메뉴 건너뛰기




Volumn 9, Issue 1, 2018, Pages

Precise temporal regulation of alternative splicing during neural development

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR GAMMA 2; MBNL PROTEIN; NOVA PROTEIN; PTBP PROTEIN; RBFOX PROTEIN; RNA BINDING PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG;

EID: 85048227566     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-04559-0     Document Type: Article
Times cited : (153)

References (78)
  • 1
    • 67651055363 scopus 로고    scopus 로고
    • Establishment of axon-dendrite polarity in developing neurons
    • Barnes, A. P. & Polleux, F. Establishment of axon-dendrite polarity in developing neurons. Annu. Rev. Neurosci. 32, 347-381 (2009).
    • (2009) Annu. Rev. Neurosci. , vol.32 , pp. 347-381
    • Barnes, A.P.1    Polleux, F.2
  • 2
    • 77954887426 scopus 로고    scopus 로고
    • The axon initial segment and the maintenance of neuronal polarity
    • Rasband, M. N. The axon initial segment and the maintenance of neuronal polarity. Nat. Rev. Neurosci. 11, 552-562 (2010).
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 552-562
    • Rasband, M.N.1
  • 3
    • 77951437255 scopus 로고    scopus 로고
    • Branching out: Mechanisms of dendritic arborization
    • Jan, Y. N. & Jan, L. Y. Branching out: mechanisms of dendritic arborization. Nat. Rev. Neurosci. 11, 316-328 (2010).
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 316-328
    • Jan, Y.N.1    Jan, L.Y.2
  • 4
    • 84996504468 scopus 로고    scopus 로고
    • The cellular and molecular landscapes of the developing human central nervous system
    • Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M. & Sestan, N. The cellular and molecular landscapes of the developing human central nervous system. Neuron 89, 248-268 (2016).
    • (2016) Neuron , vol.89 , pp. 248-268
    • Silbereis, J.C.1    Pochareddy, S.2    Zhu, Y.3    Li, M.4    Sestan, N.5
  • 5
    • 0034303585 scopus 로고    scopus 로고
    • Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
    • Jessell, T. M. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat. Rev. Genet. 1,20-29 (2000).
    • (2000) Nat. Rev. Genet. , vol.1 , pp. 20-29
    • Jessell, T.M.1
  • 7
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • Black, D. L. Mechanisms of alternative pre-messenger RNA splicing. Annu. Rev. Biochem. 72, 291-336 (2003).
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 291-336
    • Black, D.L.1
  • 8
    • 84937405196 scopus 로고    scopus 로고
    • Alternative splicing in the mammalian nervous system: Recent insights into mechanisms and functional roles
    • Raj, B. & Blencowe, B. J. Alternative splicing in the mammalian nervous system: recent insights into mechanisms and functional roles. Neuron 87, 14-27 (2015).
    • (2015) Neuron , vol.87 , pp. 14-27
    • Raj, B.1    Blencowe, B.J.2
  • 9
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang, E. T. et al. Alternative isoform regulation in human tissue transcriptomes. Nature 456, 470-476 (2008).
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1
  • 10
    • 84925321723 scopus 로고    scopus 로고
    • Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators
    • Yan, Q. et al. Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators. Proc. Natl. Acad. Sci. USA 112, 3445-3350 (2015).
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 3350-3445
    • Yan, Q.1
  • 11
    • 84906901689 scopus 로고    scopus 로고
    • An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
    • Zhang, Y. et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34, 11929-11947 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 11929-11947
    • Zhang, Y.1
  • 12
    • 84873810442 scopus 로고    scopus 로고
    • Widespread splicing changes in human brain development and aging
    • Mazin, P. et al. Widespread splicing changes in human brain development and aging. Mol. Syst. Biol. 9, 633 (2013).
