Correction: Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases(PLoS ONE (2017) 12:12 (e0187305) DOI: 10.1371/journal.pone.0187305);Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases

PLoS ONE

Volumn 12, Issue 12, 2017, Pages

  Luo, Guo ^a   Lin, Ling ^a   Jacob, Louis ^a   Bonvalet, Mélodie ^a   Ambati, Aditya ^a   Plazzi, Giuseppe ^b,c   Pizza, Fabio ^b,c   Leib, Ryan ^d   Adams, Christopher M ^d   Partinen, Markku ^e   Mignot, Emmanuel Jean Marie ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c Institute of Neurological Sciences   (Italy)

^d STANFORD UNIVERSITY   (United States)

^e Vitalmed Helsinki Sleep Clinic   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; INFLUENZA VACCINE; OREXIN 2 RECEPTOR; OREXIN RECEPTOR;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; BINDING ASSAY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; MASS SPECTROMETRY; MUTATION; NARCOLEPSY; NONHUMAN; PRESCHOOL CHILD; SCHOOL CHILD; BLOOD; CASE CONTROL STUDY; HEK293 CELL LINE; IMMUNOLOGY;

ADOLESCENT; AUTOANTIBODIES; CASE-CONTROL STUDIES; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; MALE; MASS SPECTROMETRY; NARCOLEPSY; OREXIN RECEPTORS;

EID: 85037650492     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0214340     Document Type: Erratum

References (69)

