Environmental toxic metal contaminants and risk of cardiovascular disease: Systematic review and meta-analysis

BMJ (Online)

Volumn 362, Issue , 2018, Pages

  Chowdhury, Rajiv ^a   Ramond, Anna ^a   O'Keeffe, Linda M ^b,c   Shahzad, Sara ^a   Kunutsor, Setor K ^c,d,e   Muka, Taulant ^f   Gregson, John ^g   Willeit, Peter ^a,h   Warnakula, Samantha ^a   Khan, Hassan ⁱ   Chowdhury, Susmita ^a   Gobin, Reeta ^j   Franco, Oscar H ^f   Di Angelantonio, Emanuele ^a,k,l  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^f UNIVERSITY OF BERN   (Switzerland)

^g LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^h INNSBRUCK MEDICAL UNIVERSITY   (Austria)

ⁱ EMORY UNIVERSITY   (United States)

^j UNIVERSITY OF GUYANA   (Guyana)

^k UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^l NHS BLOOD AND TRANSPLANT   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; CADMIUM; COPPER; DRINKING WATER; LEAD; MERCURY; WELL WATER; HEAVY METAL;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; HUMAN; ISCHEMIC HEART DISEASE; LEAD BLOOD LEVEL; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SMOKING; SYSTEMATIC REVIEW; URINE LEVEL; CHEMICALLY INDUCED; ENVIRONMENTAL MONITORING; META ANALYSIS; POLLUTANT; POLLUTION; RISK ASSESSMENT; TOXICITY;

CARDIOVASCULAR DISEASES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; ENVIRONMENTAL POLLUTION; HUMANS; METALS, HEAVY; RISK ASSESSMENT; RISK FACTORS;

EID: 85052664082     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.k3310     Document Type: Review

References (109)

