Lipid-based nutrient supplements for maternal, birth, and infant developmental outcomes

Cochrane Database of Systematic Reviews

Volumn 2018, Issue 8, 2018, Pages

  Das, Jai K ^a   Hoodbhoy, Zahra ^a   Salam, Rehana A ^a   Bhutta, Afsah Zulfiqar ^b   Valenzuela Rubio, Nancy G ^c,d   Weise Prinzo, Zita ^e   Bhutta, Zulfiqar A ^a,f  

^a AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

^b DOW UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

^c UNIVERSIDAD AUTÓNOMA DE SINALOA   (Mexico)

^d Mexican Association for Nutrition and Health Research   (Mexico)

^e GENERAL ELECTRIC COMPANY   (United States)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; IRON; LIPID; TRACE ELEMENT;

ANEMIA; BIRTH LENGTH; BIRTH WEIGHT; BODY HEIGHT; CHILD DEVELOPMENT; CLINICAL EFFECTIVENESS; DIET SUPPLEMENTATION; EVIDENCE BASED MEDICINE; GESTATIONAL WEIGHT GAIN; HUMAN; INTERMETHOD COMPARISON; LIPID BASED NUTRIENT SUPPLEMENTATION; LOW BIRTH WEIGHT; LOW INCOME COUNTRY; MATERNAL MORTALITY; MATERNAL NUTRITION; MATERNAL WELFARE; MIDDLE INCOME COUNTRY; NEWBORN DEATH; NEWBORN DISEASE; NUTRITIONAL COUNSELING; PARAMETERS CONCERNING THE FETUS, NEWBORN AND PREGNANCY; PREGNANCY OUTCOME; PREGNANT WOMAN; PREMATURE LABOR; PREVALENCE; PRIORITY JOURNAL; REVIEW; SMALL FOR DATE INFANT; STILLBIRTH; STUNTING; SYSTEMATIC REVIEW; TREATMENT DURATION; ADMINISTRATION AND DOSAGE; BODY WEIGHT GAIN; DIETARY SUPPLEMENT; FAT INTAKE; FEMALE; INFANT; META ANALYSIS; PREGNANCY; PREGNANCY COMPLICATION; PREMATURITY; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANEMIA; BIRTH WEIGHT; DIETARY FATS; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HUMANS; INFANT; INFANT, SMALL FOR GESTATIONAL AGE; IRON; MATERNAL MORTALITY; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREMATURE BIRTH; RANDOMIZED CONTROLLED TRIALS AS TOPIC; WEIGHT GAIN;

EID: 85052621966     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD012610.pub2     Document Type: Review

References (115)

1. Adams KP, Lybbert TJ, Vosti SA, Ayifah E, Arimond M, Adu-Afarwuah S, et al. Unintended effects of a targeted maternal and child nutrition intervention on household expenditures, labor income, and the nutritional status of non-targeted siblings in Ghana. World Development 2018;107:138-50. [DOI: 10.1016/j.worlddev.2018.02.025; NCT00970866]9050757
2. Adams KP, Okronipa H, Adu-Afarwuah S, Arimond M, Kumordzie S, Oaks BM, et al. Ghanaian parents' perceptions of pre and postnatal nutrient supplements and their effects. Maternal & Child Nutrition 2018;15:e12608. [DOI: 10.1111/mcn.12608; NCT00970866]9050758
3. Adu-Afarwuah S, Lartey A, Okronipa H, Ashorn P, Arimond M, Dewey KG. Prenatal supplementation with small quantity lipid based nutrient supplements or multiple micronutrients increase urinary iodine concentration in semi-urban Ghana: a randomized controlled trial. Annals of Nutrition and Metabolism 2017;71(Suppl 2):309. [DOI: 10.1159/000480486; EMBASE: 619277238; NCT00970866; PUBMED: 29024932]9050759
4. Adu-Afarwuah S, Lartey A, Okronipa H, Ashorn P, Ashorn U, Zeilani M, et al. Maternal supplementation with small-quantity lipid-based nutrient supplements compared with multiple micronutrients, but not with iron and folic acid, reduces the prevalence of low gestational weight gain in semi-urban Ghana: a randomized controlled trial. Journal of Nutrition 2017;147(4):697-705. [DOI: 10.3945/jn.116.242909; NCT00970866; PMC5368579; PUBMED: 28275100]9050760
5. Adu-Afarwuah S, Lartey A, Okronipa H, Ashorn P, Peerson JM, Arimond M, et al. Small-quantity, lipid-based nutrient supplements provided to women during pregnancy and 6 mo postpartum and to their infants from 6 mo of age increase the mean attained length of 18-mo-old children in semi-urban Ghana: a randomized controlled trial. American Journal of Clinical Nutrition 2016;104(3):797-808. [DOI: 10.3945/ajcn.116.134692; NCT00970866; PMC4997301; PUBMED: 27534634]9050761
6. Adu-Afarwuah S, Lartey A, Okronipa H, Ashorn P, Zeilani M, Baldiviez LM, et al. Impact of small-quantity lipid-based nutrient supplement on hemoglobin, iron status and biomarkers of inflammation in pregnant Ghanaian women. Maternal & Child Nutrition 2017;13(2):e12262. [DOI: 10.1111/mcn.12262; NCT00970866; PUBMED: 26924599]9050762
