Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

Cell Host and Microbe

Volumn 24, Issue 6, 2018, Pages 761-775.e6

  Fletcher, Adam J ^a   Vaysburd, Marina ^a   Maslen, Sarah ^a   Zeng, Jingwei ^a   Skehel, J Mark ^a   Towers, Greg J ^b   James, Leo C ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

HIV 1; innate immunity; K63 linked Ub; restriction factor; reverse transcription; TRIM5; Ube2N Ube2V2; Ube2W; UFD pathway

Indexed keywords

BETA1 INTERFERON; CRYOPYRIN; IFIT1 PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN; PTGS2 PROTEIN; TRIPARTITE MOTIF PROTEIN 5; TUMOR NECROSIS FACTOR; UBIQUITIN; UNCLASSIFIED DRUG; BACTERIAL POLYSACCHARIDE; CARRIER PROTEIN; K6-ANTIGEN; TRIM5 PROTEIN, HUMAN; UBE2N PROTEIN, HUMAN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; FETUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOSTIMULATION; INNATE IMMUNITY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRIDAE; RING FINGER MOTIF; SIGNAL TRANSDUCTION; UBIQUITINATION; VIRUS ASSEMBLY; VIRUS CAPSID; VIRUS PARTICLE; ANIMAL; C57BL MOUSE; CHEMISTRY; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; MURINE LEUKEMIA VIRUS; RETROVIRUS INFECTION; THP-1 CELL LINE; VIROLOGY;

ANIMALS; CAPSID; CARRIER PROTEINS; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; LEUKEMIA VIRUS, MURINE; MICE; MICE, INBRED C57BL; POLYSACCHARIDES, BACTERIAL; RETROVIRIDAE INFECTIONS; THP-1 CELLS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES;

EID: 85057934918     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2018.10.007     Document Type: Article

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