1. Blacksmith Institute, Green Cross. The world's worst pollution problems: assessing health risks at hazardous waste sites. http://www. worstpolluted. org/files/FileUpload/files/WWPP-2012. pdf
2. Caine ED. Health risks from toxic pollution. Lancet 2012; 380: 1532. doi: 10. 1016/S0140-6736(12)61862-5
3. Fawell J, Nieuwenhuijsen MJ. Contaminants in drinking water. Br Med Bull 2003; 68: 199-208. doi: 10. 1093/bmb/ldg027
4. World Health Organization. Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors. http://apps. who. int/iris/bitstream/handle/10665/258796/WHO-FWC-EPE-17. 01-eng. pdf; jsessionid=7368E2B81AC7C9CE8B40C38C7EED1F9E? sequence=1
5. Jarup L. Hazards of heavy metal contamination. Br Med Bull 2003; 68: 167-82. doi: 10. 1093/bmb/ldg032
6. Straif K, Benbrahim-Tallaa L, Baan R, et al, WHO International Agency for Research on Cancer Monograph Working Group. A review of human carcinogens-Part C: metals, arsenic, dusts, and fibres. Lancet Oncol 2009; 10: 453-4. doi: 10. 1016/S1470-2045(09)70134-2
7. D'Ippoliti D, Santelli E, De Sario M, Scortichini M, Davoli M, Michelozzi P. Arsenic in Drinking Water and Mortality for Cancer and Chronic Diseases in Central Italy, 1990-2010. PLoS One 2015; 10: e0138182. doi: 10. 1371/journal. pone. 0138182
8. Li Z, Ma Z, van der Kuijp TJ, Yuan Z, Huang L. A review of soil heavy metal pollution from mines in China: pollution and health risk assessment. Sci Total Environ 2014; 468-469: 843-53. doi: 10. 1016/j. scitotenv. 2013. 08. 090
9. IARC. IARC monographs on the evaluation of carcinogenic risks to humans. Arsenic, Metals, Fibres and Dusts. IARC, 2012.
10. Jomova K, Jenisova Z, Feszterova M, et al. Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol 2011; 31: 95-107.
11. Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology 2011; 283: 65-87. doi: 10. 1016/j. Tox. 2011. 03. 001
12. Tsuji JS, Perez V, Garry MR, Alexander DD. Association of low-level arsenic exposure in drinking water with cardiovascular disease: a systematic review and risk assessment. Toxicology 2014; 323: 78-94. doi: 10. 1016/j. Tox. 2014. 06. 008
13. Moon K, Guallar E, Navas-Acien A. Arsenic exposure and cardiovascular disease: an updated systematic review. Curr Atheroscler Rep 2012; 14: 542-55. doi: 10. 1007/s11883-012-0280-x
14. Tellez-Plaza M, Jones MR, Dominguez-Lucas A, Guallar E, Navas-Acien A. Cadmium exposure and clinical cardiovascular disease: a systematic review. Curr Atheroscler Rep 2013; 15: 356. doi: 10. 1007/s11883-013-0356-2
15. Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ. Lead exposure and cardiovascular disease-a systematic review. Environ Health Perspect 2007; 115: 472-82. doi: 10. 1289/ehp. 9785
16. Moon KA, Oberoi S, Barchowsky A, et al. A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease. Int J Epidemiol 2017; 46: 1924-39. doi: 10. 1093/ije/dyx202
17. Navas-Acien A, Sharrett AR, Silbergeld EK, et al. Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence. Am J Epidemiol 2005; 162: 1037-49. doi: 10. 1093/aje/kwi330
18. World Health Organization. Top ten chemicals of major public health concern. http://www. who. int/ipcs/assessment/public-health/chemicals-phc/en/
19. Bhatnagar A. Environmental cardiology: studying mechanistic links between pollution and heart disease. Circ Res 2006; 99: 692-705. doi: 10. 1161/01. RES. 0000243586. 99701. cf
20. Nakano E, Williamson MP, Williams NH, Powers HJ. Copper-mediated LDL oxidation by homocysteine and related compounds depends largely on copper ligation. Biochim Biophys Acta 2004; 1688: 33-42. doi: 10. 1016/j. bbadis. 2003. 10. 005
21. Gaetke LM, Chow CK. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology 2003; 189: 147-63. doi: 10. 1016/S0300-483X(03)00159-8
22. Jain VK, Mohan G. Serum zinc and copper in myocardial infarction with particular reference to prognosis. Biol Trace Elem Res 1991; 31: 317-22. doi: 10. 1007/BF02990200
23. Niskanen J, Marniemi J, Piironen O, et al. Trace element levels in serum and urine of subjects died of coronary heart disease. Acta Pharmacol Toxicol (Copenh) 1986; 59(Suppl 7): 340-3. doi: 10. 1111/j. 1600-0773. 1986. Tb02775. x
