메뉴 건너뛰기




Volumn 34, Issue , 2017, Pages 71-83

Retrospective multicenter matched case–control study on the risk factors for narcolepsy with special focus on vaccinations (including pandemic influenza vaccination) and infections in Germany

Author keywords

Germany; Narcolepsy; Pandemic influenza A H1N1 v vaccine; Risk factors

Indexed keywords

INFLUENZA VACCINE;

EID: 85017193283     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2017.02.026     Document Type: Article
Times cited : (12)

References (47)
  • 1
    • 84907011506 scopus 로고    scopus 로고
    • Narcolepsy: a clinical review
    • [1] Leschziner, G., Narcolepsy: a clinical review. Pract Neurol 14 (2014), 323–331.
    • (2014) Pract Neurol , vol.14 , pp. 323-331
    • Leschziner, G.1
  • 2
    • 0033826856 scopus 로고    scopus 로고
    • A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    • [2] Peyron, C., Faraco, J., Rogers, W., et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6 (2000), 991–997.
    • (2000) Nat Med , vol.6 , pp. 991-997
    • Peyron, C.1    Faraco, J.2    Rogers, W.3
  • 3
    • 0033710848 scopus 로고    scopus 로고
    • Reduced number of hypocretin neurons in human narcolepsy
    • [3] Thannickal, T.C., Moore, R.Y., Nienhuis, R., et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27 (2000), 469–474.
    • (2000) Neuron , vol.27 , pp. 469-474
    • Thannickal, T.C.1    Moore, R.Y.2    Nienhuis, R.3
  • 4
    • 70349143485 scopus 로고    scopus 로고
    • Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy
    • [4] Thannickal, T.C., Nienhuis, R., Siegel, J.M., Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. Sleep 32 (2009), 993–998.
    • (2009) Sleep , vol.32 , pp. 993-998
    • Thannickal, T.C.1    Nienhuis, R.2    Siegel, J.M.3
  • 5
    • 84871891987 scopus 로고    scopus 로고
    • Hypocretin deficiency develops during onset of human narcolepsy with cataplexy
    • [5] Savvidou, A., Knudsen, S., Olsson-Engman, M., et al. Hypocretin deficiency develops during onset of human narcolepsy with cataplexy. Sleep 36 (2013), 147–148.
    • (2013) Sleep , vol.36 , pp. 147-148
    • Savvidou, A.1    Knudsen, S.2    Olsson-Engman, M.3
  • 6
    • 0033134659 scopus 로고    scopus 로고
    • Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602
    • [6] Mignot, E., Young, T., Lin, L., et al. Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602. Sleep 22 (1999), 347–352.
    • (1999) Sleep , vol.22 , pp. 347-352
    • Mignot, E.1    Young, T.2    Lin, L.3
  • 7
    • 0022834621 scopus 로고
    • HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence
    • [7] Poirier, G., Montplaisir, J., Decary, F., et al. HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence. Sleep 9 (1986), 153–158.
    • (1986) Sleep , vol.9 , pp. 153-158
    • Poirier, G.1    Montplaisir, J.2    Decary, F.3
  • 8
    • 0023805358 scopus 로고
    • Determinants of daytime sleepiness in obstructive sleep apnea
    • [8] Guilleminault, C., Partinen, M., Quera-Salva, M.A., et al. Determinants of daytime sleepiness in obstructive sleep apnea. Chest 94 (1988), 32–37.
    • (1988) Chest , vol.94 , pp. 32-37
    • Guilleminault, C.1    Partinen, M.2    Quera-Salva, M.A.3
  • 9
    • 0028596909 scopus 로고
    • DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans
    • [9] Mignot, E., Lin, X., Arrigoni, J., et al. DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans. Sleep 17:8 Suppl. (1994), S60–S67.
    • (1994) Sleep , vol.17 , Issue.8 , pp. S60-S67
    • Mignot, E.1    Lin, X.2    Arrigoni, J.3
  • 10
    • 33746472884 scopus 로고    scopus 로고
    • Genomewide association analysis of human narcolepsy and a new resistance gene
    • [10] Kawashima, M., Tamiya, G., Oka, A., et al. Genomewide association analysis of human narcolepsy and a new resistance gene. Am J Hum Genet 79 (2006), 252–263.
