Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat

Surgery Today

Volumn 37, Issue 9, 2007, Pages 768-777

  Vuksic, Tihomir ^a   Zoricic, Ivan ^a   Brcic, Luka ^a   Sever, Marko ^a   Klicek, Robert ^a   Radic, Bozo ^a   Cesarec, Vedran ^a   Berkopic, Lidija ^a   Keller, Neike ^a   Blagaic, Alenka Boban ^a   Kokic, Neven ^a   Jelic, Ivan ^a   Geber, Juraj ^a   Anic, Tomislav ^a   Seiwerth, Sven ^a   Sikiric, Predrag ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Ileoileal anastomosis healing; Pentadecapeptide BPC 157; Rat

Indexed keywords

COLLAGEN; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTY LASPARTYLALANYLGLYCYLLEUCYLVALINE; GLYCYLGLUTAMYLPROLYLPROLYLPROLYLGLYCYLLYSYLPROLYLALANYLASPARTYLASPARTYLALANYLGLYCYLLEUCYLVALINE; PEPTIDE DERIVATIVE; PL 14736; RETICULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFICACY; ENTERITIS; EPITHELIZATION; GRANULATION TISSUE; GRANULOCYTE; HISTOLOGY; ILEUM; INTESTINE OBSTRUCTION; NONHUMAN; RAT; TREATMENT OUTCOME; WOUND DEHISCENCE; WOUND HEALING;

ADHESIONS; ANASTOMOSIS, SURGICAL; ANIMALS; ANTI-ULCER AGENTS; COLLAGEN; CROATIA; EPITHELIUM; ILEUS; INFLAMMATORY BOWEL DISEASES; MALE; PEPTIDE FRAGMENTS; PROTEINS; RATS; RATS, WISTAR; WOUND HEALING;

EID: 34548162889     PISSN: 09411291     EISSN: 14362813     Source Type: Journal    
DOI: 10.1007/s00595-006-3498-9     Document Type: Article

References (47)

