Fructokinase activity mediates dehydration-induced renal injury

Kidney International

Volumn 86, Issue 2, 2014, Pages 294-302

  Jimenez, Carlos A Roncal ^a   Ishimoto, Takuji ^a   Lanaspa, Miguel A ^a   Rivard, Christopher J ^a   Nakagawa, Takahiko ^a   Ejaz, A Ahsan ^b   Cicerchi, Christina ^a   Inaba, Shinichiro ^a   Le, Myphuong ^a   Miyazaki, Makoto ^a   Glaser, Jason ^c   Correa Rotter, Ricardo ^d   González, Marvin A ^e   Aragón, Aurora ^e   Wesseling, Catharina ^f   Sánchez Lozada, Laura G ^g   Johnson, Richard J ^a,h  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c La Isla Foundation   (Nicaragua)

^d INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^e National Autonomous University of Nicaragua   (Nicaragua)

^f UNIVERSIDAD NACIONAL   (Costa Rica)

^g INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^h Eastern Colorado Health Care System   (United States)

Author keywords

aldose reductase; fructokinase; fructose; hydration; Mesoamerican nephropathy

Indexed keywords

ALDEHYDE REDUCTASE; FRUCTOKINASE; FRUCTOSE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; POLYOL; SORBITOL; URIC ACID; WATER; KETOHEXOKINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DEHYDRATION; ELEVATED BLOOD PRESSURE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME METABOLISM; FRUCTOSE METABOLISM; GENOTYPE; HEAT STRESS; HISTOLOGY; HYDRATION; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KNOCKOUT MOUSE; MALE; MOUSE; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; RENAL PROTECTION; SYSTOLIC BLOOD PRESSURE; WEIGHT REDUCTION; WILD TYPE; ANIMAL; BLOOD PRESSURE; C57BL MOUSE; COMPLICATION; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; GENETICS; INJURIES; KIDNEY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RENAL INSUFFICIENCY, CHRONIC;

ALDEHYDE REDUCTASE; ANIMALS; BLOOD PRESSURE; DEHYDRATION; DISEASE MODELS, ANIMAL; FRUCTOKINASES; KIDNEY; KIDNEY CORTEX; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RENAL INSUFFICIENCY, CHRONIC; URIC ACID;

EID: 84905392251     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.492     Document Type: Article

References (18)

1. Torres C, Aragon A, Gonzalez M et al. Decreased kidney function of unknown cause in Nicaragua: a community-based survey. Am J Kidney Dis 2010; 55: 485-496.
2. O'Donnell JK, Tobey M, Weiner DE et al. Prevalence of and risk factors for chronic kidney disease in rural Nicaragua. Nephrol Dial Transplant 2011; 26: 2798-2805.
3. Peraza S, Wesseling C, Aragon A et al. Decreased kidney function among agricultural workers in El Salvador. Am J Kidney Dis 2012; 59: 531-540.
4. Bouby N, Fernandes S. Mild dehydration, vasopressin and the kidney: animal and human studies. Eur J Clin Nutr 2003; 57(Suppl 2): S39-S46.
5. Bolignano D, Zoccali C. Vasopressin beyond water: implications for renal diseases. Curr Opin Nephrol Hypertens 2010; 19: 499-504.
6. Bankir L, Bouby N, Ritz E. Vasopressin: a novel target for the prevention and retardation of kidney disease? Nat Rev Nephrol 2013; 9: 223-239.
7. Bouby N, Bachmann S, Bichet D et al. Effect of water intake on the progression of chronic renal failure in the 5/6 nephrectomized rat. Am J Physiol 1990; 258: F973-F979.
8. Ruepp B, Bohren KM, Gabbay KH. Characterization of the osmotic response element of the human aldose reductase gene promoter. Proc Natl Acad Sci USA 1996; 93: 8624-8629.
9. Glushakova O, Kosugi T, Roncal C et al. Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol 2008; 19: 1712-1720.
10. Cirillo P, Gersch MS, Mu W et al. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol 2009; 20: 545-553.
11. Lanaspa MA, Sanchez-Lozada LG, Choi YJ et al. Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. J Biol Chem 2012; 287: 40732-40744.
12. Diggle CP, Shires M, Leitch D et al. Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem 2009; 57: 763-774.
13. Ishimoto T, Lanaspa MA, Le MT et al. Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci USA 2012; 109: 4320-4325.
14. Nakayama T, Kosugi T, Gersch M et al. Dietary fructose causes tubulointerstitial injury in the normal rat kidney. Am J Physiol Renal Physiol 2010; 298: F712-F720.
15. Aoyama M, Isshiki K, Kume S et al. Fructose induces tubulointerstitial injury in the kidney of mice. Biochem Biophys Res Commun 2012; 419: 244-249.
16. Wijkstrom J, Leiva R, Elinder CG et al. Clinical and pathological characterization of Mesoamerican nephropathy: a new kidney disease in Central America. Am J Kidney Dis 2013; 62: 908-918.
17. Henry RJ, Sobel C, Kim J. A modified carbonate phosphotungstate method for the determination of uric acid and comparison with the spectrophoto-metric uricase method. Am J Clin Pathol 1957; 28: 152-160.
18. Takahashi N, Boysen G, Li F et al. Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate. Kidney Int 2007; 71: 266-271.