Absence of autoreactive CD4+ T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot

Journal of Neuroimmunology

Volumn 309, Issue , 2017, Pages 7-11

  Kornum, Birgitte Rahbek ^a   Burgdorf, Kristoffer Sølvsten ^a   Holm, Anja ^a   Ullum, Henrik ^a   Jennum, Poul ^a   Knudsen, Stine ^a,b  

^a University of Copenhagen   (Denmark)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

CD4+ T cells; ELISpot; HLA DQ; Hypocretin; Narcolepsy; Orexin

Indexed keywords

EPITOPE; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; OREXIN; HCRT PROTEIN, HUMAN; HLA DQ ANTIGEN; HLA-DQA1 ANTIGEN; HLA-DQB1 ANTIGEN;

ADOLESCENT; ADULT; AGED; ANTIGEN BINDING; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MALE; NARCOLEPSY; PRIORITY JOURNAL; AMINO ACID SEQUENCE; BLOOD; COHORT ANALYSIS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CHILD; COHORT STUDIES; ENZYME-LINKED IMMUNOSPOT ASSAY; EPITOPES; FEMALE; HLA-DQ ALPHA-CHAINS; HLA-DQ BETA-CHAINS; HUMANS; MALE; MIDDLE AGED; NARCOLEPSY; OREXINS; YOUNG ADULT;

EID: 85028024832     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2017.05.001     Document Type: Article

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