High levels of butyrate and propionate in early life are associated with protection against atopy

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 74, Issue 4, 2019, Pages 799-809

  Roduit, Caroline ^a,b,c   Frei, Remo ^b,d   Ferstl, Ruth ^b,d   Loeliger, Susanne ^a,b   Westermann, Patrick ^d   Rhyner, Claudio ^b,d   Schiavi, Elisa ^b,d   Barcik, Weronika ^b,d   Rodriguez Perez, Noelia ^d   Wawrzyniak, Marcin ^b,d   Chassard, Christophe ^e   Lacroix, Christophe ^e   Schmausser Hechfellner, Elisabeth ^f   Depner, Martin ^f   von Mutius, Erika ^f,g,q   Braun Fahrländer, Charlotte ^h,i   Karvonen, Anne M ^j   Kirjavainen, Pirkka V ^j,k   Pekkanen, Juha ^j,l   Dalphin, Jean Charles ^m   Riedler, Josef ⁿ   Akdis, Cezmi ^b,d   Lauener, Roger ^b,c   O'Mahony, Liam ^b,d,o   Hyvarinen A ^p   Remes, S ^p   Roponen, M ^p   Chauveau, A ^p   Dalphin, M L ^p   Kaulek, V ^p   Ege, M ^p   Genuneit, J ^p   Illi, S ^p   Kabesch, M ^p   Schaub, B ^p   Pfefferle, P ^p   Doekes, G ^p   more..

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b CHRISTINE KÜHNE CENTER FOR ALLERGY RESEARCH AND EDUCATION CK CARE   (Switzerland)

^c Children's Hospital St Gallen   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e ETH ZURICH   (Switzerland)

^f INSTITUTE OF EPIDEMIOLOGY   (Germany)

^g LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^h SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

ⁱ UNIVERSITY OF BASEL   (Switzerland)

^j NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^k UNIVERSITY OF EASTERN FINLAND   (Finland)

^l UNIVERSITY OF HELSINKI   (Finland)

^m UNIVERSITY HOSPITAL OF BESANÇON   (France)

ⁿ Children's Hospital   (Austria)

^o UNIVERSITY COLLEGE CORK   (Ireland)

^p Member of the German Center for Lung Research ^*

^q Member of the German Center for Lung Research   (Germany)

more..

Author keywords

asthma; atopic sensitization; butyrate; food allergy; Short chain fatty acid

Indexed keywords

BUTYRIC ACID; PROPIONIC ACID; BUTYRIC ACID DERIVATIVE; PROPIONIC ACID DERIVATIVE; VOLATILE FATTY ACID;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; ATOPY; COHORT ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FATTY ACID ANALYSIS; FEMALE; FOOD ALLERGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; QUESTIONNAIRE; SENSITIZATION; ANIMAL; CHEMISTRY; DIET; FECES; IMMEDIATE TYPE HYPERSENSITIVITY; INFANT; MALE;

ANIMALS; ASTHMA; BUTYRATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; FATTY ACIDS, VOLATILE; FECES; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INFANT; MALE; MICE; PROPIONATES;

EID: 85056463668     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.13660     Document Type: Article

References (36)

