Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease

APMIS

Volumn 122, Issue 1, 2014, Pages 76-80

  Pekny, Tulen ^a   Faiz, Maryam ^a   Wilhelmsson, Ulrika ^a   Curtis, Maurice A ^a   Matej, Radoslav ^c   Skalli, Omar ^b   Pekny, Milos ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b University of Memphis   (United States)

^c FAKULTNÍ THOMAYEROVA NEMOCNICE   (Czech Republic)

Author keywords

Alexander disease; Astrocytes; GFAP; Intermediate filaments; Neurodegenerative diseases

Indexed keywords

ALPHA CRYSTALLIN; BETA CRYSTALLIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN 27; PEPTIDES AND PROTEINS; SYNEMIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ALEXANDER DISEASE; ARTICLE; ASTROCYTE; CASE REPORT; CHILD; FEMALE; FIBER; GLIOSIS; HUMAN; INFANT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROSENTHAL FIBER; SCHOOL CHILD;

EID: 84891154974     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12088     Document Type: Article

References (25)

1. Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE, Messing A. Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet 2001;27:117-20.
2. Pekny M, Pekna M. Astrocyte intermediate filaments in CNS pathologies and regeneration. J Pathol 2004;204:428-37.
3. Yoshida T, Sasaki M, Yoshida M, Namekawa M, Okamoto Y, Tsujino S, et al. Nationwide survey of Alexander disease in Japan and proposed new guidelines for diagnosis. J Neurol 2011;258:1998-2008.
4. Messing A, Daniels CM, Hagemann TL. Strategies for treatment in Alexander disease. Neurotherapeutics 2010;7:507-15.
5. Tomokane N, Iwaki T, Tateishi J, Iwaki A, Goldman JE. Rosenthal fibers share epitopes with alpha B-crystallin, glial fibrillary acidic protein, and ubiquitin, but not with vimentin. Immunoelectron microscopy with colloidal gold. Am J Pathol 1991;138:875-85.
6. Nicholl ID, Quinlan RA. Chaperone activity of alpha-crystallins modulates intermediate filament assembly. EMBO J 1994;13:945-53.
7. Jing R, Wilhelmsson U, Goodwill W, Li L, Pan Y, Pekny M, et al. Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. J Cell Sci 2007;120:1267-77.
8. Matej R, Dvorakova L, Mrazova L, Houst'kova H, Elleder M. Early onset Alexander disease: a case report with evidence for manifestation of the disorder in neurohypophyseal pituicytes. Clin Neuropathol 2008;27:64-71.
9. Wilhelmsson U, Li L, Pekna M, Berthold CH, Blom S, Eliasson C, et al. Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration. J Neurosci 2004;24:5016-21.
10. Nakazawa T, Takeda M, Lewis GP, Cho KS, Jiao J, Wilhelmsson U, et al. Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin. Invest Ophthalmol Vis Sci 2007;48:2760-8.
11. Herrmann JE, Imura T, Song B, Qi J, Ao Y, Nguyen TK, et al. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci 2008;28:7231-43.
12. Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo AC, et al. Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab 2008;28:468-81.
13. Kinouchi R, Takeda M, Yang L, Wilhelmsson U, Lundkvist A, Pekny M, et al. Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin. Nat Neurosci 2003;6:863-8.
14. Cho KS, Yang L, Lu B, Feng Ma H, Huang X, Pekny M, et al. Re-establishing the regenerative potential of central nervous system axons in postnatal mice. J Cell Sci 2005;118:863-72.
15. -/- mice. Stem Cells 2007;25:2619-27.
16. Pekny M, Pekna M, Wilhelmsson U, Chen DF. Response to Quinlan and Nilsson: Astroglia sitting at the controls? Trends Neurosci 2004;27:243-4.
17. Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005;50:427-34.
18. Sofroniew MV. Reactive astrocytes in neural repair and protection. Neuroscientist 2005;11:400-7.
19. Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol 2010;119:7-35.
20. Kraft AW, Hu X, Yoon H, Yan P, Xiao Q, Wang Y, et al. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice. FASEB J 2013;27:187-98.
21. Macauley SL, Pekny M, Sands MS. The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis. J Neurosci 2011;31:15575-85.
22. Tang G, Xu Z, Goldman JE. Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease. J Biol Chem 2006;281:38634-43.
23. Tang G, Yue Z, Talloczy Z, Goldman JE. Adaptive autophagy in Alexander disease-affected astrocytes. Autophagy 2008;4:701-3.
24. Lundkvist A, Reichenbach A, Betsholtz C, Carmeliet P, Wolburg H, Pekny M. Under stress, the absence of intermediate filaments from Muller cells in the retina has structural and functional consequences. J Cell Sci 2004;117:3481-8.
25. Pekny M, Lane EB. Intermediate filaments and stress. Exp Cell Res 2007;313:2244-54.