메뉴 건너뛰기




Volumn 13, Issue 2, 2017, Pages

Impact of small-quantity lipid-based nutrient supplement on hemoglobin, iron status and biomarkers of inflammation in pregnant Ghanaian women

Author keywords

hemoglobin; inflammation; iron status; lipid based nutrient supplements; LNS; multiple micronutrients; prenatal supplementation

Indexed keywords

ALPHA1 GLYCOPROTEIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; HEMOGLOBIN; PROTOPORPHYRIN ZINC; TRANSFERRIN RECEPTOR; FOLIC ACID; IRON; PROTOPORPHYRIN; TRACE ELEMENT;

EID: 84959280094     PISSN: 17408695     EISSN: 17408709     Source Type: Journal    
DOI: 10.1111/mcn.12262     Document Type: Article
Times cited : (34)

References (62)
  • 2
    • 0034058648 scopus 로고    scopus 로고
    • Anemia and iron deficiency: effects on pregnancy outcome
    • Allen L.H. (2000) Anemia and iron deficiency: effects on pregnancy outcome. The American Journal of Clinical Nutrition 71, 1280S–1284S.
    • (2000) The American Journal of Clinical Nutrition , vol.71 , pp. 1280S-1284S
    • Allen, L.H.1
  • 3
    • 76749140533 scopus 로고    scopus 로고
    • Impact of multiple micronutrient versus iron-folic acid supplements on maternal anemia and micronutrient status in pregnancy
    • Allen L.H. & Peerson J.M. (2009) Impact of multiple micronutrient versus iron-folic acid supplements on maternal anemia and micronutrient status in pregnancy. Food and Nutrition Bulletin 30, S527–532.
    • (2009) Food and Nutrition Bulletin , vol.30 , pp. S527-532
    • Allen, L.H.1    Peerson, J.M.2
  • 4
    • 84954025585 scopus 로고    scopus 로고
    • Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project
    • Arimond M., Zeilani M., Jungjohann S., Brown K.H., Ashorn P., Allen L.H. et al. (2013) Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project. Maternal & Child Nutrition.
    • (2013) Maternal & Child Nutrition
    • Arimond, M.1    Zeilani, M.2    Jungjohann, S.3    Brown, K.H.4    Ashorn, P.5    Allen, L.H.6
  • 7
    • 24344480903 scopus 로고    scopus 로고
    • Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects
    • Brighenti F., Valtuena S., Pellegrini N., Ardigo D., Del Rio D., Salvatore S. et al. (2005) Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects. The British Journal of Nutrition 93, 619–625.
    • (2005) The British Journal of Nutrition , vol.93 , pp. 619-625
    • Brighenti, F.1    Valtuena, S.2    Pellegrini, N.3    Ardigo, D.4    Del Rio, D.5    Salvatore, S.6
  • 9
    • 0242661847 scopus 로고    scopus 로고
    • Supplementation with micronutrients in addition to iron and folic acid does not further improve the hematologic status of pregnant women in rural Nepal
    • Christian P., Shrestha J., LeClerq S.C., Khatry S.K., Jiang T., Wagner T. et al. (2003) Supplementation with micronutrients in addition to iron and folic acid does not further improve the hematologic status of pregnant women in rural Nepal. The Journal of Nutrition 133, 3492–3498.
    • (2003) The Journal of Nutrition , vol.133 , pp. 3492-3498
    • Christian, P.1    Shrestha, J.2    LeClerq, S.C.3    Khatry, S.K.4    Jiang, T.5    Wagner, T.6
  • 12
    • 0034667579 scopus 로고    scopus 로고
    • Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients
    • Devaraj S. & Jialal I. (2000) Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. Journal of Free Radicals in Biology & Medicine 29, 790–792.
    • (2000) Journal of Free Radicals in Biology & Medicine , vol.29 , pp. 790-792
    • Devaraj, S.1    Jialal, I.2
  • 13
    • 33745865210 scopus 로고    scopus 로고
    • Anti-inflammatory interventions in pregnancy: now and the future
    • Elovitz M.A. (2006) Anti-inflammatory interventions in pregnancy: now and the future. Seminars in Fetal & Neonatal Medicine 11, 327–332.
