Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: Inhibiting viral replication and decreasing viral entry

Cell Discovery

Volumn 4, Issue 1, 2018, Pages

  Yang, Shu ^a   Xu, Miao ^a   Lee, Emily M ^b   Gorshkov, Kirill ^a   Shiryaev, Sergey A ^c   He, Shihua ^d   Sun, Wei ^a   Cheng, Yu Shan ^a   Hu, Xin ^a   Tharappel, Anil Mathew ^b   Lu, Billy ^a   Pinto, Antonella ^c   Farhy, Chen ^c   Huang, Chun Teng ^c   Zhang, Zirui ^d   Zhu, Wenjun ^d   Wu, Yuying ^b   Zhou, Yi ^b   Song, Guang ^e   Zhu, Heng ^e   Shamim, Khalida ^a   Martínez Romero, Carles ^f   García Sastre, Adolfo ^f   Preston, Richard A ^g   Jayaweera, Dushyantha T ^g   Huang, Ruili ^a   Huang, Wenwei ^a   Xia, Menghang ^a   Simeonov, Anton ^a   Ming, Guoli ^h   Qiu, Xiangguo ^d,i   Terskikh, Alexey V ^c   Tang, Hengli ^b   Song, Hongjun ^h   Zheng, Wei ^a   more..

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c BURNHAM INSTITUTE   (United States)

^d PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

ⁱ UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CEPHAELINE; CHLOROQUINE; EMETINE; NONSTRUCTURAL PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CC50; CELL LYSATE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG TOLERANCE; EBOLA HEMORRHAGIC FEVER; FEMALE; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LD50; LYSOSOME; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SNB-19 CELL LINE; VERO C1008 CELL LINE; VERO CELL LINE; VIRUS ENTRY; VIRUS INHIBITION; VIRUS LOAD; VIRUS PARTICLE; VIRUS REPLICATION; WESTERN BLOTTING; ZIKA FEVER;

EID: 85048122680     PISSN: None     EISSN: 20565968     Source Type: Journal    
DOI: 10.1038/s41421-018-0034-1     Document Type: Article

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