Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

PLoS Medicine

Volumn 16, Issue 1, 2019, Pages

  Budu Aggrey, Ashley ^a,b   Brumpton, Ben ^a,c,d   Tyrrell, Jess ^e   Watkins, Sarah ^a,b   Modalsli, Ellen H ^c,d   Celis Morales, Carlos ^f   Ferguson, Lyn D ^f   Vie, Gunnhild Åberge ^c   Palmer, Tom ^g   Fritsche, Lars G ^c   Løset, Mari ^c,d   Nielsen, Jonas Bille ^h   Zhou, Wei ^h   Tsoi, Lam C ^i,j   Wood, Andrew R ^e   Jones, Samuel E ^e   Beaumont, Robin ^e   Saunes, Marit ^c,d   Romundstad, Pål Richard ^c   Siebert, Stefan ^k   McInnes, Iain B ^k   Elder, James T ^i,l   Davey Smith, George ^a,b   Frayling, Timothy M ^e   Åsvold, Bjørn Olav ^c,d   Brown, Sara J ^m,n   Sattar, Naveed ^f   Paternoster, Lavinia ^a,b   more..

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^f UNIVERSITY OF GLASGOW   (United Kingdom)

^g LANCASTER UNIVERSITY   (United Kingdom)

^h UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

ⁱ UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^j UNIVERSITY OF MICHIGAN   (United States)

^k UNIVERSITY OF GLASGOW   (United Kingdom)

^l VETERANS AFFAIRS MEDICAL CENTER   (United States)

^m UNIVERSITY OF DUNDEE   (United Kingdom)

ⁿ UNIVERSITY OF DUNDEE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

ARTICLE; BODY MASS; CASE CONTROL STUDY; CLINICAL OUTCOME; CONTROLLED STUDY; DIABETES MELLITUS; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; META ANALYSIS; OBESITY; OBSERVATIONAL STUDY; PREVALENCE; PSORIASIS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SENSITIVITY ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; ADULT; AGED; COMPLICATION; FEMALE; GENETICS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BODY MASS INDEX; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PSORIASIS; RISK FACTORS; YOUNG ADULT;

EID: 85060952703     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1002739     Document Type: Article

References (58)

