Boerhaavia diffusa inhibits key enzymes linked to type 2 diabetes in vitro and in silico; and modulates abdominal glucose absorption and muscle glucose uptake ex vivo

Biomedicine and Pharmacotherapy

Volumn 106, Issue , 2018, Pages 1116-1125

  Oyebode, Olajumoke A ^a   Erukainure, Ochuko L ^a   Chukwuma, Chika I ^a,b   Ibeji, Collins U ^c   Koorbanally, Neil A ^a   Islam, Shahidul ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF THE FREE STATE   (South Africa)

^c UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Antioxidant; Boerhaavia diffusa; Enzyme inhibition; Glucose absorption; Glucose uptake

Indexed keywords

ACARBOSE; ACETIC ACID ETHYL ESTER; ALCOHOL; ALPHA GLUCOSIDASE; ASCORBIC ACID; BOERHAAVIA DIFFUSA EXTRACT; CATALASE; GLUCOSE; GLUTATHIONE; MALONALDEHYDE; METFORMIN; STIGMASTEROL; SUPEROXIDE DISMUTASE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL LIPASE; TROLOX C; XANTHENE; ACETIC ACID; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; ANTIOXIDANT; BIOLOGICAL MARKER; ENZYME INHIBITOR; GLYCOSIDASE INHIBITOR; PLANT EXTRACT; SOLVENT; WATER;

ABDOMEN; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BOERHAVIA DIFFUSA; COMPUTER MODEL; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; ENZYME INHIBITION; FERRIC REDUCING ANTIOXIDANT POWER ASSAY; GLUCOSE ABSORPTION; GLUCOSE INTAKE; GLUCOSE TRANSPORT; IN VITRO STUDY; JEJUNUM; MALE; MASS FRAGMENTOGRAPHY; MUSCLE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS INJURY; PRIORITY JOURNAL; RAT; AERIAL PLANT PART; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; GLUCOSE BLOOD LEVEL; INTESTINE ABSORPTION; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; MOLECULAR DOCKING; NYCTAGINACEAE; OXIDATIVE STRESS; PANCREAS; PHYTOTHERAPY; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ACETATES; ANIMALS; ANTI-OBESITY AGENTS; ANTIOXIDANTS; BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHANOL; GLYCOSIDE HYDROLASE INHIBITORS; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; JEJUNUM; LIPASE; MALE; MODELS, BIOLOGICAL; MOLECULAR DOCKING SIMULATION; MUSCLE, SKELETAL; NYCTAGINACEAE; OXIDATIVE STRESS; PANCREAS; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS, SPRAGUE-DAWLEY; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 85049930192     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2018.07.053     Document Type: Article

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