Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: Attenuating role of loranthus micranthus

Redox Report

Volumn 23, Issue 1, 2018, Pages 194-205

  Ebokaiwe, Azubuike P ^a,d   Ijomone, Omamuyovwi M ^b   Osawe, Sharon O ^c   Chukwu, Chukwuma J ^a   Ejike, Chukwunonso E C C ^a   Zhang, Guolin ^d   Wang, Fei ^d  

^a ALEX EKWUEME FEDERAL UNIVERSITY NDUFU ALIKE   (Nigeria)

^b FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

^c UNIVERSITY OF IBADAN   (Nigeria)

^d CHENGDU INSTITUTE OF BIOLOGY   (China)

Author keywords

Apoptosis; Diabetes; Loranthus micranthus; Male rats; Oxidative stress; Spermiogram; Steroid hormones

Indexed keywords

ANTIDIABETIC AGENT; GLIBENCLAMIDE; GLUCOSE; LIPID; LORANTHUS MICRANTHUS EXTRACT; PLANT EXTRACT; PROTEIN BCL 2; STEROID HORMONE; UNCLASSIFIED DRUG; ANTIOXIDANT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HISTOPATHOLOGY; IMMUNOREACTIVITY; LIPID PEROXIDATION; LORANTHUS MICRANTHUS; MALE; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPERM; SPERM QUALITY; STEROIDOGENESIS; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TESTIS; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; LORANTHACEAE; METABOLISM; SPERMATOZOON; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS, EXPERIMENTAL; LIPID PEROXIDATION; LORANTHACEAE; MALE; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, WISTAR; SPERMATOZOA; TESTIS;

EID: 85055628937     PISSN: 13510002     EISSN: 17432928     Source Type: Journal    
DOI: 10.1080/13510002.2018.1540675     Document Type: Article

References (64)

