Murine pulmonary acinar mechanics during quasi-static inflation using synchrotron refraction-enhanced computed tomography

Journal of Applied Physiology

Volumn 115, Issue 2, 2013, Pages 219-228

  Sera, Toshihiro ^a,b   Yokota, Hideo ^b   Tanaka, Gaku ^c   Uesugi, Kentaro ^d   Yagi, Naoto ^d   Schroter, Robert C ^e  

^a OSAKA UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d Institute of Physical and Chemical Research   (Japan)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Alveolar duct; Alveoli; Refraction enhancement; Synchrotron

Indexed keywords

ALVEOLI; ANIMAL; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; ECONOMIC ASPECT; LUNG; LUNG ALVEOLUS; LUNG ALVEOLUS DUCT; MALE; METHODOLOGY; MOUSE; PHYSIOLOGY; REFRACTION ENHANCEMENT; SYNCHROTRON;

ALVEOLAR DUCT; ALVEOLI; REFRACTION ENHANCEMENT; SYNCHROTRON;

ANIMALS; INFLATION, ECONOMIC; LUNG; MALE; MICE; PULMONARY ALVEOLI; SYNCHROTRONS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84880551390     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01105.2012     Document Type: Article

References (44)

1. Albu G, Habre W, Fontao F, Morel DR, Petak F. The contribution of the pulmonary microvascular pressure in the maintenance of an open lung during mechanical ventilation. Respir Physiol Neurobiol 157: 262-269, 2007.
2. Campbell H, Tomkeieff SI. Calculation of the internal surface of a lung. Nature 170: 116-117, 1952.
3. Carney DE, Bredenberg CE, Schiller HJ, Picone AL, McCann UG, Gatto LA, Bailey G, Fillinger M, Nieman GF. The mechanism of lung volume change during mechanical ventilation. Am J Respir Crit Care Med 160: 1697-1702, 1999.
4. Cloetens P, Barrett R, Baruchel J, Guigay JP, Schlenker M. Phase objects in synchrotron radiation hard x-ray imaging. J Phys D Appl Phys 29: 133-146, 1996.
5. Dawson CA, Rickaby DA, Linehan JH, Bronikowski TA. Distributions of vascular volume and compliance in the lung. J Appl Physiol 64: 266-273, 1988.
6. Denny E, Schroter RC. Relationships between alveolar size and fibre distribution in a mammalian lung alveolar duct model. J Biomech Eng 119: 289-297, 1997.
7. Donnelley M, Morgan KS, Fouras A, Skinner W, Uesugi K, Yagi N, Siu KK, Parsons DW. Real-time non-invasive detection of inhalable particulates delivered into live mouse airways. J Synchrotron Radiat 16: 553-561, 2009.
8. Gil J, Bachofen H, Gehr P, Weibel ER. Alveolar volume-surface area relation in air- And saline-filled lungs fixed by vascular perfusion. J Appl Physiol 47: 990-1001, 1979.
9. Glaister DH, Schroter RC, Sudlow MF, Milic-Emili J. Bulk elastic properties of excised lungs and the effect of a transpulmonary pressure gradient. Respir Physiol 17: 347-364, 1973.
10. Hajari AJ, Yablonskiy DA, Quirk JD, Sukstanskii AL, Pierce RA, Deslée G, Conradi MS, Woods JC. Imaging alveolar-duct geometry during expiration via 3He lung morphometry. J Appl Physiol 110: 1448- 1454, 2011.
11. Hajari AJ, Yablonskiy DA, Sukstanskii AL, Quirk JD, Conradi MS, Woods JC. Morphometric changes in the human pulmonary acinus during inflation. J Appl Physiol 112: 937-943, 2012.
12. Hsia CC, Hyde DM, Ochs M, Weibel ER. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 181: 394-418, 2010.
13. Ikura H, Shimizu K, Ikezoe J, Nagareda T, Yagi N. In vitro evaluation of normal and abnormal lungs with ultra-high-resolution CT. J Thorac Imaging 19: 8-15, 2004.
14. Kitchen MJ, Lewis RA, Yagi N, Uesugi K, Paganin D, Hooper SB, Adams G, Jureczek S, Singh J, Christensen CR, Hufton AP, Hall CJ, Cheung KC, Pavlov KM. Phase contrast X-ray imaging of mice and rabbit lungs: a comparative study. Br J Radiol 78: 1018-1027, 2005.
15. Klingele TG, Staub NC. Alveolar shape changes with volume in isolated, air-filled lobes of cat lung. J Appl Physiol 28: 411-414, 1970.
16. Lewis RA, Hall CJ, Hufton AP, Evans S, Menk RH, Arfelli F, Rigon L, Tromba G, Dance DR, Ellis IO, Evans A, Jacobs E, Pinder SE, Rogers KD. X-ray refraction effects: application to the imaging of biological tissues. Br J Radiol 76: 301-308, 2003.
17. Litzlbauer HD, Korbel K, Kline TL, Jorgensen SM, Eaker DR, Bohle RM, Ritman EL, Langheinrich AC. Synchrotron-based micro-CT imaging of the human lung acinus. Anat Rec (Hoboken) 293: 1607-1614, 2010.
18. Mead J, Takishima T, Leith D. Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol 28: 596-608, 1970.
19. Meissner S, Tabuchi A, Mertens M, Kuebler WM, Koch E. Virtual four-dimensional imaging of lung parenchyma by optical coherence tomography in mice. J Biomed Opt 15: 036016, 2010.