1. Iskandar IYK, Ashcroft DM, Warren RB, Yiu ZZN, McElhone K, Lunt M, et al. Demographics and disease characteristics of patients with psoriasis enrolled in the British Association of Dermatologists Biologic Interventions Register. Br J Dermatol. 2015;173: 510-518. doi: 10.1111/bjd.13908 pmid: 25989336
2. Nestle FO, Kaplan DH, Barker J, Psoriasis. N Engl J Med. 2009;361: 496-509. doi: 10.1056/NEJMra0804595 pmid: 19641206
3. Parisi R, Symmons DPM, Griffiths CEM, Ashcroft DM, Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence. J Invest Dermatol. 2013;133: 377-385. doi: 10.1038/jid.2012.339 pmid: 23014338
4. Springate DA, Parisi R, Kontopantelis E, Reeves D, Griffiths CEM, Ashcroft DM, Incidence, prevalence and mortality of patients with psoriasis: a U.K. population-based cohort study. Br J Dermatol. 2017;176: 650-658. doi: 10.1111/bjd.15021 pmid: 27579733
5. The NHS Information Centre. Statistics on Obesity, Physical Activity and Diet: England. 2017. 2017; https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/613532/obes-phys-acti-diet-eng-2017-rep.pdf. [cited 2018 June 4].
6. Snekvik I, Smith CH, Nilsen TIL, Langan SM, Modalsli EH, Romundstad PR, et al. Obesity, Waist Circumference, Weight Change, and Risk of Incident Psoriasis: Prospective Data from the HUNT Study. J Invest Dermatol. 2017;137: 2484-2490. doi: 10.1016/j.jid.2017.07.822 pmid: 28780086
7. Jensen P, Zachariae C, Christensen R, Geiker NRW, Schaadt BK, Stender S, et al. Effect of Weight Loss on the Severity of Psoriasis. JAMA Dermatol. 2013;149: 795. doi: 10.1001/jamadermatol.2013.722 pmid: 23752669
8. Egeberg A, Sørensen JA, Gislason GH, Knop FK, Skov L, Incidence and Prognosis of Psoriasis and Psoriatic Arthritis in Patients Undergoing Bariatric Surgery. JAMA Surg. 2017;152: 344. doi: 10.1001/jamasurg.2016.4610 pmid: 28002543
9. Al-Mutairi N, Nour T, The effect of weight reduction on treatment outcomes in obese patients with psoriasis on biologic therapy: a randomized controlled prospective trial. Expert Opin Biol Ther. 2014;14: 749-756. doi: 10.1517/14712598.2014.900541 pmid: 24661040
10. Davidovici BB, Sattar N, Jörg PC, Puig L, Emery P, Barker JN, et al. Psoriasis and systemic inflammatory diseases: Potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol. 2010;130: 1785-1796. doi: 10.1038/jid.2010.103 pmid: 20445552
11. Lawlor DA, Harbord RM, Sterne JAC, Timpson N, Davey Smith G, Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27: 1133-63. doi: 10.1002/sim.3034 pmid: 17886233
12. Burgess S, Butterworth A, Thompson SG, Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37: 658-665. doi: 10.1002/gepi.21758 pmid: 24114802
13. Smith GD, Ebrahim S, "Mendelian randomization": Can genetic epidemiology contribute to understanding environmental determinants of disease?Int J Epidemiol. 1Feb200332: 1-22. doi: 10.1093/ije/dyg070 pmid: 12689998
14. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518: 197-206. doi: 10.1038/nature14177 pmid: 25673413
15. Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, et al. Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry. Preprint. bioRxiv. 2018; 274654. [cited 2018 June 4].
16. Tsoi LC, Stuart PE, Tian C, Gudjonsson JE, Das S, Zawistowski M, et al. Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nat Commun. 2017;8: 15382. doi: 10.1038/ncomms15382 pmid: 28537254
17. Perry JRB, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, et al. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet. 2010;19: 535-544. doi: 10.1093/hmg/ddp522 pmid: 19933169
18. Borenstein M, Hedges L V, Higgins JPT, Rothstein HR, Converting Among Effect Sizes. Introd to Meta-Analysis. Chichester, UK; pp. 45-49. doi: 10.1002/9780470743386.ch7
19. Chinn S, A simple method for converting an odds ratio to effect size for use in meta-analysis. Stat Med. 2000;19: 3127-3131. doi: 10.1002/1097-0258(20001130)19:22<3127::AID-SIM784>3.0.CO;2-M pmid: 11113947
20. Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age. PLoS Med. 2015;12: e1001779. doi: 10.1371/journal.pmed.1001779 pmid: 25826379
21. Krokstad S, Langhammer A, Hveem K, Holmen TL, Midthjell K, Stene TR, et al. Cohort profile: The HUNT study, Norway. Int J Epidemiol. 2013;42: 968-977. doi: 10.1093/ije/dys095 pmid: 22879362
22. Modalsli EH, Snekvik I, Åsvold BO, Romundstad PR, Naldi L, Saunes M, Validity of self-reported psoriasis in a general population: The HUNT study, Norway. J Invest Dermatol. 2016;136: 323-325. doi: 10.1038/JID.2015.386 pmid: 26763455
23. Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Artigas MS, et al. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): A genetic association study in UK Biobank. Lancet Respir Med. 2015;3: 769-781. doi: 10.1016/S2213-2600(15)00283-0 pmid: 26423011
24. Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, et al. Genome-wide genetic data on ~500,000 UK Biobank participants. bioRxiv. 2017; 166298. doi: 10.1101/166298
25. Mitchell R, Hemani G, Dudding T, Paternoster L. UK Biobank Genetic Data: MRC-IEU Quality Control, Version 1. 2017.
26. Frayling TM, Beaumont RN, Jones SE, Yaghootkar H, Tuke MA, Ruth KS, et al. A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Rep. 2018;23: 327-336. doi: 10.1016/j.celrep.2018.03.070 pmid: 29641994
27. Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, et al. Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nat Genet. 2018;50: 1234-1239. doi: 10.1038/s41588-018-0171-3 pmid: 30061737
28. Burgess S, Identifying the odds ratio estimated by a two-stage instrumental variable analysis with a logistic regression model. Stat Med. 2013;32: 4726-4747. doi: 10.1002/sim.5871 pmid: 23733419
29. Burgess S, Small DS, Thompson SG, A review of instrumental variable estimators for Mendelian randomization. Stat Methods Med Res. 2017;26: 2333-2355. doi: 10.1177/0962280215597579 pmid: 26282889
30. Burgess S, Scott RA, Timpson NJ, Smith GD, Thompson SG, Using published data in Mendelian randomization: A blueprint for efficient identification of causal risk factors. Eur J Epidemiol. 2015;30: 543-552. doi: 10.1007/s10654-015-0011-z pmid: 25773750
31. Yavorska OO, Burgess S, MendelianRandomization: An R package for performing Mendelian randomization analyses using summarized data. Int J Epidemiol. 2017;46: 1734-1739. doi: 10.1093/ije/dyx034 pmid: 28398548
32. Bowden J, Davey Smith G, Haycock PC, Burgess S, Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genet Epidemiol. 2016;40: 304-14. doi: 10.1002/gepi.21965 pmid: 27061298
33. Hartwig FP, Smith GD, Bowden J, Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol. 2017;46: 1985-1998. doi: 10.1093/ije/dyx102 pmid: 29040600
34. Bowden J, Smith GD, Burgess S, Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44: 512-525. doi: 10.1093/ije/dyv080 pmid: 26050253
35. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42: 937-948. doi: 10.1038/ng.686 pmid: 20935630
36. Gage SH, Jones HJ, Taylor AE, Burgess S, Zammit S, Munafò MR, Investigating causality in associations between smoking initiation and schizophrenia using Mendelian randomization. Sci Rep. 2017;7: 40653. doi: 10.1038/srep40653 pmid: 28102331
37. Boehncke W-H, Schön MP, Psoriasis. Lancet. 2015;386: 983-994. doi: 10.1016/S0140-6736(14)61909-7 pmid: 26025581
38. Wolkenstein P, Revuz J, Roujeau JC, Bonnelye G, Grob JJ, Bastuji-Garin S, Psoriasis in France and associated risk factors: Results of a case-control study based on a large community survey. Dermatology. 2009;218: 103-109. doi: 10.1159/000182258 pmid: 19060463
39. Kokpol C, Aekplakorn W, Rajatanavin N, Prevalence and characteristics of metabolic syndrome in South-East Asian psoriatic patients: A case-control study. J Dermatol. 2014;41: 898-902. doi: 10.1111/1346-8138.12614 pmid: 25201476
