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Volumn 150, Issue 6, 2018, Pages 661-676

The micromechanics of lung alveoli: structure and function of surfactant and tissue components

Author keywords

Acinus; Acute lung injury; Connective tissue; Fibrosis; Surfactant; Type II alveolar epithelial cell

Indexed keywords

LUNG SURFACTANT;

EID: 85055967638     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-018-1747-9     Document Type: Review
Times cited : (261)

References (121)
  • 1
    • 84859485519 scopus 로고    scopus 로고
    • The role of ventilation-induced surfactant dysfunction and atelectasis in causing acute respiratory distress syndrome
    • PID: 22227381
    • Albert RK (2012) The role of ventilation-induced surfactant dysfunction and atelectasis in causing acute respiratory distress syndrome. Am J Respir Crit Care Med 185:702–708
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 702-708
    • Albert, R.K.1
  • 2
    • 0141617173 scopus 로고    scopus 로고
    • Alveolar surface forces and lung architecture
    • COI: 1:STN:280:DC%2BD3M3ns12ntw%3D%3D, PID: 11369543
    • Bachofen H, Schürch S (2001) Alveolar surface forces and lung architecture. Comp Biochem Physiol A Mol Integr Physiol 129:183–193
    • (2001) Comp Biochem Physiol A Mol Integr Physiol , vol.129 , pp. 183-193
    • Bachofen, H.1    Schürch, S.2
  • 3
    • 0018564671 scopus 로고
    • Alterations of mechanical properties and morphology in excised rabbit lungs rinsed with a detergent
    • COI: 1:STN:280:DyaL3c%2FntFyisA%3D%3D, PID: 511700
    • Bachofen H, Gehr P, Weibel ER (1979) Alterations of mechanical properties and morphology in excised rabbit lungs rinsed with a detergent. J Appl Physiol 47:1002–1010
    • (1979) J Appl Physiol , vol.47 , pp. 1002-1010
    • Bachofen, H.1    Gehr, P.2    Weibel, E.R.3
  • 4
    • 0023239485 scopus 로고
    • Relations among alveolar surface tension, surface area, volume, and recoil pressure
    • COI: 1:STN:280:DyaL2s3ltVWnug%3D%3D, PID: 3597262
    • Bachofen H, Schürch S, Urbinelli M, Weibel ER (1987) Relations among alveolar surface tension, surface area, volume, and recoil pressure. J Appl Physiol 62:1878–1887
    • (1987) J Appl Physiol , vol.62 , pp. 1878-1887
    • Bachofen, H.1    Schürch, S.2    Urbinelli, M.3    Weibel, E.R.4
  • 6
    • 0036021841 scopus 로고    scopus 로고
    • Time dependence of recruitment and derecruitment in the lung: a theoretical model
    • PID: 12133882
    • Bates JH, Irvin CG (2002) Time dependence of recruitment and derecruitment in the lung: a theoretical model. J Appl Physiol 93:705–713
    • (2002) J Appl Physiol , vol.93 , pp. 705-713
    • Bates, J.H.1    Irvin, C.G.2
  • 7
    • 34548653839 scopus 로고    scopus 로고
    • Linking parenchymal disease progression to changes in lung mechanical function by percolation
    • PID: 17575096
    • Bates JH, Davis GS, Majumdar A, Butnor KJ, Suki B (2007) Linking parenchymal disease progression to changes in lung mechanical function by percolation. Am J Respir Crit Care Med 176:617–623
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 617-623
    • Bates, J.H.1    Davis, G.S.2    Majumdar, A.3    Butnor, K.J.4    Suki, B.5
  • 8
    • 0037308661 scopus 로고    scopus 로고
    • Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening
    • PID: 12433851
    • Bilek AM, Dee KC, Gaver DP (2003) Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening. J Appl Physiol 94:770–783
    • (2003) J Appl Physiol , vol.94 , pp. 770-783
    • Bilek, A.M.1    Dee, K.C.2    Gaver, D.P.3
  • 9
    • 0024419398 scopus 로고
    • Alveolitis and collapse in the pathogenesis of pulmonary fibrosis
    • COI: 1:STN:280:DyaL1MzkvFylug%3D%3D, PID: 2669580
    • Burkhardt A (1989) Alveolitis and collapse in the pathogenesis of pulmonary fibrosis. Am Rev Respir Dis 140:513–524
    • (1989) Am Rev Respir Dis , vol.140 , pp. 513-524
    • Burkhardt, A.1
  • 10
    • 85040520069 scopus 로고    scopus 로고
    • Integrated lung tissue mechanics one piece at a time: computational modeling across the scales of biology
    • Burrowes KS, Iravani A, Kang W (2018) Integrated lung tissue mechanics one piece at a time: computational modeling across the scales of biology. Clin Biomech. 10.1016/j.clinbiomech.2018.01.002
    • (2018) Clin Biomech
    • Burrowes, K.S.1    Iravani, A.2    Kang, W.3
  • 12
    • 84929992629 scopus 로고    scopus 로고
    • Synchrotron X-ray imaging of pulmonary alveoli in respiration in live intact mice
    • COI: 1:CAS:528:DC%2BC2MXhtFKhu7zJ, PID: 25737245
    • Chang S, Kwon N, Kim J, Kohmura Y, Ishikawa T, Rhee CK, Je JH, Tsuda A (2015) Synchrotron X-ray imaging of pulmonary alveoli in respiration in live intact mice. Sci Rep 5:8760
    • (2015) Sci Rep , vol.5 , pp. 8760
    • Chang, S.1    Kwon, N.2    Kim, J.3    Kohmura, Y.4    Ishikawa, T.5    Rhee, C.K.6    Je, J.H.7    Tsuda, A.8
  • 13
    • 1642492903 scopus 로고    scopus 로고
    • Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines
    • COI: 1:CAS:528:DC%2BD2cXhtV2lsA%3D%3D, PID: 14707576
    • Chu EK, Whitehead T, Slutsky AS (2004) Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines. Crit Care Med 32:168–174
