Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes

Cell Reports

Volumn 25, Issue 4, 2018, Pages 947-958.e4

  Jones, Jeffrey R ^a,b   Kong, Linghai ^a   Hanna, Michael G ^b,c   Hoffman, Brianna ^a   Krencik, Robert ^a   Bradley, Robert ^a   Hagemann, Tracy ^a   Choi, Jeea ^c   Doers, Matthew ^a   Dubovis, Marina ^a   Sherafat, Mohammad Amin ^a   Bhattacharyya, Anita ^a   Kendziorski, Christina ^c   Audhya, Anjon ^b,c   Messing, Albee ^a,b   Zhang, Su Chun ^a,c,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Alexander disease; CRISPR; endoplasmic reticulum; iPSC; lysosome

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; GLIAL FIBRILLARY ACIDIC PROTEIN; RNA; MESSENGER RNA; PROTEIN AGGREGATE;

ALEXANDER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL FUNCTION; CELL METABOLISM; CELL NUCLEUS; CELL ORGANELLE; CELL STRUCTURE; CELL VACUOLE; CELLULAR DISTRIBUTION; CELLULAR SECRETION; CHILD; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; LYSOSOME; MALE; MOUSE; MUTATION; NEWBORN; NONHUMAN; PATHOGENESIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN AGGREGATION; RNA SEQUENCE; SCHOOL CHILD; ANIMAL; CALCIUM SIGNALING; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; METABOLISM; PATHOLOGY;

ADENOSINE TRIPHOSPHATE; ALEXANDER DISEASE; ANIMALS; ASTROCYTES; CALCIUM SIGNALING; CELL DIFFERENTIATION; ENDOPLASMIC RETICULUM; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; LYSOSOMES; MICE; MUTATION; ORGANELLES; PROTEIN AGGREGATES; RNA, MESSENGER;

EID: 85054849992     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2018.09.083     Document Type: Article

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