1. Thorburn AN, Macia L, Mackay CR. Diet, metabolites, and “western-lifestyle” inflammatory diseases. Immunity. 2014;40:833-842.
2. David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559-563.
3. Wahn U. Considering 25 years of research on allergy prevention–have we let ourselves down? Pediatr Allergy Immunol. 2013;24:308-310.
4. Roduit C, Frei R, Depner M, et al. Increased food diversity in the first year of life is inversely associated with allergic diseases. J Allergy Clin Immunol. 2014;133:1056-1064.
5. Roduit C, Frei R, Loss G, et al. Development of atopic dermatitis according to age of onset and association with early-life exposures. J Allergy Clin Immunol. 2012;130:130-6 e5.
6. Wijga AH, Smit HA, Kerkhof M, et al. Association of consumption of products containing milk fat with reduced asthma risk in pre-school children: the PIAMA birth cohort study. Thorax. 2003;58:567-572.
7. Dunder T, Kuikka L, Turtinen J, Rasanen L, Uhari M. Diet, serum fatty acids, and atopic diseases in childhood. Allergy. 2001;56:425-428.
8. Parodi PW. Cows’ milk fat components as potential anticarcinogenic agents. J Nutr. 1997;127:1055-1060.
9. Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014;20:159-166.
10. Louis P, Hold GL, Flint HJ. The gut microbiota, bacterial metabolites and colorectal cancer. Nat Rev Microbiol. 2014;12:661-672.
11. Kim CH. B cell-helping functions of gut microbial metabolites. Microb Cell. 2016;3:529-531.
12. Byndloss MX, Olsan EE, Rivera-Chavez F, et al. Microbiota-activated PPAR-gamma signaling inhibits dysbiotic Enterobacteriaceae expansion. Science. 2017;357(6351):570-575.
13. Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009;461(7268):1282-1286.
14. Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013;341(6145):569-573.
15. Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013;504(7480):446-450.
16. Frei R, Akdis M, O'Mahony L. Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence. Curr Opin Gastroenterol. 2015;31:153-158.
17. Tan J, McKenzie C, Vuillermin PJ, et al. Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Rep. 2016;15:2809-2824.
18. Marques FZ, Nelson E, Chu PY, et al. High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice. Circulation. 2017;135:964-977.
19. von Mutius E, Schmid S, PASTURE Study Group. The PASTURE project: EU support for the improvement of knowledge about risk factors and preventive factors for atopy in Europe. Allergy. 2006;61:407-413.
20. Dostal A, Baumgartner J, Riesen N, et al. Effects of iron supplementation on dominant bacterial groups in the gut, faecal SCFA and gut inflammation: a randomised, placebo-controlled intervention trial in South African children. Br J Nutr. 2014;112:547-556.
21. Pham VT, Lacroix C, Braegger CP, Chassard C. Early colonization of functional groups of microbes in the infant gut. Environ Microbiol. 2016;18:2246-2258.
22. Payne AN, Zihler A, Chassard C, Lacroix C. Advances and perspectives in in vitro human gut fermentation modeling. Trends Biotechnol. 2012;30:17-25.
23. Hoeppli RE, Wu D, Cook L, Levings MK. The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome. Front Immunol. 2015;6:61.
24. Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013;504(7480):451-455.
25. Kim HK, Rutten NB, Besseling-van der Vaart I, et al. Probiotic supplementation influences faecal short chain fatty acids in infants at high risk for eczema. Benef Microbes. 2015;6:783-790.
26. Sandin A, Braback L, Norin E, Bjorksten B. Faecal short chain fatty acid pattern and allergy in early childhood. Acta Paediatr. 2009;98:823-827.
27. Ahmed R, Segal I, Hassan H. Fermentation of dietary starch in humans. Am J Gastroenterol. 2000;95:1017-1020.
28. McOrist AL, Miller RB, Bird AR, et al. Fecal butyrate levels vary widely among individuals but are usually increased by a diet high in resistant starch. J Nutr. 2011;141:883-889.
29. Matsumoto M, Aranami A, Ishige A, Watanabe K, Benno Y. LKM512 yogurt consumption improves the intestinal environment and induces the T-helper type 1 cytokine in adult patients with intractable atopic dermatitis. Clin Exp Allergy. 2007;37:358-370.
30. Arrieta MC, Stiemsma LT, Dimitriu PA, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med. 2015;7(307):307ra152.
31. Rueter K, Prescott SL, Palmer DJ. Nutritional approaches for the primary prevention of allergic disease: an update. J Paediatr Child Health. 2015;51:962-969.
32. Maslowski KM, Mackay CR. Diet, gut microbiota and immune responses. Nat Immunol. 2011;12:5-9.
33. Frei R, Lauener RP, Crameri R, O'Mahony L. Microbiota and dietary interactions: an update to the hygiene hypothesis? Allergy. 2012;67:451-461.
34. Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nat Rev Immunol. 2016;16:341-352.
35. Khan TK, Palmer DJ, Prescott SL. In-utero exposures and the evolving epidemiology of paediatric allergy. Curr Opin Allergy Clin Immunol. 2015;15:402-408.
36. Thorburn AN, McKenzie CI, Shen S, et al. Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015;6:7320.