    • (2004) Crit Care Med , vol.32 , pp. 168-174
    • Chu, E.K.1    Whitehead, T.2    Slutsky, A.S.3
  • 15
    • 0026873553 scopus 로고
    • Stress failure of alveolar epithelial cells studied by scanning electron microscopy
    • COI: 1:STN:280:DyaK383otFansg%3D%3D, PID: 1596017
    • Costello ML, Mathieu-Costello O, West JB (1992) Stress failure of alveolar epithelial cells studied by scanning electron microscopy. Am Rev Respir Dis 145:1446–1455
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1446-1455
    • Costello, M.L.1    Mathieu-Costello, O.2    West, J.B.3
  • 16
    • 0019977498 scopus 로고
    • Cell numbers and cell characteristics of the normal human lung
    • COI: 1:STN:280:DyaL383lsV2htg%3D%3D, PID: 7103258
    • Crapo JD, Barry BE, Gehr P, Bachofen M, Weibel ER (1982) Cell numbers and cell characteristics of the normal human lung. Am Rev Respir Dis 126:332–337
    • (1982) Am Rev Respir Dis , vol.126 , pp. 332-337
    • Crapo, J.D.1    Barry, B.E.2    Gehr, P.3    Bachofen, M.4    Weibel, E.R.5
  • 17
  • 18
    • 0031942649 scopus 로고    scopus 로고
    • Ventilator-induced lung injury: lessons from experimental studies
    • COI: 1:STN:280:DyaK1c7gs1SqsA%3D%3D, PID: 9445314
    • Dreyfuss D, Saumon G (1998) Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157:294–323
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 294-323
    • Dreyfuss, D.1    Saumon, G.2
  • 19
    • 33645984858 scopus 로고    scopus 로고
    • Stress transmission in the lung: pathways from organ to molecule
    • COI: 1:CAS:528:DC%2BD28XksFWks7k%3D, PID: 16460282
    • Fredberg JJ, Kamm RD (2006) Stress transmission in the lung: pathways from organ to molecule. Annu Rev Physiol 68:507–541
    • (2006) Annu Rev Physiol , vol.68 , pp. 507-541
    • Fredberg, J.J.1    Kamm, R.D.2
  • 21
    • 0016826482 scopus 로고
    • Does the surface tension make the lung inherently unstable?
    • COI: 1:STN:280:DyaE28%2Fkt1WrsQ%3D%3D, PID: 1182941
    • Fung YC (1975) Does the surface tension make the lung inherently unstable? Circ Res 37:497–502
    • (1975) Circ Res , vol.37 , pp. 497-502
    • Fung, Y.C.1
  • 22
    • 0014492686 scopus 로고
    • Theory of sheet flow in lung alveoli
    • COI: 1:STN:280:DyaF1M7jvFCltg%3D%3D, PID: 5775333
    • Fung YC, Sobin SS (1969) Theory of sheet flow in lung alveoli. J Appl Physiol 26:472–488
    • (1969) J Appl Physiol , vol.26 , pp. 472-488
    • Fung, Y.C.1    Sobin, S.S.2
  • 23
    • 14944340247 scopus 로고    scopus 로고
    • Alveolar mechanics in the acutely injured lung: role of alveolar instability in the pathogenesis of ventilator-induced lung injury
    • PID: 15329177
    • Gatto LA, Fluck RR (2004) Alveolar mechanics in the acutely injured lung: role of alveolar instability in the pathogenesis of ventilator-induced lung injury. Respir Care 49:1045–1055
    • (2004) Respir Care , vol.49 , pp. 1045-1055
    • Gatto, L.A.1    Fluck, R.R.2
  • 24
    • 0017879956 scopus 로고
    • The normal human lung: ultrastructure and morphometric estimation of diffusion capacity
    • COI: 1:STN:280:DyaE1c7lvFejtw%3D%3D, PID: 644146
    • Gehr P, Bachofen M, Weibel ER (1978) The normal human lung: ultrastructure and morphometric estimation of diffusion capacity. Respir Physiol 32:121–140
    • (1978) Respir Physiol , vol.32 , pp. 121-140
    • Gehr, P.1    Bachofen, M.2    Weibel, E.R.3
  • 25
    • 0014623779 scopus 로고
    • /70) Improvements in demonstration of lining layer of lung alveoli by electron microscopy
    • COI: 1:STN:280:DyaE3c%2FovFyhsQ%3D%3D, PID: 4904279
    • Gil J, Weibel ER (1969) /70) Improvements in demonstration of lining layer of lung alveoli by electron microscopy. Respir Physiol 8:13–36
    • (1969) Respir Physiol , vol.8 , pp. 13-36
    • Gil, J.1    Weibel, E.R.2
  • 26
    • 0015355938 scopus 로고
    • Morphological study of pressure-volume hysteresis in rat lungs fixed by vascular perfusion
    • COI: 1:STN:280:DyaE383jtVKltQ%3D%3D, PID: 5042167
    • Gil J, Weibel ER (1972) Morphological study of pressure-volume hysteresis in rat lungs fixed by vascular perfusion. Respir Physiol 15:190–213
    • (1972) Respir Physiol , vol.15 , pp. 190-213
    • Gil, J.1    Weibel, E.R.2
  • 27
    • 0018579118 scopus 로고
    • Alveolar volume-surface area relation in air- and saline-filled lungs fixed by vascular perfusion
    • COI: 1:STN:280:DyaL3c%2FntFyntQ%3D%3D, PID: 511725
    • Gil J, Bachofen H, Gehr P, Weibel ER (1979) Alveolar volume-surface area relation in air- and saline-filled lungs fixed by vascular perfusion. J Appl Physiol 47:990–1001
    • (1979) J Appl Physiol , vol.47 , pp. 990-1001
    • Gil, J.1    Bachofen, H.2    Gehr, P.3    Weibel, E.R.4
  • 28
    • 0023951406 scopus 로고
    • Morphometry of the human pulmonary acinus
    • COI: 1:STN:280:DyaL1c3ltVGrug%3D%3D, PID: 3382030
    • Haefeli-Bleuer B, Weibel ER (1988) Morphometry of the human pulmonary acinus. Anat Rec 220:401–414
    • (1988) Anat Rec , vol.220 , pp. 401-414
    • Haefeli-Bleuer, B.1    Weibel, E.R.2
  • 30
    • 84983738721 scopus 로고    scopus 로고
    • Predicting ventilator-induced lung injury using a lung injury cost function
