Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study

Intensive Care Medicine

Volumn 44, Issue 11, 2018, Pages 1836-1848

  Shankar Hari, Manu ^a,b   Datta, Deepankar ^c   Wilson, Julie ^a,b   Assi, Valentina ^d   Stephen, Jacqueline ^d   Weir, Christopher J ^d   Rennie, Jillian ^c   Antonelli, Jean ^d   Bateman, Anthony ^e   Felton, Jennifer M ^c   Warner, Noel ^f,g   Judge, Kevin ^f,g   Keenan, Jim ^f,g   Wang, Alice ^f,g   Burpee, Tony ^f,g   Brown, Alun K ^b   Lewis, Sion M ^b   Mare, Tracey ^b   Roy, Alistair I ^f,g   Wright, John ^h   Hulme, Gillian ⁱ   Dimmick, Ian ⁱ   Gray, Alasdair ^d,j   Rossi, Adriano G ^c   Simpson, A John ⁱ   Conway Morris, Andrew ^k   Walsh, Timothy S ^c,d   more..

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f BD Technologies   (United States)

^g SUNDERLAND ROYAL HOSPITAL   (United Kingdom)

^h ROYAL VICTORIA INFIRMARY   (United Kingdom)

ⁱ NEWCASTLE UNIVERSITY   (United Kingdom)

^j ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^k ADDENBROOKE S HOSPITAL   (United Kingdom)

more..

Author keywords

Biomarker, risk prediction; Cohort study; Infection; Mortality; Sepsis

Indexed keywords

BIOLOGICAL MARKER; HLA DR ANTIGEN; LEUKOCYTE ANTIGEN;

ADULT; AGED; BLOOD; CLINICAL TRIAL; COHORT ANALYSIS; FEMALE; HOSPITAL EMERGENCY SERVICE; HUMAN; INTENSIVE CARE UNIT; LEUKOCYTE; MALE; MIDDLE AGED; MULTICENTER STUDY; PHYSIOLOGY; PREDICTIVE VALUE; REPRODUCIBILITY; SEPSIS; STATISTICAL MODEL; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; BIOMARKERS; COHORT STUDIES; EMERGENCY SERVICE, HOSPITAL; FEMALE; HLA-DR ANTIGENS; HUMANS; INTENSIVE CARE UNITS; LEUKOCYTES; LOGISTIC MODELS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; SEPSIS;

EID: 85054592050     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-018-5389-0     Document Type: Article

References (49)