20. Mertens M, Tabuchi A, Meissner S, Krueger A, Schirrmann K, Kertzscher U, Pries AR, Slutsky AS, Koch E, Kuebler WM. Alveolar dynamics in acute lung injury: heterogeneous distension rather than cyclic opening and collapse. Crit Care Med 37: 2604-2611, 2009.
21. Namati E, Thiesse J, de Ryk J, McLennan G. Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment? Am J Respir Cell Mol Biol 38: 572-578, 2008.
22. Naureckas ET, Dawson CA, Gerber BS, Gaver DP 3rd, Gerber HL, Linehan JH, Solway J, Samsel RW. Airway reopening pressure in isolated rat lungs. J Appl Physiol 76: 1372-1377, 1994.
23. Parsons DW, Morgan K, Donnelley M, Fouras A, Crosbie J, Williams I, Boucher RC, Uesugi K, Yagi N, Siu KK. High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI). J Anat 213: 217-227, 2008.
24. Peták F, Babik B, Hantos Z, Morel DR, Pache JC, Biton C, Suki B, Habre W. Impact of microvascular circulation on peripheral lung stability. Am J Physiol Lung Cell Mol Physiol 287: L879-L889, 2004.
25. Popp A, Wendel M, Knels L, Koch T, Koch E. Imaging of the three-dimensional alveolar structure and the alveolar mechanics of a ventilated and perfused isolated rabbit lung with Fourier domain optical coherence tomography. J Biomed Opt 11: 014015, 2006.
26. Rodriguez M, Bur S, Favre A, Weibel ER. Pulmonary acinus: geometry and morphometry of the peripheral airway system in rat and rabbit. Am J Anat 180: 143-155, 1987.
27. Schulz H, Johner C, Eder G, Ziesenis A, Reitmeier P, Heyder J, Balling R. Respiratory mechanics in mice: strain and sex specific differences. Acta Physiol Scand 174: 367-375, 2002.
28. Sera T, Fujioka H, Yokota H, Makinouchi A, Himeno R, Schroter RC, Tanishita K. Localized compliance of small airways in excised rat lungs using microfocal X-ray computed tomography. J Appl Physiol 96: 1665- 1673, 2004.
29. Sera T, Uesugi K, Himeno R, Yagi N. Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation. Respir Physiol Neurobiol 156: 304-311, 2007.
30. Sera T, Uesugi K, Yagi N, Umetani K, Kobatake M, Imai S. Highresolution visualization of tumours in rabbit lung using refraction contrast X-ray imaging. Eur J Radiol 68: S54-S57, 2008.
31. Sera T, Uesugi K, Yagi N. Localized morphometric deformations of small airways and alveoli in intact mouse lungs under quasi-static inflation. Respir Physiol Neurobiol 147: 51-63, 2005.
32. Sera T, Uesugi K, Yagi N. Refraction-enhanced tomography of mouse and rabbit lungs. Med Phys 32: 2787-2792, 2005.
33. Sera T, Yokota H, Fujisaki K, Fukasaku K, Tachibana H, Uesugi K, Yagi N, Himeno R. Development of high-resolution 4D in vivo-CT for visualization of cardiac and respiratory deformations of small animals. Phys Med Biol 53: 4285-4301, 2008.
34. Snigirev A, Snigireva I, Kohn V, Kuznetsov S, Schelokov I. On the possibilities of x-ray phase contrast microimaging by coherent highenergy synchrotron radiation. Rev Sci Instrum 66: 5486, 1995.
35. Soutiere SE, Mitzner W. On defining total lung capacity in the mouse. J Appl Physiol 96: 1658-1664, 2004.
36. Suzuki Y, Yagi N, Uesugi K. X-ray refraction-enhanced imaging and a method for phase retrieval for a simple object. J Synchrotron Radiat 9: 160-165, 2002.
37. Tankersley CG, Rabold R, Mitzner W. Differential lung mechanics are genetically determined in inbred murine strains. J Appl Physiol 86: 1764-1769, 1999.
38. Tsuda A, Filipovic N, Haberthür D, Dickie R, Matsui Y, Stampanoni M, Schittny JC. Finite element 3D reconstruction of the pulmonary acinus imaged by synchrotron X-ray tomography. J Appl Physiol 105: 964-976, 2008.
39. Vasilescu DM, Klinge C, Knudsen L, Yin L, Wang G, Weibel ER, Ochs M, Hoffman EA. Stereological assessment of mouse lung parenchyma via non-destructive multi-scale micro CT imaging validated by light microscopic histology. J Appl Physiol 114: 716-724, 2013.
40. Weibel ER. The Pathway for Oxygen: Structure and Function in the Mammalian Respiratory System. Cambridge, MA: Harvard University Press, 1984.
41. Weibel ER. Functional morphology of lung parenchyma. In: Handbook of Physiology, The Respiratory System. Mechanics of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. III, pt. 1, p. 89-111.
42. Wilkins SW, Gureyev TE, Gao D, Pogany A, Stevenson AW. Phasecontrast imaging using polychromatic hard X-rays. Nature 384: 335-338, 1996.
43. Yagi N, Suzuki Y, Umetani K, Kohmura Y, Yamasaki K. Refractionenhanced x-ray imaging of mouse lung using synchrotron radiation source. Med Phys 26: 2190-2193, 1999.
44. Yong HS, Kang EY, Kim YK, Woo OH, Shin BK, Oh CH, Je JH, Han H, Seo JS. Phase contrast microradiography of mouse lung using synchrotron X-ray: correlation with optical microscopy. Yonsei Med J 50: 422-426, 2009.