    • (2013) Mol. Syst. Biol. , vol.9 , pp. 633
    • Mazin, P.1
  • 13
    • 84875664276 scopus 로고    scopus 로고
    • mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex
    • Dillman, A. A. et al. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat. Neurosci. 16, 499-506 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 499-506
    • Dillman, A.A.1
  • 14
    • 84895918609 scopus 로고    scopus 로고
    • Laminar and temporal expression dynamics of coding and noncoding RNAs in the mouse neocortex
    • Fertuzinhos, S. et al. Laminar and temporal expression dynamics of coding and noncoding RNAs in the mouse neocortex. Cell Rep. 6, 938-950 (2014).
    • (2014) Cell Rep. , vol.6 , pp. 938-950
    • Fertuzinhos, S.1
  • 15
    • 84921409129 scopus 로고    scopus 로고
    • DeCoN: Genome-wide analysis ofin vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex
    • Molyneaux, B. J. et al. DeCoN: genome-wide analysis ofin vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron 85, 275-288 (2015).
    • (2015) Neuron , vol.85 , pp. 275-288
    • Molyneaux, B.J.1
  • 16
    • 85082464238 scopus 로고    scopus 로고
    • Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs
    • Hubbard, K. S., Gut, I. M., Lyman, M. E. & McNutt, P. M. Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs. F1000Res 2, 35 (2013).
    • (2013) F1000Res , vol.2 , pp. 35
    • Hubbard, K.S.1    Gut, I.M.2    Lyman, M.E.3    McNutt, P.M.4
  • 17
    • 84964378643 scopus 로고    scopus 로고
    • The neurogenetics of alternative splicing
    • Vuong, C. K., Black, D. L. & Zheng, S. K. The neurogenetics of alternative splicing. Nat. Rev. Neurosci. 17, 265-281 (2016).
    • (2016) Nat. Rev. Neurosci. , vol.17 , pp. 265-281
    • Vuong, C.K.1    Black, D.L.2    Zheng, S.K.3
  • 18
    • 84897051164 scopus 로고    scopus 로고
    • HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism
    • Weyn-Vanhentenryck, S. et al. HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Rep. 6, 1139-1152 (2014).
    • (2014) Cell Rep. , vol.6 , pp. 1139-1152
    • Weyn-Vanhentenryck, S.1
  • 19
    • 77954838957 scopus 로고    scopus 로고
    • Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls
    • Zhang, C. et al. Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls. Science 329, 439-443 (2010).
    • (2010) Science , vol.329 , pp. 439-443
    • Zhang, C.1
  • 20
    • 84864912095 scopus 로고    scopus 로고
    • Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy
    • Charizanis, K. et al. Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy. Neuron 75, 437-450 (2012).
    • (2012) Neuron , vol.75 , pp. 437-450
    • Charizanis, K.1
  • 21
    • 84898747945 scopus 로고    scopus 로고
    • The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
    • Li, Q. et al. The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. eLife 3, e01201 (2014).
    • (2014) ELife , vol.3 , pp. e01201
    • Li, Q.1
  • 22
    • 84864020005 scopus 로고    scopus 로고
    • Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain
    • Licatalosi, D. D. et al. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 26, 1626-1642 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 1626-1642
    • Licatalosi, D.D.1
  • 23
    • 84878535352 scopus 로고    scopus 로고
    • OLego: Fast and sensitive mapping of spliced mRNA-Seq reads using small seeds
    • Wu, J., Anczukow, O., Krainer, A. R., Zhang, M. Q. & Zhang, C. OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds. Nucleic Acids Res. 41, 5149-5163 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. 5149-5163
    • Wu, J.1    Anczukow, O.2    Krainer, A.R.3    Zhang, M.Q.4    Zhang, C.5
  • 24
    • 77249142841 scopus 로고    scopus 로고
    • Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system
    • Zibetti, C. et al. Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system. J. Neurosci. 30, 2521-2532 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 2521-2532
    • Zibetti, C.1
  • 25
    • 84896696604 scopus 로고    scopus 로고
    • Phosphorylation of neuronal lysine-specific demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2
    • Toffolo, E. et al. Phosphorylation of neuronal lysine-specific demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2. J. Neurochem. 128, 603-616 (2014).
    • (2014) J. Neurochem. , vol.128 , pp. 603-616
    • Toffolo, E.1
  • 26
    • 23944458138 scopus 로고    scopus 로고
    • A general framework for weighted gene co-expression network analysis
    • Zhang, B. & Horvath, S. A general framework for weighted gene co-expression network analysis. Stat. Appl. Genet. Mol. Biol. 4, 17 (2005).