1. Osadebe PO, Okide GB, Akabogu IC. Study on antidiabetic activities of crude methanolic extracts of Loranthus micranthus (Linn.) sourced from five different host trees. J Ethnopharmacol. 2004;95:133–138.
2. Griffin S, Tittikpina NK, Al-Marby A, et al. Turning waste into value: nanosized natural plant materials of Solanum incanum L. and Pterocarpus erinaceus Poir with promising antimicrobial activities. Pharmaceutics. 2016;19(2):8.
3. Lee SH, Jeon YJ. Anti-diabetic effects of brown algae derived phlor-otannins, marine polyphenols through diverse mechanisms. Fitoterapia. 2013;86:129–136.
4. Yeh GY, Eisenberg DM, Kaptchuk TJ, et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 2003;26(4):1277–1294.
5. Osadebe PO, Omeje EO, Uzor PF, et al. Seasonal variation for the antidiabetic activity of Loranthus micranthus methanol extract. Asian Pac J Trop Med. 2010;3(3):196–199.
6. Griggs P. Mistletoe, myth, magic and medicine. Biochem (Lond). 1991;13:3–4.
7. Moghadamtousi SZ, Hajrezaei M, Abdul Kadir H, et al. Loranthus micranthus Linn: biological activities and phytochemistry. Evid Based Complement Alternat Med. 2013;12:27–37. doi:10.1155/2013/273712
8. Adesina SK, Illoh HC, Imoh JI, et al. African mistletoes (loranthaceae); ethnopharmacology, chemistry and medicinal values: an update. Afr J Tradit Complement Altern Med. 2013;10(3):161–170.
9. Orji FA, Nwachukwu NC, Onyia AU, et al. Phytochemical and antimicrobial properties of leaves of African mistletoe (Loranthus micranthus) on some selected microbial pathogens in Abia State, Nigeria. Global Adv Res J Microbiol. 2013;2(1):011–016.
10. Ramachandran V, Baojun X. Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nut Met. 2015;12:60.
11. Arts IC, Hollman PC. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr. 2005;81:317S–325S.
12. Duncan BB, Schmidt MI, Pankow JS, et al. Low-grade systemic inflammation and the development of type 2 diabetes: The atherosclerosis risk in communities study. Diabetes. 2003;52:1799–1805.
13. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27:813–823.
14. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996;20:933–956.
15. Kandaswami C, Middleton E. Free radical scavenging and antioxidant activity of plant flavonoids. Adv Exp Med Biol. 1994;366:351–376.
16. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2:270–278.
17. Bahadoran Z, Mirmiran P, Azizi F. Dietary polyphenols as potential nutraceuticals in management of diabetes: A review. J Diabetes Metab Disord. 2013;12:43.
18. Adedara IA, Awogbindin IO, Anamelechi JP, et al. Garcinia kola seed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats. Pharm Biol. 2014. DOI: 10.3109/13880209.2014.937504.
19. Rato L, Alves M, Dias G, et al. Testicular metabolic reprogramming in neonatal streptozotocin-induced type 2 diabetic rats impairs glycolytic flux and promotes glycogen synthesis. J Diabetes Res. 2015. DOI:10.1155/2015/973142.
20. Vignera SL, Condorelli R, Vicari E, et al. Diabetes mellitus and sperm parameters. J Androl. 2012;33:145–153.
21. Lutz W, Leridon H, Aitken RJ. Fertility rates and future population trends:Will Europe’s birth rate recover or continue to decline? Int J Androl. 2006;29:25–33.
22. Hamilton BE, Hoyert DL, Martin JA, et al. Annual summary of vital statistics: 2010-2011. Pediatrics. 2013;131:548–558.
23. Gillot I, Jehl-Pietr C, Gounon P. Germ cells and fatty acids induce translocation of CD36 scavenger receptor to the plasma membrane of Sertoli cells. J. Cell Sci. 2005;118:3027–3035.
24. Rato L, Alves MG, Dias TR. High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters. Andrology. 2013;1(3):495– 504.
25. Rato L, Alves MG, Socorro S, et al. Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells cultured in vitro. Biosci Rep. 2012;32(1):61–69.
26. Alves MG, Martins AD, Rato L, et al. Molecular mechanisms beyond glucose transport in diabetes-related male infertility. Biochim Biophys Acta. 2013;1832(5):626–635.
27. Rato L, Alves M, Socorro GS, et al. Metabolic regulation is important for spermatogenesis. Nat Rev Urol. 2012;9(6):330– 338.
28. Rato L, Duarte AI, Tom GD. Pre-diabetes alters testicular PGC1-α/ SIRT3 axismodulating mitochondrial bioenergetics and oxidative stress. Biochim Biophys Acta. 2014;1837(3):335–344.
29. Rato L, Alves MG, Cavaco JE, et al. High energy diets: a threat for male fertility? Obes Rev. 2014;15(12):996–1007.
30. Zemjanis R. Collection and evaluation of semen. In: Zemjanis R, editor. Diagnostic and therapeutic technique in animal reproduction. 2nd ed. Baltimore, MD: William and Wilkins Company; 1970. p. 139–153.
31. Pant N, Srivastava SP. Testicular and spermatotoxic effects of quinal-phos in rats. J Appl Toxicol. 2003;23:271–274.
32. Lowry OH, Rosenbrough NJ, Farr AL. Protein measurement with folin phenol reagent. J Biol Chem. 1951;193:265–275.
