GT-repeat polymorphism in the heme oxygenase-1 gene promoter is associated with cardiovascular mortality risk in an arsenic-exposed population in northeastern Taiwan

Toxicology and Applied Pharmacology

Volumn 248, Issue 3, 2010, Pages 226-233

  Wu, Meei Maan ^a,b,c   Chiou, Hung Yi ^a   Chen, Chi Ling ^b   Wang, Yuan Hung ^a   Hsieh, Yi Chen ^a   Lien, Li Ming ^d   Lee, Te Chang ^e   Chen, Chien Jen ^f  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^e INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^f GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

Arsenic; Cardiovascular mortality; Genetic polymorphism; Heme oxygenase 1; Prospective design

Indexed keywords

ARSENIC; HEME OXYGENASE 1;

ADULT; ARTERY DISEASE; ARTICLE; CANCER RISK; CARDIOVASCULAR RISK; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DNA STRUCTURE; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; POPULATION GENETICS; POPULATION RESEARCH; PROMOTER REGION; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; TAIWAN; TANDEM REPEAT; AGED; CARDIOVASCULAR DISEASES; COHORT ANALYSIS; COMPARATIVE STUDY; DINUCLEOTIDE REPEAT; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGY; GENETICS; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

AGED; ARSENIC; CARDIOVASCULAR DISEASES; COHORT STUDIES; DINUCLEOTIDE REPEATS; ENVIRONMENTAL EXPOSURE; FEMALE; HEME OXYGENASE-1; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK FACTORS; TAIWAN;

EID: 77957238501     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.08.005     Document Type: Article

References (40)