    • (2006) Am J Hum Genet , vol.79 , pp. 252-263
    • Kawashima, M.1    Tamiya, G.2    Oka, A.3
  • 11
    • 78149451397 scopus 로고    scopus 로고
    • Increased immune complexes of hypocretin autoantibodies in narcolepsy
    • [11] Deloumeau, A., Bayard, S., Coquerel, Q., et al. Increased immune complexes of hypocretin autoantibodies in narcolepsy. Plos One, 5, 2010, e13320.
    • (2010) Plos One , vol.5 , pp. e13320
    • Deloumeau, A.1    Bayard, S.2    Coquerel, Q.3
  • 12
    • 77949667777 scopus 로고    scopus 로고
    • Elevated tribbles homolog 2-specific antibody levels in narcolepsy patients
    • [12] Cvetkovic-Lopes, V., Bayer, L., Dorsaz, S., et al. Elevated tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Investig 120 (2010), 713–719.
    • (2010) J Clin Investig , vol.120 , pp. 713-719
    • Cvetkovic-Lopes, V.1    Bayer, L.2    Dorsaz, S.3
  • 13
    • 66649111903 scopus 로고    scopus 로고
    • Narcolepsy is strongly associated with the T-cell receptor alpha locus
    • [13] Hallmayer, J., Faraco, J., Lin, L., et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 41 (2009), 708–711.
    • (2009) Nat Genet , vol.41 , pp. 708-711
    • Hallmayer, J.1    Faraco, J.2    Lin, L.3
  • 15
    • 70349161242 scopus 로고    scopus 로고
    • Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset
    • [15] Aran, A., Lin, L., Nevsimalova, S., et al. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep 32 (2009), 979–983.
    • (2009) Sleep , vol.32 , pp. 979-983
    • Aran, A.1    Lin, L.2    Nevsimalova, S.3
  • 16
    • 84859027226 scopus 로고    scopus 로고
    • Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
    • [16] Partinen, M., Saarenpaa-Heikkila, O., Ilveskoski, I., et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. Plos One, 7, 2012, e33723.
    • (2012) Plos One , vol.7 , pp. e33723
    • Partinen, M.1    Saarenpaa-Heikkila, O.2    Ilveskoski, I.3
  • 17
    • 84859054098 scopus 로고    scopus 로고
    • AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland
    • [17] Nohynek, H., Jokinen, J., Partinen, M., et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. Plos One, 7, 2012, e33536.
    • (2012) Plos One , vol.7 , pp. e33536
    • Nohynek, H.1    Jokinen, J.2    Partinen, M.3
  • 18
    • 84873082021 scopus 로고    scopus 로고
    • The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns
    • [18] Wijnans, L., Lecomte, C., de Vries, C., et al. The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns. Vaccine 31 (2012), 1246–1254.
    • (2012) Vaccine , vol.31 , pp. 1246-1254
    • Wijnans, L.1    Lecomte, C.2    de Vries, C.3
  • 19
    • 84876400600 scopus 로고    scopus 로고
    • Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination
    • [19] Szakacs, A., Darin, N., Hallbook, T., Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination. Neurology 80 (2013), 1315–1321.
    • (2013) Neurology , vol.80 , pp. 1315-1321
    • Szakacs, A.1    Darin, N.2    Hallbook, T.3
  • 20
    • 84880943684 scopus 로고    scopus 로고
    • Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France
    • [20] Dauvilliers, Y., Arnulf, I., Lecendreux, M., et al. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain 136 (2013), 2486–2496.
    • (2013) Brain , vol.136 , pp. 2486-2496
    • Dauvilliers, Y.1    Arnulf, I.2    Lecendreux, M.3
  • 21
    • 84881660400 scopus 로고    scopus 로고
    • Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A
    • [21] Heier, M.S., Gautvik, K.M., Wannag, E., et al. Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A. Sleep Med 14 (2013), 867–871.
