Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities

Applied Microbiology and Biotechnology

Volumn 102, Issue 23, 2018, Pages 10103-10117

  Škrlec, Katja ^a,b   Ručman, Rudolf ^c   Jarc, Eva ^a   Sikirić, Predrag ^d   Švajger, Urban ^e   Petan, Toni ^a   Perišić Nanut, Milica ^a   Štrukelj, Borut ^a,b   Berlec, Aleš ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c Diagen doo   (Slovenia)

^d UNIVERSITY OF ZAGREB   (Croatia)

^e BLOOD TRANSFUSION CENTRE OF SLOVENIA   (Slovenia)

Author keywords

Antioxidant; BPC 157; Fibroblasts; Lactococcus lactis; Peptide delivery; Recombinant

Indexed keywords

ANTIBODIES; ANTIOXIDANTS; BIOLOGICAL MEMBRANES; CELL CULTURE; FIBROBLASTS; LACTIC ACID; MASS SPECTROMETRY; PATHOLOGY; PHYSIOLOGY;

ANTI-OXIDANT ACTIVITIES; BPC-157; EXPRESSION OF HETEROLOGOUS PROTEINS; INTESTINAL INFLAMMATION; LACTOCOCCUS LACTIS; PEPTIDE DELIVERY; REACTIVE OXYGEN SPECIES; RECOMBINANT;

PEPTIDES;

ACMA PROTEIN; BASIC MEMBRANE PROTEIN A; BINDING PROTEIN; DRUG VEHICLE; FUSION PROTEIN; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE; MEMBRANE PROTEIN; PEPTIDOGLYCAN; REACTIVE OXYGEN METABOLITE; TRYPSIN; UNCLASSIFIED DRUG; USP45 PROTEIN; PEPTIDE FRAGMENT; PROTEIN;

ANTIOXIDANT; BACTERIUM; CELL COMPONENT; DETECTION METHOD; GENE EXPRESSION; GROWTH; MEMBRANE; PEPTIDE; PROTEIN; REACTIVE OXYGEN SPECIES; SECRETION;

ANTIOXIDANT ACTIVITY; ARTICLE; BIOENGINEERING; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENTERITIS; FIBROBLAST; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATORY BOWEL DISEASE; LACTOCOCCUS LACTIS; MASS SPECTROMETRY; NONHUMAN; PROTEIN DOMAIN; PROTEIN SECRETION; SIGNAL TRANSDUCTION; CELL LINE; CYTOLOGY; GENETICS; METABOLISM; OXIDATIVE STRESS; PLASMID; PROTEIN ENGINEERING; TRANSGENIC MICROORGANISM;

BACTERIA (MICROORGANISMS); LACTOCOCCUS LACTIS;

CELL LINE; DRUG DELIVERY SYSTEMS; FIBROBLASTS; HUMANS; INFLAMMATORY BOWEL DISEASES; LACTOCOCCUS LACTIS; MICROORGANISMS, GENETICALLY-MODIFIED; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PLASMIDS; PROTEIN ENGINEERING; PROTEINS; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS;

EID: 85052916115     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-018-9333-6     Document Type: Article

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