7. Adu-Afarwuah S, Lartey A, Okronipa H, Ashorn P, Zeilani M, Peerson JM, et al. Lipid-based nutrient supplement increases the birth size of infants of primiparous women in Ghana. American Journal of Clinical Nutrition 2015;101(4):835-46. [DOI: 10.3945/ajcn.114.091546; NCT00970866.; PUBMED: 25833980]9050763
8. Adu-Afarwuah S, Lartey A, Zeilani M, Dewey KG. Acceptability of lipid-based nutrient supplements (LNS) among Ghanaian infants and pregnant or lactating women. Maternal & Child Nutrition 2011;7(4):344-56. [DOI: 10.1111/j.1740-8709.2010.00286.x; NCT00970866; PUBMED: 21496207]9050764
9. Klevor MK, Haskell MJ, Lartey A, Adu-Afarwuah S, Zeilani M, Dewey KG. Lipid-based nutrient supplements providing approximately the recommended daily intake of vitamin A do not increase breast milk retinol concentrations among Ghanaian women. Journal of Nutrition 2016;146(2):335-42. [DOI: 10.3945/jn.115.217786; NCT00970866; PUBMED: 26740682]9050765
10. Oaks BM, Laugero KD, Stewart CP, Adu-Afarwuah S, Lartey A, Ashorn P, et al. Late-pregnancy salivary cortisol concentrations of Ghanaian women participating in a randomized controlled trial of prenatal lipid-based nutrient supplements. Journal of Nutrition 2016;146(2):343-52. [DOI: 10.3945/jn.115.219576; NCT00970866; PUBMED: 26764321]9050766
11. Okronipa H, Adu-Afarwuah S, Lartey A, Ashorn P, Vosti SA, Young RR, et al. Maternal supplementation with small-quantity lipid-based nutrient supplements during pregnancy and lactation does not reduce depressive symptoms at 6 months postpartum in Ghanaian women: a randomized controlled trial. Archives of Women's Mental Health 2018;21(1):55-63. [DOI: 10.1007/s00737-017-0752-7; NCT00970866; PMC5762799; PUBMED: 28698916]9050768
12. Okronipa H, Adu-Afarwuah S, Lartey A, Ashorn P, Vosti SA, Young RR, et al. Maternal supplementation with small-quantity lipid-based nutrient supplements during pregnancy and lactation does not reduce depressive symptoms at 6 months postpartum in Ghanaian women: a randomized controlled trial. Archives of Women's Mental Health 2018;21(1):55-63. [DOI: 10.1007/s00737-017-0752-7; NCT00970866; PMC5762799; PUBMED: 28698916]9050767
13. Okronipa HET, Adu-Afarwuah S, Lartey A, Ashorn P, Vosti SA, Young RT, et al. The impact of lipid-based nutrient supplements on maternal depression at 6 mo postpartum in Ghana: a randomized-controlled trial. FASEB Journal 2016;30(Suppl 1):1172.11. [DOI: 10.1096/fasebj.30.1_supplement.1172.11]9050769
14. Prado EL, Adu-Afarwuah S, Lartey A, Ocansey M, Ashorn P, Vosti SA, et al. Effects of pre-and post-natal lipid-based nutrient supplements on infant development in a randomized trial in Ghana. Early Human Development 2016;99:43-51. [DOI: 10.1016/j.earlhumdev.2016.05.011; NCT00970866; PUBMED: 27391572]9050770
15. Ashorn P, Alho L, Ashorn U, Cheung YB, Dewey KG, Gondwe A, et al. Supplementation of maternal diets during pregnancy and for 6 months postpartum and infant diets thereafter with small-quantity lipid-based nutrient supplements does not promote child growth by 18 months of age in rural Malawi: a randomized controlled trial. Journal of Nutrition 2015;145(6):1345-53. [DOI: 10.3945/jn.114.207225; NCT01239693; PUBMED: 25926413]9050772
16. Ashorn P, Alho L, Ashorn U, Cheung YB, Dewey KG, Harjunmaa U, et al. The impact of lipid-based nutrient supplement provision to pregnant women on newborn size in rural Malawi: a randomized controlled trial. American Journal of Clinical Nutrition 2015;101(2):387-97. [DOI: 10.3945/ajcn.114.088617; NCT01239693; PUBMED: 25646337]9050773
17. Chandrasiri UP, Fowkes FJ, Richards JS, Langer C, Fan YM, Taylor SM, et al. The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. Malaria Journal 2015;14:193. [DOI: 10.1186/s12936-015-0707-2; NCT01239693; PMC4438573; PUBMED: 25957793]9050774
18. Jorgensen JM, Arnold C, Ashorn P, Ashorn U, Chaima D, Cheung YB, et al. Lipid-based nutrient supplements during pregnancy and lactation did not affect human milk oligosaccharides and bioactive proteins in a randomized trial. Journal of Nutrition 2017;147(10):1867-74. [DOI: 10.3945/jn.117.252981; EMBASE: 618612500; NCT01239693; PMC5610548; PUBMED: 28794206]9050775
