Multicentric Standardized Flow Cytometry Routine Assessment of Patients With Sepsis to Predict Clinical Worsening

Chest

Volumn 154, Issue 3, 2018, Pages 617-627

  Daix, Thomas ^a   Guerin, Estelle ^a,b   Tavernier, Elsa ^c   Mercier, Emmanuelle ^d   Gissot, Valérie ^c   Hérault, Olivier ^d   Mira, Jean Paul ^e   Dumas, Florence ^f   Chapuis, Nicolas ^e   Guitton, Christophe ^g   Béné, Marie C ^g   Quenot, Jean Pierre ^h   Tissier, Cindy ⁱ   Guy, Julien ⁱ   Piton, Gaël ^j   Roggy, Anne ^k   Muller, Grégoire ^l   Legac, Éric ^l   de Prost, Nicolas ^m   Khellaf, Mehdi ⁿ   Wagner Ballon, Orianne ^o   Coudroy, Rémi ^p   Dindinaud, Elodie ^p   Uhel, Fabrice ^q   Roussel, Mikaël ^r   Lafon, Thomas ^a   Jeannet, Robin ^a   Vargas, Frédéric ^s   Fleureau, Catherine ^s   Roux, Mickaël ^s   Allou, Kaoutar ^s   Vignon, Philippe ^a,t   Feuillard, Jean ^a,b   François, Bruno ^a,t   more..

^a DUPUYTREN UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ DE LIMOGES   (France)

^c UNIVERSITÉ DE TOURS   (France)

^d UNIVERSITY HOSPITAL OF TOURS   (France)

^e Institut Cochin   (France)

^f HÔTEL DIEU   (France)

^g NANTES UNIVERSITY HOSPITAL   (France)

^h UNIVERSITÉ DE BOURGOGNE   (France)

ⁱ DIJON UNIVERSITY HOSPITAL   (France)

^j UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^k ETABLISSEMENT FRANÇAIS DU SANG   (France)

^l CENTRE HOSPITALIER RÉGIONAL D ORLÉANS   (France)

^m UNIVERSITÉ PARIS EST CRÉTEIL   (France)

ⁿ HENRI MONDOR HOSPITAL   (France)

^o ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^p POITIERS UNIVERSITY HOSPITAL   (France)

^q UNIVERSITÉ DE RENNES 1   (France)

^r PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^s BORDEAUX UNIVERSITY HOSPITAL   (France)

^t UMR 1092   (France)

more..

Author keywords

flow cytometry; immunosuppression; inflammation; prognosis; sepsis

Indexed keywords

CD16 ANTIGEN; CD64 ANTIGEN; IMMUNOGLOBULIN;

AGED; AREA UNDER THE CURVE; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CLINICAL PROTOCOL; CONTROLLED STUDY; DETERIORATION; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; GENERAL CONDITION DETERIORATION; GRANULOCYTE; HUMAN; KIDNEY FAILURE; LEUKOCYTE; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MORTALITY; MULTICENTER STUDY; OVERALL SURVIVAL; PATIENT ASSESSMENT; PREDICTION; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; STANDARDIZATION; BLOOD; CLINICAL TRIAL; ORGAN DYSFUNCTION SCORE; PREDICTIVE VALUE; PROGNOSIS; PROSPECTIVE STUDY; SURVIVAL ANALYSIS;

AGED; CLINICAL DETERIORATION; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; ORGAN DYSFUNCTION SCORES; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; SEPSIS; SURVIVAL ANALYSIS;

EID: 85049449182     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1016/j.chest.2018.03.058     Document Type: Article

References (37)