    • (2005) Stat. Appl. Genet. Mol. Biol. , vol.4 , pp. 17
    • Zhang, B.1    Horvath, S.2
  • 27
    • 84926152584 scopus 로고    scopus 로고
    • Developmental regulation of human cortex transcription and its clinical relevance at single base resolution
    • Jaffe, A. E. et al. Developmental regulation of human cortex transcription and its clinical relevance at single base resolution. Nat. Neurosci. 18, 154-161 (2015).
    • (2015) Nat. Neurosci. , vol.18 , pp. 154-161
    • Jaffe, A.E.1
  • 28
    • 84871892549 scopus 로고    scopus 로고
    • RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse
    • Bandyopadhyay, U. et al. RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse. PLoS ONE 8, e53575 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e53575
    • Bandyopadhyay, U.1
  • 29
    • 84888375636 scopus 로고    scopus 로고
    • Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy
    • Zhang, Z. et al. Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy. Proc. Natl. Acad. Sci. USA 110, 19348-19353 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 19348-19353
    • Zhang, Z.1
  • 30
    • 84950289897 scopus 로고    scopus 로고
    • Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure
    • Amin, N. D. et al. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science 350, 1525-1529 (2015).
    • (2015) Science , vol.350 , pp. 1525-1529
    • Amin, N.D.1
  • 32
    • 0032444355 scopus 로고    scopus 로고
    • Altered ratios of alternatively spliced long and short gamma2 subunit mRNAs of the gamma-amino butyrate type A receptor in prefrontal cortex of schizophrenics
    • Huntsman, M. M., Tran, B. V., Potkin, S. G., Bunney, W. E. Jr. & Jones, E. G. Altered ratios of alternatively spliced long and short gamma2 subunit mRNAs of the gamma-amino butyrate type A receptor in prefrontal cortex of schizophrenics. Proc. Natl. Acad. Sci. USA 95, 15066-15071 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15066-15071
    • Huntsman, M.M.1    Tran, B.V.2    Potkin, S.G.3    Bunney, W.E.4    Jones, E.G.5
  • 33
    • 0030777180 scopus 로고    scopus 로고
    • A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart
    • Ashiya, M. & Grabowski, P. J. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. RNA 3, 996-1015 (1997).
    • (1997) RNA , vol.3 , pp. 996-1015
    • Ashiya, M.1    Grabowski, P.J.2
  • 34
    • 0035478854 scopus 로고    scopus 로고
    • Random forests
    • Breiman, L. Random forests. Mach. Learn. 45,5-32 (2001).
    • (2001) Mach. Learn. , vol.45 , pp. 5-32
    • Breiman, L.1
  • 35
    • 84866505114 scopus 로고    scopus 로고
    • Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability
    • Ince-Dunn, G. et al. Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron 75, 1067-1080 (2012).
    • (2012) Neuron , vol.75 , pp. 1067-1080
    • Ince-Dunn, G.1
  • 36
    • 84926386137 scopus 로고    scopus 로고
    • Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development
    • Quesnel-Vallieres, M., Irimia, M., Cordes, S. P. & Blencowe, B. J. Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Genes Dev. 29, 746-759 (2015).
    • (2015) Genes Dev. , vol.29 , pp. 746-759
    • Quesnel-Vallieres, M.1    Irimia, M.2    Cordes, S.P.3    Blencowe, B.J.4
  • 37
    • 84904385099 scopus 로고    scopus 로고
    • A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain
    • Thompson, C. L. et al. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron 83, 309-323 (2014).
    • (2014) Neuron , vol.83 , pp. 309-323
    • Thompson, C.L.1
  • 39
    • 76249102027 scopus 로고    scopus 로고
    • Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy
    • Du, H. et al. Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy. Nat. Struct. Mol. Biol. 17, 187-193 (2010).