1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315:801–810
2. Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862–874
3. van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG (2017) The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol 17:407–420
4. Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nurnberg P, Schultz MJ, Horn J, Cremer OL, Bonten MJ, Hinds CJ, Wong HR, Knight JC, van der Poll T, consortium M (2017) Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study. Lancet Respir Med 5:816–826
5. Venet F, Guignant C, Monneret G (2011) Flow cytometry developments and perspectives in clinical studies: examples in ICU patients. Methods Mol Biol 761:261–275
6. Angus DC, Seymour CW, Coopersmith CM, Deutschman CS, Klompas M, Levy MM, Martin GS, Osborn TM, Rhee C, Watson RS (2016) A framework for the development and interpretation of different sepsis definitions and clinical criteria. Crit Care Med 44:e113–e121
7. Shankar-Hari M (2017) How could we enhance translation of sepsis immunology to inform immunomodulation trials in sepsis? Crit Care 21:125
8. Datta D, Conway Morris A, Antonelli J, Warner N, Brown KA, Wright J, Simpson AJ, Rennie J, Hulme G, Lewis SM, Mare TA, Cookson S, Weir CJ, Dimmick I, Keenan J, Rossi AG, Shankar-Hari M, Walsh TS, Ex PSI (2016) Early PREdiction of Severe Sepsis (ExPRES-Sepsis) study: protocol for an observational derivation study to discover potential leucocyte cell surface biomarkers. BMJ Open 6:e011335
9. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, Sccm/Esicm/Accp/Ats/Sis (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 31:1250–1256
10. Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, Angus DC, Rubenfeld GD, Singer M, Sepsis Definitions Task F (2016) Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315:775–787
11. Gray A, Ward K, Lees F, Dewar C, Dickie S, McGuffie C, committee Ss (2013) The epidemiology of adults with severe sepsis and septic shock in Scottish emergency departments. Emerg Med J 30:397–401
12. Glickman SW, Cairns CB, Otero RM, Woods CW, Tsalik EL, Langley RJ, van Velkinburgh JC, Park LP, Glickman LT, Fowler VG Jr, Kingsmore SF, Rivers EP (2010) Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis. Acad Emerg Med 17:383–390
13. Fluss R, Faraggi D, Reiser B (2005) Estimation of the Youden Index and its associated cutoff point. Biometrical journal Biometrische Zeitschrift 47:458–472
14. Miller A, Tibshirani R, Cox D, Keiding N, Isham V, Louis T, Tong H, Reid N (2002) Subset selection in regression. Chapman and Hall/CRC, New York
15. Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmele T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS (2018) Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial. JCI insight. 10.1172/jci.insight.98960
16. Perner A, Gordon AC, Angus DC, Lamontagne F, Machado F, Russell JA, Timsit JF, Marshall JC, Myburgh J, Shankar-Hari M, Singer M (2017) The intensive care medicine research agenda on septic shock. Intensive Care Med 43:1294–1305
17. Perner A, Rhodes A, Venkatesh B, Angus DC, Martin-Loeches I, Preiser JC, Vincent JL, Marshall J, Reinhart K, Joannidis M, Opal SM (2017) Sepsis: frontiers in supportive care, organisation and research. Intensive Care Med 43:496–508
18. Mittag A, Tarnok A (2009) Basics of standardization and calibration in cytometry—a review. J Biophotonics 2:470–481
19. Daix T, Guerin E, Tavernier E, Mercier E, Gissot V, Herault O, Mira JP, Dumas F, Chapuis N, Guitton C, Bene MC, Quenot JP, Tissier C, Guy J, Piton G, Roggy A, Muller G, Legac E, de Prost N, Khellaf M, Wagner-Ballon O, Coudroy R, Dindinaud E, Uhel F, Roussel M, Lafon T, Jeannet R, Vargas F, Fleureau C, Roux M, Allou K, Vignon P, Feuillard J, Francois B, Septiflux Trial G (2018) Multicentric Standardized Flow Cytometry Routine Assessment of Patients With Sepsis to Predict Clinical Worsening. Chest 154:617–627
20. Guerin E, Orabona M, Raquil MA, Giraudeau B, Bellier R, Gibot S, Bene MC, Lacombe F, Droin N, Solary E, Vignon P, Feuillard J, Francois B (2014) Circulating immature granulocytes with T-cell killing functions predict sepsis deterioration. Crit Care Med 42:2007–2018
21. Conway Morris A, Datta D, Shankar-Hari M, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Warner N, Judge K, Keenan J, Wang A, Burpee T, Brown KA, Lewis SM, Mare T, Roy AI, Hulme G, Dimmick I, Rossi AG, Simpson AJ, Walsh TS (2018) Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study. Intensive Care Med 44:627–635
22. Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Captain Study G, Adib-Conquy M, Cavaillon JM (2014) CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis. J Immunol 192:2449–2459
23. Gros A, Roussel M, Sauvadet E, Gacouin A, Marque S, Chimot L, Lavoue S, Camus C, Fest T, Le Tulzo Y (2012) The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients. Intensive Care Med 38:445–452
