; Lameire, N.; Eknoyan, G. Definition and classification of chronic kidney disease: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005, 67, 2089-2100.
73. Mehta, R.L.; Kellum, J.A.; Shah, S.V.; Molitoris, B.A.; Ronco, C.; Warnock, D.G.; Levin, A. Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit. Care 2007, 11, R31.
74. Bellomo, R.; Ronco, C.; Kellum, J.A.; Mehta, R.L.; Palevsky, P. Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: The Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care 2004, 8, R204.
75. Kellum, J.A.; Lameire, N. Diagnosis, evaluation, and management of acute kidney injury: A KDIGO summary (Part 1). Crit. Care 2013, 17, 204.
76. Beierwaltes, W.H.; Harrison-Bernard, L.M.; Sullivan, J.C.; Mattson, D.L. Assessment of renal function; clearance, the renal microcirculation, renal blood flow, and metabolic balance. Compr. Physiol. 2013, 3, 165-200.
77. Traynor, J.; Mactier, R.; Geddes, C.C.; Fox, J.G. How to measure renal function in clinical practice. BMJ 2006, 333, 733-737.
78. Yong, Z.; Pei, X.; Zhu, B.; Yuan, H.; Zhao, W. Predictive value of serum cystatin C for acute kidney injury in adults: A meta-analysis of prospective cohort trials. Sci. Rep. 2017, 7, 41012.
79. Odutayo, A.; Cherney, D. Cystatin C and acute changes in glomerular filtration rate. Clin. Nephrol. 2012, 78, 64-75.
80. Parikh, C.R.; Coca, S.G. Acute kidney injury: Defining prerenal azotemia in clinical practice and research. Nat. Rev. Nephrol. 2010, 6, 641.
81. McCance, R.; Widdowson, E. The secretion of urine in man during experimental salt deficiency. J. Physiol. 1937, 91, 222-231.
82. Nadal, J.W.; Pedersen, S.; Maddock, W.G. A comparison between dehydration from salt loss and from water deprivation. J. Clin. Invest. 1941, 20, 691.
83. Kirkebø, A.; Tyssebotn, I. Effect of dehydration on renal blood flow in dog. Acta Physiol. Scand. 1977, 101, 257-263.
84. Hope, A.; Tyssebotn, I. The effect of water deprivation on local renal blood flow and filtration in the laboratory rat. Circ. Shock 1982, 11, 175-186.
85. Stocker, S.D.; Hunwick, K.J.; Toney, G.M. Hypothalamic paraventricular nucleus differentially supports lumbar and renal sympathetic outflow in water-deprived rats. J. Physiol. 2005, 563, 249-263.
86. Bardgett, M.E.; Chen, Q.-H.; Guo, Q.; Calderon, A.S.; Andrade, M.A.; Toney, G.M. Coping with dehydration: Sympathetic activation and regulation of glutamatergic transmission in the hypothalamic PVN. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2014, 306, R804-R813.
87. Bie, P. Osmoreceptors, vasopressin, and control of renal water excretion. Physiol. Rev. 1980, 60, 961-1048.
88. Di Nicolantonio, R.; Mendelsohn, F. Plasma renin and angiotensin in dehydrated and rehydrated rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1986, 250, R898-R901.
89. Mack, G.W.; Nadel, E.R. Body fluid balance during heat stress in humans. In Comprehensive Physiology; Supplement 14: Handbook of Physiology, Environmental Physiology; Wiley: Hoboken, NJ, USA, 2011; pp. 187-214.
90. Cheuvront, S.N.; Ely, B.R.; Kenefick, R.W.; Sawka, M.N. Biological variation and diagnostic accuracy of dehydration assessment markers. Am. J. Clin. Nutr. 2010, 92, 565-573.
91. Griffin, B.R.; Gist, K.M.; Faubel, S. Current status of novel biomarkers for the diagnosis of acute kidney injury: A historical perspective. J. Intensive Care Med. 2019, 0885066618824531.