40. Quan C, Zhu K-J, Zhang C, Liu Z, Liu H, Zhu C-Y, et al. Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris. Mol Biol Rep. 2014;41: 7015-7022. doi: 10.1007/s11033-014-3589-4 pmid: 25052186
41. Dhara S, Dasgupta A, Rout JK, Banerjee U, Dasgupta S, Ghosh A, Clinico-biochemical correlation between psoriasis and insulin resistance. Indian J Clin Biochem. 2015;30: 99-103. doi: 10.1007/s12291-013-0413-1 pmid: 25646049
42. Naito R, Imafuku S, Distinguishing features of body mass index and psoriasis in men and women in Japan: A hospital-based case-control study. J Dermatol. 2016;43: 1406-1411. doi: 10.1111/1346-8138.13439 pmid: 27178353
43. Wolk K, Mallbris L, Larsson P, Rosenblad A, Vingård E, Ståhle M, Excessive body weight and smoking associates with a high risk of onset of plaque psoriasis. Acta Derm Venereol. 2009;89: 492-497. doi: 10.2340/00015555-0711 pmid: 19734975
44. Burgess S, Labrecque JA. Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates. 2018; http://arxiv.org/abs/1804.05545. [cited 2018 June 4].
45. Danielsen K, Olsen AO, Wilsgaard T, Furberg A-S, Is the prevalence of psoriasis increasing? A 30-year follow-up of a population-based cohort. Br J Dermatol. 2013;168: 1303-1310. doi: 10.1111/bjd.12230 pmid: 23374051
46. Monnereau C, Vogelezang S, Kruithof CJ, Jaddoe VWV, Felix JF, Associations of genetic risk scores based on adult adiposity pathways with childhood growth and adiposity measures. BMC Genet. 2016;17: 120. doi: 10.1186/s12863-016-0425-y pmid: 27538985
47. Nakamizo S, Honda T, Kabashima K, Obesity and inflammatory skin diseases. Trends Immunother. 2017;1: 67-74.
48. Sbidian E, Chaimani A, Garcia-Doval I, Do G, Hua C, Mazaud C, et al. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev. 2017;12: CD011535. pmid: 29271481
49. Dowlatshahi EA, van der Voort EA., Arends LR, Nijsten T, Markers of systemic inflammation in psoriasis: a systematic review and meta-analysis. Br J Dermatol. 2013;169: 266-282. doi: 10.1111/bjd.12355 pmid: 23550658
50. Stjernholm T, Ommen P, Langkilde A, Johansen C, Iversen L, Rosada C, et al. Leptin deficiency in mice counteracts imiquimod (IMQ)-induced psoriasis-like skin inflammation while leptin stimulation induces inflammation in human keratinocytes. Exp Dermatol. 2017;26: 338-345. doi: 10.1111/exd.13149 pmid: 27488462
51. Löffler H, Aramaki JUN, Effendy I, The influence of body mass index on skin susceptibility to sodium lauryl sulphate. Skin Res Technol. 2002;8: 19-22. doi: 10.1046/j.0909-752x pmid: 12005116
52. Maglio C, Peltonen M, Rudin A, Carlsson LMS, Bariatric Surgery and the Incidence of Psoriasis and Psoriatic Arthritis in the Swedish Obese Subjects Study. Obesity. 2017;25: 2068-2073. doi: 10.1002/oby.21955 pmid: 29178583
53. Di Minno MND, Peluso R, Iervolino S, Russolillo A, Lupoli R, Scarpa R, Weight loss and achievement of minimal disease activity in patients with psoriatic arthritis starting treatment with tumour necrosis factor α blockers. Ann Rheum Dis. 2014;73: 1157-1162. doi: 10.1136/annrheumdis-2012-202812 pmid: 23771989
54. Upala S, Sanguankeo A, Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: a systematic review and meta-analysis. Int J Obes. 2015;39: 1197-1202. doi: 10.1038/ijo.2015.64 pmid: 25920774
55. Jindal S, Jindal N, Psoriasis and Cardiovascular Diseases: A Literature Review to Determine the Causal Relationship. Cureus. 2018;10: e2195. doi: 10.7759/cureus.2195 pmid: 29662733
56. Farh KK-H, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2015;518: 337-343. doi: 10.1038/nature13835 pmid: 25363779
57. Jebb SA, Ahern AL, Olson AD, Aston LM, Holzapfel C, Stoll J, et al. Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. Lancet. 2011;378: 1485-1492. doi: 10.1016/S0140-6736(11)61344-5 pmid: 21906798
58. Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet. 2018;391: 541-551. doi: 10.1016/S0140-6736(17)33102-1 pmid: 29221645