    • (2006) Seminars in Fetal & Neonatal Medicine , vol.11 , pp. 327-332
    • Elovitz, M.A.1
  • 14
    • 76749108130 scopus 로고    scopus 로고
    • Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation
    • Fall C.H., Fisher D.J., Osmond C. & Margetts B.M. (2009) Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation. Food and Nutrition Bulletin 30, S533–546.
    • (2009) Food and Nutrition Bulletin , vol.30 , pp. S533-546
    • Fall, C.H.1    Fisher, D.J.2    Osmond, C.3    Margetts, B.M.4
  • 15
    • 0035849580 scopus 로고    scopus 로고
    • Low circulating vitamin B6 is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels
    • Friso S., Jacques P.F., Wilson P.W.F., Rosenberg I.H. & Selhub J. (2001) Low circulating vitamin B6 is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circulation 103, 2788–2791.
    • (2001) Circulation , vol.103 , pp. 2788-2791
    • Friso, S.1    Jacques, P.F.2    Wilson, P.W.F.3    Rosenberg, I.H.4    Selhub, J.5
  • 17
    • 77955044889 scopus 로고    scopus 로고
    • GSS, GHSICF Macro, Accra, Ghana
    • Ghana Statistical Service (GSS), Ghana Health Service (GHS) & ICF Macro (2009) Ghana Demographic and Health Survey 2008. GSS, GHS, and ICF Macro: Accra, Ghana.
    • (2009) Ghana Demographic and Health Survey 2008
  • 18
    • 0028250090 scopus 로고
    • Zinc nutrition in developing countries
    • Gibson R.S. (1994) Zinc nutrition in developing countries. NutrItion Research Reviews 7, 151–173.
    • (1994) NutrItion Research Reviews , vol.7 , pp. 151-173
    • Gibson, R.S.1
  • 21
    • 79954474456 scopus 로고    scopus 로고
    • Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes
    • Haider B.A., Yakoob M.Y. & Bhutta Z.A. (2011) Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes. BMC Public Health 11 (Suppl 3), S19.
    • (2011) BMC Public Health , vol.11 , pp. S19
    • Haider, B.A.1    Yakoob, M.Y.2    Bhutta, Z.A.3
  • 22
    • 84880093829 scopus 로고    scopus 로고
    • Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis
    • Haider B.A., Olofin I., Wang M., Spiegelman D., Ezzati M., Fawzi W.W. et al. (2013) Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ 346, f3443.
    • (2013) BMJ , vol.346 , pp. f3443
    • Haider, B.A.1    Olofin, I.2    Wang, M.3    Spiegelman, D.4    Ezzati, M.5    Fawzi, W.W.6
  • 24
    • 84863113742 scopus 로고    scopus 로고
    • Routine iron/folate supplementation during pregnancy: effect on maternal anaemia and birth outcomes
    • Imdad A. & Bhutta Z.A. (2012) Routine iron/folate supplementation during pregnancy: effect on maternal anaemia and birth outcomes. Paediatric and Perinatal Epidemiology 26 (Suppl 1), 168–177.
    • (2012) Paediatric and Perinatal Epidemiology , vol.26 , pp. 168-177
    • Imdad, A.1    Bhutta, Z.A.2
  • 25
    • 85016384305 scopus 로고    scopus 로고
    • Why is iron important and what to do about it a new perspective. Washington, DC, INACG Secretariat
    • International Anemia Consultative Group (INACG) (2002) Report of the 2001 International Anemia Consultative Group Symposium. Why is iron important and what to do about it: a new perspective. Washington, DC, INACG Secretariat.
    • (2002) Report of the 2001 International Anemia Consultative Group Symposium
  • 27
    • 31044446363 scopus 로고    scopus 로고
    • Effects of prenatal multimicronutrient supplements on birth weight and perinatal mortality: a randomised, controlled trial in Guinea-Bissau
    • Kaestel P., Michaelsen K.F., Aaby P. & Friis H. (2005) Effects of prenatal multimicronutrient supplements on birth weight and perinatal mortality: a randomised, controlled trial in Guinea-Bissau. The European Journal of Clinical Nutrition 59, 1081–1089.