92. Malhotra, R.; Siew, E.D. Biomarkers for the early detection and prognosis of acute kidney injury. Clin. J. Am. Soc. Nephrol. 2017, 12, 149-173.
93. Koyner, J.L.; Parikh, C.R. Clinical utility of biomarkers of AKI in cardiac surgery and critical illness. Clin. J. Am. Soc. Nephrol. 2013, 8, 1034-1042.
94. Schrezenmeier, E.; Barasch, J.; Budde, K.; Westhoff, T.; Schmidt-Ott, K. Biomarkers in acute kidney injury-pathophysiological basis and clinical performance. Acta Physiol. 2017, 219, 556-574.
95. Schaub, J.A.; Parikh, C.R. Biomarkers of acute kidney injury and associations with short-and long-term outcomes. F1000Research 2016, 5.
96. Kashani, K.; Kellum, J.A. Novel biomarkers indicating repair or progression after acute kidney injury. Curr. Opin. Nephrol. Hypertens. 2015, 24, 21-27.
97. Haase, M.; Kellum, J.A.; Ronco, C. Subclinical AKI—An emerging syndrome with important consequences. Nat. Rev. Nephrol. 2012, 8, 735.
98. Chakraborty, S.; Kaur, S.; Guha, S.; Batra, S.K. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochim. Biophys. Acta Rev. Cancer 2012, 1826, 129-169.
99. Goetz, D.H.; Holmes, M.A.; Borregaard, N.; Bluhm, M.E.; Raymond, K.N.; Strong, R.K. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell 2002, 10, 1033-1043.
100. Mishra, J.; Mori, K.; Ma, Q.; Kelly, C.; Barasch, J.; Devarajan, P. Neutrophil gelatinase-associated lipocalin: A novel early urinary biomarker for cisplatin nephrotoxicity. Am. J. Nephrol. 2004, 24, 307-315.
101. Mishra, J.; Dent, C.; Tarabishi, R.; Mitsnefes, M.M.; Ma, Q.; Kelly, C.; Ruff, S.M.; Zahedi, K.; Shao, M.; Bean, J. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005, 365, 1231-1238.
102. Mishra, J.; Ma, Q.; Prada, A.; Mitsnefes, M.; Zahedi, K.; Yang, J.; Barasch, J.; Devarajan, P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J. Am. Soc. Nephrol. 2003, 14, 2534-2543.
103. Supavekin, S.; Zhang, W.; Kucherlapati, R.; Kaskel, F.J.; Moore, L.C.; Devarajan, P. Differential gene expression following early renal ischemia/reperfusion. Kidney Int. 2003, 63, 1714-1724.
104. Schmidt-Ott, K.M.; Mori, K.; Li, J.Y.; Kalandadze, A.; Cohen, D.J.; Devarajan, P.; Barasch, J. Dual action of neutrophil gelatinase-associated lipocalin. J. Am. Soc. Nephrol. 2007, 18, 407-413.
105. Hvidberg, V.; Jacobsen, C.; Strong, R.K.; Cowland, J.B.; Moestrup, S.K.; Borregaard, N. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett. 2005, 579, 773-777.
106. Singer, E.; Elger, A.; Elitok, S.; Kettritz, R.; Nickolas, T.L.; Barasch, J.; Luft, F.C.; Schmidt-Ott, K.M. Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney Int. 2011, 80, 405-414.
107. Nejat, M.; Pickering, J.W.; Devarajan, P.; Bonventre, J.V.; Edelstein, C.L.; Walker, R.J.; Endre, Z.H. Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int. 2012, 81, 1254-1262.
108. Ichimura, T.; Bonventre, J.V.; Bailly, V.; Wei, H.; Hession, C.A.; Cate, R.L.; Sanicola, M. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 1998, 273, 4135-4142.
109. Prozialeck, W.; Vaidya, V.; Liu, J.; Waalkes, M.; Edwards, J.; Lamar, P.; Bernard, A.; Dumont, X.; Bonventre, J. Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity. Kidney Int. 2007, 72, 985-993.