1. Gaieski, D.F., Mikkelsen, M.E., Band, R.A., et al. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 38:4 (2010), 1045–1053.
2. Kennedy, M., Joyce, N., Howell, M.D., Lawrence Mottley, J., Shapiro, N.I., Identifying infected emergency department patients admitted to the hospital ward at risk of clinical deterioration and intensive care unit transfer. Acad Emerg Med 17:10 (2010), 1080–1085.
3. Vincent, J.L., Sakr, Y., Sprung, C.L., et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 34:2 (2006), 344–353.
4. Brun-Buisson, C., Meshaka, P., Pinton, P., Vallet, B., EPISEPSIS Study Group. EPISEPSIS: a reappraisal of the epidemiology and outcome of severe Sepsis in French intensive care units. Intensive Care Med 30:4 (2004), 580–588.
5. Carpio, R., Zapata, J., Spanuth, E., Hess, G., Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department. Clin Chim Acta 450 (2015), 169–175.
6. Hong, D.Y., Kim, J.W., Paik, J.H., et al. Value of plasma neutrophil gelatinase-associated lipocalin in predicting the mortality of patients with sepsis at the emergency department. Clin Chim Acta 452 (2016), 177–181.
7. Franchini, S., Marcianò T., Sorlini, C., et al. Serum CXCL12 levels on hospital admission predict mortality in patients with severe sepsis/septic shock. Am J Emerg Med 33:12 (2015), 1802–1804.
8. Zhao, G.J., Li, D., Zhao, Q., et al. Prognostic value of plasma tight-junction proteins for sepsis in emergency department: an observational study. Shock 45:3 (2016), 326–332.
9. Lundberg, J.S., Perl, T.M., Wiblin, T., et al. Septic shock: an analysis of outcomes for patients with onset on hospital wards versus intensive care units. Crit Care Med 26:6 (1998), 1020–1024.
10. Knott, J.C., Tan, S.L., Street, A.C., Bailey, M., Cameron, P., Febrile adults presenting to the emergency department: outcomes and markers of serious illness. Emerg Med J 21:2 (2004), 170–174.
11. Davenport, E.E., Burnham, K.L., Radhakrishnan, J., Humburg, P., Hutton, P., Mills, T.C., Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med 4:4 (2016), 259–271.
12. Emonts, M., Sweep, F.C., Grebenchtchikov, N., et al. Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis. Clin Infect Dis 44:10 (2007), 1321–1328.
13. Solly, F., Rigollet, L., Baseggio, L., et al. Comparable flow cytometry data can be obtained with two types of instruments, Canto II, and Navios. A GEIL study. Cytometry A 83:12 (2013), 1066–1072.
14. Lacombe, F., Bernal, E., Bloxham, D., et al. Harmonemia: a universal strategy for flow cytometry immunophenotyping-A European LeukemiaNet WP10 study. Leukemia 30:8 (2016), 1769–1772.
15. Guérin, E., Orabona, M., Raquil, M.A., et al. Circulating immature granulocytes with T-cell killing functions predict sepsis deterioration. Crit Care Med 42:9 (2014), 2007–2018.
16. Bone, R.C., Balk, R.A., Cerra, F.B., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:6 (1992), 1644–1655.
17. Levy, M.M., Fink, M.P., Marshall, J.C., et al. SCCM / ESICM / ACCP / ATS / SIS. 2001 SCCM / ESICM / ACCP / ATS / SIS International Sepsis Definitions Conference. Crit Care Med 31:4 (2003), 1250–1256.
18. Moreno, R., Vincent, J.L., Matos, R., et al. The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM. Intensive Care Med 25:7 (1999), 686–696.
19. Knaus, W.A., Mortality risk prediction in sepsis. Crit Care Med 23:10 (1995), 1793–1794.
20. Singer, M., Deutschman, C.S., Seymour, C.W., et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315:8 (2016), 801–810.
21. Vincent, J.L., Martin, G.S., Levy, M.M., qSOFA does not replace SIRS in the definition of sepsis. Crit Care, 20(1), 2016, 210.
22. Gros, A., Roussel, M., Sauvadet, E., et al. The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients. Intensive Care Med 38:3 (2012), 445–452.
23. Wang, X., Li, Z.Y., Zeng, L., et al. Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis. Crit Care, 19, 2015, 245.
24. Icardi, M., Erickson, Y., Kilborn, S., Stewart, B., Grief, B., Scharnweber, G., CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients. J Clin Microbiol 47:12 (2009), 3914–3919.
25. de Jager, C.P., van Wijk, P.T., Mathoera, R.B., de Jongh-Leuvenink, J., van der Poll, T., Wever, P.C., Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care, 14(5), 2010, R192.
26. Gürol, G., Çiftci, İ.H., Terizi, H.A., Atasoy, A.R., Ozbek, A., Köroğlu, M., Are there standardized cutoff values for neutrophil-lymphocyte ratios in bacteremia or sepsis?. J Microbiol Biotechnol 25:4 (2015), 521–525.
27. Orr, Y., Taylor, J.M., Bannon, P.G., Geczy, C., Kritharides, L., Circulating CD10-/CD16low neutrophils provide a quantitative index of active bone marrow neutrophil release. Br J Haematol 131:4 (2005), 508–519.
28. Orr, Y., Wilson, D.P., Taylor, J.M., et al. A kinetic model of bone marrow neutrophil production that characterizes late phenotypic maturation. Am J Physiol Regul Integr Comp Physiol 292:4 (2007), R1707–R1716.
29. Bozza, F.A., Salluh, J.I., Japiassu, A.M., et al. Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care, 11(2), 2007 R49.
30. Ramírez, P., Ferrer, M., Martí V., et al. Inflammatory biomarkers and prediction for intensive care unit admission in severe community-acquired pneumonia. Crit Care Med 39:10 (2011), 2211–2217.
31. Menéndez, R., Martinez, R., Reyes, S., et al. Stability in community-acquired pneumonia: One step forward with markers?. Thorax 64:11 (2009), 987–992.
32. Suwa, T., Hogg, J.C., English, D., Van Eeden, S.F., Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow. Am J Physiol Heart Circ Physiol 279:6 (2000), H2954–H2960.
33. Drifte, G., Dunn-Siegrist, I., Tissières, P., Pugin, J., Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome. Crit Care Med 41:3 (2013), 820–832.
34. Drewry, A.M., Samra, N., Skrupky, L.P., Fuller, B.M., Compton, S.M., Hotchkiss, R.S., Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock 42:5 (2014), 383–391.
35. Monneret, G., Lepape, A., Voirin, N., et al. Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med 32:8 (2006), 1175–1183.
36. Döcke, W.D., Höflich, C., Davis, K.A., et al. Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA-DR expression: a multicenter standardized study. Clin Chem 51:12 (2005), 2341–2347.
37. Boomer, J.S., To, K., Chang, K.C., et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306:23 (2011), 2594–2605.