19. Klevor MK, Adu-Afarwuah S, Ashorn P, Arimond M, Dewey KG, Lartey A, et al. A mixed method study exploring adherence to and acceptability of small quantity lipid-based nutrient supplements (SQ-LNS) among pregnant and lactating women in Ghana and Malawi. BMC Pregnancy & Childbirth 2016;16:253. [DOI: 10.1186/s12884-016-1039-0; NCT01239693; PMC5004276; PUBMED: 27577112]9050776
20. Nkhoma M, Ashorn P, Ashorn U, Dewey KG, Gondwe A, Mbotwa J, et al. Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial. BMC Pregnancy & Childbirth 2017;17:35. [DOI: 10.1186/s12884-016-1215-2; NCT01239693; PMC5240436; PUBMED: 28095801]9050777
21. Nkhoma M, Ashorn P, Ashorn U, Dewey KG, Gondwe A, Mbotwa J, et al. Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial. BMC Pregnancy & Childbirth 2017;17:35. [DOI: 10.1186/s12884-016-1215-2; NCT01239693; PMC5240436; PUBMED: 28095801]9050778
22. Prado EL, Ashorn U, Phuka J, Maleta K, Sadalaki J, Oaks BM, et al. Associations of maternal nutrition during pregnancy and post-partum with maternal cognition and caregiving. Maternal & Child Nutrition 2018;14(2):e12546. [DOI: 10.1111/mcn.12546; NCT01239693; PMC5901033; PUBMED: 29098783]9050779
23. Prado EL, Maleta K, Ashorn P, Ashorn U, Vosti SA, Sadalaki J, et al. Effects of maternal and child lipid-based nutrient supplements on infant development: a randomized trial in Malawi. American Journal of Clinical Nutrition 2016;103(3):784-93. [DOI: 10.3945/ajcn.115.114579; NCT01239693; PUBMED: 26843155]9050780
24. Stewart CP, Oaks BM, Laugero KD, Ashorn U, Harjunmaa U, Kumwenda C, et al. Maternal cortisol and stress are associated with birth outcomes, but are not affected by lipid-based nutrient supplements during pregnancy: an analysis of data from a randomized controlled trial in rural Malawi. BMC Pregnancy & Childbirth 2015;15:346. [DOI: 10.1186/s12884-015-0793-8; NCT01239693; PMC4688934; PUBMED: 26694646]9050781
25. Stewart RC, Ashorn P, Umar E, Dewey KG, Ashorn U, Creed F, et al. The impact of maternal diet fortification with lipid-based nutrient supplements on postpartum depression in rural Malawi: a randomised-controlled trial. Maternal & Child Nutrition 2017;13(2):e12299. [DOI: 10.1111/mcn.12299; NCT01239693; PUBMED: 27060705]9050783
26. Stewart RC, Ashorn P, Umar E, Dewey KG, Ashorn U, Creed F, et al. The impact of maternal diet fortification with lipid-based nutrient supplements on postpartum depression in rural Malawi: a randomised-controlled trial. Maternal & Child Nutrition 2017;13(2):e12299. [DOI: 10.1111/mcn.12299; NCT01239693; PUBMED: 27060705]9050782
27. Huybregts L, Roberfroid D, Lanou H, Meda N, Taes Y, Valea I, et al. Prenatal lipid-based nutrient supplements increase cord leptin concentration in pregnant women from rural Burkina Faso. Journal of Nutrition 2013;143(5):576-83. [DOI: 10.3945/jn.112.171181; NCT00909974; PUBMED: 23535609]9050785
28. Huybregts L, Roberfroid D, Lanou H, Menten J, Meda N, Van Camp J, et al. Prenatal food supplementation fortified with multiple micronutrients increases birth length: a randomized controlled trial in rural Burkina Faso. American Journal of Clinical Nutrition 2009;90(6):1593-600. [DOI: 10.3945/ajcn.2009.28253; NCT00909974; PUBMED: 19812173]9050786
29. Lanou H, Huybregts L, Roberfroid D, Nikièma L, Kouanda S, Van Camp J, et al. Prenatal nutrient supplementation and postnatal growth in a developing nation: an RCT. Pediatrics 2014;133(4):e1001-8. [DOI: 10.1542/peds.2013-2850; NCT00909974; PUBMED: 24590752]9050787
30. Toe LC, Bouckaert KP, De Beuf K, Roberfroid D, Meda N, Thas O, et al. Seasonality modifies the effect of a lipid-based nutrient supplement for pregnant rural women on birth length. Journal of Nutrition 2015;145(3):643-9. [DOI: 10.3945/jn.114.203448; NCT00909974; PUBMED: 25733482]9050788
31. Dewey KG, Mridha MK, Matias SL, Arnold CD, Cummins JR, Khan MS, et al. Lipid-based nutrient supplementation in the first 1000 d improves child growth in Bangladesh: a cluster-randomized effectiveness trial. American Journal of Clinical Nutrition 2017;105(4):944-57. [DOI: 10.3945/ajcn.116.147942; NCT01715038; PUBMED: 28275125]9050790