110. Ichimura, T.; Hung, C.C.; Yang, S.A.; Stevens, J.L.; Bonventre, J.V. Kidney injury molecule-1: A tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am. J. Physiol. Ren. Physiol. 2004, 286, F552-F563.
111. Han, W.K.; Bailly, V.; Abichandani, R.; Thadhani, R.; Bonventre, J.V. Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int. 2002, 62, 237-244.
112. Wang, G.; Gong, Y.; Anderson, J.; Sun, D.; Minuk, G.; Roberts, M.S.; Burczynski, F.J. Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells. Hepatology 2005, 42, 871-879.
113. Yamamoto, T.; Noiri, E.; Ono, Y.; Doi, K.; Negishi, K.; Kamijo, A.; Kimura, K.; Fujita, T.; Kinukawa, T.; Taniguchi, H. Renal L-type fatty acid-binding protein in acute ischemic injury. J. Am. Soc. Nephrol. 2007, 18, 2894-2902.
114. Doi, K.; Negishi, K.; Ishizu, T.; Katagiri, D.; Fujita, T.; Matsubara, T.; Yahagi, N.; Sugaya, T.; Noiri, E. Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit. Crit. Care Med. 2011, 39, 2464-2469.
115. Gauer, S.; Sichler, O.; Obermüller, N.; Holzmann, Y.; Kiss, E.; Sobkowiak, E.; Pfeilschifter, J.; Geiger, H.; Mühl, H.; Hauser, I. IL-18 is expressed in the intercalated cell of human kidney. Kidney Int. 2007, 72, 1081-1087.
116. Franke, E.I.; Vanderbrink, B.A.; Hile, K.L.; Zhang, H.; Cain, A.; Matsui, F.; Meldrum, K.K. Renal IL-18 production is macrophage independent during obstructive injury. PLoS ONE 2012, 7, e47417.
117. Lin, X.; Yuan, J.; Zhao, Y.; Zha, Y. Urine interleukin-18 in prediction of acute kidney injury: A systemic review and meta-analysis. J. Nephrol. 2015, 28, 7-16.
118. Kellum, J.A.; Chawla, L.S. Cell-cycle arrest and acute kidney injury: The light and the dark sides. Nephrol. Dial. Transplant. 2015, 31, 16-22.
119. Rodier, F.; Campisi, J.; Bhaumik, D. Two faces of p53: Aging and tumor suppression. Nucleic Acids Res. 2007, 35, 7475-7484.
120. Shankland, S.J. Cell cycle regulatory proteins in glomerular disease. Kidney Int. 1999, 56, 1208-1215.
121. Witzgall, R.; Brown, D.; Schwarz, C.; Bonventre, J.V. Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J. Clin. Investig. 1994, 93, 2175-2188.
122. Yang, L.; Besschetnova, T.Y.; Brooks, C.R.; Shah, J.V.; Bonventre, J.V. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat. Med. 2010, 16, 535.
123. Kashani, K.; Al-Khafaji, A.; Ardiles, T.; Artigas, A.; Bagshaw, S.M.; Bell, M.; Bihorac, A.; Birkhahn, R.; Cely, C.M.; Chawla, L.S. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit. Care 2013, 17, R25.
124. Endre, Z.H.; Pickering, J.W. Acute kidney injury: Cell cycle arrest biomarkers win race for AKI diagnosis. Nat. Rev. Nephrol. 2014, 10, 683.
125. Price, P.M.; Safirstein, R.L.; Megyesi, J. The cell cycle and acute kidney injury. Kidney Int. 2009, 76, 604-613.
126. Johnson, A.C.; Zager, R.A. Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI. J. Am. Soc. Nephrol. 2018, 76, 604-613.
127. McCullough, P.A.; Chinnaiyan, K.M.; Gallagher, M.J.; Colar, J.M.; Geddes, T.; Gold, J.M.; Trivax, J.E. Changes in renal markers and acute kidney injury after marathon running. Nephrology 2011, 16, 194-199.