1. YS Ilhan N Bulbuller C Kirkil R Ozercan D Seckin 2005 The effect of an angiotensin converting enzyme inhibitor of intestinal wound heaking J Surg Res 128 61 5
2. P Sikiric S Seiwerth Z Grabarevic M Petek R Rucman B Turkovic 1994 The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesion induced by restraint stress, cysteamine and 96% ethanol in rates. A comparative study with H2 receptor antagonists, dopamine promoters and gut peptides Life Sci 54 PL63 8
3. P Sikiric S Seiwerth Z Grabarevic R Rucman M Petek V Jagic 1996 Beneficial effect of novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity Dig Dis Sci 41 1604 14
4. G-nitro-L-arginine methylester and L-arginine effect on stomach mucosal integrity and blood pressure Eur J Pharmacol 332 23 33
5. V Bedekovic S Mise T Anic M Staresinic M Gjurasin M Kopljar 2003 Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy European J Pharmacol 477 73 80
6. D Mikus P Sikiric S Seiwerth A Petricevic G Aralica N Druzijanic 2001 Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesion in mice Burns 127 817 27
7. P Sikiric S Seiwerth S Mise M Staresinic V Bedekovic N Zarkovic 2003 Corticosteroids-impairment healing and gastric pentadecapeptide BPC 157 creams in burned mice Burns 29 323 34
8. Veljaca M, Krnic Z, Brajsa K, Mildner B, Pavic-Saladojev D, Seveljevic-Jaran D, et al. The development of PL 14736 for treatment of inflammatory bowel disease. IUPHAR-GI Section Symposium. Honolulu, Hawaii, 2002;13-15:0-32
9. M Veljaca D Pavic Sladoljev B Mildner K Brajsa M Bubenik S Stipanicic 2003 Safety, tolerability and pharmacokinetics of PL 14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers Gut 51 Suppl III A309
10. XC Xue YJ Wu MT Gao 2004 Study of the protective effects of pentadecapeptide BPC 157 on wounds in small-type pigs Chin New Drugs J 12 602 4
11. M Staresinic B Sebecic S Jadrijevic S Suknaic D Perovic G Aralica 2003 Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth J Orthop Res 21 976 83
12. 2 laser healing in mice Burns 31 310 5
13. B Sebecic V Nikolic P Sikiric S Seiwerth T Sosa L Patrlj 1999 Osteogenic effect of gastric pentadecapeptide BPC 157 on the healing of segmental bone defects in rabbits: a comparison with the bone marrow and autologous cortical bone implantation Bone 24 195 202
14. S Seiwerth P Sikiric Z Grabarevic Z Grabarevic I Zoricic M Hanzevacki 1997 BPC 157's effect on healing J Physiol (Paris) 91 173 8
15. M Staresinic I Petrovic T Novinscak I Jukic D Pevec S Suknaic 2006 Effective therapy of transected quadriceps muscle in rat: gastric pentadecapeptide BPC 157 J Orthop Res 24 1109 17
16. R Lazic N Gabric I Dekaris D Bosnar A Boban-Blagaic P Sikiric 2005 Gastric pentadecapeptide BPC 157 promotes corneal epithelial defect healing in rats Coll Antropol 29 321 5
17. M Veljaca K Chan A Guglietta 1995 Digestion of h-EGF, h-TGF alpha and BPC-15 in human gastric juice Gastroenterology 108 761
18. MR Urist 1995 The first three decades of bone morphogenetic protein Osteologie 4 207 23
19. A Mustoe GF Pierce A Thomason P Grmates MB Sporn TF Deuel 1987 Accelarated healing of incisional wounds in rats induced by transforming growth factor-β Science 237 1333 6
20. XC Xue YJ Wu MT Gao WG Li N Zhao ZL Wang 2004 Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats World J Gastroenterol 10 1032 6
21. JD Wood 2004 The first Noleb prize for integrated systems physiology: Ivan Petrovich Pavlov, 1904 Physiology 19 326 30
22. P Sikiric S Seiwerth Z Grabarevic R Rucman M Petek V Jagic 1997 Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats J Physiol (Paris) 91 113 22
23. M Veljaca CA Lesch R Pllana B Sanchez K Chan A Guglietta 1995 BPC-15 reduces trinitrovenzene sulfonic acid-induced colonic damage in rats J Pharmacol Exp Ther 272 417 22
24. I Zoricic P Sikiric S Seiwerth 1997 Pentadecapeptide BPC 157 beneficially influences the healing of colon-colon anastomoses in rats G Mozsik L Nagy A Par KD Rainsford Cell injury and protection in the gastrointestinal trace. From basic sciences to clinical perspectives 1996 Kluwer Academic Publishers Dordrecht Boston London 249 58
25. A Pajic I Fattorini M Gjurasin D Gogolja T Vlahovic Z Vrtar 2003 Gastric pentadecapeptide BPC 157 (PL-10, PL-116) reduces and reverses peritonitis intra-abdominal adhesion in normal and sialoadenectomized rat and abolished mortality in corticosteroid-rat Dig Dis Sci 48 1894