32. Harding KL, Matias SL, Mridha MK, Moniruzzaman M, Vosti SA, Hussain S, et al. Adherence to recommendations on lipid-based nutrient supplement and iron and folic acid tablet consumption among pregnant and lactating women participating in a community health programme in northwest Bangladesh. Maternal & Child Nutrition 2017;13(1):e12252. [DOI: 10.1111/mcn.12252; NCT01715038; PUBMED: 26898720]9050791
33. Matias SL, Mridha MK, Paul RR, Hussain S, Vosti SA, Arnold CD, et al. Prenatal lipid-based nutrient supplements affect maternal anthropometric indicators only in certain subgroups of rural Bangladeshi women. Journal of Nutrition 2016;146(9):1775-82. [DOI: 10.3945/jn.116.232181; NCT01715038; PUBMED: 27440259]9050792
34. Matias SL, Mridha MK, Tofail F, Arnold CD, Khan MS, Siddiqui Z, et al. Home fortification during the first 1000 d improves child development in Bangladesh: a cluster-randomized effectiveness trial. American Journal of Clinical Nutrition 2017;105(4):958-69. [DOI: 10.3945/ajcn.116.150318; NCT01715038; PUBMED: 28275128]9050793
35. Mridha MK, Matias SL, Chaparro CM, Paul RR, Hussain S, Vosti SA, et al. Lipid-based nutrient supplements for pregnant women reduce newborn stunting in a cluster-randomized controlled effectiveness trial in Bangladesh. American Journal of Clinical Nutrition 2016;103(1):236-49. [DOI: 10.3945/ajcn.115.111336; NCT01715038; PUBMED: 26607935]9050794
36. Mridha MK, Matias SL, Khan SA, Paul RR, Siddiqui Z, Ullah B, et al. High prevalence of low urinary iodine among pregnant and lactating women of Bangladesh does not respond to daily lipid-based nutrient supplement containing 250 μg iodine. FASEB Journal 2016;30(1 Suppl):150.4. [www.fasebj.org/doi/abs/10.1096/fasebj.30.1_supplement.150.4]9050795
37. Mridha MK, Matias SL, Paul RR, Hussain S, Khan MS, Siddiqui Z, et al. Daily consumption of lipid-based nutrient supplements containing 250 μg iodine does not increase urinary iodine concentrations in pregnant and postpartum women in Bangladesh. Journal of Nutrition 2017;147(8):1586-92. [DOI: 10.3945/jn.117.248963; NCT01715038; PUBMED: 28615379]9050796
38. Mridha MK, Matias SL, Paul RR, Hussain S, Sarker M, Hossain M, et al. Prenatal lipid-based nutrient supplements do not affect pregnancy or childbirth complications or cesarean delivery in Bangladesh: a cluster-randomized controlled effectiveness trial. Journal of Nutrition 2017;147(9):1776-84. [DOI: 10.3945/jn.117.248880; NCT01715038; PUBMED: 28724657]9050797
39. Adams KP, Ayifah E, Phiri TE, Mridha MK, Adu-Afarwuah S, Arimond M, et al. Maternal and child supplementation with lipid-based nutrient supplements, but not child supplementation alone, decreases self-reported household food Insecurity in some settings. Journal of Nutrition 2017;147(12):2309-18. [DOI: 10.3945/jn.117.257386; NCT00945698; NCT00970866; NCT01239693; NCT01715038 ; PMC5697970; PUBMED: 28978680]9050799
40. Adams KP, Vosti SA, Ayifah E, Phiri TE, Adu-Afarwuah S, Maleta K, et al. Willingness to pay for small-quantity lipid-based nutrient supplements for women and children: evidence from Ghana and Malawi. Maternal & Child Nutrition 2018;14(2):e12518. [DOI: 10.1111/mcn.12518; PUBMED: 28960913]9050801
41. Flax VL, Bentley ME, Chasela CS, Kayira D, Hudgens MG, Knight RJ, et al. Use of lipid-based nutrient supplements by HIV-infected Malawian women during lactation has no effect on infant growth from 0 to 24 weeks. Journal of Nutrition 2012;142(7):1350-6. [DOI: 10.3945/jn.111.155598; NCT00164736; PMC3374670; PUBMED: 22649265]9050803
42. Flax VL, Bentley ME, Combs GF Jr, Chasela CS, Kayira D, Tegha G, et al. Plasma and breast-milk selenium in HIV-infected Malawian mothers are positively associated with infant selenium status but are not associated with maternal supplementation: results of the Breastfeeding, Antiretrovirals, and Nutrition study. American Journal of Clinical Nutrition 2014;99(4):950-6. [DOI: 10.3945/ajcn.113.073833; NCT00164736; PMC3953887; PUBMED: 24500152]9050805
