The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Röder, Pia V ^a   Geillinger, Kerstin E ^a   Zietek, Tamara S ^a   Thorens, Bernard ^b   Koepsell, Hermann ^c   Daniel, Hannelore ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLUCOSE TRANSPORTER 2; INCRETIN; INSULIN; SODIUM GLUCOSE COTRANSPORTER 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONTROLLED STUDY; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE SENSING; GLUCOSE TRANSPORT; HORMONE DETERMINATION; IMMUNOFLUORESCENCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INTESTINE ABSORPTION; INTESTINE BRUSH BORDER; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; SMALL INTESTINE; WESTERN BLOTTING;

ANIMALS; BLOOD GLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; INCRETINS; INSULIN; INTESTINAL ABSORPTION; INTESTINES; MICE; SODIUM-GLUCOSE TRANSPORTER 1;

EID: 84896386182     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089977     Document Type: Article

References (35)

1. Hu FB (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 34: 1249-1257.
2. Wright EM, Loo DD, Hirayama BA (2011) Biology of human sodium glucose transporters. Physiol Rev 91: 733-794.
3. Yoshikawa T, Inoue R, Matsumoto M, Yajima T, Ushida K, et al. (2011) Comparative expression of hexose transporters (SGLT1, GLUT1, GLUT2 and GLUT5) throughout the mouse gastrointestinal tract. Histochem Cell Biol 135: 183-194.
4. Wolffram S, Block M, Ader P (2002) Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine. J Nutr 132: 630-635. (Pubitemid 34275059)
5. Gorboulev V, Schurmann A, Vallon V, Kipp H, Jaschke A, et al. (2012) Na(+)- D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 61: 187-196.
6. Mueckler M (1994) Facilitative glucose transporters. Eur J Biochem 219: 713-725.
7. Wertheimer E (1934) Phloridzinwirkung auf die Zuckerresorption. Pflüger's Archiv für die gesamte Physiologie des Menschen und der Tiere 233: 514-528.
8. Debnam ES, Levin RJ (1975) An experimental method of identifying and quantifying the active transfer electrogenic component from the diffusive component during sugar absorption measured in vivo. J Physiol 246: 181-196.
9. Fullerton PM, Parsons DS (1956) The absorption of sugars and water from rat intestine in vivo . Experimental Physiology 41: 387-397.
10. Hediger MA, Coady MJ, Ikeda TS, Wright EM (1987) Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature 330: 379-381. (Pubitemid 18045465)
11. Pappenheimer JR, Reiss KZ (1987) Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J Membr Biol 100: 123-136. (Pubitemid 18004070)
12. Au A, Gupta A, Schembri P, Cheeseman CI (2002) Rapid insertion of GLUT2 into the rat jejunal brush-border membrane promoted by glucagon-like peptide 2. Biochem J 367: 247-254. (Pubitemid 35176912)
13. Chaudhry RM, Scow JS, Madhavan S, Duenes JA, Sarr MG (2012) Acute enterocyte adaptation to luminal glucose: a posttranslational mechanism for rapid apical recruitment of the transporter GLUT2. J Gastrointest Surg 16: 312-319; discussion 319.
14. Mace OJ, Affleck J, Patel N, Kellett GL (2007) Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol 582: 379-392. (Pubitemid 46993582)
15. Mace OJ, Morgan EL, Affleck JA, Lister N, Kellett GL (2007) Calcium absorption by Cav1.3 induces terminal web myosin II phosphorylation and apical GLUT2 insertion in rat intestine. J Physiol 580: 605-616. (Pubitemid 46564185)
16. Morgan EL, Mace OJ, Affleck J, Kellett GL (2007) Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. J Physiol 580: 593-604. (Pubitemid 46564184)
17. Shepherd EJ, Helliwell PA, Mace OJ, Morgan EL, Patel N, et al. (2004) Stress and glucocorticoid inhibit apical GLUT2-trafficking and intestinal glucose absorption in rat small intestine. J Physiol 560: 281-290. (Pubitemid 39406032)
18. Kellett GL, Helliwell PA (2000) The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane. Biochem J 350 Pt 1: 155-162.
19. Scow JS, Iqbal CW, Jones TW 3rd, Qandeel HG, Zheng Y, et al. (2011) Absence of evidence of translocation of GLUT2 to the apical membrane of enterocytes in everted intestinal sleeves. J Surg Res 167: 56-61.
20. Gouyon F, Caillaud L, Carriere V, Klein C, Dalet V, et al. (2003) Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice. J Physiol 552: 823-832. (Pubitemid 37428423)
21. Dray C, Sakar Y, Vinel C, Daviaud D, Masri B, et al. (2013) The intestinal glucose-apelin cycle controls carbohydrate absorption in mice. Gastroenterology 144: 771-780.
22. Walker J, Jijon HB, Diaz H, Salehi P, Churchill T, et al. (2005) 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK. Biochem J 385: 485-491. (Pubitemid 40173969)
23. Moriya R, Shirakura T, Ito J, Mashiko S, Seo T (2009) Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. Am J Physiol Endocrinol Metab 297: E1358-1365.
24. Cani PD, Holst JJ, Drucker DJ, Delzenne NM, Thorens B, et al. (2007) GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Mol Cell Endocrinol 276: 18-23. (Pubitemid 47337145)
25. Mace OJ, Schindler M, Patel S (2012) The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine. J Physiol 590: 2917-2936.
26. Ait-Omar A, Monteiro-Sepulveda M, Poitou C, Le Gall M, Cotillard A, et al. (2011) GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice. Diabetes 60: 2598-2607.
27. Thorens B, Guillam MT, Beermann F, Burcelin R, Jaquet M (2000) Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 275: 23751-23758. (Pubitemid 30627456)
28. Helliwell PA, Richardson M, Affleck J, Kellett GL (2000) Stimulation of fructose transport across the intestinal brush-border membrane by PMA is mediated by GLUT2 and dynamically regulated by protein kinase C. Biochem J 350 Pt 1: 149-154.
29. Kellett GL, Brot-Laroche E (2005) Apical GLUT2: a major pathway of intestinal sugar absorption. Diabetes 54: 3056-3062. (Pubitemid 41401109)
30. Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F (2009) Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia 52: 289-298.
31. Reimann F, Habib AM, Tolhurst G, Parker HE, Rogers GJ, et al. (2008) Glucose sensing in L cells: a primary cell study. Cell Metab 8: 532-539.
32. Stumpel F, Burcelin R, Jungermann K, Thorens B (2001) Normal kinetics of intestinal glucose absorption in the absence of GLUT2: evidence for a transport pathway requiring glucose phosphorylation and transfer into the endoplasmic reticulum. Proc Natl Acad Sci U S A 98: 11330-11335. (Pubitemid 32928728)
33. Punjabi M, Arnold M, Geary N, Langhans W, Pacheco-Lopez G (2011) Peripheral glucagon-like peptide-1 (GLP-1) and satiation. Physiol Behav 105: 71-76.
34. Tavakkolizadeh A, Berger UV, Shen KR, Levitsky LL, Zinner MJ, et al. (2001) Diurnal rhythmicity in intestinal SGLT-1 function, V(max), and mRNA expression topography. Am J Physiol Gastrointest Liver Physiol 280: G209-215.
35. Helliwell PA, Richardson M, Affleck J, Kellett GL (2000) Regulation of GLUT5, GLUT2 and intestinal brush-border fructose absorption by the extracellular signal-regulated kinase, p38 mitogen-activated kinase and phosphatidylinositol 3-kinase intracellular signalling pathways: implications for adaptation to diabetes. Biochem J 350 Pt 1: 163-169.