24. Wells GA, Shea B, O'connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses. Ottawa Hospital Research Institute, 2011.
25. Chene G, Thompson SG. Methods for summarizing the risk associations of quantitative variables in epidemiologic studies in a consistent form. Am J Epidemiol 1996; 144: 610-21. doi: 10. 1093/oxfordjournals. aje. a008971
26. Kromhout D. Blood lead and coronary heart disease risk among elderly men in Zutphen, The Netherlands. Environ Health Perspect 1988; 78: 43-6. doi: 10. 1289/ehp. 887843
27. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327: 557-60. doi: 10. 1136/bmj. 327. 7414. 557
28. Egger M, Davey Smith G, Schneider M, Minder C. Bias in metaanalysis detected by a simple, graphical test. BMJ 1997; 315: 629-34. doi: 10. 1136/bmj. 315. 7109. 629
29. Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol 1992; 135: 1301-9. doi: 10. 1093/oxfordjournals. aje. a116237
30. Harrell FEJr, Lee KL, Pollock BG. Regression models in clinical studies: determining relationships between predictors and response. J Natl Cancer Inst 1988; 80: 1198-202. doi: 10. 1093/jnci/80. 15. 1198
31. Afridi HI, Kazi TG, Kazi N, et al. Association of environmental toxic elements in biological samples of myocardial infarction patients at different stages. Biol Trace Elem Res 2011; 141: 26-40. doi: 10. 1007/s12011-010-8713-2
32. Chen CJ, Chiou HY, Chiang MH, et al. Dose-Response relationship between Ischemic Heart Disease mortality and long-term Arsenic exposure. Arterioscler Thromb Vasc Biol 1996; 16(4): 504-10.
33. Monrad M, Ersboll AK, Sorensen M, et al. Low-level arsenic in drinking water and risk of incident myocardial infarction: A cohort study. Environ Res 2017; 154: 318-24. doi: 10. 1016/j. envres. 2017. 01. 028
34. Chen Y, Graziano JH, Parvez F, et al. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study. BMJ 2011; 342: d2431. doi: 10. 1136/bmj. d2431
35. Liao YT, Chen CJ, Li WF, et al. Elevated lactate dehydrogenase activity and increased cardiovascular mortality in the arsenic-endemic areas of southwestern Taiwan. Toxicol Appl Pharmacol 2012; 262: 232-7. doi: 10. 1016/j. Taap. 2012. 04. 028
36. Farzan SF, Chen Y, Rees JR, Zens MS, Karagas MR. Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study. Toxicol Appl Pharmacol 2015; 287: 93-7. doi: 10. 1016/j. Taap. 2015. 05. 013
37. Ruiz-Navarro ML, Navarro-Alarcon M, Lopez Gonzalez-de la Serrana H, Perez-Valero V, Lopez-Martinez MC. Urine arsenic concentrations in healthy adults as indicators of environmental contamination: relation with some pathologies. Sci Total Environ 1998; 216: 55-61. doi: 10. 1016/S0048-9697(98)00136-3
38. Moon KA, Guallar E, Umans JG, et al. Association between exposure to low to moderate arsenic levels and incident cardiovascular disease. A prospective cohort study. Ann Intern Med 2013; 159: 649-59.
39. James KA, Byers T, Hokanson JE, Meliker JR, Zerbe GO, Marshall JA. Association between lifetime exposure to inorganic arsenic in drinking water and coronary heart disease in Colorado residents. Environ Health Perspect 2015; 123: 128-34. doi: 10. 1289/ehp. 1509791R
40. Sohel N, Persson LA, Rahman M, et al. Arsenic in drinking water and adult mortality: a population-based cohort study in rural Bangladesh. Epidemiology 2009; 20: 824-30. doi: 10. 1097/EDE. 0b013e3181bb56ec
41. Wade TJ, Xia Y, Mumford J, et al. Cardiovascular disease and arsenic exposure in Inner Mongolia, China: a case control study. Environ Health 2015; 12; 14-35. doi: 10. 1186/s12940-015-0022-y.
42. Wu MM, Chiou HY, Chen CL, et al. GT-repeat polymorphism in the heme oxygenase-1 gene promoter is associated with cardiovascular mortality risk in an arsenic-exposed population in northeastern Taiwan. Toxicol Appl Pharmacol 2010; 248: 226-33. doi: 10. 1016/j. Taap. 2010. 08. 005
43. Chowdhury R, Sarnat SE, Darrow L, McClellan W, Steenland K. Mortality among participants in a lead surveillance program. Environ Res 2014; 132: 100-4. doi: 10. 1016/j. envres. 2014. 03. 008