1. Faraco J, Lin L, Kornum BR, Kenny EE, Trynka G, Einen M, et al. ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy. PLoS genetics. 2013; 9(2):e1003270. Epub 2013/03/06. https://doi.org/10.1371/journal.pgen.1003270 PMID: 23459209
2. Han F, Faraco J, Dong XS, Ollila HM, Lin L, Li J, et al. Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic. PLoS genetics. 2013; 9(10):e1003880–e. https://doi.org/10.1371/journal.pgen.1003880 PMID: 24204295
3. Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nature genetics. 2009; 41(6):708–11. Epub 2009/05/ 05. https://doi.org/10.1038/ng.372 PMID: 19412176
4. Han F, Lin L, Schormair B, Pizza F, Plazzi G, Ollila HM, et al. HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency. Sleep. 2014; 37(10):1601–8. https://doi.org/10.5665/sleep.4066 PMID: 25197808
5. Partinen M, Saarenpaa-Heikkila O, Ilveskoski I, Hublin C, Linna M, Olsen P, et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. PLoS One. 2012; 7(3):e33723. Epub 2012/04/04. https://doi.org/10.1371/journal.pone. 0033723 PMID: 22470463
6. Szakacs A, Darin N, Hallbook T. Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination. Neurology. 2013; 80(14):1315–21. Epub 2013/03/15. https://doi.org/10.1212/WNL.0b013e31828ab26f PMID: 23486871.
7. Heier MS, Gautvik KM, Wannag E, Bronder KH, Midtlyng E, Kamaleri Y, et al. Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A. Sleep medicine. 2013; 14(9):867–71. Epub 2013/06/19. https://doi.org/10.1016/j.sleep.2013.03.020 PMID: 23773727.
8. Miller E, Andrews N, Stellitano L, Stowe J, Winstone AM, Shneerson J, et al. Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis. BMJ. 2013; 346:f794. Epub 2013/02/28.: https://doi.org/10.1136/bmj.f794 PMID: 23444425.
9. O’Flanagan D, Barret AS, Foley M, Cotter S, Bonner C, Crowe C, et al. Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009-December 2010. Euro Surveill. 2014; 19(17):15–25. PMID: 24821121.
10. Dauvilliers Y, Arnulf I, Lecendreux M, Monaca Charley C, Franco P, Drouot X, et al. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain: a journal of neurology. 2013; 136(Pt 8):2486–96. Epub 2013/07/26. https://doi.org/10.1093/brain/awt187 PMID: 23884811.
11. Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkila K, Koskimies S, et al. The prevalence of narcolepsy: an epidemiological study of the Finnish Twin Cohort. Ann Neurol. 1994; 35(6):709–16. https://doi.org/10.1002/ana.410350612 PMID: 8210228.
12. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS One. 2012; 7(3):e33536. Epub 2012/04/04. https://doi.org/10.1371/journal.pone.0033536 PMID: 22470453
13. Han F, Lin L, Warby SC, Faraco J, Li J, Dong SX, et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Annals of neurology. 2011; 70(3):410–7. Epub 2011/08/26. https://doi.org/10.1002/ana.22587 PMID: 21866560.
14. Aran A, Lin L, Nevsimalova S, Plazzi G, Hong SC, Weiner K, et al. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep. 2009; 32(8):979–83. Epub 2009/09/04. PMID: 19725248
15. Koepsell TD, Longstreth WT, Ton TG. Medical exposures in youth and the frequency of narcolepsy with cataplexy: a population-based case-control study in genetically predisposed people. J Sleep Res. 2009; 19(1 Pt 1):80–6. Epub 2009/09/08. https://doi.org/10.1111/j.1365-2869.2009.00756.x PMID: 19732319.
16. Han F, Lin L, Li J, Dong XS, Mignot E. Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. Annals of neurology. 2012. Epub 2012/12/12. https://doi.org/10.1002/ana.23799 PMID: 23225098.
17. Wu H, Zhuang J, Stone WS, Zhang L, Zhao Z, Wang Z, et al. Symptoms and occurrences of narcolepsy: a retrospective study of 162 patients during a 10-year period in eastern China. Sleep Med. 2014; 15(6):607–13. https://doi.org/10.1016/j.sleep.2013.12.012 PMID: 24767723.
18. Oberle D, Drechsel-Bauerle U, Schmidtmann I, Mayer G, Keller-Stanislawski B. Incidence of Narcolepsy in Germany. Sleep. 2015; 38(10):1619–28. https://doi.org/10.5665/sleep.5060 PMID: 25902804
19. Dauvilliers Y, Montplaisir J, Cochen V, Desautels A, Einen M, Lin L, et al. Post-H1N1 narcolepsy-cataplexy. Sleep. 2010; 33(11):1428–30. Epub 2010/11/26. PMID: 21102981
20. Dye TJ, Gurbani N, Simakajornboon N. Epidemiology and Pathophysiology of Childhood Narcolepsy. Paediatr Respir Rev. 2016. https://doi.org/10.1016/j.prrv.2016.12.005 PMID: 28108192.
21. Melen K, Partinen M, Tynell J, Sillanpaa M, Himanen SL, Saarenpaa-Heikkila O, et al. No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland. PLoS One. 2013; 8(8):e68402. Epub 2013/08/21. https://doi.org/10.1371/journal.pone.0068402 PMID: 23950869
22. SMA. A registry based comparative cohort study in four Swedish counties of the risk for narcolepsy after vaccination with Pandemrix—A first and preliminary report Uppsala, Sweden 2011. PDF].
23. Feltelius N, Persson I, Ahlqvist-Rastad J, Andersson M, Arnheim-Dahlström L, Bergman P, et al. A coordinated cross-disciplinary research initiative to address an increased incidence of narcolepsy following the 2009–2010 Pandemrix vaccination programme in Sweden. Journal of Internal Medicine. 2015; 278(4):335–53. https://doi.org/10.1111/joim.12391 PMID: 26123389