128. Hoffman, M.D.; Stuempfle, K.J.; Fogard, K.; Hew-Butler, T.; Winger, J.; Weiss, R.H. Urine dipstick analysis for identification of runners susceptible to acute kidney injury following an ultramarathon. J. Sport Sci. 2013, 31, 20-31.
129. Hou, S.-K.; Chiu, Y.-H.; Tsai, Y.-F.; Tai, L.-C.; Hou, P.C.; How, C.-K.; Yang, C.-C.; Kao, W.-F. Clinical impact of speed variability to identify ultramarathon runners at risk for acute kidney injury. PLoS ONE 2015, 10, e0133146.
130. Mansour, S.G.; Verma, G.; Pata, R.W.; Martin, T.G.; Perazella, M.A.; Parikh, C.R. Kidney injury and repair biomarkers in marathon runners. Am. J. Kidney Dis. 2017, 70, 252-261.
131. Bongers, C.C.; Alsady, M.; Nijenhuis, T.; Hartman, Y.A.; Eijsvogels, T.M.; Deen, P.M.; Hopman, M.T. Impact of acute versus repetitive moderate intensity endurance exercise on kidney injury markers. Physiol. Rep. 2017, 5, e13544.
132. Bongers, C.C.; Alsady, M.; Nijenhuis, T.; Tulp, A.D.; Eijsvogels, T.M.; Deen, P.M.; Hopman, M.T. Impact of acute versus prolonged exercise and dehydration on kidney function and injury. Physiol. Rep. 2018, 6, e13734.
133. Eichner, E.R. Is Heat Stress Nephropathy a Concern for Endurance Athletes? Curr. Sport Med. Rep. 2017, 16, 299-300.
134. Latham, A. The history of a habit: Jogging as a palliative to sedentariness in 1960s America. Cult. Geogr. 2015, 22, 103-126.
135. Rewa, O.; Bagshaw, S.M. Acute kidney injury—Epidemiology, outcomes and economics. Nat. Rev. Nephrol. 2014, 10, 193.
136. Stump, C.S. Physical activity in the prevention of chronic kidney disease. Cardiorenal Med. 2011, 1, 164-173.
137. Murray, P.T.; Mehta, R.L.; Shaw, A.; Ronco, C.; Endre, Z.; Kellum, J.A.; Chawla, L.S.; Cruz, D.; Ince, C.; Okusa, M.D. Potential use of biomarkers in acute kidney injury: Report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. Kidney Int. 2014, 85, 513-521.
138. Katz, N.; Ronco, C. Acute kidney stress—A useful term based on evolution in the understanding of acute kidney injury. Crit. Care 2015, 20, 23.
139. Kellum, J.A. Diagnostic criteria for acute kidney injury: Present and future. Crit. Care Clin. 2015, 31, 621-632.
140. Waikar, S.S.; Sabbisetti, V.S.; Bonventre, J.V. Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int. 2010, 78, 486-494.
141. Junglee, N.A.; Lemmey, A.B.; Burton, M.; Searell, C.; Jones, D.; Lawley, J.S.; Jibani, M.M.; Macdonald, J.H. Does proteinuria-inducing physical activity increase biomarkers of acute kidney injury? Kidney Blood Press. Res. 2012, 36, 278-289.
142. Schrier, R.W.; Henderson, H.S.; Tisher, C.C.; Tannen, R.L. Nephropathy associated with heat stress and exercise. Ann. Intern. Med. 1967, 67, 356-376.
143. Schrier, R.W.; Hano, J.; Keller, H.I.; Finkel, R.M.; Gilliland, P.F.; Cirksena, W.J.; Teschan, P.E. Renal, metabolic, and circulatory responses to heat and exercise. Studies in military recruits during summer training, with implications for acute renal failure. Ann. Intern. Med. 1970, 73, 213-223.
144. Montain, S.J.; Coyle, E.F. Influence of graded dehydration on hyperthermia and cardiovascular drift during exercise. J. Appl. Physiol. 1992, 73, 1340-1350.
