Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes

Kidney International

Volumn 80, Issue 4, 2011, Pages 405-414

  Singer, Eugenia ^a,b,d   Elger, Antje ^a,b   Elitok, Saban ^b   Kettritz, Ralph ^a,b   Nickolas, Thomas L ^c   Barasch, Jonathan ^c   Luft, Friedrich C ^a,b   Schmidt Ott, Kai M ^a,b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b FRANZ VOLHARD CLINIC   (Germany)

^c Columbia University College of Physicians and Surgeons ^*  (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

acute kidney injury; diagnosis; outcomes

Indexed keywords

CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UREA;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DEMOGRAPHY; DIALYSIS; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; DISEASE COURSE; FEMALE; HOSPITAL PATIENT; HUMAN; INTRINSIC ACUTE KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PATIENT CODING; PRERENAL ACUTE KIDNEY FAILURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN URINE LEVEL; REFERENCE VALUE; RISK INJURY FAILURE LOSS OF FUNCTION END STAGE RENAL DISEASE CLASSIFICATION; UREA BLOOD LEVEL;

EID: 80052263618     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.41     Document Type: Article

References (30)

1. Waikar SS, Curhan GC, Wald R et al. Declining mortality in patients with acute renal failure, 1988 to 2002. J Am Soc Nephrol 2006; 17: 1143-1150.
2. Liano F, Pascual J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group. Kidney Int 1996; 50: 811-818. (Pubitemid 26302669)
3. Bellomo R, Ronco C, Kellum JA et al. Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care) 2004; 8: R204-R212.
4. Mehta RL, Kellum JA, Shah SV et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care (Lond) 2007; 11: R31.
5. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet 2005; 365: 417-430. (Pubitemid 40179230)
6. Macedo E, Mehta RL. Prerenal failure: from old concepts to new paradigms. Curr Opin Crit Care 2009; 15: 467-473.
7. Carvounis CP, Nisar S, Guro-Razuman S. Significance of the fractional excretion of urea in the differential diagnosis of acute renal failure. Kidney Int 2002; 62: 2223-2229. (Pubitemid 35366179)
8. Pepin MN, Bouchard J, Legault L et al. Diagnostic performance of fractional excretion of urea and fractional excretion of sodium in the evaluations of patients with acute kidney injury with or without diuretic treatment. Am J Kidney Dis 2007; 50: 566-573. (Pubitemid 47444458)
9. Jurado R, Mattix H. The decreased serum urea nitrogen-creatinine ratio. Arch Intern Med 1998; 158: 2509-2511. (Pubitemid 28555511)
10. Parikh CR, Lu JC, Coca SG et al. Tubular proteinuria in acute kidney injury: a critical evaluation of current status and future promise. Ann Clin Biochem 2010; 47: 301-312.
11. Mishra J, Ma Q, Prada A et al. Identification of neutrophil gelatinaseassociated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 2003; 14: 2534-2543. (Pubitemid 37169339)
12. Mori K, Lee HT, Rapoport D et al. Endocytic delivery of lipocalinsiderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest 2005; 115: 610-621. (Pubitemid 40322235)
13. Schmidt-Ott KM, Mori K, Li JY et al. Dual action of neutrophil gelatinaseassociated lipocalin. J Am Soc Nephrol 2007; 18: 407-413. (Pubitemid 46193306)
14. Bagshaw SM, Bennett M, Haase M et al. Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med 2010; 36: 452-461.
15. Martensson J, Bell M, Oldner A et al. Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury. Intensive Care Med 2010; 36: 1333-1340.
16. Mishra J, Dent C, Tarabishi R et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365: 1231-1238. (Pubitemid 40469655)
17. Bennett M, Dent CL, Ma Q et al. Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol 2008; 3: 665-673.
18. Hirsch R, Dent C, Pfriem H et al. NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol 2007; 22: 2089-2095. (Pubitemid 350090716)
19. Hall IE, Yarlagadda SG, Coca SG et al. IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. J Am Soc Nephrol 2010; 21: 189-197.
20. Nickolas TL, O'Rourke MJ, Yang J et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Inter Med 2008; 148: 810-819. (Pubitemid 351786928)
21. Kumpers P, Hafer C, Lukasz A et al. Serum neutrophil gelatinaseassociated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury. Crit Care 2010; 14: R9.
22. Yang HN, Boo CS, Kim MG et al. Urine neutrophil gelatinase-associated lipocalin: an independent predictor of adverse outcomes in acute kidney injury. Am J Nephrol 2010; 31: 501-509.
23. Nickolas TL, Schmidt-Ott KM, Canetta PA et al. Comparative analysis of urinary biomarkers in the diagnosis of acute kidney injury and the prediction of renal replacement and mortality at the time of admission to the hospital. A Multicenter-International Study. Renal Week Meeting of the American Society of Nephrology (Abstract TH-FC007), Denver, CO, USA, 2010.
24. Bagshaw SM, Langenberg C, Bellomo R. Urinary biochemistry and microscopy in septic acute renal failure: a systematic review. Am J Kidney Dis 2006; 48: 695-705. (Pubitemid 44740042)
25. Haase M, Bellomo R, Devarajan P et al. Accuracy of neutrophil gelatinaseassociated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 2009; 54: 1012-1024.
26. Ferguson MA, Vaidya VS, Waikar SS et al. Urinary liver-type fatty acidbinding protein predicts adverse outcomes in acute kidney injury. Kidney Int 2010; 77: 708-714.
27. Devarajan P. Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury. Nephrology (Carlton) 2010; 15: 419-428.
28. Grenier FC, Ali S, Syed H et al. Evaluation of the ARCHITECT urine NGAL assay: assay performance, specimen handling requirements and biological variability. Clin Biochem 2010; 43: 615-620.
29. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988; 44: 837-845.
30. Newcombe RG. Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med 1998; 17: 857-872. (Pubitemid 28185165)