Targeting the PI3K pathway in cancer: Are we making headway?

Nature Reviews Clinical Oncology

Volumn 15, Issue 5, 2018, Pages 273-291

  Janku, Filip ^a   Yap, Timothy A ^a   Meric Bernstam, Funda ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 DIFLUOROMETHYLBENZIMIDAZOL 1 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; 2 AMINO 8 [4 (2 HYDROXYETHOXY)CYCLOHEXYL] 6 (6 METHOXY 3 PYRIDINYL) 4 METHYLPYRIDO[2,3 D]PYRIMIDIN 7(8H) ONE; 4 (4 AMINO 5 (7 METHOXY 1H INDOL 2 YL)IMIDAZO[5,1 F][1,2,4]TRIAZIN 7 YL)CYCLOHEXANECARBOXYLIC ACID; 8 (6 METHOXY 3 PYRIDINYL) 3 METHYL 1 [4 (1 PIPERAZINYL) 3 (TRIFLUOROMETHYL)PHENYL] 1H IMIDAZO[4,5 C]QUINOLIN 2(3H) ONE; ABI 009; ADZ 2014; ANTINEOPLASTIC AGENT; APITOLISIB; AZD 8055; BIMIRALISIB; BUPARLISIB; CC 223; CH 5132799; COPANLISIB; DACTOLISIB; EVEROLIMUS; FULVESTRANT; GEDATOLISIB; IDELALISIB; LY 3023414; PICTILISIB; RAPAMYCIN; RIDAFOROLIMUS; SAPANISERTIB; SONOLISIB; TEMSIROLIMUS; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VISTUSERTIB; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL)MORPHOLINIO]METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE; 2-AMINO-N-(7-METHOXY-8-(3-MORPHOLINOPROPOXY)-2,3-DIHYDROIMIDAZO(1,2-C)QUINAZOLIN-4-YL)PYRIMIDINE-5-CARBOXAMIDE; MTOR PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CA PROTEIN, HUMAN; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

AKT SIGNALING; ANTINEOPLASTIC ACTIVITY; CANCER SURVIVAL; DRUG POTENCY; DRUG RESPONSE; DRUG SELECTIVITY; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; HUMAN; MALIGNANT NEOPLASM; ONCOGENE; PIK3CA GENE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; RISK REDUCTION; ANTAGONISTS AND INHIBITORS; IMMUNOLOGY; MOLECULARLY TARGETED THERAPY; NEOPLASM; SIGNAL TRANSDUCTION;

CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; EVEROLIMUS; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS; ONCOGENE PROTEIN V-AKT; PURINES; PYRIMIDINES; QUINAZOLINES; QUINAZOLINONES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 85045583399     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2018.28     Document Type: Review

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