    • (2013) Sleep Med , vol.14 , pp. 867-871
    • Heier, M.S.1    Gautvik, K.M.2    Wannag, E.3
  • 22
    • 84874605485 scopus 로고    scopus 로고
    • Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis
    • [22] Miller, E., Andrews, N., Stellitano, L., et al. Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis. BMJ, 346, 2013, f794.
    • (2013) BMJ , vol.346 , pp. f794
    • Miller, E.1    Andrews, N.2    Stellitano, L.3
  • 23
    • 84965017909 scopus 로고    scopus 로고
    • Risk of narcolepsy after AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine in adults: a case-coverage study in England
    • [23] Stowe, J., Miller, E., Andrews, N., et al. Risk of narcolepsy after AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine in adults: a case-coverage study in England. Sleep 39 (2016), 1051–1057.
    • (2016) Sleep , vol.39 , pp. 1051-1057
    • Stowe, J.1    Miller, E.2    Andrews, N.3
  • 24
    • 84907494540 scopus 로고    scopus 로고
    • Risk of narcolepsy associated with inactivated adjuvanted (AS03) A/H1N1 (2009) pandemic influenza vaccine in Quebec
    • [24] Montplaisir, J., Petit, D., Quinn, M.-J., et al. Risk of narcolepsy associated with inactivated adjuvanted (AS03) A/H1N1 (2009) pandemic influenza vaccine in Quebec. Plos One, 9, 2014, e108489.
    • (2014) Plos One , vol.9 , pp. e108489
    • Montplaisir, J.1    Petit, D.2    Quinn, M.-J.3
  • 25
    • 84899831630 scopus 로고    scopus 로고
    • Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009-December 2010
    • [25] O'Flanagan, D., Barret, A.S., Foley, M., et al. Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009-December 2010. Euro Surveill 19 (2014), 15–25.
    • (2014) Euro Surveill , vol.19 , pp. 15-25
    • O'Flanagan, D.1    Barret, A.S.2    Foley, M.3
  • 26
    • 84892502553 scopus 로고    scopus 로고
    • Risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix: a population- and registry-based cohort study with over 2 years of follow-up
    • [26] Persson, I., Granath, F., Askling, J., et al. Risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix: a population- and registry-based cohort study with over 2 years of follow-up. J Intern Med 275 (2014), 172–190.
    • (2014) J Intern Med , vol.275 , pp. 172-190
    • Persson, I.1    Granath, F.2    Askling, J.3
  • 27
    • 84899102996 scopus 로고    scopus 로고
    • 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: what is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants
    • [27] Ahmed, S.S., Schur, P.H., MacDonald, N.E., et al. 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: what is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants. J Autoimmun 50 (2014), 1–11.
    • (2014) J Autoimmun , vol.50 , pp. 1-11
    • Ahmed, S.S.1    Schur, P.H.2    MacDonald, N.E.3
  • 28
    • 84934312439 scopus 로고    scopus 로고
    • Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2
    • [28] Ahmed, S.S., Volkmuth, W., Duca, J., et al. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. Sci Transl Med, 7, 2015, 294.
    • (2015) Sci Transl Med , vol.7 , pp. 294
    • Ahmed, S.S.1    Volkmuth, W.2    Duca, J.3
  • 29
    • 84923268310 scopus 로고    scopus 로고
    • Is narcolepsy a classical autoimmune disease?
    • [29] Arango, M.-T., Kivity, S., Shoenfeld, Y., Is narcolepsy a classical autoimmune disease?. Pharmacol Res 92 (2015), 6–12.
    • (2015) Pharmacol Res , vol.92 , pp. 6-12
    • Arango, M.-T.1    Kivity, S.2    Shoenfeld, Y.3
  • 30
    • 85007496568 scopus 로고    scopus 로고
    • Mechanistic insights into influenza vaccine-associated narcolepsy
    • [30] Ahmed, S.S., Steinman, L., Mechanistic insights into influenza vaccine-associated narcolepsy. Hum Vaccines Immunother 12 (2016), 3196–3201.