24. Gadroen K, Straus SM, Pacurariu A, Weibel D, Kurz X, Sturkenboom MC. Patterns of spontaneous reports on narcolepsy following administration of pandemic influenza vaccine; a case series of individual case safety reports in Eudravigilance. Vaccine. 2016; 34(41):4892–7. https://doi.org/10.1016/j.vaccine.2016.08.062 PMID: 27577558.
25. Montplaisir J, Petit D, Quinn MJ, Ouakki M, Deceuninck G, Desautels A, et al. Risk of narcolepsy associated with inactivated adjuvanted (AS03) A/H1N1 (2009) pandemic influenza vaccine in Quebec. Plos one. 2014;in press.
26. Bardage C, Persson I, Örtqvist Å, Bergman U, Ludvigsson JF, Granath F. Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden. The BMJ. 2011; 343:d5956. https://doi.org/10.1136/bmj.d5956 PMID: 21994316
27. Dauvilliers Y, Arnulf I, Lecendreux M, Monaca Charley C, Franco P, Drouot X, et al. Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France. Brain. 2013; 136 (8):2486–96. https://doi.org/10.1093/brain/awt187 PMID: 23884811
28. Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, et al. AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland. PLOS ONE. 2012; 7(3):e33536. https://doi.org/10.1371/journal.pone.0033536 PMID: 22470453
29. O’Flanagan D, Barret As Fau—Foley M, Foley M Fau—Cotter S, Cotter S Fau—Bonner C, Bonner C Fau—Crowe C, Crowe C Fau—Lynch B, et al. Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009-December 2010. (1560–7917 (Electronic)).
30. Partinen M, Saarenpää-Heikkilä O, Ilveskoski I, Hublin C, Linna M, Olsén P, et al. Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland. PLOS ONE. 2012; 7(3):e33723. https://doi.org/10.1371/journal.pone.0033723 PMID: 22470463
31. Winstone AM, Stellitano L, Verity C, Andrews N, Miller E, Stowe J, et al. Clinical features of narcolepsy in children vaccinated with AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine in England. Developmental Medicine & Child Neurology. 2014; 56(11):1117–23. https://doi.org/10.1111/dmcn. 12522 PMID: 25041214
32. Ahmed SS, Schur PH, Macdonald NE, Steinman L. Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: What is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants. Journal of autoimmunity. 2014. Epub 2014/02/25. https://doi.org/10.1016/j.jaut.2014.01.033 PMID: 24559657.
33. Jacob L, Leib R, Ollila HM, Bonvalet M, Adams CM, Mignot E. Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development. Brain Behav Immun. 2015; 47:44–57. https://doi.org/10.1016/j.bbi.2014.11.004 PMID: 25452148.
34. Clarke SH, Staudt LM, Kavaler J, Schwartz D, Gerhard WU, Weigert MG. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. The Journal of Immunology. 1990; 144(7):2795. PMID: 2108213
35. Kavaler J, Caton AJ, Staudt LM, Gerhard W. A B cell population that dominates the primary response to influenza virus hemagglutinin does not participate in the memory response. European Journal of Immunology. 1991; 21(11):2687–95. https://doi.org/10.1002/eji.1830211107 PMID: 1936117
36. McKean D, Huppi K, Bell M, Staudt L, Gerhard W, Weigert M. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America. 1984; 81(10):3180–4. PMID: 6203114
37. Waffarn EE, Baumgarth N. Protective B cell responses to flu—no fluke! Journal of immunology (Baltimore, Md: 1950). 2011; 186(7):3823–9. https://doi.org/10.4049/jimmunol.1002090 PMID: 21422252
38. Fulvini AA, Ramanunninair M, Le J, Pokorny BA, Arroyo JM, Silverman J, et al. Gene Constellation of Influenza A Virus Reassortants with High Growth Phenotype Prepared as Seed Candidates for Vaccine Production. PLOS ONE. 2011; 6(6):e20823. https://doi.org/10.1371/journal.pone.0020823 PMID: 21695145
39. Robertson JS, Nicolson C, Harvey R, Johnson R, Major D, Guilfoyle K, et al. The development of vaccine viruses against pandemic A(H1N1) influenza. Vaccine. 2011; 29(9):1836–43. https://doi.org/10.1016/j.vaccine.2010.12.044 PMID: 21199698.
40. Nicolson C, Harvey R, Johnson R, Guilfoyle K, Engelhardt OG, Robertson JS. An additional oligosac-charide moiety in the HA of a pandemic influenza H1N1 candidate vaccine virus confers increased antigen yield in eggs. Vaccine. 2012; 30(4):745–51. https://doi.org/10.1016/j.vaccine.2011.11.081 PMID: 22138177.
41. Robertson JS, Nicolson C, Harvey R, Johnson R, Major D, Guilfoyle K, et al. The development of vaccine viruses against pandemic A(H1N1) influenza. Vaccine. 2011; 29(9):1836–43. https://doi.org/10.1016/j.vaccine.2010.12.044. PMID: 21199698
42. Vaarala O, Vuorela A, Partinen M, Baumann M, Freitag TL, Meri S, et al. Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for pandemrix-associated narcolepsy risk. PLoS One. 2014; 9(12):e114361. https://doi.org/10.1371/journal.pone.0114361 PMID: 25501681
43. Ahmed SS, Volkmuth W, Duca J, Corti L, Pallaoro M, Pezzicoli A, et al. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. Sci Transl Med. 2015; 7(294):294ra105. https://doi.org/10.1126/scitranslmed.aab2354 PMID: 26136476.
44. Summary of Product Characteristics-Pandemrix. URL 'http://www.ema.europa.eu/docs/en_GB/ document_library/EPAR_-_Product_Information/human/000832/WC500038121.pdf'