44. Pocock SJ, Shaper AG, Ashby D, Delves HT, Clayton BE. The relationship between blood lead, blood pressure, stroke, and heart attacks in middle-aged British men. Environ Health Perspect 1988; 78: 23-30. doi: 10. 1289/ehp. 887823
45. McElvenny DM, Miller BG, MacCalman LA, et al. Mortality of a cohort of workers in Great Britain with blood lead measurements. Occup Environ Med 2015; 72: 625-32. doi: 10. 1136/oemed-2014-102637
46. Moller L, Kristensen TS. Blood lead as a cardiovascular risk factor. Am J Epidemiol 1992; 136: 1091-100. doi: 10. 1093/oxfordjournals. aje. a116574
47. Lustberg M, Silbergeld E. Blood lead levels and mortality. Arch Intern Med 2002; 162: 2443-9. doi: 10. 1001/archinte. 162. 21. 2443
48. Schober SE, Mirel LB, Graubard BI, Brody DJ, Flegal KM. Blood lead levels and death from all causes, cardiovascular disease, and cancer: results from the NHANES III mortality study. Environ Health Perspect 2006; 114: 1538-41.
49. Menke A, Muntner P, Batuman V, Silbergeld EK, Guallar E. Blood lead below 0. 48 micromol/L (10 microg/dL) and mortality among US adults. Circulation 2006; 114: 1388-94. doi: 10. 1161/CIRCULATIONAHA. 106. 628321
50. Aoki Y, Brody DJ, Flegal KM, Fakhouri TH, Axelrad DA, Parker JD. Blood Lead and Other Metal Biomarkers as Risk Factors for Cardiovascular Disease Mortality. Medicine (Baltimore) 2016; 95: e2223. doi: 10. 1097/MD. 0000000000002223
51. Khalil N, Wilson JW, Talbott EO, et al. Association of blood lead concentrations with mortality in older women: a prospective cohort study. Environmental Health 2009; 8: 15. doi: 10. 1186/1476-069X-8-15
52. Weisskopf MG, Jain N, Nie H, et al. A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging Study. Circulation 2009; 120: 1056-64. doi: 10. 1161/CIRCULATIONAHA. 108. 827121
53. Nawrot TS, Van Hecke E, Thijs L, et al. Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population. Environ Health Perspect 2008; 116: 1620-8. doi: 10. 1289/ehp. 11667
54. Yoshizawa K, Rimm EB, Morris JS, et al. Mercury and the risk of coronary heart disease in men. N Engl J Med 2002; 347: 1755-60. doi: 10. 1056/NEJMoa021437
55. Li Q, Nishijo M, Nakagawa H, et al. Relationship between urinary cadmium and mortality in habitants of a cadmium-polluted area: a 22-year follow-up study in Japan. Chin Med J (Engl) 2011; 124: 3504-9.
56. Barregard L, Sallsten G, Fagerberg B, et al. Blood Cadmium Levels and Incident Cardiovascular Events during Follow-up in a Population-Based Cohort of Swedish Adults: The Malmo Diet and Cancer Study. Environ Health Perspect 2016; 124: 594-600.
57. Tellez-Plaza M, Navas-Acien A, Menke A, Crainiceanu CM, Pastor-Barriuso R, Guallar E. Cadmium exposure and all-cause and cardiovascular mortality in the U. S. general population. Environ Health Perspect 2012; 120: 1017-22. doi: 10. 1289/ehp. 1104352
58. Menke A, Muntner P, Silbergeld EK, Platz EA, Guallar E. Cadmium levels in urine and mortality among U. S. adults. Environ Health Perspect 2009; 117: 190-6. doi: 10. 1289/ehp. 11236
59. Tellez-Plaza M, Guallar E, Howard BV, et al. Cadmium exposure and incident cardiovascular disease. Epidemiology 2013; 24: 421-9. doi: 10. 1097/EDE. 0b013e31828b0631
60. Guallar E, Sanz-Gallardo MI, van't Veer P, et al, Heavy Metals and Myocardial Infarction Study Group. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med 2002; 347: 1747-54. doi: 10. 1056/NEJMoa020157
61. Bergdahl IA, Ahlqwist M, Barregard L, et al. Mercury in serum predicts low risk of death and myocardial infarction in Gothenburg women. Int Arch Occup Environ Health 2013; 86: 71-7. doi: 10. 1007/s00420-012-0746-8
62. Hallgren CG, Hallmans G, Jansson JH, et al. Markers of high fish intake are associated with decreased risk of a first myocardial infarction. Br J Nutr 2001; 86: 397-404. doi: 10. 1079/BJN2001415
63. Mozaffarian D, Shi P, Morris JS, et al. Mercury exposure and risk of cardiovascular disease in two U. S. cohorts. N Engl J Med 2011; 364: 1116-25. doi: 10. 1056/NEJMoa1006876
64. Virtanen JK, Voutilainen S, Rissanen TH, et al. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arterioscler Thromb Vasc Biol 2005; 25: 228-33.