145. Farquhar, W.; Morgan, A.; Zambraski, E.; Kenney, W. Effects of acetaminophen and ibuprofen on renal function in the stressed kidney. J. Appl. Physiol. 1999, 86, 598-604.
146. Radigan, L.R.; Robinson, S. Effects of environmental heat stress and exercise on renal blood flow and filtration rate. J. Appl. Physiol. 1949, 2, 185-191.
147. Barclay, J.; Cooke, W.; Kenney, R.; Nutt, M.E. The effects of water diuresis and exercise on the volume and composition of the urine. Am. J. Physiol. 1947, 148, 327-337.
148. Kenney, W.; Zappe, D. Effect of age on renal blood flow during exercise. Aging Clin. Exp. Res. 1994, 6, 293-302.
149. Kawakami, S.; Yasuno, T.; Matsuda, T.; Fujimi, K.; Ito, A.; Yoshimura, S.; Uehara, Y.; Tanaka, H.; Saito, T.; Higaki, Y. Association between exercise intensity and renal blood flow evaluated using ultrasound echo. Clin. Exp. Nephrol. 2018, 22, 1061-1068.
150. Smith, J.; Robinson, S.; Pearcy, M. Renal responses to exercise, heat and dehydration. J. Appl. Physiol. 1952, 4, 659-665.
151. Wilson, T.E. Renal sympathetic nerve, blood flow, and epithelial transport responses to thermal stress. Auton. Neurosci. Basic Clin. 2017, 204, 25-34.
152. Azzawi, S.; Shirley, D. The effect of vasopressin on renal blood flow and its distribution in the rat. J. Physiol. 1983, 341, 233-244.
153. Freeman, R.H.; Davis, J.O.; Vitale, S.J.; Johnson, J.A. Intrarenal role of angiotensin II: Homeostatic regulation of renal blood flow in the dog. Circ. Res. 1973, 32, 692-698.
154. Mittleman, K.D. Influence of angiotensin II blockade during exercise in the heat. Eur. J. Appl. Physiol. Occup. Physiol. 1996, 72, 542-547.
155. Miyamoto, M. Renal cortical and medullary tissue blood flow during experimental hyperthermia in dogs. Therm. Med 1994, 10, 78-89.
156. Devarajan, P. Update on mechanisms of ischemic acute kidney injury. J. Am. Soc. Nephrol. 2006, 17, 1503-1520.
157. Zhuo, J.L.; Li, X.C. Proximal nephron. Compr. Physiol. 2013, 3, 1079-1123.
158. Palmer, L.G.; Schnermann, J. Integrated control of Na transport along the nephron. Clin. J. Am. Soc. Nephrol. 2015, 10, 676-687.
159. El Mernissi, G.; Doucet, A. Short-term effect of aldosterone on renal sodium transport and tubular Na−K-ATPase in the rat. Pflügers Arch. 1983, 399, 139-146.
160. Johnson, M.D.; Malvin, R.L. Stimulation of renal sodium reabsorption by angiotensin II. Am. J. Physiol. Ren. Physiol. 1977, 232, F298-F306.
161. Bell-Reuss, E.; Trevino, D.; Gottschalk, C. Effect of renal sympathetic nerve stimulation on proximal water and sodium reabsorption. J. Clin. Investig. 1976, 57, 1104-1107.
162. Montain, S.J.; Laird, J.E.; Latzka, W.A.; Sawka, M.N. Aldosterone and vasopressin responses in the heat: Hydration level and exercise intensity effects. Med. Sci. Sports Exerc. 1997, 29, 661-668.
163. Kenney, M.J.; Barney, C.C.; Hirai, T.; Gisolfi, C.V. Sympathetic nerve responses to hyperthermia in the anesthetized rat. J. Appl. Physiol. 1995, 78, 881-889.
164. Melin, B.; Koulmann, N.; Jimenez, C.; Savourey, G.; Launay, J.-C.; Cottet-Emard, J.-M.; Pequignot, J.-M.; Allevard, A.-M.; Gharib, C. Comparison of passive heat or exercise-induced dehydration on renal water and electrolyte excretion: The hormonal involvement. Eur. J. Appl. Physiol. 2001, 85, 250-258.