43. Haber JA, Solomons NW, Hampel D, Orozco MN, Allen LH. The effect of maternal supplementation with a lipid-based nutrient supplement on infant micronutrient intake in Guatemalan women and infants. FASEB Journal 2016;30(1 Suppl):1150.3. [www.fasebj.org/doi/10.1096/fasebj.30.1_supplement.1150.3]9050807
44. Hampel D, Shahab-Ferdows S, Gertz E, Flax VL, Adair LS, Bentley ME, et al. The effects of a lipid-based nutrient supplement and antiretroviral therapy in a randomized controlled trial on iron, copper, and zinc in milk from HIV-infected Malawian mothers and associations with maternal and infant biomarkers. Maternal & Child Nutrition 2018;14(2):e12503. [DOI: 10.1111/mcn.12503; PMC5832511; PUBMED: 28851037]9050809
45. Johnson W, Darboe MK, Sosseh F, Nshe P, Prentice AM, Moore SE. Association of prenatal lipid-based nutritional supplementation with fetal growth in rural Gambia. Maternal & Child Nutrition 2017;13(2):e12367. [DOI: 10.1111/mcn.12367; PMC5396370; PUBMED: 27696720]9050811
46. Kayira D, Bentley ME, Wiener J, Mkhomawanthu C, King CC, Chitsulo P, et al. A lipid-based nutrient supplement mitigates weight loss among HIV-infected women in a factorial randomized trial to prevent mother-to-child transmission during exclusive breastfeeding. American Journal of Clinical Nutrition 2012;95(3):759-65. [DOI: 10.3945/ajcn.111.018812; NCT00164762; PMC3278250; PUBMED: 22258269]9050813
47. Oaks BM, Young RR, Adu-Afarwuah S, Ashorn U, Jackson KH, Lartey A, et al. Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: results of two randomized controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 2017;117:28-35. [DOI: 10.1016/j.plefa.2017.01.007; PMC5338685; PUBMED: 28237085]9050815
48. Prado EL, Abbeddou S, Adu-Afarwuah S, Arimond M, Ashorn P, Ashorn U, et al. Predictors and pathways of language and motor development in four prospective cohorts of young children in Ghana, Malawi, and Burkina Faso. Journal of Child Psychology and Psychiatry 2017;58(11):1264-75. [DOI: 10.1111/jcpp.12751; PMC5697619; PUBMED: 28543426]9050817
49. Schlossman N, Brown C, Batra P, de Sa AB, Balan I, Balan A, et al. A randomized controlled trial of two ready-to-use supplementary foods demonstrates benefit of the higher dairy supplement for reduced wasting in mothers, and differential impact in infants and children associated with maternal supplement response. Food and Nutrition Bulletin 2017;38(3):275-90. [DOI: 10.1177/0379572117700754; PUBMED: 28374648]9050819
50. Young S, Natamba B, Luwedde F, Nyafwono D, Okia B, Osterbauer B, et al. "I have remained strong because of that food": acceptability and use of lipid-based nutrient supplements among pregnant HIV-infected Ugandan women receiving combination antiretroviral therapy. AIDS and Behavior 2015;19(8):1535-47. [DOI: 10.1007/s10461-014-0947-0; NCT 00993031; PMC4441598; PUBMED: 25416075]9050821
51. Fernald LCH, Galasso E, Qamruddin J, Ranaivoson C, Ratsifandrihamanana L, Stewart CP, et al. A cluster-randomized, controlled trial of nutritional supplementation and promotion of responsive parenting in Madagascar: the MAHAY study design and rationale. BMC Public Health 2016;16:466. [DOI: 10.1186/s12889-016-3097-7; ISRCTN14393738; PMC4891833; PUBMED: 27255923]9050823
52. Adu-Afarwuah S, Lartey A, Zeilani M, Dewey KG. Acceptability of lipid-based nutrient supplements (LNS) among Ghanaian infants and pregnant or lactating women. Maternal & Child Nutrition 2011;7(4):344-56. [DOI: 10.1111/j.1740-8709.2010.00286.x; PUBMED: 21496207]
53. Arimond M, Zeilani M, Jungjohann S, Brown KH, Ashorn P, Allen LH, et al. Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project. Maternal & Child Nutrition 2015;11(Suppl 4):31-61. [DOI: 10.1111/mcn.12049; PUBMED: 23647784]
54. Balshem H, Helfanda M, Schünemann HJ, Oxman AD, Kunze R, Brozek J, et al. GRADE guidelines: 3. Rating the quality of evidence. Journal of Clinical Epidemiology 2011;64(4):401-6. [DOI: 10.1016/j.jclinepi.2010.07.015; PUBMED: 21208779]
55. Belkacemi L, Nelson DM, Desai M, Ross MG. Maternal undernutrition influences placental-fetal development. Biology of Reproduction 2010;83(3):325-31. [DOI: 10.1095/biolreprod.110.084517; PUBMED: 20445129]