65. Daneshmand R, Kurl S, Tuomainen TP, Virtanen JK. Associations of serum n-3 and n-6 PUFA and hair mercury with the risk of incident stroke in men: the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). Br J Nutr 2016; 115: 1851-9. doi: 10. 1017/S0007114516000982
66. Wennberg M, Bergdahl IA, Hallmans G, et al. Fish consumption and myocardial infarction: a second prospective biomarker study from northern Sweden. Am J Clin Nutr 2011; 93: 27-36. doi: 10. 3945/ajcn. 2010. 29408
67. Wennberg M, Bergdahl IA, Stegmayr B, et al. Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden. Br J Nutr 2007; 98: 1038-45. doi: 10. 1017/S0007114507756519
68. Downer MK, Martinez-Gonzalez MAG, Gea A, et al, PREDIMED Study Investigators. Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study. BMC Cardiovasc Disord 2017; 17: 9. doi: 10. 1186/s12872-016-0435-8
69. Kok FJ, Van Duijn CM, Hofman A, et al. Serum copper and zinc and the risk of death from cancer and cardiovascular disease. Am J Epidemiol 1988; 128: 352-9. doi: 10. 1093/oxfordjournals. aje. a114975
70. Salonen JT, Salonen R, Korpela H, Suntioinen S, Tuomilehto J. Serum copper and the risk of acute myocardial infarction: a prospective population study in men in eastern Finland. Am J Epidemiol 1991; 134: 268-76. doi: 10. 1093/oxfordjournals. aje. a116080
71. Marniemi J, Alanen E, Impivaara O, et al. Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects. Nutr Metab Cardiovasc Dis 2005; 15: 188-97. doi: 10. 1016/j. numecd. 2005. 01. 001
72. Ford ES. Serum copper concentration and coronary heart disease among US adults. Am J Epidemiol 2000; 151: 1182-8. doi: 10. 1093/oxfordjournals. aje. a010168
73. Leone N, Courbon D, Ducimetiere P, Zureik M. Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology 2006; 17: 308-14. doi: 10. 1097/01. ede. 0000209454. 41466. b7
74. Reunanen A, Knekt P, Marniemi J, Maki J, Maatela J, Aromaa A. Serum calcium, magnesium, copper and zinc and risk of cardiovascular death. Eur J Clin Nutr 1996; 50: 431-7.
75. Dubben HH, Beck-Bornholdt HP. Systematic review of publication bias in studies on publication bias. BMJ 2005; 331: 433-4. doi: 10. 1136/bmj. 38478. 497164. F7
76. Mitchell E, Frisbie S, Sarkar B. Exposure to multiple metals from groundwater-a global crisis: geology, climate change, health effects, testing, and mitigation. Metallomics 2011; 3: 874-908. doi: 10. 1039/c1mt00052g
77. Singh R, Singh S, Parihar P, Singh VP, Prasad SM. Arsenic contamination, consequences and remediation techniques: a review. Ecotoxicol Environ Saf 2015; 112: 247-70. doi: 10. 1016/j. ecoenv. 2014. 10. 009
78. Lemaire M, Lemarie CA, Molina MF, et al. Exposure to moderate arsenic concentrations increases atherosclerosis in ApoE mouse model. Toxicol Sci. 2011; 122: 211-21. doi: 10. 1093/toxsci/kfr097
79. Srivastava S, Vladykovskaya EN, Haberzettl P, Sithu SD, D'Souza SE, States JC. Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-mice. Toxicol Appl Pharmacol 2009; 241: 90-100. doi: 10. 1016/j. Taap. 2009. 08. 004
80. Ellinsworth DC. Arsenic, reactive oxygen, and endothelial dysfunction. J Pharmacol Exp Ther 2015; 353: 458-64. doi: 10. 1124/jpet. 115. 223289
81. Druwe IL, Sollome JJ, Sanchez-Soria P, Hardwick RN, Camenisch TD, Vaillancourt RR. Arsenite activates NF?B through induction of C-reactive protein. Toxicol Appl Pharmacol 2012; 261: 263-70. doi: 10. 1016/j. Taap. 2012. 04. 005
82. Abhyankar LN, Jones MR, Guallar E, Navas-Acien A. Arsenic exposure and hypertension: a systematic review. Environ Health Perspect 2012; 120: 494-500. doi: 10. 1289/ehp. 1103988
83. Waghe P, Sarath TS, Gupta P, et al. Arsenic causes aortic dysfunction and systemic hypertension in rats: Augmentation of angiotensin II signaling. Chem Biol Interact 2015; 237: 104-14. doi: 10. 1016/j. cbi. 2015. 06. 014
84. Shiue I. Higher urinary heavy metal, arsenic, and phthalate concentrations in people with high blood pressure: US NHANES, 2009-2010. Blood Press 2014; 23: 363-9. doi: 10. 3109/08037051. 2014. 925228
85. Tseng CH. Cardiovascular disease in arsenic-exposed subjects living in the arseniasis-hyperendemic areas in Taiwan. Atherosclerosis 2008; 199: 12-8. doi: 10. 1016/j. atherosclerosis. 2008. 02. 013
