Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity

Science

Volumn 317, Issue 5839, 2007, Pages 825-828

  Yang, Zhi Yong ^a   Wei, Chih Jen ^a   Kong, Wing Pui ^a   Wu, Lan ^a   Xu, Ling ^a   Smith, David F ^b   Nabel, Gary J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2,3 SIALIC ACID; ALPHA2,6 SIALIC ACID; HEMAGGLUTININ; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; SIALIC ACID; SIALIC ACID DERIVATIVE; SIALIC ACID RECEPTOR; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANTIBODY; IMMUNIZATION; INFLUENZA; MUTATION; VIRUS;

ARTICLE; AVIAN INFLUENZA; BINDING AFFINITY; EVOLUTIONARY ADAPTATION; IMMUNIZATION; INFLUENZA VIRUS A H5N1; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR BINDING; STRAIN IDENTIFICATION; STRUCTURE ACTIVITY RELATION; VACCINE PRODUCTION; VIRUS MUTATION; VIRUS TRANSMISSION; VIRUS TYPING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; CARBOHYDRATE CONFORMATION; CELL LINE; FEMALE; GENES, VIRAL; HEMAGGLUTINATION INHIBITION TESTS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTATION; NEUTRALIZATION TESTS; RECEPTORS, VIRUS; SIALIC ACIDS; VACCINATION;

AVES; ORTHOMYXOVIRIDAE;

EID: 34547886820     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1135165     Document Type: Article

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