56. Bhatnagar S, Taneja S. Zinc and cognitive development. British Journal of Nutrition 2001;85(Suppl 2):S139-S45. [DOI: 10.1079/BJN2000306; PUBMED: 11509102]
57. Bhutta ZA, Das JK, Rizvi A, Gaffey MF, Walker N, Horton S, et al. Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?. Lancet 2013;382(9890):452-77. [DOI: 10.1016/S0140-6736(13)60996-4; PUBMED: 23746776]
58. Black RE, Victoria CG, Walker SP, Bhutta ZA, Christian P, de Onis MD, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet 2013;382(9890):427-51. [DOI: 10.1016/S0140-6736(13)60937-X; PUBMED: 23746772]
59. Chaparro CM, Dewey KG. Use of lipid-based nutrient supplements (LNS) to improve the nutrient adequacy of general food distribution rations for vulnerable sub-groups in emergency settings. Maternal & Child Nutrition 2010;6(Suppl 1):1-69. [DOI: 10.1111/j.1740-8709.2009.00224.x; PUBMED: 20055936]
60. Clapp JF 3rd, Kiess W. Cord blood leptin reflects fetal fat mass. Journal of the Society for Gynecologic Investigation 1998;5(6):300-3. [PUBMED: 9824809]
61. Coletta JM, Bell SJ, Roman AS. Omega-3 fatty acids and pregnancy. Reviews in Obstetrics and Gynecology 2010;3(4):163-71. [PMC3046737; PUBMED: 21364848]
62. Das JK, Salam RA, Weise Prinzo Z, Sadiq Sheikh S, Bhutta ZA. Provision of preventive lipid-based nutrient supplements given with complementary foods to infants and young children 6 to 23 months of age for health, nutrition, and developmental outcomes. Cochrane Database of Systematic Reviews (in press).
63. De Souza AS, Fernandes FS, do Carmo MG. Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory. Nutrition Reviews 2011;69(3):132-44. [DOI: 10.1111/j.1753-4887.2011.00374.x; PUBMED: 21348877]
64. Deeks JJ, Higgins JPT, Altman DG, editor(s). Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.handbook.cochrane.org.
65. Dewey KG. Another iLiNS-ZINC paper [personal communication]. Email to: ZA Bhutta 04 February 2017.
66. Dewey KG. RE: preliminary results of LNS reviews [personal communication]. Email to: ZA Bhutta 14 November 2016.
67. Diop el HI, Dossou NI, Ndour MM, Briend A, Wade SC. Comparison of the efficacy of a solid ready-to-use food and a liquid, milk-based diet for the rehabilitation of severely malnourished children: a randomized trial. American Journal of Clinical Nutrition 2003;78(2):302-7. [DOI: 10.1093/ajcn/78.2.302; PUBMED: 12885713]
68. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629-34. [DOI: 10.1136/bmj.315.7109.629; PMC2127453; PUBMED: 9310563]
69. Food, Agriculture Organization of the United Nations (FAO). World Health Organization, United Nations University. Human Energy Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation. Rome, 17-24 October 2001. Food and Nutrition Technical Report Series. Vol. 1, Rome (IT): FAO, 2004.
70. Forhead AJ, Fowden AL. The hungry fetus? Role of leptin as a nutritional signal before birth. Journal of Physiology 2009;587(6):1145-52. [DOI: 10.1113/jphysiol.2008.167072; PMC2674987; PUBMED: 19188249]
71. McMaster University (developed by Evidence Prime). GRADEpro GDT. Version accessed 29 April 2016. Hamilton (ON): McMaster University (developed by Evidence Prime), 2015.
72. Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database of Systematic Reviews 2017, Issue 4. [DOI: 10.1002/14651858.CD004905.pub5]
73. Harbord RM, Egger M, Sterne JA. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Statistics in Medicine 2006;25(20):3443-57. [DOI: 10.1002/sim.2380; PUBMED: 16345038]
74. Harder T, Rodekamp E, Schellong K, Dudenhausen JW, Plagemann A. Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. American Journal of Epidemiology 2007;165(8):849-57. [DOI: 10.1093/aje/kwk071; PUBMED: 17215379]
75. Harding KL, Matias Sl, Moniruzzaman M, Stewart CP, Mridha MK, Vosti SA, et al. Rang-Din Nutrition Study: Assessment of Participant Adherence to Lipid-Based Nutrient and Iron-Folic Acid Supplements among Pregnant and Lactating Women in the Context of a Study on the Effectiveness of Supplements in Bangladesh. Washington (DC): FHI 360/FANTA, 2014.