86. Tseng CH. Blackfoot disease and arsenic: a never-ending story. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2005; 23: 55-74. doi: 10. 1081/GNC-200051860
87. Muntner P, Menke A, DeSalvo KB, Rabito FA, Batuman V. Continued decline in blood lead levels among adults in the United States: the National Health and Nutrition Examination Surveys. Arch Intern Med 2005; 165: 2155-61. doi: 10. 1001/archinte. 165. 18. 2155
88. Tong S, von Schirnding YE, Prapamontol T. Environmental lead exposure: a public health problem of global dimensions. Bull World Health Organ 2000; 78: 1068-77.
89. Fewtrell LKR, Pruss-Ustun A. Lead: assessing the environmental burden of disease at national and local level. World Health Organization, 2003.
90. Ekong EB, Jaar BG, Weaver VM. Lead-related nephrotoxicity: a review of the epidemiologic evidence. Kidney Int 2006; 70: 2074-84. doi: 10. 1038/sj. ki. 5001809
91. Kinsman GD, Howard AN, Stone DL, Mullins PA. Studies in copper status and atherosclerosis. Biochem Soc Trans 1990; 18: 1186-8. doi: 10. 1042/bst0181186
92. Misra R, Bhambal SA, Misra NP, Misra SM. Serum copper, ceruloplasmin & iron in ischaemic heart disease. Indian Heart J 1978; 30: 339-44.
93. Kang YJ. Copper and homocysteine in cardiovascular diseases. Pharmacol Ther 2011; 129: 321-31. doi: 10. 1016/j. pharmthera. 2010. 11. 004
94. Nakagawa H, Nishijo M, Morikawa Y, et al. Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan. Environ Res 2006; 100: 323-9. doi: 10. 1016/j. envres. 2005. 08. 014
95. ATSDR. Toxicological profile for Mercury. Department of Health and Human Services, Public Health Service, 1999.
96. Garland M, Morris JS, Rosner BA, et al. Toenail trace element levels as biomarkers: reproducibility over a 6-year period. Cancer Epidemiol Biomarkers Prev 1993; 2: 493-7.
97. Clarke R, Shipley M, Lewington S, et al. Underestimation of risk associations due to regression dilution in long-term followup of prospective studies. Am J Epidemiol 1999; 150: 341-53. doi: 10. 1093/oxfordjournals. aje. a010013
98. Navas-Acien A, Silbergeld EK, Sharrett R, Calderon-Aranda E, Selvin E, Guallar E. Metals in urine and peripheral arterial disease. Environ Health Perspect 2005; 113: 164-9. doi: 10. 1289/ehp. 7329
99. Chowdhury R, Alam DS, Fakir II, et al, Cardiology Research Group. The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design. Eur J Epidemiol 2015; 30: 577-87. doi: 10. 1007/s10654-015-0037-2
100. Capable study. Available from: http://www. capable-bangladesh. org/.
101. Lamas GA, Goertz C, Boineau R, et al, TACT Investigators. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013; 309: 1241-50. doi: 10. 1001/jama. 2013. 2107
102. Lei L, Chang X, Rentschler G, et al. A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin. Toxicol Appl Pharmacol 2012; 265: 373-9. doi: 10. 1016/j. Taap. 2012. 09. 006
103. Pierce BL, Kibriya MG, Tong L, et al. Genome-wide association study identifies chromosome 10q24. 32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh. PLoS Genet 2012; 8: e1002522. doi: 10. 1371/journal. pgen.
104. Zhang H, Ge Y, He P, et al. Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation. Toxicol Sci. 2015; 146(2): 354-62. doi: 10. 1093/toxsci/kfv101
105. Davey Smith G, Ebrahim S. What can mendelian randomisation tell us about modifiable behavioural and environmental exposures? BMJ 2005; 330: 1076-9. doi: 10. 1136/bmj. 330. 7499. 1076
106. Sania N, Sauli N, Maithripala S, et al. Time to deliver: report of the WHO Independent High-Level Commission on NCDs. World Health Organisation, 2018.
107. Ghiani A, Fumagalli P, Nguyen Van T, Gentili R, Citterio S. The combined toxic and genotoxic effects of Cd and As to plant bioindicator Trifolium repens L. PLoS One 2014; 9: e99239. doi: 10. 1371/journal. pone. 0099239
108. Masters SB, Trevor AJ, Katzung BG. Katzung & Trevor's Pharmacology: Examination & Board Review (8th ed.). McGraw Hill Medical. 2008.
109. Kosnett MJ. Chelation for heavy metals (arsenic, lead, and mercury): protective or perilous? Clin Pharmacol Ther 2010; 88: 412-5. doi: 10. 1038/clpt. 2010. 132