    • PID: 27174922
    • Hamlington KL, Smith BJ, Allen GB, Bates JH (2016) Predicting ventilator-induced lung injury using a lung injury cost function. J Appl Physiol 121:106–114
    • (2016) J Appl Physiol , vol.121 , pp. 106-114
    • Hamlington, K.L.1    Smith, B.J.2    Allen, G.B.3    Bates, J.H.4
  • 31
    • 84863885531 scopus 로고    scopus 로고
    • Interfacial stress affects rat alveolar type II cell signaling and gene expression
    • COI: 1:CAS:528:DC%2BC38Xht1OksrrM, PID: 22610352
    • Hobi N, Ravasio A, Haller T (2012) Interfacial stress affects rat alveolar type II cell signaling and gene expression. Am J Physiol Lung Cell Mol Physiol 303:L117–L129
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.303 , pp. L117-L129
    • Hobi, N.1    Ravasio, A.2    Haller, T.3
  • 32
    • 85013493473 scopus 로고    scopus 로고
    • Lung structure and the intrinsic challenges of gas exchange
    • PID: 27065169
    • Hsia CCW, Hyde DM, Weibel ER (2016) Lung structure and the intrinsic challenges of gas exchange. Compr Physiol 6:827–895
    • (2016) Compr Physiol , vol.6 , pp. 827-895
    • Hsia, C.C.W.1    Hyde, D.M.2    Weibel, E.R.3
  • 34
    • 0037383404 scopus 로고    scopus 로고
    • Tensegrity I. Cell structure and hierarchical systems biology
    • COI: 1:CAS:528:DC%2BD3sXivFWhtbY%3D, PID: 12615960
    • Ingber DE (2003) Tensegrity I. Cell structure and hierarchical systems biology. J Cell Sci 116:1157–1173
    • (2003) J Cell Sci , vol.116 , pp. 1157-1173
    • Ingber, D.E.1
  • 35
    • 0015948307 scopus 로고
    • contractile interstitial cells” in pulmonary alveolar septa: a possible regulator of ventilation/perfusion ratio?
    • COI: 1:STN:280:DyaE2c7gtVCqtQ%3D%3D, PID: 4204972
    • Kapanci Y, Assimacopoulos A, Irle C, Zwahlen A, Gabbiani G (1974) “contractile interstitial cells” in pulmonary alveolar septa: a possible regulator of ventilation/perfusion ratio? J Cell Biol 60:375–392
    • (1974) J Cell Biol , vol.60 , pp. 375-392
    • Kapanci, Y.1    Assimacopoulos, A.2    Irle, C.3    Zwahlen, A.4    Gabbiani, G.5
  • 36
    • 3042512164 scopus 로고    scopus 로고
    • Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening
    • PID: 15004001
    • Kay SS, Bilek AM, Dee KC, Gaver DP (2004) Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening. J Appl Physiol 97:269–276
    • (2004) J Appl Physiol , vol.97 , pp. 269-276
    • Kay, S.S.1    Bilek, A.M.2    Dee, K.C.3    Gaver, D.P.4
  • 37
    • 75749129053 scopus 로고    scopus 로고
    • Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach
    • PID: 19959763
    • Knudsen L, Weibel ER, Gundersen HJ, Weinstein FV, Ochs M (2010) Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach. J Appl Physiol 108:412–421
    • (2010) J Appl Physiol , vol.108 , pp. 412-421
    • Knudsen, L.1    Weibel, E.R.2    Gundersen, H.J.3    Weinstein, F.V.4    Ochs, M.5
  • 38
    • 85006151122 scopus 로고    scopus 로고
    • Tissue remodelling in pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BC28XitFamsbnP, PID: 27981380
    • Knudsen L, Ruppert C, Ochs M (2017) Tissue remodelling in pulmonary fibrosis. Cell Tissue Res 367:607–626
    • (2017) Cell Tissue Res , vol.367 , pp. 607-626
    • Knudsen, L.1    Ruppert, C.2    Ochs, M.3
  • 41
    • 84992413001 scopus 로고    scopus 로고
    • Lung surfactant metabolism: early in life, early in disease and target in cell therapy
    • COI: 1:CAS:528:DC%2BC28XhslGrtb%2FN, PID: 27783217
    • Lopez-Rodriguez E, Gay-Jordi G, Mucci A, Lachmann N, Serrano-Mollar A (2017) Lung surfactant metabolism: early in life, early in disease and target in cell therapy. Cell Tissue Res 367:721–735
    • (2017) Cell Tissue Res , vol.367 , pp. 721-735
    • Lopez-Rodriguez, E.1    Gay-Jordi, G.2    Mucci, A.3    Lachmann, N.4    Serrano-Mollar, A.5
  • 42
    • 85007420681 scopus 로고    scopus 로고
    • Transpulmonary pressure: the importance of precise definitions and limiting assumptions
    • PID: 27606837
    • Loring SH, Topulos GP, Hubmayr RD (2016) Transpulmonary pressure: the importance of precise definitions and limiting assumptions. Am J Respir Crit Care Med 194:1452–1457
    • (2016) Am J Respir Crit Care Med , vol.194 , pp. 1452-1457
    • Loring, S.H.1    Topulos, G.P.2    Hubmayr, R.D.3
  • 45
    • 84863312286 scopus 로고    scopus 로고
    • Continuum vs. spring network models of airway-parenchymal interdependence
    • PID: 22500006
    • Ma B, Bates JH (2012) Continuum vs. spring network models of airway-parenchymal interdependence. J Appl Physiol 113:124–129
    • (2012) J Appl Physiol , vol.113 , pp. 124-129
    • Ma, B.1    Bates, J.H.2
  • 46
    • 84901044598 scopus 로고    scopus 로고
    • Mechanical interactions between adjacent airways in the lung
    • PID: 24481963
    • Ma B, Bates JH (2014) Mechanical interactions between adjacent airways in the lung. J Appl Physiol 116:628–634
    • (2014) J Appl Physiol , vol.116 , pp. 628-634
    • Ma, B.1    Bates, J.H.2
  • 47
    • 84880104252 scopus 로고    scopus 로고
    • Influence of parenchymal heterogeneity on airway-parenchymal interdependence
    • PID: 23770309
