Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone

Science

Volumn 349, Issue 6253, 2015, Pages 1224-1228

  Lau, Warren ^a   Sattely, Elizabeth S ^a  

^a Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' DESMETHYLEPIPODOPHYLLOTOXIN; AGLYCONE; CYCLOHEXANE; DIOXYGENASE; DNA TOPOISOMERASE INHIBITOR; ENZYME; ETOPOSIDE DERIVATIVE; LIGNAN; OXOGLUTARATE DEPENDENT DIOXYGENASE; PODOPHYLLOTOXIN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TETRALIN DERIVATIVE; TRANSCRIPTOME; UNCLASSIFIED DRUG; ETOPOSIDE; MIXED FUNCTION OXIDASE;

CULTIVATION; DRUG; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; HERB; INHIBITOR; PHENOL; PLANT EXTRACT; TOBACCO; TOXIN;

ARTICLE; BIOSYNTHESIS; DEMETHYLATION; EPIMERIZATION; GENE EXPRESSION; NONHUMAN; PODOPHYLLUM HEXANDRUM; PRIORITY JOURNAL; TOBACCO; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; METABOLISM; METHYLATION; MOLECULAR GENETICS; PODOPHYLLUM PELTATUM;

NICOTIANA BENTHAMIANA; NICOTIANA TABACUM; PODOPHYLLUM; SINOPODOPHYLLUM HEXANDRUM;

AMINO ACID SEQUENCE; BIOSYNTHETIC PATHWAYS; ETOPOSIDE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, PLANT; GENETIC ENGINEERING; METHYLATION; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; PODOPHYLLOTOXIN; PODOPHYLLUM PELTATUM; TOBACCO; TOPOISOMERASE INHIBITORS; TRANSCRIPTOME;

EID: 84942442755     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac7202     Document Type: Article

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