76. Higgins JPT, Altman DG, Sterne JAC, editor(s). Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
77. Higgins JPT, Deeks JJ, Altman DG, editor(s). Chapter 16: Special topics in statistics. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
78. Huybregts L, Roberfroid D, Lanou H, Meda N, Taes Y, Valea I, et al. Prenatal lipid-based nutrient supplements increase cord leptin concentration in pregnant women from rural Burkina Faso. Journal of Nutrition 2013;143(5):576-83. [DOI: 10.3945/jn.112.171181; NCT00909974; PUBMED: 23535609]
79. Iannotti LL, Dulience SJL, Green J, Joseph S, François J, Anténor M-L, et al. Linear growth increased in young children in an urban slum of Haiti: a randomized controlled trial of a lipid-based nutrient supplement. American Journal of Clinical Nutrition 2014;99(1):198-208. [DOI: 10.3945/ajcn.113.063883; NCT01552512; PMC3862455; PUBMED: 24225356]
80. Inter-Agency Standing Committee. Definition of complex emergencies. interagencystandingcommittee.org/system/files/legacy_files/WG16_4.pdf (accessed prior to 16 March 2017).
81. UC Davis. iLiNS Project. ilins.ucdavis.edu (accessed 12 January 2016).
82. Imdad A, Bhutta ZA. Effect of balanced protein energy supplementation during pregnancy on birth outcomes. BMC Public Health 2011;11(Suppl 3):S17. [DOI: 10.1186/1471-2458-11-S3-S17; PMC3231890; PUBMED: 21501434]
83. Lanou H, Huybregts L, Roberfroid D, Nikièma L, Kouanda S, Van Camp J, et al. Prenatal nutrient supplementation and postnatal growth in a developing nation: an RCT. Pediatrics 2014;133(4):e1001-8. [DOI: 10.1542/peds.2013-2850; NCT00909974; PUBMED: 24590752]
84. Larroque B, Bertrais S, Czernichow P, Léger J. School difficulties in 20-year-olds who were born small for gestational age at term in a regional cohort study. Pediatrics 2001;108(1):111-5. [PUBMED: 11433062]
85. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
86. Lepercq J, Challier JC, Guerre-Millo M, Cauzac M, Vidal H, Hauguel-De Mouzon S. Prenatal leptin production: evidence that fetal adipose tissue produces leptin. Journal of Clinical Endocrinology & Metabolism 2001;86(6):2409-13. [DOI: 10.1210/jcem.86.6.7529; PUBMED: 11397832]
87. Lozoff B, Georgieff MK. Iron deficiency and brain development. Seminars in Pediatric Neurology 2006;13(3):158-65. [DOI: 10.1016/j.spen.2006.08.004; PUBMED: 17101454]
88. Makrides M, Duley L, Olsen SF. Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction. Cochrane Database of Systematic Reviews 2006, Issue 3. [DOI: 10.1002/14651858.CD003402.pub2]
89. Moher D, Liberati A, Tetzlaff J, Altman DG, for the PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009;339:b2535. [DOI: 10.1136/bmj.b2535]
90. Moran VH. Free access issue of MCN now available: policy, program and innovation in complementary feeding [personal communication]. Email to: ZA Bhutta 11 January 2016.
91. Mridha MK, Chaparro CM, Matias SL, Hussain S, Munira S, Saha S, et al. Acceptability of Lipid-Based Nutrient Supplements and Micronutrient Powders among Pregnant and Lactating Women and Infants and Young Children in Bangladesh and Their Perceptions about Malnutrition and Nutrient Supplements. Washington (DC): FHI 360/FANTA-2 Bridge, 2012.