24. Chang K, Svabek C, Vazquez-Guillamet C, Sato B, Rasche D, Wilson S, Robbins P, Ulbrandt N, Suzich J, Green J, Patera AC, Blair W, Krishnan S, Hotchkiss R (2014) Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis. Crit Care 18:R3
25. Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H, Reinke P, Volk HD (2009) Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 180:640–648
26. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP (1995) The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 273:117–123
27. Rangel-Frausto MS, Pittet D, Hwang T, Woolson RF, Wenzel RP (1998) The dynamics of disease progression in sepsis: Markov modeling describing the natural history and the likely impact of effective antisepsis agents. Clin Infect Dis 27:185–190
28. van der Ploeg T, Austin PC, Steyerberg EW (2014) Modern modelling techniques are data hungry: a simulation study for predicting dichotomous endpoints. BMC Med Res Methodol 14:137
29. Shankar-Hari M, Harrison DA, Rowan KM (2016) Differences in impact of definitional elements on mortality precludes international comparisons of sepsis epidemiology—a Cohort Study illustrating the need for standardized reporting. Crit Care Med 44:2223–2230
30. Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS (2016) Frontline Science: defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1. J Leukoc Biol 100:1239–1254
31. Wilson JK, Zhao Y, Singer M, Spencer J, Shankar-Hari M (2018) Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis—pilot study. Crit Care 22:95
32. Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS (2011) Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306:2594–2605
33. Wang JF, Li JB, Zhao YJ, Yi WJ, Bian JJ, Wan XJ, Zhu KM, Deng XM (2015) Up-regulation of programmed cell death 1 ligand 1 on neutrophils may be involved in sepsis-induced immunosuppression: an animal study and a prospective case-control study. Anesthesiology 122:852–863
34. Pene F, Courtine E, Cariou A, Mira JP (2009) Toward theragnostics. Crit Care Med 37:S50–S58
35. Shankar-Hari M, Rubenfeld GD (2017) The use of enrichment to reduce statistically indeterminate or negative trials in critical care. Anaesthesia 72:560–565
36. Prescott HC, Calfee CS, Thompson BT, Angus DC, Liu VX (2016) Toward smarter lumping and smarter splitting: rethinking strategies for sepsis and acute respiratory distress syndrome clinical trial design. Am J Respir Crit Care Med 194:147–155
37. Hotchkiss RS, Sherwood ER (2015) Immunology. Getting sepsis therapy right. Science 347:1201–1202
38. Venet F, Monneret G (2018) Advances in the understanding and treatment of sepsis-induced immunosuppression. Nat Rev Nephrol 14:121–137
39. Jalava-Karvinen P, Hohenthal U, Laitinen I, Kotilainen P, Rajamaki A, Nikoskelainen J, Lilius EM, Nuutila J (2009) Simultaneous quantitative analysis of Fc gamma RI (CD64) and CR1 (CD35) on neutrophils in distinguishing between bacterial infections, viral infections, and inflammatory diseases. Clin Immunol 133:314–323
40. Wang X, Li ZY, Zeng L, Zhang AQ, Pan W, Gu W, Jiang JX (2015) Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis. Crit Care 19:245
41. Lewis SM, Treacher DF, Edgeworth J, Mahalingam G, Brown CS, Mare TA, Stacey M, Beale R, Brown KA (2015) Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for sepsis and systemic inflammation. Clin Exp Immunol 182:184–194
42. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O’Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA (2017) A guiding map for inflammation. Nat Immunol 18:826–831
43. Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, Lammers JW, Ulfman LH, Leenen LP, Pickkers P, Koenderman L (2012) A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest 122:327–336
44. Pillay J, Tak T, Kamp VM, Koenderman L (2013) Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences. Cell Mol Life Sci 70:3813–3827
45. Mare TA, Treacher DF, Shankar-Hari M, Beale R, Lewis SM, Chambers DJ, Brown KA (2015) The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation. Crit Care 19:57
46. Jamsa J, Huotari V, Savolainen ER, Syrjala H, Ala-Kokko T (2015) Kinetics of leukocyte CD11b and CD64 expression in severe sepsis and non-infectious critical care patients. Acta Anaesthesiol Scand 59:881–891
47. Brunialti MK, Martins PS, Barbosa de Carvalho H, Machado FR, Barbosa LM, Salomao R (2006) TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock. Shock 25:351–357
48. Wagner C, Kotsougiani D, Pioch M, Prior B, Wentzensen A, Hansch GM (2008) T lymphocytes in acute bacterial infection: increased prevalence of CD11b(+) cells in the peripheral blood and recruitment to the infected site. Immunology 125:503–509
49. Demaret J, Venet F, Friggeri A, Cazalis MA, Plassais J, Jallades L, Malcus C, Poitevin-Later F, Textoris J, Lepape A, Monneret G (2015) Marked alterations of neutrophil functions during sepsis-induced immunosuppression. J Leukoc Biol 98:1081–1090