    • (2005) The European Journal of Clinical Nutrition , vol.59 , pp. 1081-1089
    • Kaestel, P.1    Michaelsen, K.F.2    Aaby, P.3    Friis, H.4
  • 28
    • 0037995258 scopus 로고    scopus 로고
    • A micronutrient-fortified beverage prevents iron deficiency, reduces anemia and improves the hemoglobin concentration of pregnant Tanzanian women
    • Makola D., Ash D.M., Tatala S.R., Latham M.C., Ndossi G. & Mehansho H. (2003) A micronutrient-fortified beverage prevents iron deficiency, reduces anemia and improves the hemoglobin concentration of pregnant Tanzanian women. The Journal of Nutrition 133, 1339–1346.
    • (2003) The Journal of Nutrition , vol.133 , pp. 1339-1346
    • Makola, D.1    Ash, D.M.2    Tatala, S.R.3    Latham, M.C.4    Ndossi, G.5    Mehansho, H.6
  • 29
    • 84901329496 scopus 로고    scopus 로고
    • Iron-containing micronutrient supplementation of Chinese women with no or mild anemia during pregnancy improved iron status but did not affect perinatal anemia
    • Mei Z., Serdula M.K., Liu J.M., Flores-Ayala R.C., Wang L., Ye R. et al. (2014) Iron-containing micronutrient supplementation of Chinese women with no or mild anemia during pregnancy improved iron status but did not affect perinatal anemia. The Journal of Nutrition 144, 943–948.
    • (2014) The Journal of Nutrition , vol.144 , pp. 943-948
    • Mei, Z.1    Serdula, M.K.2    Liu, J.M.3    Flores-Ayala, R.C.4    Wang, L.5    Ye, R.6
  • 30
    • 79952237035 scopus 로고    scopus 로고
    • Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6–24 months), and pregnant and lactating women
    • Michaelsen K.F., Dewey K.G., Perez-Exposito A.B., Nurhasan M., Lauritzen L. & Roos N. (2011) Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6–24 months), and pregnant and lactating women. Maternal & Child Nutrition 7 (Suppl 2), 124–140.
    • (2011) Maternal & Child Nutrition , vol.7 , pp. 124-140
    • Michaelsen, K.F.1    Dewey, K.G.2    Perez-Exposito, A.B.3    Nurhasan, M.4    Lauritzen, L.5    Roos, N.6
  • 32
    • 0022602844 scopus 로고
    • Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy
    • Murphy J.F., O'Riordan J., Newcombe R.G., Coles E.C. & Pearson J.F. (1986) Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet 1, 992–995.
    • (1986) Lancet , vol.1 , pp. 992-995
    • Murphy, J.F.1    O'Riordan, J.2    Newcombe, R.G.3    Coles, E.C.4    Pearson, J.F.5
  • 33
    • 0942287451 scopus 로고    scopus 로고
    • INACG, Washington, DC [cited 2014-Jan 10]. Available from
    • Nestel P. & INACG Steering Committee (2002) Adjusting hemoglobin values in program surveys [Internet]. INACG, Washington, DC [cited 2014-Jan 10]. Available from: http://pdf.usaid.gov/pdf_docs/PNACQ927.pdf.
    • (2002) Adjusting hemoglobin values in program surveys [Internet]
    • Nestel, P.1
  • 38
    • 0038463560 scopus 로고    scopus 로고
    • Dietary α-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients
    • Rallidis L.S., Paschos G., Liakos G.K., Velissaridou A.H., Anastasiadis G. & Zampelas A. (2003) Dietary α-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 167, 237–242.
    • (2003) Atherosclerosis , vol.167 , pp. 237-242
    • Rallidis, L.S.1    Paschos, G.2    Liakos, G.K.3    Velissaridou, A.H.4    Anastasiadis, G.5    Zampelas, A.6
  • 39
    • 1842582871 scopus 로고    scopus 로고
    • Multiple micronutrient supplements during pregnancy do not reduce anemia or improve iron status compared to iron-only supplements in Semirural Mexico
    • Ramakrishnan U., Neufeld L.M., Gonzalez-Cossio T., Villalpando S., Garcia-Guerra A., Rivera J. et al. (2004) Multiple micronutrient supplements during pregnancy do not reduce anemia or improve iron status compared to iron-only supplements in Semirural Mexico. The Journal of Nutrition 134, 898–903.