92. Mridha MK, Matias SL, Chaparro CM, Paul RR, Hussain S, Vosti SA, et al. Lipid-based nutrient supplements for pregnant women reduce newborn stunting in a cluster-randomized controlled effectiveness trial in Bangladesh. American Journal of Clinical Nutrition 2016;103(1):236-49. [DOI: 10.3945/ajcn.115.111336; NCT01715038; PUBMED: 26607935]
93. Nkhoma M, Ashorn P, Ashorn U, Dewey KG, Gondwe A, Mbotwa J, et al. Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial. BMC Pregnancy & Childbirth 2017;17:35. [DOI: 10.1186/s12884-016-1215-2; PMC5240436; PUBMED: 28095801]
94. Nyaradi A, Li J, Hickling S, Foster J, Oddy WH. The role of nutrition in children's neurocognitive development, from pregnancy through childhood. Frontiers in Human Neuroscience 2013;7:97. [DOI: 10.3389/fnhum.2013.00097; PMC3607807; PUBMED: 23532379]
95. Ota E, Mori R, Middleton P, Tobe-Gai R, Mahomed K, Miyazaki C, et al. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database of Systematic Reviews 2015, Issue 2. [DOI: 10.1002/14651858.CD000230.pub5]
96. Ota E, Hori H, Mori R, Tobe-Gai R, Farrar D. Antenatal dietary education and supplementation to increase energy and protein intake. Cochrane Database of Systematic Reviews 2015, Issue 6. [DOI: 10.1002/14651858.CD000032.pub3]
97. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem?. Journal of Steroid Biochemistry and Molecular Biology 2014;144(Pt A):138-45. [DOI: 10.1016/j.jsbmb.2013.11.003; NIHMS541186; PMC4018438; PUBMED: 24239505]
98. Phuka JC, Maleta K, Thakwalakwa C, Cheung YB, Briend A, Manary MJ, et al. Complementary feeding with fortified spread and incidence of severe stunting in 6- to 18-month-old rural Malawians. Archives of Pediatrics & Adolescent Medicine 2008;162(7):619-26. [DOI: 10.1001/archpedi.162.7.619; NCT00131209; PMC3721756; PUBMED: 18606932]
99. Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager 5 (RevMan 5). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
100. Risnes KR, Vatten LJ, Baker JL, Jameson K, Sovio U, Kajantie E, et al. Birthweight and mortality in adulthood: a systematic review and meta-analysis. International Journal of Epidemiology 2011;40(3):647-61. [DOI: 10.1093/ije/dyq267; PUBMED: 21324938]
101. Schofield D, Huffman SL, Young Child Nutrition Working Group: Formulation Subgroup. Formulations for fortified complementary foods and supplements: review of successful products for improving the nutritional status of infants and young children. Food and Nutrition Bulletin 2009;30(2):S239-55. [PUBMED: 20496618]
102. Shenkin SD, Starr JM, Deary IJ. Birthweight and cognitive ability in childhood: a systematic review. Psychological Bulletin 2004;130(6):989-1013. [DOI: 10.1037/0033-2909.130.6.989; PUBMED: 15535745]
103. Stewart CP. RE: [personal communication]. Email to: ZA Bhutta 27 April 2017.
104. Thakwalakwa C, Ashorn P, Phuka J, Cheung YB, Briend A, Puumalainen T, et al. A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6- to 18-month-old moderately underweight children in rural Malawi. Journal of Nutrition 2010;140(11):2008-13. [DOI: 10.3945/jn.110.122499; NCT00420368; PUBMED: 20861218]
105. UNICEF. Humanitarian action for children 2014: overview. www.unicef.org/gambia/Humanitarian_Action_for_Childen_2014_Overview.pdf (accessed 22 November 2015).
106. Vosti S, Humber J, Phiri T, Ashorn P, Maleta K, Dewey K. The cost of home delivery schemes for lipid-based nutrient supplement products: a policy experiment from rural Malawi. European Journal of Nutrition & Food Safety 2015;5(5):1053-4. [DOI: 10.9734/EJNFS/2015/21238]
107. World Health Organization (WHO), World Food Programme (WFP), United Nations System Standing Committe on Nutrition (UNSSCN), United Nations Children's Fund (UNICEF). Community-Based Management of Severe Acute Malnutrition: A Joint Statement by the World Health Organization, the World Food Programme, the United Nations System Standing Committee on Nutrition and the United Nations Children's Fund. Geneva: WHO; WFP; UNSSCN; UNICEF, 2007.
108. World Health Organization (WHO). Supplementary Foods for the Management of Moderate Acute Malnutrition in Infants and Children 6-59 Months of Age: Technical Note. Geneva: WHO, 2012.
109. World Health Organization (WHO). Guideline: Updates on the Management of Severe Acute Malnutrition in Infants and Children. Geneva: WHO, 2013.
110. World Health Organization (WHO). Global Nutrition Targets 2025: Low Birth Weight Policy Brief. Geneva: WHO, 2014.
111. World Health Organization (WHO). The Global Prevalence of Anaemia in 2011. Geneva: WHO, 2015.
112. World Health Organization (WHO). Use of Multiple Micronutrient Powders for Point-Of-Use Fortification of Foods Consumed by Pregnant Women. Geneva: WHO, 2016.
113. Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annual Review of Nutrition 2006;26:229-50. [DOI: 10.1146/annurev.nutr.26.061505.111156; NIHMS50836; PMC2441939; PUBMED: 16848706]
114. Zimmermann MB. The role of iodine in human growth and development. Seminars in Cell & Developmental Biology 2011;22(6):645-52. [DOI: 10.1016/j.semcdb.2011.07.009; PUBMED: 21802524]
115. Das JK, Salam RA, Weise Prinzo Z, Hoodbhoy Z, Bhutta ZA. Lipid-based nutrient supplements for pregnant women and their impact on pregnancy, birth, and infant developmental outcomes in stable and emergency settings. Cochrane Database of Systematic Reviews 2017, Issue 3. [DOI: 10.1002/14651858.CD012610]