Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats

BMC Complementary and Alternative Medicine

Volumn 16, Issue 1, 2016, Pages

  Taher, Muhammad ^a   Tg Zakaria, Tg Muhamad Faris Syafiq ^a   Susanti, Deny ^a   Zakaria, Zainul Amiruddin ^b  

^a INTERNATIONAL ISLAMIC UNIVERSITY MALAYSIA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Garcinia mangostana; Glibenclamide; Hypoglycaemic effect; Single dose; Streptozotocin

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATININE; GARCINIA MANGOSTANA EXTRACT; GLIBENCLAMIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PLANT EXTRACT; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; VERY LOW DENSITY LIPOPROTEIN; ALCOHOL;

ACUTE TOXICITY; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMICAL ANALYSIS; BODY WEIGHT; CELL POPULATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; GARCINIA MANGOSTANA; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SINGLE DRUG DOSE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DOSE RESPONSE; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GARCINIA MANGOSTANA; GLYBURIDE; HYPOGLYCEMIC AGENTS; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84969528750     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-016-1118-9     Document Type: Article

References (56)

1. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta: U.S. Department of Health and Human Services; 2014.
2. International Diabetes Federation: Diabetes Malaysia. http://www.idf.org/membership/wp/malaysia. Accessed 7 Mar 2016.
3. Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Rad Biol Med. 2011;50:567-75.
4. Mahabusarakam W, Wiriyachitra P, Taylor WC. Chemical constituents of Garcinia mangostana. J Nat Prod. 1987;50:474-8.
5. Balasubramanian K, Rajagopalan K. Novel xanthones from Garcinia mangostana, structures of BR-xanthone-A and BR-xanthone-B. Phytochemistry. 1988;27:1552-4.
6. Sen AK, Sarkar KK, Mazumder PC, Banerji N, Uusvuori R, Hase TA. The structures of garcinones a, b and c: Three new xanthones from Garcinia mangostana. Phytochemistry. 1982;21:1747-50.
7. Peres V, Nagem TJ, de Oliveira FF. Tetraoxygenated naturally occurring xanthones. Phytochemistry. 2000;55:683-710.
8. Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Pérez-Rojas JM. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol. 2008;46:3227-39.
9. Jung H-A, Su B-N, Keller WJ, Mehta RG, Kinghorn AD. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric Food Chem. 2006;54:2077-82.
10. Doi H, Shibata M-A, Shibata E, Morimoto J, Akao Y, Iinuma M, Tanigawa N, Otsuki Y. Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer. Anticancer Res. 2009;29:2485-95.
11. Chen L-G, Yang L-L, Wang C-C. Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem Toxicol. 2008;46:688-93.
12. Cui J, Hu W, Cai Z, Liu Y, Li S, Tao W, Xiang H. New medicinal properties of mangostins: Analgesic activity and pharmacological characterisation of active ingredients from the fruit hull of Garcinia mangostana L. Pharmacol Biochem Behav. 2010;95:166-72.
13. Chen S-X, Wan M, Loh B-N. Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med. 1996;62:381-2.
14. Kondo M, Zhang L, Ji H, Kou Y, Ou B. Bioavailability and antioxidant effects of a xanthone-rich Mangosteen (Garcinia mangostana) product in humans. J Agric Food Chem. 2009;57:8788-92.
15. Kaomongkolgit R, Jamdee K, Chaisomboon N. Antifungal activity of alpha-mangostin against Candida albicans. J Oral Sci. 2009;51:401-6.
16. Nakatani K, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, Ohizumi Y. Inhibitions of histamine release and prostaglandin E 2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull. 2002;25:1137-41.
17. Sakagami Y, Iinuma M, Piyasena K, Dharmaratne H. Antibacterial activity of α-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics. Phytomedicine. 2005;12:203-8.
18. Suksamrarn S, Suwannapoch N, Phakhodee W, Thanuhiranlert J, Ratananukul P, Chimnoi N, Suksamrarn A. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull. 2003;51:857-9.
19. Tang Y-P, Li P-G, Kondo M, Ji H-P, Kou Y, Ou B. Effect of a mangosteen dietary supplement on human immune function: a randomised, double-blind, placebo-controlled trial. J Med Food. 2009;12:755-63.
20. Ryu HW, Cho JK, Curtis-Long MJ, Yuk HJ, Kim YS, Jung S, Kim YS, Lee BW, Park K. H: α-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana. Phytochemistry. 2011;72:2148-54.
21. Manaharan T, Palanisamy UD, Ming CH. Tropical plant extracts as potential antihyperglycemic agents. Molecules. 2012;17:5915-23.
22. Nelli GB, Kilari EK. Antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin induced diabetic male rats. Syst Biol Reprod Med. 2013;59:319-28.
23. Duckworth WC. Hyperglycemia and cardiovascular disease. Curr Atheros Rep. 2001;3:383-91.
24. Elmalí E, Altan N, Bukan N. Effect of the sulphonylurea glibenclamide on liver and kidney antioxidant enzymes in streptozocin-induced diabetic rats. Drugs R D. 2004;5:203-8.
25. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Rad Biol Med. 1996;20:463-6.