    • Ma B, Breen B, Bates JH (2013a) Influence of parenchymal heterogeneity on airway-parenchymal interdependence. Respir Physiol Neurobiol 188:94–101
    • (2013) Respir Physiol Neurobiol , vol.188 , pp. 94-101
    • Ma, B.1    Breen, B.2    Bates, J.H.3
  • 48
    • 84871926037 scopus 로고    scopus 로고
    • Airway-parenchymal interdependence in the lung slice
    • PID: 23128069
    • Ma B, Sanderson M, Bates JH (2013b) Airway-parenchymal interdependence in the lung slice. Respir Physiol Neurobiol 185:211–216
    • (2013) Respir Physiol Neurobiol , vol.185 , pp. 211-216
    • Ma, B.1    Sanderson, M.2    Bates, J.H.3
  • 49
    • 84926374652 scopus 로고    scopus 로고
    • Resistance to alveolar shape change limits range of force propagation in lung parenchyma
    • PID: 25812796
    • Ma B, Smith BJ, Bates JH (2015) Resistance to alveolar shape change limits range of force propagation in lung parenchyma. Respir Physiol Neurobiol 211:22–28
    • (2015) Respir Physiol Neurobiol , vol.211 , pp. 22-28
    • Ma, B.1    Smith, B.J.2    Bates, J.H.3
  • 51
    • 21244468701 scopus 로고    scopus 로고
    • Thin and strong! The bioengineering dilemma in the structural and functional design of the blood-gas barrier
    • Maina JN, West JB (2006) Thin and strong! The bioengineering dilemma in the structural and functional design of the blood-gas barrier. Physiol Rev 85:811–844
    • (2006) Physiol Rev , vol.85 , pp. 811-844
    • Maina, J.N.1    West, J.B.2
  • 52
    • 84926123900 scopus 로고    scopus 로고
    • Stress concentration around an atelectatic region: a finite element model
    • COI: 1:STN:280:DC%2BC2cbks1yhuw%3D%3D, PID: 25048678
    • Makiyama AM, Gibson LJ, Harris RS, Venegas JG (2014) Stress concentration around an atelectatic region: a finite element model. Respir Physiol Neurobiol 201:101–110
    • (2014) Respir Physiol Neurobiol , vol.201 , pp. 101-110
    • Makiyama, A.M.1    Gibson, L.J.2    Harris, R.S.3    Venegas, J.G.4
  • 53
    • 0024264995 scopus 로고
    • Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study
    • COI: 1:STN:280:DyaL1M7ls1Shug%3D%3D, PID: 3230208
    • Mascheroni D, Kolobow T, Fumagalli R, Moretti MP, Chen V, Buckhold D (1988) Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med 15:8–14
    • (1988) Intensive Care Med , vol.15 , pp. 8-14
    • Mascheroni, D.1    Kolobow, T.2    Fumagalli, R.3    Moretti, M.P.4    Chen, V.5    Buckhold, D.6
  • 54
    • 0014786734 scopus 로고
    • Stress distribution in lungs: a model of pulmonary elasticity
    • COI: 1:STN:280:DyaE3c7nslOgtQ%3D%3D, PID: 5442255
    • Mead J, Takishima T, Leith D (1970) Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol 28:596–608
    • (1970) J Appl Physiol , vol.28 , pp. 596-608
    • Mead, J.1    Takishima, T.2    Leith, D.3
  • 55
    • 0024997680 scopus 로고
    • Spatial distribution of collagen and elastin fibers in the lungs
    • COI: 1:STN:280:DyaK3M%2FjsFWisQ%3D%3D, PID: 2228886
    • Mercer R, Crapo J (1990) Spatial distribution of collagen and elastin fibers in the lungs. J Appl Physiol 69:756–765
    • (1990) J Appl Physiol , vol.69 , pp. 756-765
    • Mercer, R.1    Crapo, J.2
  • 56
    • 0023255592 scopus 로고
    • Three-dimensional reconstruction of alveoli in the rat lung for pressure-volume relationships
    • COI: 1:STN:280:DyaL2s3ltVSqsA%3D%3D, PID: 3597219
    • Mercer RR, Laco JM, Crapo JD (1987) Three-dimensional reconstruction of alveoli in the rat lung for pressure-volume relationships. J Appl Physiol 62:1480–1487
    • (1987) J Appl Physiol , vol.62 , pp. 1480-1487
    • Mercer, R.R.1    Laco, J.M.2    Crapo, J.D.3
  • 60
    • 85014248184 scopus 로고    scopus 로고
    • Predicting structure-function relations and survival following surgical and bronchoscopic lung volume reduction treatment of emphysema
    • PID: 28182686
    • Mondoñedo JR, Suki B (2017) Predicting structure-function relations and survival following surgical and bronchoscopic lung volume reduction treatment of emphysema. PLoS Comput Biol 13:e1005282
    • (2017) PLoS Comput Biol , vol.13
    • Mondoñedo, J.R.1    Suki, B.2
  • 62
    • 77954584251 scopus 로고    scopus 로고
    • Is length an appropriate estimator to characterize pulmonary alveolar capillaries? A critical evaluation in the human lung
    • Mühlfeld C, Weibel ER, Hahn U, Kummer W, Nyengaard JR, Ochs M (2010) Is length an appropriate estimator to characterize pulmonary alveolar capillaries? A critical evaluation in the human lung. Anat Rec 293:1270–1275
    • (2010) Anat Rec , vol.293 , pp. 1270-1275
    • Mühlfeld, C.1    Weibel, E.R.2    Hahn, U.3    Kummer, W.4    Nyengaard, J.R.5    Ochs, M.6
  • 63
    • 0028350295 scopus 로고
    • Tidal ventilation at low airway pressures can augment lung injury
    • COI: 1:STN:280:DyaK2c3ivVSkug%3D%3D, PID: 8173774
    • Muscedere JG, Mullen JB, Gan K, Slutsky AS (1994) Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 149:1327–1334
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 1327-1334
    • Muscedere, J.G.1    Mullen, J.B.2    Gan, K.3    Slutsky, A.S.4
  • 64
    • 0030309580 scopus 로고    scopus 로고
    • Pulmonary surfactant: no mere paint on the alveolar wall
    • COI: 1:STN:280:DyaK1c%2FlvFGlsQ%3D%3D, PID: 9441113