165. Doucet, A. Function and control of Na-K-ATPase in single nephron segments of the mammalian kidney. Kidney Int. 1988, 34, 749-760.
166. Barrera-Chimal, J.; Pérez-Villalva, R.; Ortega, J.A.; Sánchez, A.; Rodríguez-Romo, R.; Durand, M.; Jaisser, F.; Bobadilla, N.A. Mild ischemic injury leads to long-term alterations in the kidney: Amelioration by spironolactone administration. Int. J. Biol. Sci. 2015, 11, 892.
167. Lattenist, L.; Lechner, S.M.; Messaoudi, S.; Le Mercier, A.; El Moghrabi, S.; Prince, S.; Bobadilla, N.A.; Kolkhof, P.; Jaisser, F.; Barrera-Chimal, J. Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury-Mediated Chronic Kidney Disease: Role of Oxidative Stress. Hypertension 2017, 69, 870-878.
168. Otani, H.; Kaya, M.; Tsujita, J. Effect of the volume of fluid ingested on urine concentrating ability during prolonged heavy exercise in a hot environment. J. Sports Sci. Med. 2013, 12, 197.
169. Evans, R.G.; Ince, C.; Joles, J.A.; Smith, D.W.; May, C.N.; O’Connor, P.M.; Gardiner, B.S. Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology. Clin. Exp. Pharmacol. Physiol. 2013, 40, 106-122.
170. Chayoth, R.; Kleinman, D.; Kaplanski, J.; Sod Moriah, U. Renal clearance of urea, inulin, and p-aminohippurate in heat-acclimated rats. J. Appl. Physiol. 1984, 57, 731-732.
171. Taylor, N.A. Human heat adaptation. Compr. Physiol. 2014, 4, 325-365.
172. Omassoli, J.; Hill, N.E.; Woods, D.R.; Delves, S.K.; Fallowfield, J.L.; Brett, S.J.; Wilson, D.; Corbett, R.W.; Allsopp, A.J.; Stacey, M.J. Variation in renal responses to exercise in the heat with progressive acclimatisation. J. Sci. Med. Sport 2019, 22, 1004-1009.
173. Ho, C.W.; Beard, J.L.; Farrell, P.A.; Minson, C.T.; Kenney, W.L. Age, fitness, and regional blood flow during exercise in the heat. J. Appl. Physiol. 1997, 82, 1126-1135.
174. Minson, C.T.; Wladkowski, S.L.; Cardell, A.F.; Pawelczyk, J.A.; Kenney, W.L. Age alters the cardiovascular response to direct passive heating. J. Appl. Physiol. 1998, 84, 1323-1332.
175. Lim, Y.-H.; So, R.; Lee, C.; Hong, Y.-C.; Park, M.; Kim, L.; Yoon, H.-J. Ambient temperature and hospital admissions for acute kidney injury: A time-series analysis. Sci. Total Environ. 2018, 616, 1134-1138.
176. McTavish, R.K.; Richard, L.; McArthur, E.; Shariff, S.Z.; Acedillo, R.; Parikh, C.R.; Wald, R.; Wilk, P.; Garg, A.X. Association between high environmental heat and risk of acute kidney injury among older adults in a northern climate: A matched case-control study. Am. J. Kidney Dis. 2018, 71, 200-208.
177. Kim, E.; Kim, H.; Kim, Y.C.; Lee, J.P. Association between extreme temperature and kidney disease in South Korea, 2003-2013: Stratified by sex and age groups. Sci. Total Environ. 2018, 642, 800-808.
178. Bobb, J.F.; Obermeyer, Z.; Wang, Y.; Dominici, F. Cause-specific risk of hospital admission related to extreme heat in older adults. JAMA 2014, 312, 2659-2667.
