Heparin-Binding EGF-Like Growth Factor Induces Heart Interstitial Fibrosis via an Akt/mTor/p70s6k Pathway

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Lian, Hong ^a   Ma, Yuanwu ^a   Feng, Juan ^a   Dong, Wei ^a   Yang, Qing ^a   Lu, Dan ^a   Zhang, Lianfeng ^a  

^a INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; DIPHTHERIA TOXOID CRM197; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; FIBROBLAST; GENE; GENE EXPRESSION; GENE FUNCTION; HB EGF GENE; HEART INTERSTITIAL FIBROSIS; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE FIBROSIS; HEART SIZE; HEART SYSTOLIC DIAMETER; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SYSTOLIC DYSFUNCTION; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; DNA, COMPLEMENTARY; ECHOCARDIOGRAPHY; FEMALE; FIBROBLASTS; FIBROSIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; PHOSPHORYLATION; PLASMIDS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SYSTOLE; TOR SERINE-THREONINE KINASES;

MUS; MUS MUSCULUS;

EID: 84866316624     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044946     Document Type: Article

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