Challenges for the clinical development of PI3K inhibitors: Strategies to improve their impact in solid tumors

Cancer Discovery

Volumn 9, Issue 4, 2019, Pages 482-491

  Hanker, Ariella B ^a   Kaklamani, Virginia ^b   Arteaga, Carlos L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPELISIB; FULVESTRANT; PROTEIN KINASE INHIBITOR;

AKT SIGNALING; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL OUTCOME; DRUG DELIVERY SYSTEM; GENE MUTATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; IC50; INSULIN SENSITIVITY; NONHUMAN; ONCOGENE; PHASE 1 CLINICAL TRIAL (TOPIC); PROGRESSION FREE SURVIVAL; PROTEIN PHOSPHORYLATION; SANGER SEQUENCING; SIGNAL TRANSDUCTION; SOLID MALIGNANT NEOPLASM; TUMOR GROWTH; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION; NEOPLASM; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; NEOPLASMS; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 85064125968     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-18-1175     Document Type: Article

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