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 187-193
    • Du, H.1
  • 40
    • 84991661078 scopus 로고    scopus 로고
    • Developmental regulation of RNA processing by Rbfox proteins
    • Conboy, J. G. Developmental regulation of RNA processing by Rbfox proteins. Wiley Interdiscip. Rev. RNA 8, https://doi.org/10.1002/wrna.1398 (2017).
    • (2017) Wiley Interdiscip. Rev. RNA , vol.8
    • Conboy, J.G.1
  • 41
    • 85044860922 scopus 로고    scopus 로고
    • Rbfox splicing factors promote neuronal maturation and axon initial segment assembly
    • Jacko, M. et al. Rbfox splicing factors promote neuronal maturation and axon initial segment assembly. Neuron 97, 853-868 (2018).
    • (2018) Neuron , vol.97 , pp. 853-868
    • Jacko, M.1
  • 42
    • 70349620615 scopus 로고    scopus 로고
    • An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons
    • Lee, J. A., Tang, Z. Z. & Black, D. L. An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons. Genes Dev. 23, 2284-2293 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 2284-2293
    • Lee, J.A.1    Tang, Z.Z.2    Black, D.L.3
  • 43
    • 84897448226 scopus 로고    scopus 로고
    • Establishing the pre-placodal region and breaking it into placodes with distinct identities
    • St-Jeannet, J. P. & Moody, S. A. Establishing the pre-placodal region and breaking it into placodes with distinct identities. Dev. Biol. 389,13-27 (2014).
    • (2014) Dev. Biol. , vol.389 , pp. 13-27
    • St-Jeannet, J.P.1    Moody, S.A.2
  • 44
    • 84964746514 scopus 로고    scopus 로고
    • Intrinsic control of axon regeneration
    • He, Z. & Jin, Y. Intrinsic control of axon regeneration. Neuron 90, 437-451 (2016).
    • (2016) Neuron , vol.90 , pp. 437-451
    • He, Z.1    Jin, Y.2
  • 45
    • 0018757804 scopus 로고
    • Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy
    • Graziadei, G. A. & Graziadei, P. P. Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy. J. Neurocytol. 8, 197-213 (1979).
    • (1979) J. Neurocytol. , vol.8 , pp. 197-213
    • Graziadei, G.A.1    Graziadei, P.P.2
  • 46
    • 84959019531 scopus 로고    scopus 로고
    • Rapid and continuous activity-dependent plasticity of olfactory sensory input
    • Cheetham, C. E., Park, U. & Belluscio, L. Rapid and continuous activity-dependent plasticity of olfactory sensory input. Nat. Commun. 7, 10729 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 10729
    • Cheetham, C.E.1    Park, U.2    Belluscio, L.3
  • 47
    • 79959897174 scopus 로고    scopus 로고
    • Neuronal intrinsic mechanisms of axon regeneration
    • Liu, K., Tedeschi, A., Park, K. K. & He, Z. Neuronal intrinsic mechanisms of axon regeneration. Annu. Rev. Neurosci. 34, 131-152 (2011).
    • (2011) Annu. Rev. Neurosci. , vol.34 , pp. 131-152
    • Liu, K.1    Tedeschi, A.2    Park, K.K.3    He, Z.4
  • 48
    • 84973649741 scopus 로고    scopus 로고
    • Retina regeneration in zebrafish
    • Wan, J. & Goldman, D. Retina regeneration in zebrafish. Curr. Opin. Genet. Dev. 40,41-47 (2016).
    • (2016) Curr. Opin. Genet. Dev. , vol.40 , pp. 41-47
    • Wan, J.1    Goldman, D.2
  • 49
    • 84925296648 scopus 로고    scopus 로고
    • Subtype-specific regeneration of retinal ganglion cells following axotomy: Effects of osteopontin and mTOR signaling
    • Duan, X. et al. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron 85, 1244-1256 (2015).
    • (2015) Neuron , vol.85 , pp. 1244-1256
    • Duan, X.1
  • 50
    • 84960343152 scopus 로고    scopus 로고
    • A systems-level analysis of the peripheral nerve intrinsic axonal growth program
    • Chandran, V. et al. A systems-level analysis of the peripheral nerve intrinsic axonal growth program. Neuron 89, 956-970 (2016).
