The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Mare, Tracey Anne ^a,b   Treacher, David Floyd ^a,b   Shankar Hari, Manu ^a,b   Beale, Richard ^a,b   Lewis, Sion Marc ^a,b   Chambers, David John ^a   Brown, Kenneth Alun ^a,b  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ADVERSE OUTCOME; AGED; ARTICLE; BLOOD LEVEL; CELL DIFFERENTIATION; CELL MATURATION; CELLULAR DISTRIBUTION; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; GENERAL CONDITION DETERIORATION; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONITORING; NEUTROPHIL; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBOCYTE COUNT; BLOOD; BLOOD SAMPLING; CASE CONTROL STUDY; CELL COUNT; DIFFERENTIAL DIAGNOSIS; GRANULOCYTE PRECURSOR; INTENSIVE CARE UNIT; METABOLISM; MIDDLE AGED; MORTALITY; SEPSIS;

C REACTIVE PROTEIN;

AGED; BLOOD SPECIMEN COLLECTION; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CELL COUNT; DIAGNOSIS, DIFFERENTIAL; FEMALE; GRANULOCYTE PRECURSOR CELLS; HUMANS; INTENSIVE CARE UNITS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NEUTROPHILS; PLATELET COUNT; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 84924874075     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-0778-z     Document Type: Article

References (39)

