Inhibition of interleukin-12 production in mouse macrophagesvia decreased nuclear factor-κB DNA binding activity by myricetin, a naturally occurring flavonoid

Archives of Pharmacal Research

Volumn 28, Issue 3, 2005, Pages 274-279

  Kang, Bok Yun ^b,c   Kim, Seung Hyun ^b   Cho, Daeho ^a,b   Kim, Tae Sung ^b  

^a Sookmyung Women's University   (South Korea)

^b Chonnam National University   (South Korea)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Interleukin 12; Macrophage; Myricetin; Nuclear factor B

Indexed keywords

FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; MYRICETIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; DBA MOUSE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GEL MOBILITY SHIFT ASSAY; MACROPHAGE; METABOLISM; MOUSE; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; FLAVONOIDS; INTERLEUKIN-2; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED DBA; NF-KAPPA B; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 23344437517     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/BF02977791     Document Type: Article

References (25)

1. Adorini, L., Interleukin-12, a key cytokine in Th1-mediated autoimmune diseases.Cell Mol. Life Sci., 55, 1610–1625 (1999). DOI: 10.1007/s000180050400
2. Chen, C. C., Chow, M. P., Huang, W. C., Lin, Y. C., and Chang, Y. J., Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: structure-activity relationships.Mol. Pharmacol., 66, 683–693 (2004). DOI: 10.1124/mol.104.001206
3. Chu, S. C., Hsieh, Y. S., and Lin, J. Y., Inhibitory effects of flavonoids on Moloney murine leukemia virus reverse transcriptase activity.J. Nat. Prod., 55, 179–183 (1992). DOI: 10.1021/np50080a005
4. Constantinescu, C. S., Goodman, D. B., and Ventura, E. S., Captopril and lisinopril suppress production of interleukin-12 by human peripheral blood mononuclear cells.Immunol. Lett., 62, 25–31 (1998). DOI: 10.1016/S0165-2478(98)00025-X
5. 3. Involvement of NF-κB downregulation in transcriptional repression of the p40 gene.J. Clin. Invest., 101, 252–262 (1998). DOI: 10.1172/JCI1050
6. + lymphocytes by inhibiting IL-12 production.J. Immunol., 160, 2231–2237 (1998).
7. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.Nucleic Acids Res., 11, 1475–1489 (1993). DOI: 10.1093/nar/11.5.1475
8. Falcone, M. and Sarvetnick, N., Cytokines that regulate autoimmune responses.Curr. Opin. Immunol., 11, 670–676 (1999). DOI: 10.1016/S0952-7915(99)00035-7
9. Gri, G., Savio, D., Trinchieri, G., and Ma, X., Synergistic regulation of the human interleukin-12 p40 promoter by NF-κB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.J. Biol. Chem., 273, 6431–6438 (1998). DOI: 10.1074/jbc.273.11.6431
10. Joo, S. S., Chang, J. K., Park, J. H., Kang, H. C., and Lee, D. I., Immunoactivation of lectin-conjugated praecoxin A on IL-6, IL-12 expression.Arch. Pharm. Res., 25, 954–963 (2002). DOI: 10.1007/BF02977019
11. Kang, B. Y., Chung, S. W., Cho, D., and Kim, T. S., Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid.Biochem. Pharmacol., 63, 1901–1910 (2002). DOI: 10.1016/S0006-2952(02)00982-6
12. Kang, B. Y., Chung, S. W., Im, S. Y., Hwang, S. Y., and Kim, T. S., Chloromethyl ketones inhibit interleukin-12 production in mouse macrophages stimulated with lipopolysaccharide.Immunol. Lett., 70, 135–138 (1999). DOI: 10.1016/S0165-2478(99)00136-4
13. Kang, K., Kubin, M., Cooper, K. D., Lessin, S. R., Trinchieri, G., and Rook, A. H., IL-12 synthesis by human Langerhans cells.J. Immunol., 156, 1402–1407 (1996).
14. + T cells from the Th1 to the Th2 pathway.Br. J. Pharmacol., 134, 571–578 (2001). DOI: 10.1038/sj.bjp.0704298
15. Landolfi, R., Mower, R. L., and Steiner, M., Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations.Biochem. Pharmacol., 33, 1525–1530 (1984). DOI: 10.1016/0006-2952(84)90423-4
16. Ma, X., Chow, J. M., Gri, G., Carra, G., Gerosa, F., Wolf, S. F., Dzialo, R., and Trinchieri, G., The interleukin 12 p40 gene promoter is primed by interferon-γ in monocytic cells.J. Exp. Med., 83, 147–157 (1996). DOI: 10.1084/jem.183.1.147
17. Ma, X. and Trinchieri, G., Regulation of interleukin-12 production in antigen-presenting cells.Adv. Immunol., 79, 55–92 (2001). DOI: 10.1016/S0065-2776(01)79002-5
18. Moller, D. R., Wysocka, W., Greenlee, B. M., Ma, X., Wahl, L., Flockhart, D. A., Trinchieri, G., and Karp, C. L., Inhibition of IL-12 production by thalidomide.J. Immunol., 159, 5157–1561 (1997).
19. Na, S. Y., Kang, B. Y., Chung, S. W., Han, S. J., Ma, X., Trinchieri, G., Im, S. Y., Lee, J. W., and Kim, T. S., Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NF-κB.J. Biol. Chem., 274, 7674–7680 (1999). DOI: 10.1074/jbc.274.12.7674
20. Ong, K. C. and Khoo, H. E., Effects of myricetin on glycemia and glycogen metabolism in diabetic rats.Life Sci., 67, 1695–1705 (2000). DOI: 10.1016/S0024-3205(00)00758-X
21. 2-Agonists prevent Th1 development by selective inhibition of interleukin 12.J. Clin. Invest., 100, 1513–1519 (1997). DOI: 10.1172/JCI119674
22. Prud’homme, G. J., Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors.J. Gene Med., 2, 222–232 (2000). DOI: 10.1002/1521-2254(200007/08)2:4<222::AID-JGM117>3.0.CO;2-P
23. Ross, J. A. and Kasum, C. M., Dietary flavonoids: bioavailability, metabolic effects, and safety.Annu. Rev. Nutr., 22, 19–33 (2002). DOI: 10.1146/annurev.nutr.22.111401.144957
24. Theoharides, T. C., Alexandrakis, M., Kempuraj, D., and Lytinas, M., Anti-inflammatory actions of flavonoids and structural requirements for new design.Int. J. Immunopathol. Pharmacol., 14, 119–127 (2001).
25. Tsai, S. H., Liang, Y. C., Lin-Shiau, S. Y., and Lin, J. K., Suppression of TNFalpha-mediated NFκB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells.J. Cell Biochem., 74, 606–615 (1999). DOI: 10.1002/(SICI)1097-4644(19990915)74:4<606::AID-JCB10>3.0.CO;2-W