    • Nicholas TE (1996) Pulmonary surfactant: no mere paint on the alveolar wall. Respirology 1:247–257
    • (1996) Respirology , vol.1 , pp. 247-257
    • Nicholas, T.E.1
  • 65
    • 84949206947 scopus 로고    scopus 로고
    • Impact of mechanical ventilation on the pathophysiology of progressive acute lung injury
    • COI: 1:CAS:528:DC%2BC28XpsFyitLg%3D, PID: 26472873
    • Nieman GF, Gatto LA, Habashi NM (2015) Impact of mechanical ventilation on the pathophysiology of progressive acute lung injury. J Appl Physiol 119:1245–1261
    • (2015) J Appl Physiol , vol.119 , pp. 1245-1261
    • Nieman, G.F.1    Gatto, L.A.2    Habashi, N.M.3
  • 67
    • 73849123135 scopus 로고    scopus 로고
    • The closer we look the more we see? Quantitative microscopic analysis of the pulmonary surfactant system
    • COI: 1:CAS:528:DC%2BC3cXhtF2ltw%3D%3D, PID: 20054142
    • Ochs M (2010) The closer we look the more we see? Quantitative microscopic analysis of the pulmonary surfactant system. Cell Physiol Biochem 25:27–40
    • (2010) Cell Physiol Biochem , vol.25 , pp. 27-40
    • Ochs, M.1
  • 68
    • 51049099074 scopus 로고    scopus 로고
    • Functional design of the human lung for gas exchange
    • Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, Senior RM, (eds), 5, McGraw-Hill, New York
    • Ochs M, Weibel ER (2015) Functional design of the human lung for gas exchange. In: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, Senior RM (eds) Fishman’s pulmonary diseases and disorders, 5th edn. McGraw-Hill, New York, pp 20–62
    • (2015) Fishman’s pulmonary diseases and disorders , pp. 20-62
    • Ochs, M.1    Weibel, E.R.2
  • 69
    • 0032779619 scopus 로고    scopus 로고
    • Ultrastructural alterations in intraalveolar surfactant subtypes after experimental ischemia and reperfusion
    • COI: 1:STN:280:DyaK1MzlvFOhsg%3D%3D, PID: 10430751
    • Ochs M, Nenadic I, Fehrenbach A, Albes J, Wahlers T, Richter J, Fehrenbach H (1999) Ultrastructural alterations in intraalveolar surfactant subtypes after experimental ischemia and reperfusion. Am J Respir Crit Care Med 160:718–724
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 718-724
    • Ochs, M.1    Nenadic, I.2    Fehrenbach, A.3    Albes, J.4    Wahlers, T.5    Richter, J.6    Fehrenbach, H.7
  • 71
    • 54049115030 scopus 로고    scopus 로고
    • Cell wounding and repair in ventilator injured lungs
    • COI: 1:CAS:528:DC%2BD1cXht12rtr%2FO, PID: 18638574
    • Oeckler RA, Hubmayr RD (2008) Cell wounding and repair in ventilator injured lungs. Respir Physiol Neurobiol 163:44–53
    • (2008) Respir Physiol Neurobiol , vol.163 , pp. 44-53
    • Oeckler, R.A.1    Hubmayr, R.D.2
  • 72
    • 0026316716 scopus 로고
    • Alveolar septal folding and lung inflation history
    • COI: 1:STN:280:DyaK387jvVGgsw%3D%3D, PID: 1778935
    • Oldmixon EH, Hoppin FG (1991) Alveolar septal folding and lung inflation history. J Appl Physiol 71:2369–2379
    • (1991) J Appl Physiol , vol.71 , pp. 2369-2379
    • Oldmixon, E.H.1    Hoppin, F.G.2
  • 73
    • 84998717707 scopus 로고    scopus 로고
    • Pulmonary surfactant metabolism in the alveolar airspace: biogenesis, extracellular conversions, recycling
    • PID: 27773772
    • Olmeda B, Martinez-Calle M, Perez-Gil J (2017) Pulmonary surfactant metabolism in the alveolar airspace: biogenesis, extracellular conversions, recycling. Ann Anat 209:78–92
    • (2017) Ann Anat , vol.209 , pp. 78-92
    • Olmeda, B.1    Martinez-Calle, M.2    Perez-Gil, J.3
  • 74
    • 34447526510 scopus 로고    scopus 로고
    • Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics
    • Pavone LA, Albert S, Carney D, Gatto LA, Halter JM, Nieman GF (2007) Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics. Crit Care 11:R64. 10.1186/cc5940 pii]
    • (2007) Crit Care , vol.11 , pp. R64
    • Pavone, L.A.1    Albert, S.2    Carney, D.3    Gatto, L.A.4    Halter, J.M.5    Nieman, G.F.6
  • 75
    • 50949083025 scopus 로고    scopus 로고
    • Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions
    • COI: 1:CAS:528:DC%2BD1cXnsFCrtrw%3D, PID: 18515069
    • Perez-Gil J (2008) Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions. Biochim Biophys Acta 1778:1676–1695
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 1676-1695
    • Perez-Gil, J.1
  • 77
    • 85038410072 scopus 로고    scopus 로고
    • Increased expiratory computed tomography density reveals possible abnormalities in radiologically preserved lung parenchyma in idiopathic pulmonary fibrosis
    • PID: 28817393
    • Petroulia V, Funke M, Zumstein P, Berezowska S, Ebner L, Geiser T, Torbica N, Heverhagen J, Poellinger A (2018) Increased expiratory computed tomography density reveals possible abnormalities in radiologically preserved lung parenchyma in idiopathic pulmonary fibrosis. Invest Radiol 53:45–51
    • (2018) Invest Radiol , vol.53 , pp. 45-51
    • Petroulia, V.1    Funke, M.2    Zumstein, P.3    Berezowska, S.4    Ebner, L.5    Geiser, T.6    Torbica, N.7    Heverhagen, J.8    Poellinger, A.9
  • 81
    • 80055104820 scopus 로고    scopus 로고
    • What do we know about mechanical strain in lung alveoli?