179. Roncal-Jimenez, C.A.; Ishimoto, T.; Lanaspa, M.A.; Milagres, T.; Hernando, A.A.; Jensen, T.; Miyazaki, M.; Doke, T.; Hayasaki, T.; Nakagawa, T. Aging-associated renal disease in mice is fructokinase dependent. Am. J. Physiol. Ren. Physiol. 2016, 311, F722-F730.
180. Stachenfeld, N.S.; Mack, G.W.; Takamata, A.; DiPietro, L.; Nadel, E.R. Thirst and fluid regulatory responses to hypertonicity in older adults. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1996, 271, R757-R765.
181. Phillips, P.A.; Rolls, B.J.; Ledingham, J.G.; Forsling, M.L.; Morton, J.J.; Crowe, M.J.; Wollner, L. Reduced thirst after water deprivation in healthy elderly men. New Engl. J. Med. 1984, 311, 753-759.
182. Garcia-Arroyo, F.E.; Cristóbal, M.; Arellano-Buendía, A.S.; Osorio, H.; Tapia, E.; Soto, V.; Madero, M.; Lanaspa, M.A.; Roncal-Jimenez, C.A.; Bankir, L. Rehydration with Soft Drink-like Beverages Exacerbates Dehydration and Worsens Dehydration-associated Renal Injury. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2016, 111, R57-R65.
183. García-Arroyo, F.E.; Tapia, E.; Blas-Marron, M.G.; Gonzaga, G.; Silverio, O.; Cristóbal, M.; Osorio, H.; Arellano-Buendía, A.S.; Zazueta, C.; Aparicio-Trejo, O.E. Vasopressin Mediates the Renal Damage Induced by Limited Fructose Rehydration in Recurrently Dehydrated Rats. Int. J. Biol. Sci. 2017, 13, 961-975.
184. Burg, M.B. Molecular basis of osmotic regulation. Am. J. Physiol. Ren. Physiol. 1995, 268, F983-F996.
185. Johnson, R.J.; Rodriguez-Iturbe, B.; Roncal-Jimenez, C.; Lanaspa, M.A.; Ishimoto, T.; Nakagawa, T.; Correa-Rotter, R.; Wesseling, C.; Bankir, L.; Sanchez-Lozada, L.G. Hyperosmolarity drives hypertension and CKD--water and salt revisited. Nat. Rev. Nephrol. 2014, 10, 415-420.
186. Cirillo, P.; Gersch, M.S.; Mu, W.; Scherer, P.M.; Kim, K.M.; Gesualdo, L.; Henderson, G.N.; Johnson, R.J.; Sautin, Y.Y. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J. Am. Soc. Nephrol. 2009, 20, 545-553.
187. Lanaspa, M.A.; Ishimoto, T.; Cicerchi, C.; Tamura, Y.; Roncal-Jimenez, C.A.; Chen, W.; Tanabe, K.; Andres-Hernando, A.; Orlicky, D.J.; Finol, E. Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J. Am. Soc. Nephrol. 2014, 25, 2526-2538.
188. Sanchez-Lozada, L.G.; Tapia, E.; Santamaria, J.; Avila-Casado, C.; Soto, V.; Nepomuceno, T.; Rodriguez-Iturbe, B.; Johnson, R.J.; Herrera-Acosta, J. Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats. Kidney Int. 2005, 67, 237-247.
189. Huang, Z.; Hong, Q.; Zhang, X.; Xiao, W.; Wang, L.; Cui, S.; Feng, Z.; Lv, Y.; Cai, G.; Chen, X. Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations. Cell Commun. Signal. 2017, 15, 3.
190. Song, Z.; Roncal-Jimenez, C.A.; Lanaspa-Garcia, M.A.; Oppelt, S.A.; Kuwabara, M.; Jensen, T.; Milagres, T.; Andres-Hernando, A.; Ishimoto, T.; Garcia, G.E. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J. Neurophysiol. 2016, 117, 646-654.
191. Schrier, R.; Berl, T.; Anderson, R. Osmotic and nonosmotic control of vasopressin release. Am. J. Physiol. Ren. Physiol. 1979, 236, F321-F332.