    • (2016) Hum Vaccines Immunother , vol.12 , pp. 3196-3201
    • Ahmed, S.S.1    Steinman, L.2
  • 31
    • 79955685941 scopus 로고    scopus 로고
    • Monitoring pandemic influenza A(H1N1) vaccination coverage in Germany 2009/10-results from thirteen consecutive cross-sectional surveys
    • [31] Walter, D., Böhmer, M.M., an der Heiden, M., et al. Monitoring pandemic influenza A(H1N1) vaccination coverage in Germany 2009/10-results from thirteen consecutive cross-sectional surveys. Vaccine 29 (2011), 4008–4012.
    • (2011) Vaccine , vol.29 , pp. 4008-4012
    • Walter, D.1    Böhmer, M.M.2    an der Heiden, M.3
  • 32
    • 84934311217 scopus 로고    scopus 로고
    • Incidence of narcolepsy in Germany
    • [32] Oberle, D., Drechsel-Bäuerle, U., Schmidtmann, I., et al. Incidence of narcolepsy in Germany. Sleep 38 (2015), 1619–1628.
    • (2015) Sleep , vol.38 , pp. 1619-1628
    • Oberle, D.1    Drechsel-Bäuerle, U.2    Schmidtmann, I.3
  • 33
    • 0142213114 scopus 로고    scopus 로고
    • The pediatric daytime sleepiness scale (PDSS): sleep habits and school outcomes in middle-school children
    • [33] Drake, C., Nickel, C., Burduvali, E., et al. The pediatric daytime sleepiness scale (PDSS): sleep habits and school outcomes in middle-school children. Sleep 26 (2003), 455–458.
    • (2003) Sleep , vol.26 , pp. 455-458
    • Drake, C.1    Nickel, C.2    Burduvali, E.3
  • 34
    • 84872619045 scopus 로고    scopus 로고
    • Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation
    • [34] Poli, F., Overeem, S., Lammers, G.J., et al. Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation. Vaccine 31 (2012), 994–1007.
    • (2012) Vaccine , vol.31 , pp. 994-1007
    • Poli, F.1    Overeem, S.2    Lammers, G.J.3
  • 35
    • 0030867241 scopus 로고    scopus 로고
    • Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy
    • [35] Aldrich, M., Chervin, R., Malow, B., Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy. Sleep 20 (1997), 620–629.
    • (1997) Sleep , vol.20 , pp. 620-629
    • Aldrich, M.1    Chervin, R.2    Malow, B.3
  • 36
    • 85017207387 scopus 로고    scopus 로고
    • AWMF-Leitlinien-register Nr. 030/056: Narkolepsie
    • Available at: [Accessed 25 August 2016]
    • [36] Deutsche Gesellschaft für Neurologie, AWMF-Leitlinien-register Nr. 030/056: Narkolepsie. 2012 Available at: http://www.awmf.org/leitlinien/detail/ll/030-056.html [Accessed 25 August 2016].
    • (2012)
    • Deutsche Gesellschaft für Neurologie1
  • 37
    • 84899054517 scopus 로고    scopus 로고
    • Increased risk of narcolepsy observed also among adults vaccinated with Pandemrix in Finland
    • Available at: [Accessed 23 May 2013]
    • [37] THL Press Release, Increased risk of narcolepsy observed also among adults vaccinated with Pandemrix in Finland. 2013 Available at: https://www.thl.fi/en/web/thlfi-en/whats-new/press-releases-and-news/press-release/-/asset_publisher/dwJikhRa3Ejc/content/increased-risk-of-narcolepsy-observed-also-among-adults-vaccinated-with-pandemrix-in-finland [Accessed 23 May 2013].
    • (2013)
    • THL Press Release1
  • 38
    • 84901000625 scopus 로고    scopus 로고
    • Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination
    • [38] Partinen, M., Kornum, B.R., Plazzi, G., et al. Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination. Lancet Neurol 13 (2014), 600–613.