    • COI: 1:CAS:528:DC%2BC3MXhsFaktr7I, PID: 21873445
    • Roan E, Waters CM (2011) What do we know about mechanical strain in lung alveoli? Am J Physiol Lung Cell Mol Physiol 301:L625–L635
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , pp. L625-L635
    • Roan, E.1    Waters, C.M.2
  • 82
    • 0003019810 scopus 로고
    • An analysis of pressure-volume characteristics of the lung
    • COI: 1:STN:280:DyaF2c%2FmtF2rsg%3D%3D, PID: 14104296
    • Salazar E, Knowles JH (1964) An analysis of pressure-volume characteristics of the lung. J Appl Physiol 19:97–104
    • (1964) J Appl Physiol , vol.19 , pp. 97-104
    • Salazar, E.1    Knowles, J.H.2
  • 84
    • 77950691576 scopus 로고    scopus 로고
    • Theoretical modeling of the interaction between alveoli during inflation and deflation in normal and diseased lungs
    • PID: 20031137
    • Schirrmann K, Mertens M, Kertzscher U, Kuebler WM, Affeld K (2010) Theoretical modeling of the interaction between alveoli during inflation and deflation in normal and diseased lungs. J Biomech 43:1202–1207
    • (2010) J Biomech , vol.43 , pp. 1202-1207
    • Schirrmann, K.1    Mertens, M.2    Kertzscher, U.3    Kuebler, W.M.4    Affeld, K.5
  • 85
    • 79954439491 scopus 로고    scopus 로고
    • Quantifying the roles of tidal volume and PEEP in the pathogenesis of ventilator-induced lung injury
    • PID: 21203845
    • Seah AS, Grant KA, Aliyeva M, Allen GB, Bates JH (2011) Quantifying the roles of tidal volume and PEEP in the pathogenesis of ventilator-induced lung injury. Ann Biomed Eng 39:1505–1516
    • (2011) Ann Biomed Eng , vol.39 , pp. 1505-1516
    • Seah, A.S.1    Grant, K.A.2    Aliyeva, M.3    Allen, G.B.4    Bates, J.H.5
  • 86
    • 84880551390 scopus 로고    scopus 로고
    • Murine pulmonary acinar mechanics during quasi-static inflation using synchrotron refraction-enhanced computed tomography
    • PID: 23661619
    • Sera T, Yokota H, Tanaka G, Uesugi K, Yagi N, Schroter RC (2013) Murine pulmonary acinar mechanics during quasi-static inflation using synchrotron refraction-enhanced computed tomography. J Appl Physiol 115:219–228
    • (2013) J Appl Physiol , vol.115 , pp. 219-228
    • Sera, T.1    Yokota, H.2    Tanaka, G.3    Uesugi, K.4    Yagi, N.5    Schroter, R.C.6
  • 87
    • 0346732057 scopus 로고    scopus 로고
    • Human alveolar wall fibroblasts directly link epithelial type 2 cells to capillary endothelium
    • PID: 14551162
    • Sirianni FE, Chu FS, Walker DC (2003) Human alveolar wall fibroblasts directly link epithelial type 2 cells to capillary endothelium. Am J Respir Crit Care Med 168:1532–1537
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1532-1537
    • Sirianni, F.E.1    Chu, F.S.2    Walker, D.C.3
  • 88
    • 84889568065 scopus 로고    scopus 로고
    • Assessing the progression of ventilator-induced lung injury in mice
    • PID: 23751952
    • Smith BJ, Bates JHT (2013) Assessing the progression of ventilator-induced lung injury in mice. IEEE Trans Biomed Eng 60:3449–3457
    • (2013) IEEE Trans Biomed Eng , vol.60 , pp. 3449-3457
    • Smith, B.J.1    Bates, J.H.T.2
  • 89
    • 84876172915 scopus 로고    scopus 로고
    • Linking the development of ventilator-induced injury to mechanical function in the lung
    • PID: 23161164
    • Smith BJ, Grant KA, Bates JH (2013) Linking the development of ventilator-induced injury to mechanical function in the lung. Ann Biomed Eng 41:527–536
    • (2013) Ann Biomed Eng , vol.41 , pp. 527-536
    • Smith, B.J.1    Grant, K.A.2    Bates, J.H.3
  • 94
    • 85021982844 scopus 로고    scopus 로고
    • Evidence for age-dependent air-space enlargement contributing to loss of lung tissue elastic recoil pressure and increased shear modulus in older age
    • COI: 1:CAS:528:DC%2BC1cXitVeku7vK, PID: 28450548
    • Subramaniam K, Kumar H, Tawhai MH (2017) Evidence for age-dependent air-space enlargement contributing to loss of lung tissue elastic recoil pressure and increased shear modulus in older age. J Appl Physiol 123:79–87
    • (2017) J Appl Physiol , vol.123 , pp. 79-87
    • Subramaniam, K.1    Kumar, H.2    Tawhai, M.H.3
  • 95
    • 17644421823 scopus 로고    scopus 로고
    • Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces
    • PID: 15829722
    • Suki B, Ito S, Stamenovic D, Lutchen KR, Ingenito EP (2005) Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces. J Appl Physiol 98:1892–1899
    • (2005) J Appl Physiol , vol.98 , pp. 1892-1899