26. FJ Thornton A Barbul 1997 Healing in the gastrointestinal tract Surg Clin North Am 77 549 73
27. T Hendriks WJB Mastboom 1990 Healing of experimental intestinal anastomoses. Parameters for repair Dis Colon Rectum 33 891 901
28. K Ishimura T Tsubouchi K Okano T Maeba H Maeta 1998 Wound healing of intestinal anastomosis after digestive surgery under septic condition: participation of local interleukin-6 expression World J Surg 22 1069 75
29. M Veljaca CA Lesch B Sanchez J Low A Guglietta 1995 Protection of BPC-15 on TNBS-induced colitis in rats: possible mechanisms of action Gastroenterology 108 936
30. S Frank M Madlener J Pfeilschifter S Werner 1998 Induction of inducible nitric oxide synthase and its corresponding retrahydrobiopterin-cofactor synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair J Invest Dermatol 111 1058 64
31. JA Attard MJ Raval GR Martin J Kolb M Afrouzian WD Buie 2005 The effects of systemic hypoxia on colon anastomotic healing: an animal model Dis Colon Rectum 48 1460 70
32. B Turkovic P Sikiric S Seiwerth S Mise T Anic M Petek 2004 Stable gastric pentadecapeptide BPC 157 studied for inflammatory bowel disease (PLD-116, PL14736, Pliva) induces nitric oxide synthesis Gastroenterology 126 287
33. P Sikiric J Separovic T Anic G Buljat D Mikus S Seiwerth 1999 The effect of pentadecapeptide BPC 157, H2-blockers, omeprazole and sucralfate on new vessels and new granulation tissue formation J Physiol (Paris) 93 479 85
34. M Lovric-Bencic P Sikiric J Separovic S Seiwerth D Rogic V Kusec 2004 Doxorubicin congestive heart failure-increased big-endothelin 1 plasma concentration. Reversal by amlodipine, losartan and gastric pentadecapeptide BPC 157 in rat and mouse J Pharmacol Sci 95 19 26
35. AE Ulland JD Shearer C Coulter MD Caldwell 1997 Altered wound arginine metabolism by corticosterone and retinoic acid J Surg Res 70 84 8
36. A Camli M Barlas A Yagmurlu 2005 Does L-arginine induce intestinal adaptation by epithelial growth factor? Aust NZ J Surg 75 73 5
37. L Kalogjera M Ries T Baudoin Z Ferencic R Trotic B Pegan 1997 Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats Eur Arch Otorhyinolaryngol 254 S9 11
38. M Gjurasin P Miklic G Buljat D Perovic I Jukic P Sikiric 2003 Selective healing effect of the gastric pentadecapeptide BPC 157 on injured part of the nerve in subtotal sciatic nerve transection Dig Dis Sci 48 1878
39. M Seyer-Hansen TT Andreassen H Oxlund 1999 Strength of colonic anastomoses and skin incisional wounds in old rates - influence by diabetes and growth hormone Growth Hormone IGF Res 9 254 61
40. M Schaffer N Fuchs J Volker M Kapischke R Viebach 2005 Differential effect of tacrolimus on dermal and intestinal wound healing J Invest Surg 18 71 9
41. TI Petersen P Kissmeyer-Nielsen A Flyvbjery S Laurbery H Christensen 1996 Effect of insulin-like growth factor I (IGF-I) administration on the healing of colonic anastomoses in rats Int J Colorectal Dis 11 19 24
42. MA Gulcelik S Dinc F Bir O Elitok H Alagol M Oz 2005 Locally applied molgramostim improves wound healing at colonic anastomoses in rats after ligation of the common bile duct Can J Surg 48 213 8
43. K Cetinkaya S Dinc MA Gulcelik N Renda H Ustun M Caydere 2005 Granulocyte macrophate-colony stimulating factor improves impaired anastomotic wound healing in rats treated with intraperitoneal mitomycin-C Surg Today 35 290 4
44. AE Sakallioglu A Yagmurlu H Dindar N Hasirci N Renda MS Deveci 2004 Sustained local application of low-dose epidermal growth factor on steroid-inhibited colonic wound healing J Pediatr Surg 39 591 5
45. E Papalambros K Filis R Angelopoulou T Diamantis C Tsigris E Bastounis 2004 Does octreotide impair anastomotic healing after small bowel resection? Acta Chir Belg 104 198 203
46. J Migaly J Lieberman W Long C Fisher RH Rolandelli 2004 Effect of adenoviral-mediated transfer of transforming growth factor-betal on colonic anastomotic healing Dis Colon Rectum 47 1699 705
47. A Meddahi J Benoit N Ayoub A Sezeur D Barritault 1996 Heparin-like polymers derived from dextran enhance colonic anastomosis resistance to leakage J Biomed Mater Res 31 293 7