1. Vincent JL, Opal SO, Marshall JC, Tracey KJ. Sepsis definitions, time for a change. Lancet. 2013;381:774-5.
2. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864-74.
3. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250-6.
4. Benez EI. Hematologic response to acute inflammation: the band neutrophil revisited. Tex Med. 1990;86:26-8.
5. Summers C, Rankin SM, Condliffe AM, Singh N, Peters AM, Chilvers ER. Neutrophil kinetics in health and disease. Trends Immunol. 2010;31:318-24.
6. Sadik CD, Kim ND, Luster AD. Neutrophils cascading their way to inflammation. Trends Immunol. 2011;32:452-60.
7. Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13:159-75.
8. Cornbleet P. Clinical utility of the band count. Clin Lab Med. 2002;22:101-36.
9. Al-Gwaiz LA, Babay HH. The diagnostic value of absolute neutrophil count, band count and morphologic changes of neutrophils in predicting bacterial infections. Med Princ Pract. 2007;16:344-7.
10. Abraham E, Mathay M, Dinarello C, Vincent J, Cohen J, Opal S, et al. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med. 2000;28:232-5.
11. Vincent J. Dear SIRS, I'm sorry to say that I don't like you... Crit Care Med. 1997;25:372-4.
12. Cavallazzi R, Bennin CL, Hirani A, Gilbert C, Marik PE. Is the band count useful in the diagnosis of infection? An accuracy study in critically ill patients. J Intensive Care Med. 2010;25:353-7.
13. Nierhaus A, Klatte S, Linssen J, Eismann NM, Wichmann D, Hedke J, et al. Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis - a prospective, observational study. BMC Immunol. 2013;14:8.
14. Guérin E, Orabona M, Raquil MA, Giraudeau B, Bellier R, Gibot S, et al. Circulating immature granulocytes with T-cell killing functions predict sepsis deterioration. Crit Care Med. 2014;42:2007-18.
15. Ha SO, Park SH, Park SH, Park JS, Huh JW, Lim CM, et al. Fraction of immature granulocytes reflects severity but not mortality in sepsis. Scand J Clin Lab Invest. 2015;75:36-43.
16. Van der Geest PJ, Mohseni M, Brouwer R, van der Hoven B, Steyerberg EW, Groeneveld AB. Immature granulocytes predict microbial infection and its adverse sequelae in the intensive care unit. J Crit Care. 2014;29:523-7.
17. Segal AW. How neutrophils kill microbes. Annu Rev Immunol. 2005;23:197-223.
18. Brown KA, Brain SD, Pearson JD, Edgeworth JD, Lewis SM, Treacher DF. Neutrophils in development of multiple organ failure in sepsis. Lancet. 2006;368:157-69.
19. Vincent JL, Abraham E. The last 100 years of sepsis. Am J Respir Crit Care Med. 2006;173:256-63.
20. Bermejo-Martín JF, Tamayo E, Ruiz G, Andaluz-Ojeda D, Herrán-Monge R, Muriel-Bombín A, et al. Circulating neutrophil counts and mortality in septic shock. Crit Care. 2014;18:407.
21. European Society of Intensive Care Medicine. The problem of sepsis. Intensive Care Med. 1994;20:300-4.
22. Kuppermann N, Walton EA. Immature neutrophils in the blood smears of young febrile children. Arch Pediatr Adolesc Med. 1999;153:261-6.
23. Baron RM, Baron M, Perrella M. Pathobiology of sepsis: are we still asking the same questions? Am J Respir Cell Mol Biol. 2006;34:129-34.
24. Chang P, Harris J, Bhumbra N, Puczynski M, Kherallah N, Lewis T, et al. Index of suspicion. Pediatr Rev. 2006;27:73-8.
25. Glasser L, Fiederlein RL. Functional differentiation of normal human neutrophils. Blood. 1987;69:937-44.
26. Drifte G, Dunn-Siegrist I, Tissières P, Pugin J. Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome. Crit Care Med. 2013;41:820-32.
27. Ward MJ, Fertel BS, Bonomo JB, Smith CL, Hart KW, Lindsell CJ, et al. The degree of bandemia in septic ED patients does not predict inpatient mortality. Am J Emerg Med. 2012;30:181-3.
28. Cimenti C, Ewra E, Herkner K, Kasper D, Müller W, Resch B. The predictive value of immature granulocyte count and immature myeloid information in the diagnosis of neonatal sepsis. Clin Chem Lab Med. 2012;50:1429-42.
29. Chiesa C, Panero A, Osborne J, Simonetti A, Pacifico L. Opinion diagnosis of neonatal sepsis: a clinical and laboratory challenge. Clin Chem. 2004;50:279-87.
30. Lichtman M, Weed R. Alteration in the cell periphery during granulocyte maturation. Blood. 1972;39:301-16.
31. Linderkamp O, Reuf R, Brenner B, Gulbins E, Lang F. Passive deformability of mature, immature, and active neutrophils in healthy and septicemic neonates. Pediatr Res. 1998;44:946-50.
32. Doerschuk C, Beyers N, Coxon H, Wiggs B, Hogg J. The importance of the neutrophil and capillary diameter in margination of PMN in the lung. J Appl Physiol. 1993;74:3040-5.
33. Van Eeden SF, Lawrence E, Sato Y, Kitagawa Y, Hogg JC. Neutrophils released from the bone marrow by granulocyte colony-stimulating factor sequester in lung microvessels but are slow to migrate. Eur Respir J. 2000;15:1079-86.
34. Downey G, Doherty D, Schwab B, Elson E, Henson P, Scott G. Retention of leukocytes in capillaries: role of cell size and deformability. J Appl Physiol. 1990;69:1767-78.
35. Pöschl JMB, Ruef P, Linderkamp O. Deformability of passive and activated neutrophils in children with Gram-negative septicemia. Scand J Clin Lab Invest. 2005;65:333-9.
36. Park DH, Park K, Park J, Park HH, Chae H, Lim J, et al. Screening of sepsis using leukocyte cell population data from the Coulter automatic blood cell analyzer DxH800. Int J Lab Hematol. 2011;33:391-9.
37. Park BH, Kang YA, Park MS, Jung WJ, Lee SH, Lee SK, et al. Delta neutrophil index as an early marker of disease severity in critically ill patients with sepsis. BMC Infect Dis. 2011;11:299.
38. Bernstein L, Rucinski J. Measurement of granulocyte maturation may improve the early diagnosis of the septic state. Clin Chem Lab Med. 2011;49:2089-95.
39. Mora-Jenson H, Jendholm J, Fossum A, Porse B, Borregaard N, Theilgaard-Monch K. Immunophenotypical characterization of human neutrophil differentiation. J Leukoc Biol. 2011;90:629-34.