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PID: 24381371, A large genome-wide association (GWAS) study with over 1200 narcolepsy patients and 3500 controls. It was shown that the majority of the genetic risk of narcolepsy is explained by the HLA DQB1 locus only. HLA DQB1*06:02 positive individuals carry a 251-fold increased risk of developing narcolepsy
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• Tafti M, Hor H, Dauvilliers Y, Lammers GJ, Overeem S, Mayer G, et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe. Sleep. 2014;37(1):19–25. A large genome-wide association (GWAS) study with over 1200 narcolepsy patients and 3500 controls. It was shown that the majority of the genetic risk of narcolepsy is explained by the HLA DQB1 locus only. HLA DQB1*06:02 positive individuals carry a 251-fold increased risk of developing narcolepsy.
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39
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40
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Mignot E, Lin L, Rogers W, Honda Y, Qiu X, Lin X, et al. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Gen. 2001;68(3):686–99.
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41
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84920733875
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HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy
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PID: 25574827, One of the first reports to find HLA class I associations in narcolepsy
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• Ollila HM, Ravel JM, Han F, et al. HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy. Am J Hum Genet. 2015;96:136–46. One of the first reports to find HLA class I associations in narcolepsy.
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Am J Hum Genet
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Ollila, H.M.1
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84960462903
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Narcolepsy-associated HLA class I alleles implicate cell-mediated cytotoxicity
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PID: 26518595, One of the first reports to find HLA class I associations in narcolepsy
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• Tafti M, Lammers GJ, Dauvilliers Y, et al. Narcolepsy-associated HLA class I alleles implicate cell-mediated cytotoxicity. Sleep. 2016;39:581–7. One of the first reports to find HLA class I associations in narcolepsy.
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Tafti, M.1
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44
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45
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84940896288
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Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus
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PID: 26227560
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Saariaho AH, Vuorela A, Freitag TL, Pizza F, Plazzi G, Partinen M, et al. Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus. J Autoimmun. 2015;63:68–75.
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46
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Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients
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PID: 20160349
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Cvetkovic-Lopes V, Bayer L, Dorsaz S, Maret S, Pradervand S, Dauvilliers Y, et al. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest. 2010;120(3):713–9.
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Mühlethaler, M.14
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47
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77954369866
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Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy
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PID: 20614846
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Kawashima M, Lin L, Tanaka S, Jennum P, Knudsen S, Nevsimalova S, et al. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep. 2010;33(7):869–74.
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48
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Katzav A, Arango MT, Kivity S, Tanaka S, Givaty G, Agmon-Levin N, et al. Passive transfer of narcolepsy: anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice. J Autoimmun. 2013;45:24–30.
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Shoenfeld, Y.10
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49
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84899093017
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A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010
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PID: 24485154
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Lind A, Ramelius A, Olsson T, Arnheim-Dahlstrom L, Lamb F, Khademi M, et al. A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010. J Autoimmun. 2014;50:99–106.
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50
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Anti-tribbles pseudokinase 2 (TRIB2)-immunization modulates hypocretin/orexin neuronal functions
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Tanaka S, Honda Y, Honda M, Yamada H, Honda K, Kodama T. Anti-tribbles pseudokinase 2 (TRIB2)-immunization modulates hypocretin/orexin neuronal functions. Sleep. 2017; 10.1093/sleep/zsw036.
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53
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Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns
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PID: 25136085, In this study, 27% of narcolepsy patients showed autoantibodies against three different neuronal structures in immunohistochemical stainings on rat brain. Although staining against hypocretin neurons was not seen, autoantibodies against hypothalamic NEI/αMSH neurons were found. Passive transfer of sera from NEI/αMSH-positive subject into a rat brain produced disturbed REM and slow wave sleep patterns
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• Bergman P, Adori C, Vas S, Kai-Larsen Y, Sarkanen T, Cederlund A, et al. Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. Proc Natl Acad Sci U S A. 2014;111(35):E3735–44. In this study, 27% of narcolepsy patients showed autoantibodies against three different neuronal structures in immunohistochemical stainings on rat brain. Although staining against hypocretin neurons was not seen, autoantibodies against hypothalamic NEI/αMSH neurons were found. Passive transfer of sera from NEI/αMSH-positive subject into a rat brain produced disturbed REM and slow wave sleep patterns.
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54
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Jacob L, Leib R, Ollila HM, Bonvalet M, Adams CM, Mignot E. Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development. Brain Behav Immun. 2015;47:44–57.
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PID: 28121444, The authors presented a novel method for screening autoantibodies, namely high-density peptide arrays. They recognized a potential new autoantigen neurexin 1 in narcolepsy
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PID: 29449194, The authors describe a potentially new autoantigen prostaglandireceptor against which narcolepsy patient have developed autoantibodies
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