T cells in patients with narcolepsy target self-antigens of hypocretin neurons

Nature

Volumn 562, Issue 7725, 2018, Pages 63-68

  Latorre, Daniela ^a,b   Kallweit, Ulf ^c,d   Armentani, Eric ^a   Foglierini, Mathilde ^a,e   Mele, Federico ^a   Cassotta, Antonino ^a,b   Jovic, Sandra ^a   Jarrossay, David ^a   Mathis, Johannes ^c   Zellini, Francesco ^f   Becher, Burkhard ^g   Lanzavecchia, Antonio ^a   Khatami, Ramin ^h   Manconi, Mauro ^c,f   Tafti, Mehdi ⁱ   Bassetti, Claudio L ^c   Sallusto, Federica ^a,b  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c Neurologische Universitatsklinik Bern   (Switzerland)

^d UNIVERSITY OF WITTEN HERDECKE   (Germany)

^e SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^f REGIONAL HOSPITAL OF LUGANO   (Switzerland)

^g UNIVERSITY OF ZURICH   (Switzerland)

^h Clinic Barmelweid   (Switzerland)

ⁱ UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD19 ANTIGEN; CD4 ANTIGEN; HLA DQB1 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OREXIN A; OREXIN B; AUTOANTIGEN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; HCRT PROTEIN, HUMAN; OREXIN; SIGNAL PEPTIDE; TRIB2 PROTEIN, HUMAN; VIRUS ANTIGEN;

ANTIGEN; BLOOD; CELL; CELL COMPONENT; DISEASE TREATMENT; ETIOLOGY; INFLUENZA; NERVOUS SYSTEM; NERVOUS SYSTEM DISORDER; PROTEIN; SLEEP; VACCINATION;

ADOLESCENT; ADULT; ANTIGEN RECOGNITION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE DURATION; EX VIVO STUDY; HUMAN; HUMAN CELL; LIMIT OF QUANTITATION; LYMPHOCYTE PROLIFERATION; NARCOLEPSY; NERVE CELL; PATHOPHYSIOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BLOOD; CASE CONTROL STUDY; CELL SEPARATION; CEREBROSPINAL FLUID; CROSS REACTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; ORTHOMYXOVIRIDAE; PATHOLOGY;

ANTIGENS, VIRAL; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CROSS REACTIONS; HUMANS; IMMUNOLOGIC MEMORY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NARCOLEPSY; NEURONS; OREXINS; ORTHOMYXOVIRIDAE;

EID: 85054151119     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-018-0540-1     Document Type: Article

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