    • (2016) Neuron , vol.89 , pp. 956-970
    • Chandran, V.1
  • 51
    • 84992159421 scopus 로고    scopus 로고
    • The calcium channel subunit alpha2delta2 suppresses axon regeneration in the adult CNS
    • Tedeschi, A. et al. The calcium channel subunit alpha2delta2 suppresses axon regeneration in the adult CNS. Neuron 92, 419-434 (2016).
    • (2016) Neuron , vol.92 , pp. 419-434
    • Tedeschi, A.1
  • 52
    • 84944520306 scopus 로고    scopus 로고
    • Transcriptomic approaches to neural repair
    • Dulin, J. N. et al. Transcriptomic approaches to neural repair. J. Neurosci. 35, 13860-13867 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 13860-13867
    • Dulin, J.N.1
  • 53
    • 80755130137 scopus 로고    scopus 로고
    • Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. I. Loss of VGLUT1/IA synapses on motoneurons
    • Alvarez, F. J. et al. Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. I. Loss of VGLUT1/IA synapses on motoneurons. J. Neurophysiol. 106, 2450-2470 (2011).
    • (2011) J. Neurophysiol. , vol.106 , pp. 2450-2470
    • Alvarez, F.J.1
  • 54
    • 85048225985 scopus 로고    scopus 로고
    • Robust axonal regeneration occurs in the injured CAST/Ei mouse CNS
    • Omura, T. et al. Robust axonal regeneration occurs in the injured CAST/Ei mouse CNS. Neuron 90, 662 (2016).
    • (2016) Neuron , vol.90 , pp. 662
    • Omura, T.1
  • 55
    • 84979655940 scopus 로고    scopus 로고
    • NOVA2-mediated RNA regulation is required for axonal pathfinding during development
    • Saito, Y. et al. NOVA2-mediated RNA regulation is required for axonal pathfinding during development. eLife 5, e14371 (2016).
    • (2016) ELife , vol.5 , pp. e14371
    • Saito, Y.1
  • 56
    • 84961327715 scopus 로고    scopus 로고
    • Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
    • Tasic, B. et al. Adult mouse cortical cell taxonomy revealed by single cell transcriptomics. Nat. Neurosci. 19, 335-346 (2016).
    • (2016) Nat. Neurosci. , vol.19 , pp. 335-346
    • Tasic, B.1
  • 57
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289-300 (1995).
    • (1995) J. R. Stat. Soc. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 58
    • 74949092081 scopus 로고    scopus 로고
    • Detection of nonneutral substitution rates on mammalian phylogenies
    • Pollard, K. S., Hubisz, M. J., Rosenbloom, K. R. & Siepel, A. Detection of nonneutral substitution rates on mammalian phylogenies. Genome Res. 20, 110-121 (2010).
    • (2010) Genome Res. , vol.20 , pp. 110-121
    • Pollard, K.S.1    Hubisz, M.J.2    Rosenbloom, K.R.3    Siepel, A.4
  • 59
    • 67650720515 scopus 로고    scopus 로고
    • Systems approach to explore components and interactions in the presynapse
    • Abul-Husn, N. S. et al. Systems approach to explore components and interactions in the presynapse. Proteomics 9, 3303-3315 (2009).
    • (2009) Proteomics , vol.9 , pp. 3303-3315
    • Abul-Husn, N.S.1
  • 61
    • 77949441465 scopus 로고    scopus 로고
    • SFARI Gene: An evolving database for the autism research community
    • Banerjee-Basu, S. & Packer, A. SFARI Gene: an evolving database for the autism research community. Dis. Model Mech. 3, 133-135 (2010).
    • (2010) Dis. Model Mech. , vol.3 , pp. 133-135
    • Banerjee-Basu, S.1    Packer, A.2
  • 62
    • 84860780495 scopus 로고    scopus 로고
    • De novo mutations revealed by whole-exome sequencing are strongly associated with autism
    • Sanders, S. J. et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 485, 237-241 (2012).
    • (2012) Nature , vol.485 , pp. 237-241
    • Sanders, S.J.1
  • 63
    • 84860741138 scopus 로고    scopus 로고
    • Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
    • O'Roak, B. J. et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485, 246-250 (2012).