    • Suki, B.1    Ito, S.2    Stamenovic, D.3    Lutchen, K.R.4    Ingenito, E.P.5
  • 98
    • 84937824407 scopus 로고    scopus 로고
    • Permanent alveolar collapse is the predominant mechanism in idiopathic pulmonary fibrosis
    • COI: 1:CAS:528:DC%2BC2MXht1ajsLjE, PID: 26165208
    • Todd NW, Atamas SP, Luzina IG, Galvin JR (2015) Permanent alveolar collapse is the predominant mechanism in idiopathic pulmonary fibrosis. Expert Rev Respir Med 9:411–418
    • (2015) Expert Rev Respir Med , vol.9 , pp. 411-418
    • Todd, N.W.1    Atamas, S.P.2    Luzina, I.G.3    Galvin, J.R.4
  • 99
    • 1942485906 scopus 로고    scopus 로고
    • Three-dimensional architecture of elastin and collagen fiber networks in the human and rat lung
    • COI: 1:CAS:528:DC%2BD2cXjslekurs%3D, PID: 15125021
    • Toshima M, Ohtani Y, Ohtani O (2004) Three-dimensional architecture of elastin and collagen fiber networks in the human and rat lung. Arch Histol Cytol 67:31–40
    • (2004) Arch Histol Cytol , vol.67 , pp. 31-40
    • Toshima, M.1    Ohtani, Y.2    Ohtani, O.3
  • 100
    • 84862002344 scopus 로고    scopus 로고
    • Structure and composition of pulmonary arteries, capillaries and veins
    • PID: 23606929
    • Townsley MI (2012) Structure and composition of pulmonary arteries, capillaries and veins. Compr Physiol 2:675–709
    • (2012) Compr Physiol , vol.2 , pp. 675-709
    • Townsley, M.I.1
  • 101
    • 0033061238 scopus 로고    scopus 로고
    • Alveolar epithelial surface area-volume relationship in isolated rat lungs
    • COI: 1:STN:280:DyaK1M3pvVaksQ%3D%3D, PID: 10368370
    • Tschumperlin DJ, Margulies SS (1999) Alveolar epithelial surface area-volume relationship in isolated rat lungs. J Appl Physiol 86:2026–2033
    • (1999) J Appl Physiol , vol.86 , pp. 2026-2033
    • Tschumperlin, D.J.1    Margulies, S.S.2
  • 102
    • 0033837424 scopus 로고    scopus 로고
    • Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude
    • COI: 1:STN:280:DC%2BD3cvjtleqtw%3D%3D, PID: 10934053
    • Tschumperlin DJ, Oswari J, Margulies AS (2000) Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude. Am J Respir Crit Care Med 162:357–362
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 357-362
    • Tschumperlin, D.J.1    Oswari, J.2    Margulies, A.S.3
  • 103
    • 0036089848 scopus 로고    scopus 로고
    • Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant
    • PID: 11842055
    • Veldhuizen RA, Welk B, Harbottle R, Hearn S, Nag K, Petersen N, Possmayer F (2002) Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant. J Appl Physiol 92:1169–1175
    • (2002) J Appl Physiol , vol.92 , pp. 1169-1175
    • Veldhuizen, R.A.1    Welk, B.2    Harbottle, R.3    Hearn, S.4    Nag, K.5    Petersen, N.6    Possmayer, F.7
  • 104
    • 0031908102 scopus 로고    scopus 로고
    • A comprehensive equation for the pulmonary pressure-volume curve
    • COI: 1:STN:280:DyaK1c7htlKgsg%3D%3D, PID: 9451661
    • Venegas JG, Harris RS, Simon BA (1998) A comprehensive equation for the pulmonary pressure-volume curve. J Appl Physiol 84:389–395
    • (1998) J Appl Physiol , vol.84 , pp. 389-395
    • Venegas, J.G.1    Harris, R.S.2    Simon, B.A.3
  • 105
    • 20444392352 scopus 로고    scopus 로고
    • Cellular stress failure in ventilator-injured lungs
    • PID: 15695492
    • Vlahakis NE, Hubmayr RD (2005) Cellular stress failure in ventilator-injured lungs. Am J Respir Crit Care Med 171:1328–1342
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1328-1342
    • Vlahakis, N.E.1    Hubmayr, R.D.2
  • 106
    • 0036840592 scopus 로고    scopus 로고
    • Role of deformation-induced lipid trafficking in the prevention of plasma membrane stress failure
    • PID: 12403699
    • Vlahakis NE, Schroeder MA, Pagano RE, Hubmayr RD (2002) Role of deformation-induced lipid trafficking in the prevention of plasma membrane stress failure. Am J Respir Crit Care Med 166:1282–1289
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1282-1289
    • Vlahakis, N.E.1    Schroeder, M.A.2    Pagano, R.E.3    Hubmayr, R.D.4
  • 108
    • 0015609534 scopus 로고
    • Morphological basis of alveolar-capillary gas exchange
    • COI: 1:STN:280:DyaE3s3lslCgtA%3D%3D, PID: 4581654
    • Weibel ER (1973) Morphological basis of alveolar-capillary gas exchange. Physiol Rev 53:419–495
    • (1973) Physiol Rev , vol.53 , pp. 419-495
    • Weibel, E.R.1
  • 110
    • 67650447649 scopus 로고    scopus 로고
    • What makes a good lung?