26. Smith PR, Thornalley PJ. Mechanism of the degradation of non-enzymatically glycated proteins under physiological conditions. Eur J Biochem. 1992;210:729-39.
27. Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother Res. 2009;23:1047-65.
28. Li L, Brunner I, Han AR, Hamburger M, Kinghorn AD, Frye R, Butterweck V. Pharmacokinetics of α-mangostin in rats after intravenous and oral application. Mol Nutr Food Res. 2011;55:S67-74.
29. Chin Y-W, Kinghorn AD. Structural characterisation, biological effects, and synthetic studies on xanthones from mangosteen (Garcinia mangostana), a popular botanical dietary supplement. Mini Rev Org Chem. 2008;5:355-64.
30. Li L, Han A-R, Kinghorn AD, Frye RF, Derendorf H, Butterweck V. Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats. Planta Med. 2013;79:646-53.
31. Nathan DM, Buse JB, Davidson MB, Heine RJ, Holman RR, Sherwin R, Zinman B. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2006;29:1963-72.
32. Ferreira SB, Sodero AC, Cardoso MF, Lima ES, Kaiser CR, Silva Jr FP, Ferreira VF. Synthesis, biological activity, and molecular modeling studies of 1 h-1, 2, 3-triazole derivatives of carbohydrates as α-glucosidases inhibitors. J Med Chem. 2010;53:2364-75.
33. Krentz AJ, Bailey CJ. Oral antidiabetic agents: Current Role in Type 2 Diabetes Mellitus. Drug. 2005;65:385-411.
34. Kamalakkannan N, Prince PSM. Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin Pharmacol Toxicol. 2006;98:97-103.
35. Eliza J, Daisy P, Ignacimuthu S, Duraipandiyan V. Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.) Sm. in STZ-induced diabetic rats. Chem-Biol Interact. 2009;182:67-72.
36. Chivapat S, Wongsinkongman PCP, Rungsipipat CPA. Chronic toxicity study of Garcinia mangostana Linn. pericarp extract. Thai J Vet Med. 2011;41:45-53.
37. Zhou H-C, Lin Y-M, Wei S-D, Nora Tam T-Y. Structural diversity and antioxidant activity of condensed tannins fractionated from mangosteen pericarp. Food Chem. 2011;129:1710-20.
38. Peaslee MH, Einhellig FA. Tannic acid-induced alterations in mouse growth and pituitary melanocyte-stimulating hormone activity. Toxicol Appl Pharmacol. 1973;25:507-14.
39. Jambunathan R, Mertz ET. Relation between tannin levels, rat growth, and distribution of proteins in sorghum. J Agric Food Chem. 1973;21:692-6.
40. Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EGT, Swapna S, Ramesh B, Rao CA. Antihyperglycemic and antihyperlipidemic activities of methanol: water (4: 1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats. Food Chem Toxicol. 2010;48:1078-84.
41. Bai VN. Effect of Gymnema montanum leaves on serum and tissue lipids in alloxan diabetic rats. J Diabetes Res. 2003;4:183-9.
42. Ohaeri O. Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats. Biosci Rep. 2001;21:19-24.
43. Zakaria ZA, Abdul Hisam EE, Rofiee MS, Norhafizah M, Somchit MN, Teh LK, Salleh MZ. In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. J Ethnopharmacol. 2011;137:1047-54.
44. Nadkarni KM, Nadkarni AK. Indian Materia Medica - with Ayurvedic, Unani-Tibbi, Siddha, Allopathic, Homeopathic, Naturopathic and Home remedies, vol. 1. Bombay: Popular Prakashan Private Ltd.; 1999.
45. Yoshimura M, Ninomiya K, Tagashira Y, Maejima K, Yoshida T, Amakura Y. Polyphenolic constituents of the pericarp of mangosteen (Garcinia mangostana L.). J Agric Food Chem. 2015;63:7670-4.
46. Asai F, Tosa H, Tanaka T, Iinuma M. A xanthone from pericarps of Garcinia mangostana. Phytochem. 1995;39:943-4.
47. Mohamed GA, Ibrahim SR, Shaaban MI, Ross SA. Mangostanaxanthones I and II, new xanthones from the pericarp of Garcinia mangostana. Fitoterapia. 2014;98:215-21.
48. Xu Z, Huang L, Chen X-H, Zhu X-F, Qian X-J, Feng G-K, Lan W-J, Li H-J. Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana. Molecules. 2014;19:1820-7.
49. Zhou X, He L, Wu X, Zhong Y, Zhang J, Wang Y, Wang B, Xu Z, Qiu S. Two new xanthones from the pericarp of Garcinia mangostana. Nat Prod Res. 2015;29:19-23.
50. Xu T, Deng Y, Zhao S, Shao Z. A new xanthone from the pericarp of Garcinia mangostana. J Chem Res. 2016;40:10-1.
51. Kumari M, Jain S. Tannins: An antinutrient with positive effect to manage diabetes. Res J Recent Sci. 2012;1:70-3.
52. Kim MJ, Ryu GR, Chung JS, Sim SS, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH. Protective effects of epicatechin against the toxic effects of streptozotocin on rat pancreatic islets: in vivo and in vitro. Pancreas. 2003;26:292-9.
53. Jariyapongskul A, Areebambud C, Suksamrarn S, Mekseepralard C. Alpha-Mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats. BioMed Res Int. 2015;2015:785826. Available at http://dx.doi.org/ 10.1155/2015/785826.
54. Sellamuthu PS, Muniappan BP, Perumal SM, Kandasamy M. Antihyperglycemic effect of mangiferin in streptozotocin induced diabetic rats. J Heatlh Sci. 2009;55:206-14.
55. Miura T, Ichiki H, Hashimoto I, Iwamoto N, Kato M, Kubo M, Ishihara E, Komatsu Y, Okada M, Ishida T, Tanigawa K. Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine. 2001;8:85-7.
56. Ryu HW, Cho JK, Curtis-Long MJ, Yuk HJ, Kim YS, Jung S, Kim YS, Lee BW, Park KH. α-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana. Phytochemistry. 2011;72:2148-54.