33. Misra HP, Fridovich I. The role of superoxide anion in the autooxida-tion of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170–3175.
34. Clairborne A. Catalase activity. In: Greewald AR, editor. Handbook of methods for oxygen radical research. Boca Raton, FL: CRC; 1995. p. 237–242.
35. Jollow DJ, Mitchell JR, Zampaglione N. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4 bromobenzene oxide as the hepatotoxic metabolite. Pharmacology. 1974;11:151–169.
36. Rotruck JT, Pope AL, Ganther HE. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973;179:588–590.
37. Farombi EO, Tahnteng JG, Agboola AO. Chemoprevention of 2 acet-ylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron-a Garcinia kola seed extract. Food Chem Toxicol. 2000;38:535–541.
38. Bergmeyer HU. β-Hydroxysteroid dehydrogenase. In: Bergmeyer HU, editor. Methods of enzymatic analysis, vol. 1. New York: Academic Press; 1974. p. 447–489.
39. Branstrup N, Krik JE, Bruni C. The hexokinase and phosphoglucoi-somerase activities of aorta and pulmonary artery tissue in individuals of various ages. J Gerontol. 1957;12:166–171.
40. Dawson RCM, Elliott DC, Elliott WH, et al. Data For biockemical research. 2nd ed. Oxford: Clarendon Press; 1969; p.483–498.
41. Tuominen VJ, Ruotoistenmäki S, Viitanen A, et al. Immunoratio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67. Breast Cancer Res 2010;12(4):56.
42. Elham G, Vahid N, Mozafar K. Antioxidant and protective effects of Royal jelly on histopathological changes in testis of diabetic rats. Int J Reprod Biomed. 2016;14(8):519–526.
43. Atalay UB, Ilhan F, Gulyuz F, et al. The effects of sildenafil citrate and vitamins A. C and E on testicular damage in alloxan-diabetic rats. J Anim Vet Adv. 2012;11:56–63.
44. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–685.
45. Rambir S, Priyanka B, Poonam S. Antioxidant and toxicological evaluation of Cassia sopherain streptozotocin-induced diabetic Wistar rats. Pharmacognosy Res. 2013;5(4):225–232.
46. Al-Maghrebi M, Waleed MR. Altered expression profile of glycolytic enzymes during testicular ischemia reperfusion injury is associated with the p53/TIGAR pathway: effect of fructose 1,6-diphosphate. PeerJ. 2016;4:e2195. DOI10.7717/peerj.2195.
47. Oliveira PF, Martins AD, Moreira AC, et al. The Warburg effect revisited—lesson from the Sertoli cell. Med Res Rev. 2015;35:126–151.
48. Boussouar F, Benahmed M. Lactate and energy metabolism in male germ cells. Trends Endocrinol Metab. 2004;15:345–350.
49. Miki K. Energy metabolism and sperm function. Soc Reprod Fertil Suppl. 2007;65:309–325.
50. Mukai C, Okuno M. Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement. Biol Reprod. 2004;71:540–547.
51. Travis AJ, Tutuncu L, Jorgez CJ. Requirements for glucose beyond sperm capacitation during in vitro fertilization in the mouse. Biol Reprod. 2004;71:139–145.
52. Williams AC, Ford WC. The role of glucose in supporting motility and capacita-tion in human spermatozoa. J Androl. 2001;22:680– 695.
53. Rao PM, Kelly DM, Jones TH. Testosterone and insulin resistance in the metabolic syndrome and T2DM in men. Nat Rev Endocrinol. 2013;9(8):479–493.
54. Alberts B, Johnson A, Lewis J, et al. Molecular biology of the cell. 4th ed. New York: Garland Science; 2002.
55. Pitteloud N, Hardin M, Dwyer AA. Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. J Clin Endocrinol Metab. 2005;90(5):2636–2641.
56. Amaral S, Mota PC, Lacerda B, et al. Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats. Mitochondrion. 2009;9:41–50.
57. Khaneshi F, Nasrolahi O, Azizi S, et al. Sesame effects on testicular damage in streptozotocin-induced diabetes rats. Avicenna J Phytomed. 2013;3(4):347–355.
58. Navarro-Casado L, Juncos-Tobarra MA, Chafer-Rudilla M, et al. Effect of experimental diabetes and STZ on male fertility capacity study in rats. J Androl. 2010;31:584–592.
59. Ballester J, Munoz MC, Dominguez J, et al. Insulin-dependent diabetes affects testicular function by FSH-and LH-linked mechanisms. J Androl. 2004;25:706–719.
60. Yadav R, Goel A, Sankhwar SN, et al. Incidentally detected bilaterally symmetrical seminal and vas calcification in young infertile male: a case report, literature review and algorithm for diagnosis. Can Urol Assoc J. 2012;6(5):206–208.
61. González OFJ, Duque F, Vega S, et al. Bilateral calcification of seminal vesicles and vas deferens. Actas Urol Esp. 2009;33:216.
62. Culver GJ, Tannenhaus J. Calcification of the vas deferens in diabetes. J Am Med Assoc. 1960;173:648–651.
63. Guvel S, Pourbagher MA, Torun DT, et al. Calcification of the epididy-mis and the tunica albuginea of the corpora cavernosa in patients on maintenance hemodialysis. J Androl. 2004;25:752–756.
64. Richenberg J, Belfield J, Ramchandani P, et al. Testicular microlithia-sis imaging and follow-up: guidelines of the ESUR scrotal imaging subcommittee. Eur Radiol. 2015;25:323–330.