    • (2012) Nature , vol.485 , pp. 246-250
    • O'Roak, B.J.1
  • 64
    • 84860712363 scopus 로고    scopus 로고
    • Patterns and rates of exonic de novo mutations in autism spectrum disorders
    • Neale, B. M. et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 485, 242-245 (2012).
    • (2012) Nature , vol.485 , pp. 242-245
    • Neale, B.M.1
  • 65
    • 84860297457 scopus 로고    scopus 로고
    • De novo gene disruptions in children on the autistic spectrum
    • Iossifov, I. et al. De novo gene disruptions in children on the autistic spectrum. Neuron 74, 285-299 (2012).
    • (2012) Neuron , vol.74 , pp. 285-299
    • Iossifov, I.1
  • 66
    • 84912101541 scopus 로고    scopus 로고
    • The contribution of de novo coding mutations to autism spectrum disorder
    • Iossifov, I. et al. The contribution of de novo coding mutations to autism spectrum disorder. Nature 515, 216-221 (2014).
    • (2014) Nature , vol.515 , pp. 216-221
    • Iossifov, I.1
  • 67
    • 84912144889 scopus 로고    scopus 로고
    • Synaptic, transcriptional and chromatin genes disrupted in autism
    • De Rubeis, S. et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515, 209-215 (2014).
    • (2014) Nature , vol.515 , pp. 209-215
    • De Rubeis, S.1
  • 70
    • 84906791713 scopus 로고    scopus 로고
    • Rbfox2-coordinated alternative splicing ofMef2d and Rock2 controls myoblast fusion during myogenesis
    • Singh, R. K. et al. Rbfox2-coordinated alternative splicing ofMef2d and Rock2 controls myoblast fusion during myogenesis. Mol. Cell 55, 592-603 (2014).
    • (2014) Mol. Cell , vol.55 , pp. 592-603
    • Singh, R.K.1
  • 71
    • 84865201988 scopus 로고    scopus 로고
    • Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins
    • Wang, E. T. et al. Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell 150, 710-724 (2012).
    • (2012) Cell , vol.150 , pp. 710-724
    • Wang, E.T.1
  • 72
    • 84881493949 scopus 로고    scopus 로고
    • Prediction of clustered RNA-binding protein motif sites in the mammalian genome
    • Zhang, C., Lee, K.-Y., Swanson, M. S. & Darnell, R. B. Prediction of clustered RNA-binding protein motif sites in the mammalian genome. Nucleic Acids Res. 41, 6793-6807 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. 6793-6807
    • Zhang, C.1    Lee, K.-Y.2    Swanson, M.S.3    Darnell, R.B.4
  • 73
    • 0030878682 scopus 로고    scopus 로고
    • Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo
    • Perez, I., Lin, C. H., McAfee, J. G. & Patton, J. G. Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo. RNA 3, 764-778 (1997).
    • (1997) RNA , vol.3 , pp. 764-778
    • Perez, I.1    Lin, C.H.2    McAfee, J.G.3    Patton, J.G.4
  • 74
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 75
    • 84880427394 scopus 로고    scopus 로고
    • A compendium of RNA-binding motifs for decoding gene regulation
    • Ray, D. et al. A compendium of RNA-binding motifs for decoding gene regulation. Nature 499, 172-177 (2013).
    • (2013) Nature , vol.499 , pp. 172-177
    • Ray, D.1
  • 76
    • 0345040873 scopus 로고    scopus 로고
    • Classification and regression by randomForest
    • Liaw, A. & Wiener, M. Classification and regression by randomForest. R. News 2,18-22 (2002).
    • (2002) R. News , vol.2 , pp. 18-22
    • Liaw, A.1    Wiener, M.2
  • 78
    • 0038382977 scopus 로고    scopus 로고
    • Nova regulates GABAA receptor y2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer
    • Dredge, B. K. & Darnell, R. B. Nova regulates GABAA receptor y2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Mol. Cell. Biol. 23, 4687-4700 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 4687-4700
    • Dredge, B.K.1    Darnell, R.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.