Myricetin protects against high glucose-induced β-cell apoptosis by attenuating endoplasmic reticulum stress via inactivation of cyclin-dependent kinase 5

Diabetes and Metabolism Journal

Volumn 43, Issue 2, 2019, Pages 192-205

  Karunakaran, Udayakumar ^a,b   Elumalai, Suma ^b   Moon, Jun Sung ^b   Jeon, Jae Han ^a   Kim, Nam Doo ^c   Park, Keun Gyu ^a   Won, Kyu Chang ^b   Leem, Jaechan ^d   Lee, In Kyu ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

^c Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

^d Catholic University of Daegu   (South Korea)

Author keywords

Apoptosis; Cyclin dependent kinase 5; Endoplasmic reticulum stress; Insulin secreting cells; Myricetin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATE; BETA ACTIN; CASPASE 3; CYCLIN DEPENDENT KINASE 5; CYTOCHROME C; GLUCOSE; INSULIN; MESSENGER RNA; MYRICETIN; REACTIVE OXYGEN METABOLITE; SARCOENDOPLASMIC RETICULUM CALCIUM ATPASE 2B; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; ATP2A2 PROTEIN, RAT; CDK5 PROTEIN, RAT; FLAVONOID; HOMEODOMAIN PROTEIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; PROTECTIVE AGENT; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; DRUG PROTEIN BINDING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INACTIVATION; INS-1 CELL LINE; INSULIN RELEASE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; MRNA EXPRESSION LEVEL; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN EXPRESSION LEVEL; RAT; ANIMAL; DRUG EFFECT; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 5; ENDOPLASMIC RETICULUM STRESS; FLAVONOIDS; GLUCOSE; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR DOCKING SIMULATION; PROTECTIVE AGENTS; RATS; REACTIVE OXYGEN SPECIES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 85064588108     PISSN: 22336079     EISSN: 22336087     Source Type: Journal    
DOI: 10.4093/dmj.2018.0052     Document Type: Article

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