    • (2004) The Journal of Nutrition , vol.134 , pp. 898-903
    • Ramakrishnan, U.1    Neufeld, L.M.2    Gonzalez-Cossio, T.3    Villalpando, S.4    Garcia-Guerra, A.5    Rivera, J.6
  • 42
    • 85016375021 scopus 로고    scopus 로고
    • REFINE. Boston, MA. [cited 2015 Jun 23]. Available from
    • Research Engagement on Food Innovation for Nutritional Effectiveness (REFINE) (2013) Ongoing studies using Lipid Based Nutrient Supplement (LNS) [Internet]. REFINE. Boston, MA. [cited 2015 Jun 23]. Available from: http://refinenutrition.org/research/REFINE-product-LNS.pdf.
    • (2013) Ongoing studies using Lipid Based Nutrient Supplement (LNS) [Internet]
  • 43
    • 79955422387 scopus 로고    scopus 로고
    • Randomized controlled trial of 2 prenatal iron supplements: is there a dose–response relation with maternal hemoglobin?
    • Roberfroid D., Huybregts L., Habicht J.P., Lanou H., Henry M.C., Meda N. et al. (2011) Randomized controlled trial of 2 prenatal iron supplements: is there a dose–response relation with maternal hemoglobin? The American Journal of Clinical Nutrition 93, 1012–1018.
    • (2011) The American Journal of Clinical Nutrition , vol.93 , pp. 1012-1018
    • Roberfroid, D.1    Huybregts, L.2    Habicht, J.P.3    Lanou, H.4    Henry, M.C.5    Meda, N.6
  • 45
    • 0031825025 scopus 로고    scopus 로고
    • Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis
    • Sacks G.P., Studena K., Sargent I.L. & Redman C.W.G. (1998) Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. American Journal of Obstetrics and Gynecology 179, 80–86.
    • (1998) American Journal of Obstetrics and Gynecology , vol.179 , pp. 80-86
    • Sacks, G.P.1    Studena, K.2    Sargent, I.L.3    Redman, C.W.G.4
  • 46
    • 24144458327 scopus 로고    scopus 로고
    • Easy SAS calculations for risk or prevalence ratios and differences
    • Spiegelman D. & Hertzmark E. (2005) Easy SAS calculations for risk or prevalence ratios and differences. American Journal of Epidemiology 162, 199–200.
    • (2005) American Journal of Epidemiology , vol.162 , pp. 199-200
    • Spiegelman, D.1    Hertzmark, E.2
  • 47
    • 0028957967 scopus 로고
    • Relation between maternal haemoglobin concentration and birth weight in different ethnic groups
    • Steer P., Alam M.A., Wadsworth J. & Welch A. (1995) Relation between maternal haemoglobin concentration and birth weight in different ethnic groups. BMJ 310, 489–491.
    • (1995) BMJ , vol.310 , pp. 489-491
    • Steer, P.1    Alam, M.A.2    Wadsworth, J.3    Welch, A.4
  • 48
    • 0036455001 scopus 로고    scopus 로고
    • Effect of low-dosage vitamin A and riboflavin on iron-folate supplementation in anaemic pregnant women
    • Suprapto B., Widardo & Suhanantyo (2002) Effect of low-dosage vitamin A and riboflavin on iron-folate supplementation in anaemic pregnant women. Asia Pacific Journal Clinical Nutrition 11, 263–267.
    • (2002) Asia Pacific Journal Clinical Nutrition , vol.11 , pp. 263-267
    • Suprapto, B.1    Widardo2    Suhanantyo3
  • 49
    • 0031781647 scopus 로고    scopus 로고
    • Low dietary iron availability is a major cause of anemia: a nutrition survey in the Lindi District of Tanzania
    • Tatala S., Svanberg U. & Mduma B. (1998) Low dietary iron availability is a major cause of anemia: a nutrition survey in the Lindi District of Tanzania. The American Journal of Clinical Nutrition 68, 171–178.
