Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum

Proceedings of the National Academy of Sciences of the United States of America

Volumn 116, Issue 17, 2019, Pages 8269-8274

  Araki, Yasuko ^a   Awakawa, Takayoshi ^b   Matsuzaki, Motomichi ^c,d,e   Cho, Rihe ^c   Matsuda, Yudai ^b   Hoshino, Shotaro ^b   Shinohara, Yasutomo ^a   Yamamoto, Masaichi ^f   Kido, Yasutoshi ^c,f,g   Inaoka, Daniel Ken ^c,d   Nagamune, Kisaburo ^e,h   Ito, Kotaro ^a   Abe, Ikuro ^b   Kita, Kiyoshi ^c,d  

^a KIKKOMAN CORPORATION   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NAGASAKI UNIVERSITY   (Japan)

^e NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^f Institute of Mitochondrial Science Company   (Japan)

^g OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

African trypanosomiasis; Ascochlorin; Ascofuranone; Secondary metabolism; Terpene cyclase

Indexed keywords

ASCOCHLORIN; ASCOFURANONE; EPOXIDE; ILICICOLIN A EPOXIDE; LYASE; TERPEN CYCLASE; TERPENOID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; ALKENE; FUNGAL PROTEIN; PHENOL DERIVATIVE; SESQUITERPENE;

ACREMONIUM; ACREMONIUM EGYPTIACUM; ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGAL METABOLISM; FUNGAL STRAIN; GENE CLUSTER; GENE EXPRESSION; GENETIC MANIPULATION; HETEROLOGOUS EXPRESSION; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; SECONDARY METABOLISM; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; FUNGAL GENE; GENETICS; METABOLISM; MOLECULAR MODEL; MULTIGENE FAMILY; PHYSIOLOGY;

ACREMONIUM; ALKENES; BIOSYNTHETIC PATHWAYS; FUNGAL PROTEINS; GENES, FUNGAL; MODELS, MOLECULAR; MULTIGENE FAMILY; PHENOLS; SESQUITERPENES;

EID: 85064871336     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1819254116     Document Type: Article

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