Surfactant dysfunction during overexpression of TGF-β1 precedes profibrotic lung remodeling in vivo

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 11, 2016, Pages L1260-L1271

  Lopez Rodriguez, Elena ^a   Boden, Caroline ^a   Echaide, Mercedes ^b   Perez Gil, Jesus ^b   Kolb, Martin ^c   Gauldie, Jack ^c   Maus, Ulrich A ^a,d   Ochs, Matthias ^a,d,e   Knudsen, Lars ^a,d  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c MCMASTER UNIVERSITY   (Canada)

^d Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)   (Germany)

^e Excellence Cluster REBIRTH   (Germany)

Author keywords

AE2C polarity; Pulmonary fibrosis; Surfactant; TGF 1; TTF 1

Indexed keywords

LUNG SURFACTANT; SMAD3 PROTEIN; THYROID TRANSCRIPTION FACTOR 1; TRANSFORMING GROWTH FACTOR BETA1; DNA BINDING PROTEIN; SMAD3 PROTEIN, MOUSE; TTF1 PROTEIN, MOUSE;

AIRWAY REMODELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CELL POLARITY; COLLAGEN FIBRIL; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ELECTRON MICROSCOPY; FLUORESCENCE MICROSCOPY; IN VIVO STUDY; LAMELLAR BODY; LUNG COMPLIANCE; LUNG FIBROSIS; LUNG FUNCTION; LUNG HOMOGENATE; LUNG STRUCTURE; LUNG VENTILATION; LUNG VOLUME; MALE; MECHANICAL STRESS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROFIBROTIC LUNG REMODELING; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURFACE AREA; SURFACE TENSION; TYPE 2 EPITHELIAL CELL; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; FIBROSIS; GENE EXPRESSION; GENETICS; INTERSTITIAL LUNG DISEASE; LUNG; LUNG ALVEOLUS EPITHELIUM CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

AIRWAY REMODELING; ALVEOLAR EPITHELIAL CELLS; ANIMALS; CELL POLARITY; DNA-BINDING PROTEINS; DOWN-REGULATION; FIBROSIS; GENE EXPRESSION; LUNG; LUNG DISEASES, INTERSTITIAL; MALE; MICE, INBRED C57BL; PULMONARY SURFACTANTS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84984636008     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00065.2016     Document Type: Article

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