    • (1998) The American Journal of Clinical Nutrition , vol.68 , pp. 171-178
    • Tatala, S.1    Svanberg, U.2    Mduma, B.3
  • 50
    • 84883410937 scopus 로고    scopus 로고
    • Report Priorities in the assessment of vitamin A and iron status in populations, Panama City, Panama, 15–17 September 2010 [Internet]. World Health Organization, Geneva [cited 2014 Nov 14]. Available from
    • Thurnham D.I. & McCabe G.P. (2012) Influence of infection and inflammation on biomarkers of nutritional status with an emphasis on vitamin A and iron. In: World Health Organization. Report: Priorities in the assessment of vitamin A and iron status in populations, Panama City, Panama, 15–17 September 2010 [Internet]. World Health Organization, Geneva [cited 2014 Nov 14]. Available from: http://www.who.int/nutrition/publications/micronutrients/background_paper4_report_assessment_vitAandIron_status.pdf.
    • (2012) Influence of infection and inflammation on biomarkers of nutritional status with an emphasis on vitamin A and iron. In: World Health Organization
    • Thurnham, D.I.1    McCabe, G.P.2
  • 55
    • 84856476213 scopus 로고    scopus 로고
    • Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization (WHO/NMH/NHD/MNM/11.1) [cited 2015 Oct 21]. Available from
    • WHO (2011) Hemoglobin concentrations for the diagnosis of anemia and assessment of severity [Internet]. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization (WHO/NMH/NHD/MNM/11.1) [cited 2015 Oct 21]. Available from: http://www.who.int/vmnis/indicators/haemoglobin.pdf.
    • (2011) Hemoglobin concentrations for the diagnosis of anemia and assessment of severity [Internet]
  • 56
    • 85016358713 scopus 로고    scopus 로고
    • World Health Organization, Geneva;, [cited 2014 Jul 13]. Available from
    • WHO (2012) Guideline: Daily iron and folic acid supplementation in pregnant women [Internet]. World Health Organization, Geneva; 2012 [cited 2014 Jul 13]. Available from: http://apps.who.int/iris/bitstream/10665/77770/1/9789241501996_eng.pdf?ua=1.
    • (2001) Guideline: Daily iron and folic acid supplementation in pregnant women [Internet]
  • 60
    • 0033923227 scopus 로고    scopus 로고
    • Significance of an abnormally low or high hemoglobin concentration during pregnancy: special consideration of iron nutrition
    • Yip R. (2000) Significance of an abnormally low or high hemoglobin concentration during pregnancy: special consideration of iron nutrition. The American Journal of Clinical Nutrition 72, 272S–279S.
    • (2000) The American Journal of Clinical Nutrition , vol.72 , pp. 272S-279S
    • Yip, R.1
  • 61
    • 0032533576 scopus 로고    scopus 로고
    • Relation of hemoglobin measured at different times in pregnancy to preterm birth and low birth weight in Shanghai, China
    • Zhou L.-M., Yang W.-W., Hua J.-Z., Deng C.-Q., Tao X. & Stoltzfus R.J. (1998) Relation of hemoglobin measured at different times in pregnancy to preterm birth and low birth weight in Shanghai, China. American Journal of Epidemiology 148, 998–1006.
    • (1998) American Journal of Epidemiology , vol.148 , pp. 998-1006
    • Zhou, L.-M.1    Yang, W.-W.2    Hua, J.-Z.3    Deng, C.-Q.4    Tao, X.5    Stoltzfus, R.J.6
  • 62
    • 59849120858 scopus 로고    scopus 로고
    • Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose–response trial
    • Zhou S.J., Gibson R.A., Crowther C.A. & Makrides M. (2009) Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose–response trial. European Journal of Clinical Nutrition 63, 183–190.
    • (2009) European Journal of Clinical Nutrition , vol.63 , pp. 183-190
    • Zhou, S.J.1    Gibson, R.A.2    Crowther, C.A.3    Makrides, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.