Nisin-inducible secretion of a biologically active single-chain insulin analog by Lactococcus lactis NZ9000

Biotechnology and Bioengineering

Volumn 108, Issue 8, 2011, Pages 1987-1996

  Ng, Daphne T W ^a   Sarkar, Casim A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Lactococcus lactis; Oral protein delivery; Single chain insulin

Indexed keywords

3T3-L1 ADIPOCYTES; ALKALINE PH; ALTERNATIVE APPROACH; DIABETIC PATIENT; ENZYMATIC DEGRADATION; GASTROINTESTINAL TRACT; INHIBITORY EFFECT; LACTOCOCCUS LACTIS; LOCAL SYNTHESIS; NON-INVASIVE; ORAL DELIVERY; ORAL INSULIN DELIVERY; ORAL PROTEIN DELIVERY; SIGNAL PEPTIDE; SINGLE-CHAIN INSULIN; SMALL INTESTINE; THERAPEUTIC PROTEIN;

ALKALINITY; ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CELL GROWTH; GROWTH KINETICS; PHYSIOLOGY;

INSULIN;

INSULIN DERIVATIVE; NISIN; POLYHISTIDINE TAG; PROTEIN KINASE B; RGS PROTEIN; SCI 57; SIGNAL PEPTIDE; SIGNAL PEPTIDE USP45; UNCLASSIFIED DRUG;

ADIPOCYTE; ALKALINITY; ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; GROWTH INHIBITION; GROWTH RATE; LACTOCOCCUS LACTIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SMALL INTESTINE;

ADIPOCYTES; ANIMALS; CELL LINE; CULTURE MEDIA, CONDITIONED; GENE EXPRESSION; INSULIN; LACTOCOCCUS LACTIS; MICE; NISIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); LACTOCOCCUS LACTIS;

EID: 79959257699     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23130     Document Type: Article

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