Integrated stress response mediates epithelial injury in mechanical ventilation

American Journal of Respiratory Cell and Molecular Biology

Volumn 57, Issue 2, 2017, Pages 193-203

  Dolinay, Tamas ^a   Himes, Blanca E ^a   Shumyatcher, Maya ^a   Lawrence, Gladys Gray ^b   Margulies, Susan S ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alveolar epithelium; Integrated stress response; Ventilator induced lung injury

Indexed keywords

GSK 2606414; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; 7-METHYL-5-(1-((3-(TRIFLUOROMETHYL)PHENYL)ACETYL)-2,3-DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO(2,3-D)PYRIMIDIN-4-AMINE; ACTIVATING TRANSCRIPTION FACTOR 4; ADENINE; ATF4 PROTEIN, RAT; CYTOKINE; DDIT3 PROTEIN, RAT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INDOLE DERIVATIVE; PERK KINASE; PROTEIN KINASE R; PROTEINASE INHIBITOR;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; CELL PERMEABILIZATION; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; INTEGRATED STRESS RESPONSE; LUNG ALVEOLUS; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM CELL; MECHANICAL STRESS; NONHUMAN; PERMEABILITY BARRIER; RAT; SIGNAL TRANSDUCTION; VENTILATOR INDUCED LUNG INJURY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL DEATH; CELL MEMBRANE PERMEABILITY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PRECLINICAL STUDY; PULMONARY EDEMA; RNA INTERFERENCE; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; UNFOLDED PROTEIN RESPONSE;

ACTIVATING TRANSCRIPTION FACTOR 4; ADENINE; ALVEOLAR EPITHELIAL CELLS; ANIMALS; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CYTOKINES; DRUG EVALUATION, PRECLINICAL; EIF-2 KINASE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; INDOLES; PROTEASE INHIBITORS; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE; VENTILATOR-INDUCED LUNG INJURY;

EID: 85026868845     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2016-0404OC     Document Type: Article

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