1. Abraham N.G., Kappas A. Pharmacological and clinical aspects of heme oxygenase. Pharmacol. Rev. 2008, 60:79-127.
2. Brydun A., Watari Y., Yamamoto Y., Okuhara K., Teragawa H., Kono F., Chayama K., Oshima T., Ozono R. Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis. Hypertens. Res. 2007, 30:341-348.
3. Chen C.J., Wang C.J. Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res. 1990, 50:5470-5474.
4. Chen C.J., Chiou H.Y., Chiang M.H., Lin L.J., Tai T.Y. Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure. Arterioscler. Thromb. Vasc. Biol. 1996, 16:504-510.
5. Chen Y.H., Lin S.J., Lin M.W., Tsai H.L., Kuo S.S., Chen J.W., Charng M.J., Wu T.C., Chen L.C., Ding Y.A., et al. Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum. Genet. 2002, 111:1-8.
6. Chen C.L., Hsu L.I., Chiou H.Y., Hsueh Y.M., Chen S.Y., Wu M.M., Chen C.J. Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan. JAMA 2004, 292:2984-2990.
7. Chen Y.H., Chau L.Y., Lin M.W., Chen L.C., Yo M.H., Chen J.W., Lin S.J. Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting. Eur. Heart J. 2004, 25:39-47.
8. Chen C.L., Chiou H.Y., Hsu L.I., Hsueh Y.M., Wu M.M., Wang Y.H., Chen C.J. Arsenic in drinking water and risk of urinary tract cancer: a follow-up study from northeastern Taiwan. Cancer Epidemiol. Biomark. Prev. 2010, 19:101-110.
9. Cheng C., Noordeloos A.M., Jeney V., Soares M.P., Moll F., Pasterkamp G., Serruys P.W., Duckers H.J. Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque. Circulation 2009, 119:3017-3027.
10. Chiou H.Y., Huang W.I., Su C.L., Chang S.F., Hsu Y.H., Chen C.J. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 1997, 28:1717-1723.
11. Del Razo L.M., Quintanilla-Vega B., Brambila-Colombres E., Calderon-Aranda E.S., Manno M., Albores A. Stress proteins induced by arsenic. Toxicol. Appl. Pharmacol. 2001, 177:132-148.
12. Dick P., Schillinger M., Minar E., Mlekusch W., Amighi J., Sabeti S., Schlager O., Raith M., Endler G., Mannhalter C., et al. Haem oxygenase-1 genotype and cardiovascular adverse events in patients with peripheral artery disease. Eur. J. Clin. Invest. 2005, 35:731-737.
13. Elbirt K.K., Whitmarsh A.J., Davis R.J., Bonkovsky H.L. Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases. J. Biol. Chem. 1998, 273:8922-8931.
14. Endler G., Exner M., Schillinger M., Marculescu R., Sunder-Plassmann R., Raith M., Jordanova N., Wojta J., Mannhalter C., Wagner O.F., et al. A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease. Thromb. Haemost. 2004, 91:155-161.
15. Ghosh S., Karanjawala Z.E., Hauser E.R., Ally D., Knapp J.I., Rayman J.B., Musick A., Tannenbaum J., Te C., Shapiro S., et al. Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers. FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group. Genome Res. 1997, 7:165-178.
16. Glynn R.J., Rosner B. Comparison of risk factors for the competing risks of coronary heart disease, stroke, and venous thromboembolism. Am. J. Epidemiol. 2005, 162:975-982.
17. Hackam D.G., Anand S.S. Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. JAMA 2003, 290:932-940.
18. Hernandez A., Marcos R. Genetic variations associated with interindividual sensitivity in the response to arsenic exposure. Pharmacogenomics 2008, 9:1113-1132.
19. Hirai H., Kubo H., Yamaya M., Nakayama K., Numasaki M., Kobayashi S., Suzuki S., Shibahara S., Sasaki H. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Blood 2003, 102:1619-1621.
20. Idriss N.K., Blann A.D., Lip G.Y. Hemoxygenase-1 in cardiovascular disease. J. Am. Coll. Cardiol. 2008, 52:971-978.
21. International Agency for Research on Cancer Some drinking-water disinfectants and contaminants, including arsenic. IARC Monogr. Eval. Carcinog. Risks Hum. 2004, 1-477. IARC, Lyon.
22. Kaneda H., Ohno M., Taguchi J., Togo M., Hashimoto H., Ogasawara K., Aizawa T., Ishizaka N., Nagai R. Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. Arterioscler. Thromb. Vasc. Biol. 2002, 22:1680-1685.
23. Kimpara T., Takeda A., Watanabe K., Itoyama Y., Ikawa S., Watanabe M., Arai H., Sasaki H., Higuchi S., Okita N., et al. Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease. Hum. Genet. 1997, 100:145-147.
24. Lavrovsky Y., Schwartzman M.L., Levere R.D., Kappas A., Abraham N.G. Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc. Natl. Acad. Sci. USA 1994, 91:5987-5991.
25. Lee P.C., Ho I.C., Lee T.C. Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. Toxicol. Sci. 2005, 85:541-550.
26. Lunn M., McNeil D. Applying Cox regression to competing risks. Biometrics 1995, 51:524-532.
27. Morita T. Heme oxygenase and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2005, 25:1786-1795.
28. National Research Council Arsenic in Drinking Water, 2001 Update, Washington, DC 2001.
29. Navas-Acien A., Sharrett A.R., Silbergeld E.K., Schwartz B.S., Nachman K.E., Burke T.A., Guallar E. Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence. Am. J. Epidemiol. 2005, 162:1037-1049.
30. Schillinger M., Exner M., Minar E., Mlekusch W., Mullner M., Mannhalter C., Bach F.H., Wagner O. Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor. J. Am. Coll. Cardiol. 2004, 43:950-957.
31. States J.C., Srivastava S., Chen Y., Barchowsky A. Arsenic and cardiovascular disease. Toxicol. Sci. 2009, 107:312-323.
32. Tiroch K., Koch W., von Beckerath N., Kastrati A., Schomig A. Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting. Eur. Heart J. 2007, 28:968-973.
33. Tseng C.H. Cardiovascular disease in arsenic-exposed subjects living in the arseniasis-hyperendemic areas in Taiwan. Atherosclerosis 2008, 199:12-18.
34. Wang C.H., Jeng J.S., Yip P.K., Chen C.L., Hsu L.I., Hsueh Y.M., Chiou H.Y., Wu M.M., Chen C.J. Biological gradient between long-term arsenic exposure and carotid atherosclerosis. Circulation 2002, 105:1804-1809.
35. Wang Y.H., Wu M.M., Hong C.T., Lien L.M., Hsieh Y.C., Tseng H.P., Chang S.F., Su C.L., Chiou H.Y., Chen C.J. Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan. Atherosclerosis 2007, 192:305-312.
36. Wu M.M., Chiou H.Y., Ho I.C., Chen C.J., Lee T.C. Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects. Environ. Health Perspect. 2003, 111:1429-1438.
37. Wu M.M., Chiou H.Y., Lee T.C., Ma W.C., Wang I.H., Huang W.L., Chen C.J. A length polymorphism in the heme oxygenase-1 gene promoter may modify the risk of carotid atherosclerosis related to arsenic exposure. 12th World Congress on Heart Disease - New Trends in Research, Diagnosis and Treatment, 16-19 July, International Academy of Cardiology, Vancouver, BC, Canada 2005.
38. Wu M.M., Chiou H.Y., Hsueh Y.M., Hong C.T., Su C.L., Chang S.F., Huang W.L., Wang H.T., Wang Y.H., Hsieh Y.C., et al. Effect of plasma homocysteine level and urinary monomethylarsonic acid on the risk of arsenic-associated carotid atherosclerosis. Toxicol. Appl. Pharmacol. 2006, 216:168-175.
39. Yagi K. Simple assay for the level of total lipid peroxides in serum or plasma. Meth. Mol. Biol. 1998, 108:101-106.
40. Yamada N., Yamaya M., Okinaga S., Nakayama K., Sekizawa K., Shibahara S., Sasaki H. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am. J. Hum. Genet. 2000, 66:187-195.