    • PID: 19629765
    • Weibel ER (2009) What makes a good lung? Swiss Med Wkly 139:375–386
    • (2009) Swiss Med Wkly , vol.139 , pp. 375-386
    • Weibel, E.R.1
  • 111
    • 85006163500 scopus 로고    scopus 로고
    • Lung morphometry: the link between structure and function
    • PID: 27981379
    • Weibel ER (2017) Lung morphometry: the link between structure and function. Cell Tissue Res 367:413–426
    • (2017) Cell Tissue Res , vol.367 , pp. 413-426
    • Weibel, E.R.1
  • 112
    • 0013211754 scopus 로고    scopus 로고
    • The fiber scaffold of lung parenchyma
    • Crystal RG, West JB, Weibel ER, Barnes PJ, (eds), 2, Lippincott-Raven, New York
    • Weibel ER, Bachofen H (1997) The fiber scaffold of lung parenchyma. In: Crystal RG, West JB, Weibel ER, Barnes PJ (eds) The lung: scientific foundations, 2nd ed. Lippincott-Raven, New York, pp 1139–1146
    • (1997) The lung: scientific foundations , pp. 11391146
    • Weibel, E.R.1    Bachofen, H.2
  • 113
    • 0002161479 scopus 로고    scopus 로고
    • Structural organization of the pulmonary interstitium
    • Crystal RG, West JB, Weibel ER, Barnes PJ, (eds), 2, Lippincott-Raven, New York
    • Weibel ER, Crystal RG (1997) Structural organization of the pulmonary interstitium. In: Crystal RG, West JB, Weibel ER, Barnes PJ (eds) The lung: scientific foundations, 2nd ed. Lippincott-Raven, New York, pp 685–695
    • (1997) The lung: scientific foundations , pp. 685695
    • Weibel, E.R.1    Crystal, R.G.2
  • 114
    • 0014244934 scopus 로고
    • Electron microscopic demonstration of an extracellular duplex lining layer of alveoli
    • COI: 1:STN:280:DyaF1c7lsV2ltw%3D%3D, PID: 4867416
    • Weibel ER, Gil J (1968) Electron microscopic demonstration of an extracellular duplex lining layer of alveoli. Respir Physiol 4:42–57
    • (1968) Respir Physiol , vol.4 , pp. 42-57
    • Weibel, E.R.1    Gil, J.2
  • 116
    • 0025787971 scopus 로고
    • The concept of symmorphosis: a testable hypothesis of structure-function relationship
    • COI: 1:STN:280:DyaK38%2Flt1aluw%3D%3D, PID: 1946456
    • Weibel ER, Taylor CR, Hoppeler H (1991) The concept of symmorphosis: a testable hypothesis of structure-function relationship. Proc Natl Acad Sci USA 88:10357–10361
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10357-10361
    • Weibel, E.R.1    Taylor, C.R.2    Hoppeler, H.3
  • 117
    • 0026566197 scopus 로고
    • Variations in function and design: testing symmorphosis in the respiratory system
    • COI: 1:STN:280:DyaK383psVGnsg%3D%3D, PID: 1604056
    • Weibel ER, Taylor CR, Hoppeler H (1992) Variations in function and design: testing symmorphosis in the respiratory system. Respir Physiol 87:325–348
    • (1992) Respir Physiol , vol.87 , pp. 325-348
    • Weibel, E.R.1    Taylor, C.R.2    Hoppeler, H.3
  • 118
    • 23644455973 scopus 로고    scopus 로고
    • Design of peripheral airways for efficient gas exchange
    • PID: 15921964
    • Weibel ER, Sapoval B, Filoche M (2005) Design of peripheral airways for efficient gas exchange. Respir Physiol Neurobiol 148:3–21
    • (2005) Respir Physiol Neurobiol , vol.148 , pp. 3-21
    • Weibel, E.R.1    Sapoval, B.2    Filoche, M.3
  • 119
    • 0019951291 scopus 로고
    • A model for mechanical structure of the alveolar duct
    • COI: 1:STN:280:DyaL383htlCnsw%3D%3D, PID: 7085408
    • Wilson TA, Bachofen H (1982) A model for mechanical structure of the alveolar duct. J Appl Physiol 52:1064–1070
    • (1982) J Appl Physiol , vol.52 , pp. 1064-1070
    • Wilson, T.A.1    Bachofen, H.2
  • 120
    • 84908477750 scopus 로고    scopus 로고
    • Lung ventilation injures areas with discrete alveolar flooding, in a surface tension-dependent fashion
    • PID: 25080924
    • Wu Y, Kharge AB, Perlman CE (2014) Lung ventilation injures areas with discrete alveolar flooding, in a surface tension-dependent fashion. J Appl Physiol 117:788–796
    • (2014) J Appl Physiol , vol.117 , pp. 788-796
    • Wu, Y.1    Kharge, A.B.2    Perlman, C.E.3
  • 121
    • 0033911525 scopus 로고    scopus 로고
    • Effects of collagenase and elastase on the mechanical properties of lung tissue strips
    • COI: 1:CAS:528:DC%2BD3cXlslGjtbk%3D, PID: 10904029
    • Yuan H, Kononov S, Cavalcante FS, Lutchen KR, Ingenito EP, Suki B (2000) Effects of collagenase and elastase on the mechanical properties of lung tissue strips. J Appl Physiol 89:3–14
    • (2000) J Appl Physiol , vol.89 , pp. 3-14
    • Yuan, H.1    Kononov, S.2    Cavalcante, F.S.3    Lutchen, K.R.4    Ingenito, E.P.5    Suki, B.6


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