Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening

Journal of Applied Physiology

Volumn 97, Issue 1, 2004, Pages 269-276

  Kay, Sarina S ^a   Bilek, Anastacia M ^a   Dee, Kay C ^a   Gaver III, Donald P ^a  

^a Tulane University   (United States)

Author keywords

Acute respiratory distress syndrome; Lung epithelial cells; Surfactant replacement therapy; Ventilator induced lung injury

Indexed keywords

ARTIFICIAL LUNG SURFACTANT;

AIRWAY OBSTRUCTION; ARTICLE; ARTIFICIAL VENTILATION; CELL DAMAGE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MECHANICAL STRESS; PRESSURE GRADIENT; PRIORITY JOURNAL; RESPIRATORY DISTRESS; TIDAL VOLUME; VELOCITY; VISCOSITY;

AIR PRESSURE; ALGORITHMS; CELL LINE; DIFFUSION CHAMBERS, CULTURE; EPITHELIAL CELLS; HUMANS; LUNG; STRESS; VISCOSITY;

EID: 3042512164     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01288.2003     Document Type: Article

References (32)

1. Alencar AM, Arold SP, Buldyrev SV, Majumdar A, Stamenovic D, Stanley HE, and Suki B. Physiology: dynamic instabilities in the inflating lung. Nature 417: 809-811, 2002.
2. [Anon]. International consensus conferences in intensive care medicine: ventilator-associated lung injury in ARDS. Am J Respir Crit Care Med 160: 2118-2124, 1999.
3. Argiras EP, Blakeley CR, Dunnill MS, Otremski S, and Sykes MK. High PEEP decreases hyaline membrane formation in surfactant deficient lungs. Br J Anaesth 59: 1278-1285, 1987.
4. Behnia R, Molteni A, Waters CM, Panos RJ, Ward WF, Schnaper HW, and CHTSA. Early markers of ventilator-induced lung injury in rats. Ann Clin Lab Sci 26: 437-450, 1996.
5. Bilek AM, Dee KC, and Gaver DP III. Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening. J Appl Physiol 94: 770-783, 2003.
6. 2 washout. J Appl Physiol 25: 139-148, 1968.
7. Cavanaugh KJ Jr and Margulies SS. Measurement of stretch-induced loss of alveolar epithelial barrier integrity with a novel in vitro method. Am J Physiol Cell Physiol 283: C1801-C1808, 2002.
8. Cavanaugh KJ Jr, Oswari J, and Margulies SS. Role of stretch on tight junction structure in alveolar epithelial cells. Am J Respir Cell Mol Biol 25: 584-591, 2001.
9. Dos Santos CC and Slutsky AS. Invited Review: Mechanisms of ventilator-induced lung injury: a perspective. J Appl Physiol 89: 1645-1655, 2000.
10. Dreyfuss D and Saumon G. Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157: 294-323, 1998.
11. +-ATPase activity in alveolar epithelial cells increases with cyclic stretch. Am J Physiol Lung Cell Mol Physiol 283: L737-L746, 2002.
12. Gaver DP III, Halpern D, Jensen OE, and Grotberg JB. The steady motion of a semi-infinite bubble through a flexible-walled channel. J Fluid Mech 319: 25-65, 1996.
13. Gaver DP III, Jensen OE, and Halpern D. Surfactant and airway liquid flows. In: Molecular Mechanisms in Lung (Dys)function, edited by Nag K. New York: Dekker, In press.
14. Gaver DP III, Samsel RW, and Solway J. Effects of surface tension and viscosity on airway reopening. J Appl Physiol 69: 74-85, 1990.
15. Ghadiali SN and Gaver DP III. An investigation of pulmonary surfactant physicochemical behavior under airway reopening conditions. J Appl Physiol 88: 493-506, 2000.
16. Ghadiali SN and Gaver DP III. The influence of non-equilibrium surfactant dynamics on the flow of a semi-infinite bubble in a rigid cylindrical tube. J Fluid Mech 478: 165-196, 2003.
17. Halpern D and Grotberg JB. Dynamics and transport of a localized soluble surfactant on a thin film. J Fluid Mech 237: 1-11, 1992.
18. Halpern D and Grotberg JB. Surfactant effects on fluid-elastic instabilities of liquid-lined flexible tubes: a model of airway closure. J Biomech Eng 115: 271-277, 1993.
19. Hartog A, Gomers D, and Lachmann B. Role of surfactant in the pathophysiology of the acute respiratory distress syndrome. Monaldi Arch Chest Dis 50: 372-377, 1995.
20. Jensen OE, Horsburgh MK, Halpern D, and Gaver DP. The steady propagation of a bubble in a flexible-walled channel: asymptotic and computational models. Phys Fluids 14: 443-457, 2002.
21. Krueger MA and Gaver DP III. A theoretical model of pulmonary surfactant multilayer collapse under oscillating area conditions. J Colloid Interface Sci 229: 353-364, 2000.
22. Mead J, Takishima T, and Leith D. Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol 28: 596-608, 1970.
23. Muscedere JG, Mullen JBM, Gan K, and Slutsky AS. Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 149: 1327-1334, 1994.
24. Oswari J, Matthay MA, and Margulies SS. Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation. Am J Physiol Lung Cell Mol Physiol 281: L1068-L1077, 2001.
25. Otis DR Jr, Johnson M, Pedley TJ, and Kamm RD. Role of pulmonary surfactant in airway closure: a computational study. J Appl Physiol 75: 1323-1333, 1993.
26. Savia U, Sporn PH, and Waters CM. Cyclic stretch of airway epithelium inhibits prostanoid synthesis. Am J Physiol Lung Cell Mol Physiol 273: L1013-L1019, 1997.
27. Suki B, Barabasi AL, Hantos Z, Petak F, and Stanley HE. Avalanches and power-law behaviour in lung inflation. Nature 368: 615-618, 1994.
28. Taskar V, John J, Evander E, Robertson B, and Jonson B. Surfactant dysfunction makes lungs vulnerable to repetitive collapse and reexpansion. Am J Respir Crit Care Med 155: 313-320, 1997.
29. Taskar V, John J, Evander E, Wollmer P, Robertson B, and Jonson B. Healthy lung tolerates repetitive collapse and reexpansion. Acta Anaesthesiol Scand 39: 370-376, 1995.
30. Tschumperlin DJ, Oswari J, and Margulies AS. Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude. Am J Respir Crit Care Med 162: 357-362, 2000.
31. Vlahakis NE and Hubmayr RD. Invited Review: Plasma membrane stress failure in alveolar epithelial cells. J Appl Physiol 89: 2490-2497, 2000.
32. Whitehead T and Slutsky AS. The pulmonary physician in critical care * 7: ventilator induced lung injury. Thorax 57: 635-642, 2002.