The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients

Intensive Care Medicine

Volumn 38, Issue 3, 2012, Pages 445-452

  Gros, Antoine ^a   Roussel, Mikael ^a   Sauvadet, Elise ^a   Gacouin, Arnaud ^a   Marqué, Sophie ^a   Chimot, Loïc ^a   Lavoué, Sylvain ^a   Camus, Christophe ^a   Fest, Thierry ^a   Le Tulzo, Yves ^a  

^a PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

Bacterial infection; Critically ill patients; Diagnostic accuracy; Neutrophil CD64; Sepsis; SIRS

Indexed keywords

CD64 ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL INFECTION; CRITICALLY ILL PATIENT; DISEASE MARKER; FEMALE; FLOW CYTOMETRY; HUMAN; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MICROBIOLOGY; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; UNIVERSITY HOSPITAL;

AGED; BACTEREMIA; BIOLOGICAL MARKERS; CRITICAL ILLNESS; DIAGNOSIS, DIFFERENTIAL; FEMALE; FLOW CYTOMETRY; FRANCE; HOSPITALS, UNIVERSITY; HUMANS; MALE; MIDDLE AGED; NEUTROPHILS; PROSPECTIVE STUDIES; RECEPTORS, IGG; ROC CURVE; SEVERITY OF ILLNESS INDEX;

EID: 84862565639     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-012-2483-6     Document Type: Article

References (21)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310
2. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Cheang M (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34:1589-1596
3. Peters RP, van Agtmael MA, Danner SA, Savelkoul PH, Vandenbroucke- Grauls CM (2004) New developments in the diagnosis of bloodstream infections. Lancet Infect Dis 4:751-760
4. Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY (2006) Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 34:1996-2003
5. Tang BM, Eslick GD, Craig JC, McLean AS (2007) Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis 7:210-217
6. Mongardon N, Lemiale V, Perbet S, Dumas F, Legriel S, Guerin S, Charpentier J, Chiche JD, Mira JP, Cariou A (2010) Value of procalcitonin for diagnosis of early onset pneumonia in hypothermia-treated cardiac arrest patients. Intensive Care Med 36:92-99
7. Jiyong J, Tiancha H, Wei C, Huahao S (2009) Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med 35:587-595
8. Davis BH, Olsen SH, Ahmad E, Bigelow NC (2006) Neutrophil CD64 is an improved indicator of infection or sepsis in emergency department patients. Arch Pathol Lab Med 130:654-661
9. Icardi M, Erickson Y, Kilborn S, Stewart B, Grief B, Scharnweber G (2009) CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients. J Clin Microbiol 47:3914-3919
10. Groselj-Grenc M, Ihan A, Pavcnik- Arnol M, Kopitar AN, Gmeiner-Stopar T, Derganc M (2009) Neutrophil and monocyte CD64 indexes, lipopolysaccharide- binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children. Intensive Care Med 35: 1950-1958
11. Bhandari V, Wang C, Rinder C, Rinder H (2008) Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics 121:129-134
12. Cardelli P, Ferraironi M, Amodeo R, Tabacco F, De Blasi RA, Nicoletti M, Sessa R, Petrucca A, Costante A, Cipriani P (2008) Evaluation of neutrophil CD64 expression and procalcitonin as useful markers in early diagnosis of sepsis. Int J Immunopathol Pharmacol 21:43-49
13. Hsu KH, Chan MC, Wang JM, Lin LY, Wu CL (2011) Comparison of Fcgamma receptor expression on neutrophils with procalcitonin for the diagnosis of sepsis in critically ill patients. Respirology 16:152-160
14. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM/ESICM/ACCP/ ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31:1250-1256
15. Groselj-Grenc M, Ihan A, Derganc M (2008) Neutrophil and monocyte CD64 and CD163 expression in critically ill neonates and children with sepsis: comparison of fluorescence intensities and calculated indexes. Mediators Inflamm 2008:202646
16. Martin C, Garnier F, Vallet B (2005) Recommendations for management of severe sepsis and septic shock. Surviving Sepsis Campaign. Ann Fr Anesth Reanim 24:440-443
17. Cohen J, Brun-Buisson C, Torres A, Jorgensen J (2004) Diagnosis of infection in sepsis: an evidence-based review. Crit Care Med 32:S466-S494
18. Cid J, Aguinaco R, Sanchez R, Garcia- Pardo G, Llorente A (2010) Neutrophil CD64 expression as marker of bacterial infection: a systematic review and meta-analysis. J Infect 60:313-319
19. Gamez-Diaz LY, Enriquez LE, Matute JD, Velasquez S, Gomez ID, Toro F, Ospina S, Bedoya V, Arango CM, Valencia ML, De La Rosa G, Gomez CI, Garcia A, Patino PJ, Jaimes FA (2011) Diagnostic accuracy of HMGB-1, sTREM-1, and CD64 as markers of sepsis in patients recently admitted to the emergency department. Acad Emerg Med 18:807-815
20. Nuutila J (2010) The novel applications of the quantitative analysis of neutrophil cell surface FcgammaRI (CD64) to the diagnosis of infectious and inflammatory diseases. Curr Opin Infect Dis 23:268-274
21. Livaditi O, Kotanidou A, Psarra A, Dimopoulou I, Sotiropoulou C, Augustatou K, Papasteriades C, Armaganidis A, Roussos C, Orfanos SE, Douzinas EE (2006) Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis. Cytokine 36:283-290