45. Assessment Report for Arepanrix-European Medicines Agency. URL 'http://www.ema.europa.eu/ docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/001201/WC500089740. pdf'
46. R Core Team R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2014;URL 'http://www.RProject.org'.
47. Chaturvedi P, Hengeveld R, Zechel MA, Lee-Chan E, Singh B. The functional role of class II-associated invariant chain peptide (CLIP) in its ability to variably modulate immune responses. International Immunology. 2000; 12(6):757–65. https://doi.org/10.1093/intimm/12.6.757 PMID: 10837403
48. Stern LJ, Potolicchio I, Santambrogio L. MHC class II compartment subtypes: structure and function. Curr Opin Immunol. 2006; 18(1):64–9.: https://doi.org/10.1016/j.coi.2005.11.005 PMID: 16337363.
49. Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA. Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif. J Mol Biol. 2003; 326(4):1157–74.: https://doi.org/10.1016/s0022-2836(02)01437-7 PMID: 12589760.
50. Mellins ED, Stern LJ. HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation. Curr Opin Immunol. 2014; 0:115–22. https://doi.org/10.1016/j.coi.2013.11.005 PMID: 24463216
51. Yin L, Maben ZJ, Becerra A, Stern LJ. Evaluating the Role of HLA-DM in MHC Class II–Peptide Association Reactions. The Journal of Immunology. 2015; 195(2):706. https://doi.org/10.4049/jimmunol. 1403190 PMID: 26062997
52. DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Molecular and Cellular Biology. 1987; 7(1):379–87. PMID: 3031469
53. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proceedings of the National Academy of Sciences of the United States of America. 1993; 90(18):8392–6. PMID: 7690960
54. Amatoury M, Merheb V, Langer J, Wang XM, Dale RC, Brilot F. High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum. Journal of Visualized Experiments: JoVE. 2013;(81):50935. https://doi.org/10.3791/ 50935 PMID: 24300941
55. Van Elssen CHMJ, Clausen H, Germeraad WTV, Bennet EP, Menheere PP, Bos GMJ, et al. Flow cytometry-based assay to evaluate human serum MUC1-Tn antibodies. Journal of Immunological Methods. 2011; 365(1–2):87–94. http://dx.doi.org/10.1016/j.jim.2010.12.006. PMID: 21194532
56. Tanaka S, Honda Y, Inoue Y, Honda M. Detection of autoantibodies against hypocretin, hcrtrl, and hcrtr2 in narcolepsy: anti-Hcrt system antibody in narcolepsy. Sleep. 2006; 29(5):633–8. Epub 2006/06/ 16. PMID: 16774153.
57. Kao FT, Puck TT. Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells. Proceedings of the National Academy of Sciences of the United States of America. 1968; 60(4):1275–81. PMID: 5244736
58. Kao F-T, Johnson RT, Puck TT. Complementation Analysis on Virus-Fused Chinese Hamster Cells with Nutritional Markers. Science. 1969; 164(3877):312. PMID: 5813351
59. Nielsen M, Lund O. NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction. BMC Bioinformatics. 2009; 10:296-. https://doi.org/10.1186/1471-2105-10-296 PMID: 19765293
60. Nielsen M, Lundegaard C, Lund O. Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method. BMC Bioinformatics. 2007; 8(1):238. https://doi.org/10.1186/ 1471-2105-8-238 PMID: 17608956
61. Giannoccaro MP, Waters P, Pizza F, Liguori R, Plazzi G, Vincent A. Antibodies against hypocretin receptor 2 are rare in narcolepsy. Sleep. 2016.
62. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, et al. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol. 2001; 435(1):6–25. PMID: 11370008.
63. Vassalli A, Li S, Tafti M. Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2". Sci Transl Med. 2015; 7(314):314le2. https://doi.org/10.1126/scitranslmed. aad2353 PMID: 26582896.
64. Cvetkovic-Lopes V, Bayer L, Dorsaz S, Maret S, Pradervand S, Dauvilliers Y, et al. Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients. The Journal of Clinical Investigation. 2010; 120(3):713–9. https://doi.org/10.1172/JCI41366 PMID: 20160349
65. Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, et al. IGFBP3 Colocalizes with and Regulates Hypocretin (Orexin). PLOS ONE. 2009; 4(1):e4254. https://doi.org/10.1371/journal.pone.0004254 PMID: 19158946
66. Dalal J, Roh JH, Maloney SE, Akuffo A, Shah S, Yuan H, et al. Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation. Genes & Development. 2013; 27(5):565–78. https://doi.org/10.1101/gad.207654.112 PMID: 23431030
67. Aran A, Weiner K, Lin L, Finn LA, Greco MA, Peppard P, et al. Post-streptococcal auto-antibodies inhibit protein disulfide isomerase and are associated with insulin resistance. PLoS One. 2010; 5(9):e12875. Epub 2010/10/05. https://doi.org/10.1371/journal.pone.0012875 PMID: 20886095
68. Deloumeau A, Bayard S, Coquerel Q, Dechelotte P, Bole-Feysot C, Carlander B, et al. Increased immune complexes of hypocretin autoantibodies in narcolepsy. PLoS One. 2010; 5(10):e13320. Epub 2010/10/23. https://doi.org/10.1371/journal.pone.0013320 PMID: 20967199
69. Skowronski DM, Janjua NZ, De Serres G, Sabaiduc S, Eshaghi A, Dickinson JA, et al. Low 2012–13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses. PLoS One. 2014; 9(3):e92153. https://doi.org/10.1371/journal.pone.0092153 PMID: 24667168