    • (2014) Lancet Neurol , vol.13 , pp. 600-613
    • Partinen, M.1    Kornum, B.R.2    Plazzi, G.3
  • 39
    • 84918802053 scopus 로고    scopus 로고
    • Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for Pandemrix-associated narcolepsy risk
    • [39] Vaarala, O., Vuorela, A., Partinen, M., et al. Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for Pandemrix-associated narcolepsy risk. Plos One, 9, 2014, e114361.
    • (2014) Plos One , vol.9 , pp. e114361
    • Vaarala, O.1    Vuorela, A.2    Partinen, M.3
  • 40
    • 84992315732 scopus 로고    scopus 로고
    • Post tick-borne encephalitis virus vaccination narcolepsy with cataplexy
    • [40] Hidalgo, H., Kallweit, U., Mathis, J., et al. Post tick-borne encephalitis virus vaccination narcolepsy with cataplexy. Sleep 39 (2016), 1811–1814.
    • (2016) Sleep , vol.39 , pp. 1811-1814
    • Hidalgo, H.1    Kallweit, U.2    Mathis, J.3
  • 41
    • 70349110856 scopus 로고    scopus 로고
    • Narcoleptic patients’ perceptions of nicotine
    • [41] Krahn, L.E., Martin, K.A., Silber, M.H., Narcoleptic patients’ perceptions of nicotine. J Clin Sleep Med, 5, 2009, 390.
    • (2009) J Clin Sleep Med , vol.5 , pp. 390
    • Krahn, L.E.1    Martin, K.A.2    Silber, M.H.3
  • 42
    • 1542471912 scopus 로고    scopus 로고
    • A putative link between childhood narcolepsy and obesity
    • [42] Kotagal, S., Krahn, L.E., Slocumb, N., A putative link between childhood narcolepsy and obesity. Sleep Med 5 (2004), 147–150.
    • (2004) Sleep Med , vol.5 , pp. 147-150
    • Kotagal, S.1    Krahn, L.E.2    Slocumb, N.3
  • 43
    • 79955010031 scopus 로고    scopus 로고
    • Autonomic disturbances in narcolepsy
    • [43] Plazzi, G., Moghadam, K.K., Maggi, L.S., et al. Autonomic disturbances in narcolepsy. Sleep Med Rev 15 (2011), 187–196.
    • (2011) Sleep Med Rev , vol.15 , pp. 187-196
    • Plazzi, G.1    Moghadam, K.K.2    Maggi, L.S.3
  • 44
    • 84914105236 scopus 로고    scopus 로고
    • Clinical features of narcolepsy in children vaccinated with AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine in England
    • [44] Winstone, A.M., Stellitano, L., Verity, C., et al. Clinical features of narcolepsy in children vaccinated with AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine in England. Dev Med Child Neurol 56 (2014), 1117–1123.
    • (2014) Dev Med Child Neurol , vol.56 , pp. 1117-1123
    • Winstone, A.M.1    Stellitano, L.2    Verity, C.3
  • 45
    • 84860390294 scopus 로고    scopus 로고
    • Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
    • [45] Han, F., Lin, L., Warby, S.C., et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol 70 (2011), 410–417.
    • (2011) Ann Neurol , vol.70 , pp. 410-417
    • Han, F.1    Lin, L.2    Warby, S.C.3
  • 46
    • 84881345115 scopus 로고    scopus 로고
    • No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland
    • [46] Melén, K., Partinen, M., Tynell, J., et al. No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland. Plos One, 8, 2013, e68402.
    • (2013) Plos One , vol.8 , pp. e68402
    • Melén, K.1    Partinen, M.2    Tynell, J.3
  • 47
    • 84962113305 scopus 로고    scopus 로고
    • Pandemic influenza vaccine and narcolepsy: simulations on the potential impact of bias
    • [47] Wijnans, L., Dodd, C., de Ridder, M., et al. Pandemic influenza vaccine and narcolepsy: simulations on the potential impact of bias. Expert Rev Vaccines 15 (2016), 573–584.
    • (2016) Expert Rev Vaccines , vol.15 , pp. 573-584
    • Wijnans, L.1    Dodd, C.2    de Ridder, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.